Neural correlates of eye tracking deficits in first-degree relatives of schizophrenic patients: A positron emission tomography study

Archives of General Psychiatry

Volumn 56, Issue 12, 1999, Pages 1127-1134

  O'Driscoll, Gillian A ^a,b,c   Benkelfat, Chawki ^a,b,c   Florencio, Patrik S ^a   Wolff, Anne Lise V G ^a   Joober, Ridha ^a,b   Lal, Samarthji ^a,b   Evans, Alan C ^c  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

WATER O 15;

ADULT; ARTICLE; BRAIN BLOOD FLOW; CLINICAL ARTICLE; CONTROLLED STUDY; EYE FIXATION; EYE TRACKING; FEMALE; FRONTAL CORTEX; FRONTAL LOBE; GENETIC RISK; HUMAN; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; RELATIVE; SCHIZOPHRENIA; SMOOTH PURSUIT EYE MOVEMENT;

EID: 0032709865     PISSN: 0003990X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archpsyc.56.12.1127     Document Type: Article

References (65)

1. Gottesman II, Bertelsen A. Confirming unexpressed genotypes for schizophrenia: risks in the offspring of Fischer's Danish identical and fraternal discordant twins. Arch Gen Psychiatry. 1989;46:867-872.
2. Freedman R, Adler LE, Leonard S. Alternative phenotypes for the complex genetics of schizophrenia. Biol Psychiatry. 1999;45:551-558.
3. Callicott JH, Egan MF, Bertolino A, Mattay VS, Langheim FJ, Frank JA, Weinberger DR. Hippocampal N-acetyl aspartate in unaffected siblings of patients with schizophrenia: a possible intermediate neurobiological phenotype. Biol Psychiatry. 1998;44:941-950.
4. Levy DL, Holzman PS, Matthysse S, Mendell NR. Eye tracking dysfunction and schizophrenia: a critical perspective. Schizophr Bull. 1993;19:461-505.
5. Holzman PS, Proctor LR, Levy DL, Yasillo NJ, Meltzer HY, Hurt SW. Eye-tracking dysfunctions in schizophrenic patients and their relatives. Arch Gen Psychiatry. 1974;31:143-151.
6. Keefe RSE, Silverman JM, Mohs RC, et al. Eye tracking, attention, and schizotypal symptoms in nonpsychotic relatives of patients with schizophrenia. Arch Gen Psychiatry. 1997;54:169-176.
7. Siever LJ, Keefe RSE, Bernstein DP, Coccaro EF, Klar HM, Zemishlany Z, Peterson AE, Davidson M, Mahon T, Horvath T. Eye tracking impairment in clinically identified patients with schizotypal personality disorder. Am J Psychiatry. 1990; 6:740-745.
8. Schroeder J, Buchsbaum MS, Siegel BV, Geider FJ, Haier RJ, Lohr J, Wu J, Potkin SG. Patterns of cortical activity in schizophrenia. Psychol Med. 1994;24:947-955.
9. Weinberger DR, Aloia MS, Goldberg TE, Berman KF. The frontal lobes and schizophrenia. J Neuropsychiatry Clin Neurosci. 1994;6:419-427.
10. Levin S. Frontal lobe dysfunction in schizophrenia, I: eye movement impairments. J Psychiatr Res. 1984;18:27-55.
11. Katsanis J, Iacono WG. Clinical, neuropsychological and brain structural correlates of smooth-pursuit eye tracking performance in chronic schizophrenics. J Abnorm Psychol. 1991;100:526-534.
12. Thaker GK, Ross DE, Buchanan RW, Moran MJ, Lahti A, Kim C, Medoff D. Does pursuit abnormality in schizophrenia represent a deficit in the predictive mechanism? Psychiatry Res. 1996;59:221-237.
13. Sweeney JA, Luna B, Srinivasagam NM, Keshavan MS, Schooler NR, Haas GL, Carl JR. Eye tracking abnormalities in schizophrenia: evidence for dysfunction in the frontal eye fields. Biol Psychiatry. 1998;44:698-708.
14. Sereno AB, Holzman PS. Antisaccades and smooth pursuit eye movements in schizophrenia. Biol Psychiatry. 1995;37:394-401.
15. MacAvoy MG, Bruce CJ. Comparison of smooth eye tracking disorder of schizophrenics with that of non-human primates with specific brain lesions. Int J Neurosci. 1995;80:117-151.
16. Radant AD, Claypoole K, Wingerson DK, Cowley DS, Roy-Byrne PP. Relationships between neuropsychological and oculomotor measures in schizophrenia patients and normal controls. Biol Psychiatry. 1997;42:797-805.
17. Clementz BA. Psychophysiological measures of (dis)inhibition as liability indicators for schizophrenia. Psychophysiology. 1998;35:648-668.
18. O'Driscoll GA, Lenzenweger MF, Holzman PS. Antisaccades and smooth pursuit eye tracking and schizotypy. Arch Gen Psychiatry. 1998;55:837-843.
