Structure-activity relationship study of the cell-penetrating peptide pVEC

Biochimica et Biophysica Acta - Biomembranes

Volumn 1758, Issue 6, 2006, Pages 721-729

  Elmquist, Anna ^a   Hansen, Mats ^a   Langel, Ülo ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Cell penetrating peptide; Cellular uptake; l Ala scan, S.A.R study; pVEC; VE cadherin

Indexed keywords

9 (N ETHYL N ISOPROPYL)AMILORIDE; ALANINE; AMILORIDE DERIVATIVE; AMINO ACID; ARGININE; CARBOXYFLUORESCEIN; HEPARIN LYASE; NYSTATIN; PEPTIDE DERIVATIVE; SERINE; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN; WORTMANNIN;

AMINO ACID COMPOSITION; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CELL TRANSPORT; CHEMICAL LABELING; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXICITY; ENDOCYTOSIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; INTERNALIZATION; MELANOMA CELL; MONITORING; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN TRANSPORT; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; CELL LINE, TUMOR; ENDOCYTOSIS; HUMANS; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; PEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

MURINAE;

EID: 33746060161     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamem.2006.05.013     Document Type: Article

References (30)

1. Rousselle C., Clair P., Lefauconnier J.M., Kaczorek M., Scherrmann J.M., and Temsamani J. New advances in the transport of doxorubicin through the blood-brain barrier by a peptide vector-mediated strategy. Mol. Pharmacol. 57 (2000) 679-686
2. Pooga M., Soomets U., Hällbrink M., Valkna A., Saar K., Rezaei K., Kahl U., Hao J.X., Xu X.J., Wiesenfeld-Hallin Z., Hökfelt T., Bartfai T., and Langel Ü. Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo. Nat. Biotechnol. 16 (1998) 857-861
3. Elmquist A., Lindgren M., Bartfai T., and Langel Ü. VE-cadherin-derived cell-penetrating peptide, pVEC, with carrier functions. Exp. Cell. Res 269 (2001) 237-244
4. Elmquist A., and Langel Ü. In vitro uptake and stability study of pVEC and its all-D analog. Biol. Chem. 384 (2003) 387-393
5. Säälik P., Elmquist A., Hansen M., Padari K., Saar K., Viht K., Langel Ü., and Pooga M. Protein cargo delivery properties of cell-penetrating peptides. A comparative study. Bioconjug. Chem. 15 (2004) 1246-1253
6. Nekhotiaeva N., Elmquist A., Rajarao G.K., Hällbrink M., Langel Ü., and Good L. Cell entry and antimicrobial properties of eukaryotic cell-penetrating peptides. FASEB J. 18 (2004) 394-396
7. Suzuki T., Futaki S., Niwa M., Tanaka S., Ueda K., and Sugiura Y. Possible existence of common internalization mechanisms among arginine-rich peptides. J. Biol. Chem. 277 (2002) 2437-2443
8. Fischer R., Kohler K., Fotin-Mleczek M., and Brock R. A stepwise dissection of the intracellular fate of cationic cell-penetrating peptides. J. Biol. Chem. 279 (2004) 12625-12635
9. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
10. Korzeniewski C., and Callewaert D.M. An enzyme-release assay for natural cytotoxicity. J. Immunol. Methods 64 (1983) 313-320
11. Simonsen A., Lippe R., Christoforidis S., Gaullier J.M., Brech A., Callaghan J., Toh B.H., Murphy C., Zerial M., and Stenmark H. EEA1 links PI(3)K function to Rab5 regulation of endosome fusion. Nature 394 (1998) 494-498
12. Rothberg K.G., Ying Y.S., Kamen B.A., and Anderson R.G. Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate. J. Cell Biol. 111 (1990) 2931-2938
