Modern molecular genetic approaches to psychiatric disease

British Medical Bulletin

Volumn 52, Issue 3, 1996, Pages 434-452

  Craddock, Nick ^a   Owen, Michael J ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; DIABETES MELLITUS; GENE MAPPING; GENETIC ASSOCIATION; GENETIC DISTANCE; GENETIC LINKAGE; GENETIC PREDISPOSITION; HUMAN; HUMAN CELL; MENTAL DISEASE; MOLECULAR CLONING; MOLECULAR GENETICS; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 0029736803     PISSN: 00071420     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.bmb.a011558     Document Type: Review

References (63)

1. Watson JD. The Human Genome Project: past, present, and future. Science 1990; 248: 44-9
2. McGuffin P, Owen MJ, O'Donovan MC, Thapar A, Gottesman II. Psychiatric Genetics. London: Gaskell, 1994
3. Bodmer W, McKie R. The Book of Man. The Quest to Discover Our Genetic Heritage. London: Abacus, 1995
4. Strachan T. The Human Genome. Oxford: Bios Scientific Publishers, 1992
5. Nicholl DST. An Introduction to Genetic Engineering. Cambridge: Cambridge University Press, 1994
6. Watson JD, Gilman M, Witowski J, Zoller M. Recombinant DNA (2nd edn). New York: Scientific American Books, 1992
7. Sham P. Genetic epidemiology. Br Med Bull 1996; 52: XXX-XXX
8. Maddox J. Directory to the human genome. Nature 1995; 376: 459-60
9. Rommens JM, lannuzzi MC, Kerem B-S et al. Identification of the cystic fibrosis gene: chromosome walking and jumping. Science 1989; 245: 1059-65
10. The Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 1993; 72: 971-83
11. Collins FS. Positional cloning: let's not call it reverse anymore. Nature Genet 1992; 1: 3-6
12. Ott J. Analysis of Human Genetic Linkage. Revised edition. Baltimore: The Johns Hopkins University Press, 1991
13. Sherrington R, Rogaev EI, Liang Y et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 1995; 375: 754-67
14. Collins FS. Positional cloning moves from perditional to traditional. Nature Genet 1995; 9: 347-50
15. Goate A, Chartier-Harlin M-C, Mullan M et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991; 349: 704-7
16. Davies JL, Kawaguchi Y, Bennett et al. A genome-wide search for human type 1 diabetes susceptibility genes. Nature 1994; 371: 130-6
17. Lander ES, Schork NJ. Genetic dissection of complex traits. Science 1994; 265: 2037-48
18. Craddock N, Khodel V, Van Eerdewegh P, Reich T. Mathematical limits of multilocus models: the genetic transmission of bipolar disorder. Am J Hum Genet 1995; 57: 690-702
19. Risch N. Linkage strategies for genetically complex traits. I. Multilocus models. Am J Hum Genet 1990; 46: 222-8
20. Sandbrink R, Hartmann T, Masters CL, Beyreuther K. Genes contributing to Alzheimer's disease. Mol Psychiatry 1996; 1: 27-40
21. Tsuang MT, Faraone SV. The Genetics of Mood Disorders. Baltimore: The Johns Hopkins University Press, 1990
22. Sandkuyl LA, Ott J. Affective disorders: evaluation of a three-allele model accounting for clinical heterogeneity. Genet Epidemiol 1989; 6: 265-9
23. O'Donovan MC, Owen MJ. Dynamic mutations and psychiatric genetics. Psychol Med 1996; 26: 1-6
24. McInnis MG, McMahon FJ, Chase GA, Simpson SG, Ross CA, DePaulo JRJ. Anticipation in bipolar affective disorder. Am J Hum Genet 1993; 53: 385-90
25. Bassett AS, Honer WG. Evidence for anticipation in schizophrenia. Am J Hum Genet 1994; 54: 864-70
26. Hall JG. Genomic imprinting: review and relevance to human diseases. Am J Hum Genet 1990; 46: 857-73
27. McMahon FJ, Stine OC, Myers DA, Simpson SG, DePaulo JR. Patterns of maternal transmission in bipolar affective disorder. Am J Hum Genet 1995; 56: 1277-86
28. Farmer AE, Williams J, Jones I. Phenotypic definitions of psychotic illness for molecular genetic research. Am J Med Genet 1994; 54: 365-71
29. Bassett AS. Chromosomal aberrations and schizophrenia. Br J Psychiatry 1992; 161: 323-34
30. Craddock N, Owen M. Chromosomal aberrations and bipolar affective disorder. Br J Psychiatry 1994; 164: 507-12
31. Weeks DE, Lange K. The affected-pedigree-member method of linkage analysis. Am J Hum Genet 1988; 42: 315-26
32. Curtis D, Sham PC. Model-free linkage analysis using likelihoods. Am J Hum Genet 1995; 57: 703-16
33. Blackwelder WC, Elston RC. A comparison of sib-pair linkage tests for disease susceptibility loci. Genet Epidemiol 1985; 2: 85-97
34. Risch N. Linkage strategies for genetically complex traits. II. The power of affected relative pairs. Am J Hum Genet 1990; 46: 229-41