19. Ross DE, Thaker GK, Holcomb HH, Cascella NG, Medoff DR. Abnormal smooth pursuit eye movements in schizophrenic patients are associated with cerebral glucose metabolism in oculomotor regions. Psychiatry Res. 1995;58:53-67.
20. Zeki S, Watson JD, Lueck CJ, Friston KJ, Kennard C, Frackowiak RS. A direct demonstration of functional specialization in human visual cortex. J Neurosci. 1991;11:641-649.
21. Stuve TA, Friedman L, Jesberger JA, Gilmore GC, Strauss ME, Meltzer HY. The relationship between smooth pursuit performance, motion perception and sustained visual attention in patients with schizophrenia and normal controls. PsyChol Med 1997;27:143-152.
22. Chen Y, Nakayama K, Levy DL, Matthysse SW, Holzman PS. Psychophysical isolation of a motion-processing deficit in schizophrenics and their relatives and its association with impaired smooth pursuit, Proc Natl Acad Sci U S A. 1999;96: 4724-4729.
23. Chen Y, Palafox GP, Nakayama K , Levy DL, Matthysse S, Holzman PS. Motion perception in schizophrenia. Arch Gen Psychiatry. 1999;56:149-154.
24. Clementz BA. Saccades to moving targets in schizophrenia: evidence for normal posterior cortex functioning. Psychophysiology. 1996;33:650-654.
25. Thaker GK, Ross DE, Cassady SL, Adami HM, LaPorte D, Medoff DR, Lahti A. Smooth pursuit eye movements to extraretinal motion signals: deficits in relatives of patients with schizophrenia. Arch Gen Psychiatry. 1998;55:830-836.
26. Hollignshead A, Redlich F. Social Class and Mental Illness. New York, NY: Wiley and Sons Inc; 1958.
27. Oldfield RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia. 1971;9:97-113.
28. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders. New York: New York State Psychiatric Institute; 1996.
29. Silverstein AB. Reappraisal of the validity of a short short form of Wechsler's scales. Psychol Rep. 1970;26:559-561.
30. Amador XF, Sackeim HA, Mukherjee S, Halperin R, Neeley P, Maclin E, Schnur D. Specificity of smooth pursuit eye movement and visual fixation abnormalities in schizophrenia: comparison to mania and normal controls. Schizophr Res. 1991; 5:135-144.
31. Collins DL, Neelin P, Peters TM, Evans AC. Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space. J Comput Assist Tomogr. 1994;18:192-205.
32. Evans AC, Collins DL, Mills SR, Brown ED, Kelly RL. 3D statistical neuroanatomical models from 305 MRI volumes. IEEE Conference Record, Nuclear Sciences Symposium and Medical Imaging Conference. San Francisco, Calif: IEEE; 1993:1813-1817.
33. Evans AC, Thompson CJ, Marrett S, Meyer E, Mazza M. Performance characteristics of the PC-2048: a new 15-slice encoded crystal PET scanner for neurological studies. IEEE Trans Med Imaging. 1991;10:90-98.
34. Fox PT, Mintun MA, Reiman EM, Raichle ME. Enhanced detection of focal brain responses using intersubject averaging and change-distribution analysis of subtracted PET images. J Cereb Blood Flow Metab. 1988;8:642-653.
35. Raichle ME, Martin WR, Herscovitch P, Mintun MA, Markham J. Brain blood flow measured with intravenous H2(15)0, II: implementation and validation. J Nucl Med. 1983;24:790-798.
36. Woods RP, Mazziotta JC, Cherry SR. MRI-PET registration with automated algorithm. J Comput Assist Tomogr. 1993;17:536-546.
37. Worsley KJ, Evans AC, Marrett S, Neelin P. A three-dimensional statistical analysis for CBF activation studies in human brain. J Cereb Blood Flow Metab. 1992; 12:900-918.
38. Benitez JT. Eye-tracking and optokinetic tests: diagnostic significance in peripheral and central vestibular disorders. Laryngoscope. 1970;80:834-848.
39. Friedman L, Jesberger JA, Siever LJ, Thompson P, Mobs R, Meltzer HY. Smooth pursuit performance in patients with affective disorders or schizophrenia and normal controls: analysis with specific oculomotor measures, RMS error and qualitative ratings. Psychol Med. 1995;25:387-403.
40. Talairach J, Tournoux P. Co-Planar Stereotactic Atlas of the Human Brain. Stuttgart, Germany: Thieme; 1988.
41. Anderson TJ, Jenkins IH, Brooks DJ, Hawken MB, Frackowiak RS, Kennard C. Cortical control of saccades and fixation in man: a PET study. Brain. 1994;117: 1073-1084.
42. Sweeney JA, Mintun MA, Kwee S, Wiseman MB, Brown DL, Rosenberg DR, Carl JR. Positron emission tomography study of voluntary saccadic eye movements and spatial working memory. J Neurophysiol. 1996;75:454-468.