13. Rothberg K.G., Heuser J.E., Donzell W.C., Ying Y.S., Glenney J.R., and Anderson R.G. Caveolin, a protein component of caveolae membrane coats. Cell 68 (1992) 673-682
14. Yahalom J., Eldor A., Fuks Z., and Vlodavsky I. Degradation of sulfated proteoglycans in the subendothelial extracellular matrix by human platelet heparitinase. J. Clin. Invest. 74 (1984) 1842-1849
15. West M.A., Bretscher M.S., and Watts C. Distinct endocytotic pathways in epidermal growth factor-stimulated human carcinoma A431 cells. J. Cell Biol. 109 (1989) 2731-2739
16. Richard J.P., Melikov K., Vivés E., Ramos C., Verbeure B., Gait M.J., Chernomordik L.V., and Lebleu B. Cell-penetrating peptides. A reevaluation of the mechanism of cellular uptake. J. Biol. Chem. 278 (2003) 585-590
17. Thorén P.E., Persson D., Isakson P., Goksör M., Önfelt A., and Nordén B. Uptake of analogs of penetratin, Tat(48-60) and oligoarginine in live cells. Biochem. Biophys. Res. Commun. 307 (2003) 100-107
18. Weigel P.H., and Oka J.A. Temperature dependence of endocytosis mediated by the asialoglycoprotein receptor in isolated rat hepatocytes. Evidence for two potentially rate-limiting steps. J. Biol. Chem. 256 (1981) 2615-2617
19. Silverstein S.C., Steinman R.M., and Cohn Z.A. Endocytosis. Annu. Rev. Biochem. 46 (1977) 669-722
20. Wender P.A., Mitchell D.J., Pattabiraman K., Pelkey E.T., Steinman L., and Rothbard J.B. The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 13003-13008
21. Drin G., Mazel M., Clair P., Mathieu D., Kaczorek M., and Temsamani J. Physico-chemical requirements for cellular uptake of pAntp peptide. Role of lipid-binding affinity. Eur. J. Biochem. 268 (2001) 1304-1314
22. Fischer P.M., Zhelev N.Z., Wang S., Melville J.E., Fahraeus R., and Lane D.P. Structure-activity relationship of truncated and substituted analogues of the intracellular delivery vector Penetratin. J. Pept. Res. 55 (2000) 163-172
23. Soomets U., Lindgren M., Gallet X., Hällbrink M., Elmquist A., Balaspiri L., Zorko M., Pooga M., Brasseur R., and Langel Ü. Deletion analogues of transportan. Biochim. Biophys. Acta 1467 (2000) 165-176
24. Lindgren M., Gallet X., Soomets U., Hällbrink M., Bråkenhielm E., Pooga M., Brasseur R., and Langel Ü. Translocation properties of novel cell penetrating transportan and penetratin analogues. Bioconjug. Chem. 11 (2000) 619-626
25. Scheller A., Oehlke J., Wiesner B., Dathe M., Krause E., Beyermann M., Melzig M., and Bienert M. Structural requirements for cellular uptake of alpha-helical amphipathic peptides. J. Pept. Sci. 5 (1999) 185-194
26. Futaki S., Suzuki T., Ohashi W., Yagami T., Tanaka S., Ueda K., and Sugiura Y. Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery. J. Biol. Chem. 276 (2001) 5836-5840
27. Mitchell D.J., Kim D.T., Steinman L., Fathman C.G., and Rothbard J.B. Polyarginine enters cells more efficiently than other polycationic homopolymers. J. Pept. Res. 56 (2000) 318-325
28. Wadia J.S., Stan R.V., and Dowdy S.F. Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis. Nat. Med. 10 (2004) 310-315
29. Nakase I., Niwa M., Takeuchi T., Sonomura K., Kawabata N., Koike Y., Takehashi M., Tanaka S., Ueda K., Simpson J.C., Jones A.T., Sugiura Y., and Futaki S. Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement. Mol. Ther. 10 (2004) 1011-1022
30. Araki N., Johnson M.T., and Swanson J.A. A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages. J. Cell Biol. 135 (1996) 1249-1260