Nanotechnology for cancer diagnostics: Promises and challenges

Expert Review of Molecular Diagnostics

Volumn 6, Issue 3, 2006, Pages 307-318

  Grodzinski, Piotr ^a   Silver, Mike ^b   Molnar, Linda K ^a,c  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Feinstein Kean Healthcare   (United States)

^c SCIENCE APPLICATIONS INTERNATIONAL CORPORATION   (United States)

Author keywords

Biosensor; Cancer; Image contrast; Molecular diagnostics; Nanocantilever; Nanoparticle; Nanotechnology; Nanotube; Nanowire; Quantum dot

Indexed keywords

BIOSENSOR; CANCER DIAGNOSIS; DIAGNOSTIC IMAGING; IN VITRO STUDY; IN VIVO STUDY; NANOTECHNOLOGY; REVIEW; ANIMAL; DIAGNOSTIC PROCEDURE; GENETIC PROCEDURES; GENETICS; HUMAN; METABOLISM; METASTASIS; METHODOLOGY; MOUSE; NANOMEDICINE; NEOPLASM; NUCLEAR MAGNETIC RESONANCE IMAGING; SENSITIVITY AND SPECIFICITY; WHOLE BODY IMAGING;

CONTRAST MEDIUM;

ANIMALS; BIOSENSING TECHNIQUES; CONTRAST MEDIA; HUMANS; MAGNETIC RESONANCE IMAGING; MICE; MOLECULAR DIAGNOSTIC TECHNIQUES; NANOMEDICINE; NANOTECHNOLOGY; NEOPLASM METASTASIS; NEOPLASMS; SENSITIVITY AND SPECIFICITY; WHOLE BODY IMAGING;

EID: 33745959582     PISSN: 14737159     EISSN: 17448352     Source Type: Journal    
DOI: 10.1586/14737159.6.3.307     Document Type: Review

References (77)