43. O'Driscoll GA, Alpert NM, Matthysse SW, Levy DL, Rauch SL, Holzman PS. Functional neuroanatomy of antisaccade eye movements investigated with positron emission tomography. Proc Natl Acad Sci U S A. 1995;92:925-929.
44. Paus T. Location and function of the human frontal eye-field: a selective review. Neuropsychologia. 1996;34:475-483.
45. O'Driscoll GA, Strakowski SM, Alpert NM, Matthysse SW, Rauch SL, Levy DL, Holzman PS. Differences in cerebral activation during smooth pursuit and saccadic eye movements using positron emission tomography. Biol Psychiatry. 1998; 44:685-689.
46. Watson JD, Myers R, Frackowiak RS, Hajnal JV, Woods RP, Mazziotta JC, Shipp S, Zeki S. Area V5 of the human brain: evidence from a combined study using positron emission tomography and magnetic resonance imaging. Cereb Cortex. 1993;3:70-94.
47. Tootell RB, Reppas JB, Kwong KK, Malach R, Born RT, Brady TJ, Rosen BR, Belliveau JW. Functional analysis of human MT and related visual cortical areas using magnetic resonance imaging. J Neurosci. 1995;15:3215-3230.
48. Orban GA, Dupont P, Debruyn B, Vandenberghe R, Rosier A, Mortelmans L. Human brain activity related to speed discrimination tasks. Exp Brain Res. 1998; 122:9-22.
49. Barton JJ, Simpson T, Kiriakopoulos E, Stewart C, Crawley A, Guthrie B, Wood M, Mikulis D. Functional MRI of lateral occipitotemporal cortex during pursuit and motion perception. Ann Neurol. 1996;40:387-398.
50. Hasnain MK, Fox PT, Woldorff MG. Intersubject variability of functional areas in the human visual cortex. Hum Brain Mapping. 1998;6:301-315.
51. Schlag J, Schlag-Rey M. Evidence for a supplementary eye field. J Neurophysiol. 1987;57:179-200.
52. MacAvoy MG, Gottlieb JP, Bruce CJ. Smooth pursuit eye movement representation in the primate frontal eye field. Cereb Cortex. 1991;1:95-102.
53. Tian JR, Lynch JC. Functionally defined smooth and saccadic eye movement sub-regions in the frontal eye field of Cebus monkeys. J Neurophysiol. 1996;76:2740-2753.
54. Groh JM, Born RT, Newsome WT. How is a sensory map read out? effects of microstimulation in visual area MT on saccades and smooth pursuit eye movements. J Neurosci. 1997;17:4312-4330.
55. Bremmer F, Ilg UJ, Thiele A, Distler C, Hoffmann KP. Eye position effects in monkey cortex, I: visual and pursuit-related activity in extrastriate areas MT and MST. J Neurophysiol. 1997;77:944-961.
56. Morrow MJ, Sharpe JA. Retinotopic and directional deficits of smooth pursuit initiation after posterior cerebral hemispheric lesions. Neurology. 1993;43:595-603.
57. Rivaud S, Muri R, Gaymard B, Vermersch A, Pierrot-Deseilligny C. Eye movement disorders after frontal eye field lesions in humans. Exp Brain Res. 1994; 102:110-120.
58. Morrow MJ, Sharpe JA. Deficits of smooth-pursuit eye movement after unilateral frontal lobe lesions. Ann Neurol. 1995;37:443-451.
59. Heide W, Kurzidim K, Kompf D. Deficits of smooth pursuit eye movements after frontal and parietal lesions. Brain. 1996;119:1951-1969.
60. Gottlieb JP, Bruce CJ, MacAvoy MG. Smooth eye movements elicited by microstimulation in the primate frontal eye field. J Neurophysiol. 1993;69:786-799.
61. Gottlieb JP, MacAvoy MG, Bruce CJ. Neural responses related to smooth-pursuit eye movements and their correspondence with electrically elicited smooth eye movements in the primate frontal eye field. J Neurophysiol. 1994;72:1634-1653.
62. Burman D, Bruce CJ. Suppression of task-related saccades by electrical stimulation in the primate's frontal eye field. J Neurophysiol. 1997;77:2252-2267.
63. Rosenthal R, Rosnow RL. Essentials of Behavioural Research: Methods and Data Analysis. New York, NY: McGraw-Hill; 1984.
64. Suddath RL, Christison GW, Torrey EF, Casanova MF, Weinberger DR. Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. N Engl J Med. 1990;322:789-794.
65. Cannon TD, Mednick SA, Parnas J, Schulsinger F, Praestholm J, Vestergaard A. Developmental brain abnormalities in the offspring of schizophrenic mothers, I: contributions of genetic and perinatal factors. Arch Gen Psychiatry. 1993;50: 551-564.