Increased in vitro activation of EGFR by membrane-bound TGF-α from gastric and colonic mucosa of aged rats

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 281, Issue 1 44-1, 2001, Pages

  Xiao, Z Q ^a   Majumdar, A P N ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Autocrine juxtacrine mechanism; Epidermal growth factor receptor signal transduction; Transforming growth factor ; Tyrosine kinase

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; TRANSFORMING GROWTH FACTOR ALPHA;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; COLON MUCOSA; CONTROLLED STUDY; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; MEMBRANE BINDING; MUCOSA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; STEM CELL; STOMACH MUCOSA;

EID: 0034814931     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2001.281.1.g111     Document Type: Article

References (31)

1. Gastrointestinal proliferation and aging
2. Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology
3. Autocrine regulation of membrane transforming growth factor-α cleavage
4. Transmembrane TGF-α precursors activate EGF/TGF-α receptors
5. Transforming growth factor α and epidermal growth factor levels in normal human gastrointestinal mucosa
6. Human transforming growth factor-alpha: Precursor structure and expression in E. coli
7. Heterodimerization and functional interaction between EGF receptor family members: A new signaling paradigm with implications for breast cancer research
8. Colonic proliferation is increased in senescent rats
9. Altered controls of proliferation in proximal small intestine of senescent rat
10. Aging and cancer of the stomach and colon
11. Regulation of gastrointestinal mucosal growth
12. Gene expression of keratinocyte and hepatocyte growth factors during the healing of rat gastric mucosal lesions
13. Cloning and sequence analysis of a cDNA for rat transforming growth factoralpha
14. Aging: Altered responsiveness of gastric mucosa to epidermal growth factor
15. Gastrin: Levels and trophic action during advancing age
16. Morphological and biochemical changes in gastric mucosa of aged rats
17. Effect of aging on the gastrointestinal tract and pancreas
18. Role of tyrosine kinases in bombesin regulation of gastric mucosal proliferative activity in young and aged rats
19. Increased activation of EGF-receptor tyrosine kinase by EGF and TGF-α in the colonic mucosa of aged rats
20. Epidermal growth factor-like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A 431 cells
21. Signal transduction cascades triggered by EGF receptor activation. Relevance to gastric injury repair and ulcer healing
22. Cleavage of membrane precursor for transforming growth factor alpha is a regulated process
23. Peptide growth factors in the gastrointestinal tract
24. Transforming growth factor a receptor binding sites in the canine gastrointestinal tract
25. Increased expression of EGFR in gastric mucosa of aged rats
26. Aging alters gastric mucosal responses to epidermal growth factor and transforming growth factor-α
27. Signal transduction by receptors with tyrosine kinase activity
28. Affinity chromatography
29. 1 phase in the colonic mucosa of aged rats
30. Induction of transcriptional activity of AP-1 and NF-κB in the gastric mucosa during aging
31. 1 checkpoint in the gastric mucosa of aged rats