1. Edwards BK, Brown M, Wingo PA et al. Annual report to the nation on the status of cancer, 1975-2002, featuring population-based trends in cancer treatment. J. Natl Cancer Inst. 97(19), 1407-1427 (2005).
2. Rosenthal A, Jacobs I. Ovarian cancer screening. Semin Oncol. 25(3), 315-325 (1998).
3. Ferrari M. Cancer nanotechnology: opportunities and challenges. Nature Rev. Cancer 5(3), 161-171 (2005). • Concerns in cancer nanotechnology.
4. Fortina P, Kricka LJ, Surrey S, Grodzinski P. Nanobiotechnology: the promise and reality of new approaches to molecular recognition. Trends Biotechnol. 23(4), 168-173 (2005).
5. Whitesides GM. The 'right' size in nanobiotechnology. Nature Biotechnol. 21(10), 1161-11655 (2003). • Smart review of techniques that constitute nanobiotechnology.
6. Wickline SA, Lanza GM. Molecular imaging, targeted therapeutics, and nanoscience. J. Cell. Biochem. Suppl. 39, 90-97 (2002).
7. Morawski AM, Lanza GA, Wickline SA. Targeted contrast agents for magnetic resonance imaging and ultrasound. Curr. Opin. Biotechnol. 16(1), 89-92 (2005).
8. Chan WC, Nie S. Luminescent quantum dots for multiplexed biological detection and imaging. Curr. Opin. Biotechnol. 13, 40-46 (2002). • Fundamental paper on the use of quantum dots for in vivo imaging.
9. Gao X, Cui Y, Levenson RM, Chung LWK, Nie S. In vivo cancer targeting and imaging with semiconductor quantum dots. Nature Biotechnol. 22, 969-976 (2004).
10. Michalet X, Pinaud FF, Bentolila LA et al. Quantum dots for live cells, in vivo imaging, and diagnostics. Science 307, 538-544 (2005). • Very nice, comprehensive review of quantum dot applications.
11. Fritz J, Baller MK, Lang HP et al. Translating biomolecular recognition into nanomechanics. Science 288, 316-318 (2000). • Fundamental paper on the concept of label-free sensors using cantilevers.
12. Saleh OA, Sohn LL. Direct detection of antibody-antigen binding using an on-chip artificial pore. Proc. Natl Acad. Sci. USA 100(3), 820-824 (2003).
13. Cui Y, Wei Q, Park H, Lieber CM. Nanowire nanosensors for highly sensitive and selective detection of biological and chemical species. Science 293, 1289-12992 (2001).
14. Chen RJ, Bangsaruntip S, Drouvalakis KA et al. Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors. Proc. Natl Acad. Sci. USA 100(9), 4984-4989 (2003).
15. Kukowska-Latallo JF, Candido KA, Cao Z et al. Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer. Cancer Res. 65(12), 5317-5324 (2005). • Early demonstration of a multifunctional nanoplatform that is capable of targeting, imaging and treating tumor in animals.
16. West JL, Halas NJ. Engineered nanomaterials for biophotonics applications: improving sensing, imaging, and therapeutics. Ann. Rev. Biomed. Eng. 5, 285-292 (2003).
17. Walt DR. Techview: molecular biology. Bead based fiber optic arrays. Science 287, 451-452 (2000).
18. Venditto VJ, Regino CAS, Brechbiel MW. PAMAM dendrimer based macromolecules as improved contrast agents. Mol. Pharm. 2, 302-311 (2005).
19. Gabizon A, Martin F. Polyethylene glycol-coated (pegylated) liposomal doxorubicin: rationale for use in solid tumors. Drugs 54(Suppl. 4), 15-21 (1997).
20. Tomalia DA, Baker H, Dewald J et al. A new class of polymers: starburst dendritic macromolecules. Polymer J. 17, 117-132 (1985).
21. Tomalia DA. The dendritic state. Mat. Today 8(3), 34-46 (2005).
22. Wilson SR. Nanomedicine: fullerene and carbon nanotube biology. In: Perspectives in Fullerene Nanotechnology. Osawa E (Ed.), Kluwer Academic Publishers, Dordrecht, Netherlands, 155-163 (2002).
23. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 100(1), 57-70 (2000).
24. Sitharaman B, Kissell KR, Hartman KB et al. Superparamagnetic gadonanotubes are high-performance MRI contrast agents. Chem. Commun. 3915-3917 (2005).
25. Kobayashi H, Kawamoto S, Sakai Y et al. Lymphatic drainage imaging of breast cancer in mice by micro-magnetic resonance lymphangiography using a nano-size paramagnetic contrast agent. J. Natl Cancer Inst. 96(9), 703-708 (2004).
