Homology modeling and site-directed mutagenesis of pyroglutamyl peptidase II: Insights into omega- versus aminopeptidase specificity in the M1 family

Journal of Biological Chemistry

Volumn 281, Issue 27, 2006, Pages 18581-18590

  Chávez Gutiérrez, Lucía ^a   Matta Camacho, Edna ^a   Osuna, Joel ^a   Horjales, Eduardo ^a   Joseph Bravo, Patricia ^a   Maigret, Bernard ^b   Charli, Jean Louis ^a  

^a INSTITUTO DE BIOTECNOLOGÍA   (Mexico)

^b NANCY UNIVERSITÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CATALYSIS; ENZYME INHIBITION; HORMONES; HYDROGEN BONDS; MATHEMATICAL MODELS; MUTAGENESIS; SUBSTRATES;

AMINOPEPTIDASE (APN); ANIONIC BINDING SITES; SALT BRIDGE INTERACTIONS; THYROTROPIN-RELEASING HORMONES;

ENZYMES;

5 OXOPROLYL PEPTIDASE; AMINO ACID; AMINO TERMINAL TELOPEPTIDE; AMINOPEPTIDASE; EXOPEPTIDASE; METALLOPROTEINASE; MICROSOMAL AMINOPEPTIDASE; PROTIRELIN; PYROGLUTAMYL PEPTIDASE II; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; GENE MUTATION; HYDROGEN BOND; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN MOTIF; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; AMINOPEPTIDASES; ANIMALS; BINDING SITES; CATALYTIC DOMAIN; CERCOPITHECUS AETHIOPS; COS CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PYRROLIDONECARBOXYLIC ACID; RATS; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 33745863100     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M601392200     Document Type: Article

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