Sensitization of multidrug resistant (MDR) cancer cells to vinblastine by novel acridones: Correlation between anti-calmodulin activity and anti-MDR activity

Medicinal Chemistry

Volumn 2, Issue 1, 2006, Pages 63-77

  Mayur, Y C ^b   Padma, T ^c   Parimala, B H ^a   Chandramouli, K H ^d   Jagadeesh, S ^e   Made Gowda, N M ^a   Thimmaiah, K N ^a  

^a WESTERN ILLINOIS UNIVERSITY   (United States)

^b V L COLLEGE OF PHARMACY   (India)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^d UNIVERSITY OF SOUTH ALABAMA   (United States)

^e GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

2 Bromoacridones; Anti calmodulin activity; Anti MDR activity; Correlation study; Structure activity relationships

Indexed keywords

10 (3' MORPHOLINOPROPYL) 2 BROMOACRIDONE; 10 (3' N CHLOROPROPYL) 2 BROMOACRIDONE; 10 (3' N PIPERIDINOPROPYL) 2 BROMOACRIDONE; 10 (3' N PYRROLIDINOPROPYL) 2 BROMOACRIDONE; 10 (3' N THIOMORPHOLINOPROPYL) 2 BROMOACRIDONE; 10 (4' N CHLOROBUTYL) 2 BROMOACRIDONE; 10 (4' N MORPHOLINOBUTYL) 2 BROMOACRIDONE; 10 (4' N PIPERIDINOBUTYL) 2 BROMOACRIDONE; 10 (4' N PYRROLIDINOBUTYL) 2 BROMOACRIDONE; 10 [3' [N (BETA HYDROXYETHYL)PIPERAZINO]PROPYL] 2 BROMOACRIDONE; 10 [4' (N DIETHYLAMINO)BUTYL] 2 BROMOACRIDONE; 10 [4' N (METHYLPIPERAZINO)BUTYL] 2 BROMOACRIDONE; 2 BROMOACRIDONE; ACRIDINE DERIVATIVE; ACRIDONE DERIVATIVE; AMINE; ANILINE DERIVATIVE; AZIDOPINE; BROMINE; CALMODULIN; CHLOROBENZOIC ACID DERIVATIVE; CYCLIC AMP PHOSPHODIESTERASE; GLYCOPROTEIN P; HYDROGEN; IODIDE; MEMBRANE PROTEIN; TRITIUM; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERAPAMIL; VINBLASTINE;

ALKYLATION; ARTICLE; CANCER CELL; CATALYSIS; CATALYST; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG SENSITIZATION; DRUG TREATMENT FAILURE; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ACRIDINES; ALKYLATION; ANILINE COMPOUNDS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BENZILATES; CALMODULIN; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG SYNERGISM; HUMANS; INHIBITORY CONCENTRATION 50; KB CELLS; P-GLYCOPROTEIN; P-GLYCOPROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; VINBLASTINE;

EID: 33746131563     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340606775197732     Document Type: Article

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