26. Harishinghani MG, Barentsz J, Hahn PF et al. Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N. Engl. J. Med. 348, 2491-2499 (2003).
27. Wisner ER, Ferrara KW, Short RE, Ottoboni TB, Gabe JD, Patel D. Sentinel node detection using contrast enhanced power Doppler ultrasound lymphography. Invest. Radiol. 38(6), 358-365 (2003).
28. Alivisatos P. Semiconductor clusters, nanocrystals, and quantum dots. Science 271, 933-937 (1996).
29. Bruchez M Jr, Moronne M, Gin P, Weiss S, Alivisatos AP. Semiconductor nanocrystals as fluorescent biological labels. Science 281(5385), 2013-2016 (1998).
30. Lim YT, Kim S, Nakayama A, Stott NE, Bawendi MG, Frangioni JV. Selection of quantum dot wavelengths for biomedical assays and imaging. Mol. Imaging 2, 50-64 (2003).
31. Kim S, Lim YT, Soltesz EG et al. Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping. Nature Biotechnol. 22(1), 93-97 (2004).
32. Medintz IL, Uyeda HT, Goldman ER, Mattoussi H. Quantum dot bioconjugates for imaging, labelling and sensing. Nature Mater. 4, 435-446 (2005).
33. Wu X, Liu H, Liu J et al. Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots. Nature Biotechnol. 21, 41-46 (2003).
34. Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86, 353-364 (1996).
35. Winter PM, Caruthers SD, Kassner A et al. Molecular imaging of angiogenesis in nascent Vx-2 rabbit tumors using a novel α(nu)β(3)- targeted nanoparticle and 1.5 tesla magnetic resonance imaging. Cancer Res. 63, 5838-5843 (2003). • Targeting angiogenic vasculature for in vivo imaging.
36. Anderson SA, Wickline SA, Kotyk JJ. Magnetic resonance contrast enhancement of neovasculature with α(nu)β(3) targeted nanoparticles. Magn. Reson. Med. 44, 433-439 (2000).
37. Schmieder AH, Winter PM, Caruthers SD et al. Molecular MR imaging of melanoma angiogenesis with α(nu)β(3)-targeted paramagnetic nanoparticles. Magn. Reson. Med. 53(3), 621-627 (2005).
38. Schellenberger EA, Reynolds F, Weissleder R, Josephson L. Surface-functionalized nanoparticle library yields probes for apoptotic cells. Chembiochem 5(3), 275-279 (2004).
39. Gao X, Chan WC, Nie S. Quantum dot nanocrystals for ultrasensitive biological labeling and multicolor optical encoding. J. Biomed. Opt. 7, 532-537 (2002).
40. Louie AY, Huber MM, Ahrens ET et al. In vivo visualization of gene expression using magnetic resonance imaging. Nature Biotechnol. 18, 321-325 (2000).
41. Chang E, Miller JS, Sun J et al. Protease-activated quantum dot probes. Biochem. Biophys. Res. Commun. 334, 1317-1321 (2005).
42. Liu RH, Yang J, Lenigk R, Bonanno J, Grodzinski P. Self-contained, fully integrated biochip for sample preparation, polymerase chain reaction amplification, and DNA microarray detection. Anal. Chem. 76(7), 1824-1831 (2004).
43. Wang YC, Stevens AL, Han J. Million-fold preconcentration of proteins and peptides by nanofluidic filter. Anal. Chem. 77(14), 4293-4299 (2005).
44. Fodor SP, Read JL, Pirrung MC, Stryer L, Lu AT, Solas D. Light-directed, spatially addressable parallel chemical synthesis. Science 251(4995), 767-773 (1991).
45. Nuwaysir EF, Huang W, Albert TJ, Singh J, Nuwaysir K et al. Gene expression analysis using oligonucleotide arrays produced by maskless photolithography. Genome Res. 12, 1749-1755 (2002). • Mask-free synthesis of DNA microarrays.
46. Li J, Ng TG, Cassell A et al. Carbon nanotube nanoelectrode array for ultrasensitive DNA detection. Nano Lett. 3, 597-602 (2003).
47. Lee KB, Lim JH, Mirkin CA. Protein nanostructures formed via direct-write dip-pen nanolithography. J. Am. Chem. Soc. 125, 5588-5589 (2003).
48. Lee KB, Park SJ, Mirkin CA, Smith JC, Mrksich M. Protein nanoarrays generated by dip-pen nanolithography. Science 295(5560), 1702-1705 (2002).
49. Arntz Y, Seelig JD, Lang HP et al. Label-free protein assay based on a nanomechanical cantilever array. J. Nanotechnol. 14, 86-90 (2003).
50. McKendry R, Zhang J, Arntz Y et al. Multiple label-free biodetection and quantitative DNA-binding assays on a nanomechanical cantilever array. Proc. Natl Acad. Sci. USA 99, 9783-9788 (2002).
