Structure-activity studies with high-affinity inhibitors of pyroglutamyl-peptidase II

Biochemical Journal

Volumn 389, Issue 2, 2005, Pages 569-576

  Kelly, Julie A ^a   Scalabrino, Gaia A ^a   Slator, Gillian R ^a   Cullen, Aoife A ^a   Gilmer, John F ^a   Lloyd, David G ^a   Bennett, Geoffrey W ^b   Bauer, Karl ^c   Tipton, Keith F ^a   Williams, Carvell H ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b QUEEN S MEDICAL CENTRE   (United Kingdom)

^c MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

Pyroglutamyl peptidase II (PPII); Pyroglutamyl peptidase II inhibitor; Thyrotropin releasing hormone (TRH); Thyrotropin releasing hormone degrading ectoenzyme (TRH DE); Thyrotropin releasing hormone degrading ectoenzyme inhibitor

Indexed keywords

AMINO ACIDS; CHEMICAL MODIFICATION; ENZYME KINETICS; HORMONES; SYNTHESIS (CHEMICAL);

HIGH-AFFINITY INHIBITORS; MOLECULAR MODELING; PYROGLUTAMYL-PEPTIDASE II (PPII); THERAPEUTIC AGENTS;

ENZYME INHIBITION;

5 OXOPROLYL PEPTIDASE; COUMARIN DERIVATIVE; ENZYME INHIBITOR; PEPTIDE; PROTEIN PYROGLUTAMYL PEPTIDASE II; PROTIRELIN; PROTIRELIN DERIVATIVE; PYROGLUTAMYLASPARAGINYLPROLINEAMIDE; PYROGLYCYLASPARAGINYLPROLYLTYROSYLTRYPTOPHANYLTRYPTOPHANYL 7 AMIDO 4 METHYLCOUMARIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; HYDROGEN BOND; MALE; MOLECULAR MODEL; NONHUMAN; PEPTIDE ANALYSIS; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN STRUCTURE; RAT; STRUCTURE ACTIVITY RELATION;

EID: 22544440278     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20041722     Document Type: Article

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