35. Holmans P. Asymptotic properties of affected-sib-pair linkage analysis. Am J Hum Genet 1993; 52: 362-74
36. Kelsoe JR, Ginns EI, Egeland JA et al. Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish. Nature 1989; 342: 238-43
37. Rice JP, Rochberg N, Endicott J, Lavori PW, Miller C. Stability of psychiatric diagnoses. An application to the affective disorders. Arch Gen Psychiatry 1992; 49: 824-30
38. Durner M, Greenberg DA, Hodge SE. Inter- and intrafamilial heterogeneity: effective sampling strategies and comparison of analysis methods. Am J Hum Genet 1992; 51: 859-70
39. Risch N. Mapping genes for psychiatric disorders. In: Gershon ES, Cloninger CR. eds. Genetic Approaches to Mental Disorders. Washington DC: American Psychiatric Press, 1994
40. Kruglyak L, Lander ES. High-resolution genetic mapping of complex traits. Am J Hum Genet 1995; 56: 1212-23
41. Rotter JI, Vadheim CM. Diabetes mellitus. In: King RA, Rotter JI. eds. The Genetic Basis of Common Diseases. Oxford: Oxford University Press, 1992: 413-81
42. Corder EH, Saunders AM, Risch NJ et al. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nature Genet 1994; 7: 180-4
43. Sobell JL, Heston LL, Sommer SS. Novel association approach for determining the genetic predisposition to schizophrenia: case control resource and testing of a candidate gene. Am J Med Genet 1993; 48: 28-35
44. Schaid DJ, Sommer SS. Comparison of statistics for candidate-gene association studies using cases and parents. Am J Hum Genet 1994; 55: 402-9
45. Plomin R, Owen MJ, McGuffin P. The genetic basis of complex human behaviours. Science 1994; 264: 1733-9
46. Cardon LR, Smith SD, Fulker DW, Kimberling WJ, Pennington BF, DeFries JC. Quantitative trait locus for reading disability on chromosome 6. Science 1994; 266: 276-9
47. Risch N, Zhang H. Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science 1995; 268: 1584-9
48. Claridge G. Schizotypy and schizophrenia. In: McGuffin P. ed. Schizophrenia: The Major Issues. London: Heinemann, 1988: 187-201
49. Todd JA, Aitman TJ, Cornall RJ. et al. Genetic analysis of autoimmune type 1 diabetes mellitus in mice. Nature 1991; 351: 542-7
50. Henn FA, Edwards E. Animal models in the study of genetic factors in human psychopathology. In: Papolos DF, Lachman HM. eds. Genetic Studies in Affective Disorders. Overview of Basic Methods, Current Directions, and Critical Research Issues. New York: John Wiley, 1994: 177-92
51. Flint J, Corley R, DeFries JC, Fulker DW, Gray JA, Miller S, Collins AC. A simple genetic basis for a complex psychological trait in laboratory mice. Science 1995; 269: 1432-5
52. Berrettini W. Quantitative trait loci mapping: a novel approach to candidate genes for psychiatric diseases. Psychiatr Genet 1993; 3: 203-5
53. Games D, Adams D, Alessandrini R et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F B-amyloid precursor protein. Nature 1995; 373: 523-7
54. McGuffin P, Owen MJ, Farmer AE. Genetic basis of schizophrenia. Lancet 1995; 346: 678-82
55. Wang S, Sun C-E, Walczak CA et al. Evidence for a susceptibility locus for schizophrenia on chromosome 6pter-p22. Nature 1995; 10: 41-6
56. Vallada HP, Gill M, Sham P et al. Linkage studies on chromosome 22 in familial schizophrenia. Am J Med Genet 1995; 60: 139-46
57. Berrettini WH, Ferraro TN, Goldin LR et al. Chromosome 18 DNA markers and manicdepressive illness: evidence for a susceptibility gene. Proc Natl Acad Sci USA 1994; 91: 5918-21
58. Dawson E, Parfitt E, Roberts Q et al. Linkage studies of bipolar disorder in the region of the Darier's disease gene on chromosome 12q23-24.1. Am J Med Genet 1995; 60: 94-102
59. Suarez BK, Hampe CL, Van Eerdewegh P. Problems of replicating linkage claims in psychiatry. In: Gershon ES, Cloninger CR. eds. Genetic Approaches to Mental Disorders. Washington, DC: American Psychiatric Press, 1994: 23-46
60. Elston RC. P values, power, and pitfalls in the linkage analysis of psychiatric disorders. In: Gershon ES, Cloninger CR. eds. Genetic Approaches to Mental Disorders. Washington, DC: American Psychiatric Press, 1994: 3-21
61. Holmans P, Craddock N. Strategies for efficient genome screening using maximum likelihood sib-pair analysis. Psychiatr Genet 1995; 5 Suppl: S106
62. Houwen RHJ, Baharloo S, Blamkenship K et al. Genome screening by searching for shred segments: mapping a gene for benign recurrent intrahepatic cholestasis. Nature Genet 1994; 8: 380-6
63. Lander ES. Finding similarities and differences among genomes. Nature Genet 1993; 4: 5-6