51. Wu G, Datar RH, Hansen KM, Thundat T, Cote RJ, Majumdar A. Bioassay of prostate-specific antigen (PSA) using microcantilevers. Nature Biotechnol. 19(9), 856-860 (2001).
52. Ilic B, Yang Y, Aubin K, Reichenbach R, Krylov S, Craighead HG. Enumeration of DNA molecules bound to a nanomechanical oscillator. Nano Lett. 5(5), 925-929 (2005).
53. Jin S, Whang D, McAlpine MC, Friedman RS, Wu Y, Lieber CM. Scalable interconnection and integration of nanowire devices without registration. Nano Lett. 4, 915-919 (2004).
54. Nicewarner-Pena SR, Freeman RG, Reiss BD et al. Submicrometer metallic barcodes. Science 294, 137-141 (2001). • Clever multiplex scheme for molecular labeling.
55. Dejneka MJ, Streltsov A, Pal S et al. Rare earth-doped glass microbarcodes. Proc. Natl Acad. Sci. USA 100, 389-393 (2003).
56. Park SJ, Taton TA, Mirkin CA. Array-based electrical detection of DNA with nanoparticle probes. Science 295, 1503-1506 (2002).
57. Hirsch LR, Jackson JB, Lee A, Halas NJ, West JL. A whole blood immunoassay using gold nanoshells. Anal. Chem. 75(10), 2377-2381 (2003).
58. Nam JM, Thaxton CS, Mirkin CA. Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins. Science 301(5641), 1884-1886 (2003). • High sensitivity, barcode DNA assay.
59. Nam JM, Stoeva SI, Mirkin CA. Bio-barcode-based DNA detection with PCR-like sensitivity. J. Am. Chem. Soc. 126(19), 5932-5933 (2004).
60. Sayes C, Fortner J, Lyon D et al. The differential cytotoxicity of water-soluble fullerenes. Nano Lett. 4, 1881-1887 (2004).
61. 60) induce oxidative stress in the brain of juvenile largemouth bass. Eviron. Health Perspect. 112, 1058-1062 (2004).
62. Derfus AM, Chan WCW, Bhatia SN. Probing the cytotoxicity of semiconductor quantum dots. Nano Lett. 4, 11-18 (2004).
63. Lovric J, Cho SJ, Winnik FM, Maysinger D. Unmodified cadmium telluride quantum dots induce reactive oxygen species formation leading to multiple organelle damage and cell death. Chem. Biol. 12(11), 1227-1234 (2005).
64. Ferrari M, Downing G. Medical nanotechnology: shortening clinical trials and regulatory pathways? BioDrugs 19(4), 203-210 (2005).
65. Buetow KH. Cyberinfrastructure: empowering a "third way" in biomedical research. Science 308, 821-824 (2005).
66. Kobayashi H, Brechbiel MW. Dendrimer-based nanosized MRI contrast agents. Curr. Pharm. Biotechnol. 5, 539-549 (2004).
67. Websites
68. Ries LAG, Eisner MP, Kosary CL et al. (Eds) SEER Cancer Statistics Review, 1975-2002, National Cancer Institute, MD, USA http://seer.cancer.gov/ csr/1975_2002 (Viewed September 2005).
69. National Nanotechnology Initiative: What is Nanotechnology? www.nano.gov/html/facts/whatIsNano.html
70. Kang HK, Seo J, Di Carlo D, Choi Y-K, Lee LP. Planar nanogap capacitor arrays on quartz for optical and dielectric bioassays. 7th Int. Conf. On Miniaturized Chem. Biochem. Anal. Systems. CA, USA (2003) www.chem.ualberta.ca/ ~microtas/Volume1/173-473.pdf (Viewed September 2005).
71. The Royal Society & The Royal Academy of Engineering. Nanoscience and nanotechnologies: opportunities and uncertainties (2004) www.nanotec.org.uk/ finalReport.htm (Viewed September 2005).
72. National Cancer Institute: Nanotechnology Characterization Lab http://NCL.cancer.gov
73. National Cancer Institute Alliance for Nanotechnology in Cancer http://nano.cancer.gov
74. American Cancer Society: Overview: Breast Cancer www.cancer.org/docroot/ CRI/content/CRI_2_2_3X_After_the_tests_Staging_5.asp?sitearea=
75. American Cancer Society: Detailed Guide: Ovarian Cancer www.cancer.org/docroot/CRI/content/CRI_2_4_3X_How_is_ovarian_cancer_staged_33. asp?sitearea=CRI&viewmode=print&
76. American Cancer Society: Detailed Guide: Stomach Cancer www.cancer.org/docroot/cri/content/cri_2_4_3x_how_is_stomach_cancer_staged_40. asp?sitearea=cri
77. Detailed Guide: Lung Cancer - Non-small Cell www.cancer.org/docroot/CRI/ content/CRI_2_4_3x_How_Is_Non-Small_Cell_Lung_Cancer_Staged.asp?sitearea=