-
2
-
-
0037013147
-
Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression
-
Pelengaris S, Khan M, Evan GI (2002) Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. Cell 109:321-334
-
(2002)
Cell
, vol.109
, pp. 321-334
-
-
Pelengaris, S.1
Khan, M.2
Evan, G.I.3
-
3
-
-
0030025773
-
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
-
Graeber TG, Osmanian C, Jacks T et al (1996) Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379:88-91
-
(1996)
Nature
, vol.379
, pp. 88-91
-
-
Graeber, T.G.1
Osmanian, C.2
Jacks, T.3
-
4
-
-
0026642195
-
Induction of apoptosis in fibroblasts by c-myc protein
-
Evan GI, Wyllie AH, Gilbert CS et al (1992) Induction of apoptosis in fibroblasts by c-myc protein. Cell 69:119-128
-
(1992)
Cell
, vol.69
, pp. 119-128
-
-
Evan, G.I.1
Wyllie, A.H.2
Gilbert, C.S.3
-
5
-
-
0034806972
-
Enhanced ROS production in oncogenically transformed cells potentiates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase activation and sensitization to genotoxic stress
-
Benhar M, Dalyot I, Engelberg D, Levitzki A (2001) Enhanced ROS production in oncogenically transformed cells potentiates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase activation and sensitization to genotoxic stress. Mol Cell Biol 21:6913-6926
-
(2001)
Mol Cell Biol
, vol.21
, pp. 6913-6926
-
-
Benhar, M.1
Dalyot, I.2
Engelberg, D.3
Levitzki, A.4
-
6
-
-
0030694260
-
Oncogenic transformation potentiates apoptosis, S-phase arrest and stress-kinase activation by etoposide
-
Chen G, Shu J, Stacey DW (1997) Oncogenic transformation potentiates apoptosis, S-phase arrest and stress-kinase activation by etoposide. Oncogene 15:1643-1651
-
(1997)
Oncogene
, vol.15
, pp. 1643-1651
-
-
Chen, G.1
Shu, J.2
Stacey, D.W.3
-
7
-
-
0033769681
-
Primary cells suppress oncogene-dependent apoptosis
-
Duelli DM, Lazebnik YA (2000) Primary cells suppress oncogene-dependent apoptosis. Nat Cell Biol 2:859-862
-
(2000)
Nat Cell Biol
, vol.2
, pp. 859-862
-
-
Duelli, D.M.1
Lazebnik, Y.A.2
-
8
-
-
0026639932
-
The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins
-
USA
-
Rao L, Debbas M, Sabbatini P et al (1992) The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins. Proc Natl Acad Sci USA 89:7742-7746
-
(1992)
Proc Natl Acad Sci
, vol.89
, pp. 7742-7746
-
-
Rao, L.1
Debbas, M.2
Sabbatini, P.3
-
9
-
-
0028789109
-
Oncogenic transformation alters cisplatin-induced apoptosis in rat embryo fibroblasts
-
Basu A, Cline JS (1995) Oncogenic transformation alters cisplatin-induced apoptosis in rat embryo fibroblasts. Int J Cancer 63:597-603
-
(1995)
Int J Cancer
, vol.63
, pp. 597-603
-
-
Basu, A.1
Cline, J.S.2
-
10
-
-
0033118475
-
Apoptosis, p53, and tumor cell sensitivity to anticancer agents
-
Brown JM, Wouters BG (1999) Apoptosis, p53, and tumor cell sensitivity to anticancer agents. Cancer Res 59:1391-1399
-
(1999)
Cancer Res
, vol.59
, pp. 1391-1399
-
-
Brown, J.M.1
Wouters, B.G.2
-
11
-
-
0036728834
-
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
-
Letai A, Bassik MC, Walensky LD et al (2002) Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2:183-192
-
(2002)
Cancer Cell
, vol.2
, pp. 183-192
-
-
Letai, A.1
Bassik, M.C.2
Walensky, L.D.3
-
12
-
-
0034653608
-
The PI3K-PDK1 connection: More than just a road to PKB
-
Vanhaesebroeck B, Alessi DR (2000) The PI3K-PDK1 connection: more than just a road to PKB. Biochem J 346(Pt 3):561-576
-
(2000)
Biochem J
, vol.346
, Issue.3 PART
, pp. 561-576
-
-
Vanhaesebroeck, B.1
Alessi, D.R.2
-
13
-
-
1342321750
-
PI 3-kinase, Akt and cell survival
-
Downward J (2004) PI 3-kinase, Akt and cell survival. Semin Cell Dev Biol 15:177-182
-
(2004)
Semin Cell Dev Biol
, vol.15
, pp. 177-182
-
-
Downward, J.1
-
14
-
-
0030584088
-
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
-
Zha J, Harada H, Yang E, Jockel J, Korsmeyer SJ (1996) Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell 87:619-628
-
(1996)
Cell
, vol.87
, pp. 619-628
-
-
Zha, J.1
Harada, H.2
Yang, E.3
Jockel, J.4
Korsmeyer, S.J.5
-
15
-
-
18144416611
-
The transcriptional targets of p53 in apoptosis control
-
Yu J, Zhang L (2005) The transcriptional targets of p53 in apoptosis control. Biochem Biophys Res Commun 331:851-858
-
(2005)
Biochem Biophys Res Commun
, vol.331
, pp. 851-858
-
-
Yu, J.1
Zhang, L.2
-
16
-
-
0033676967
-
Bax is a transcriptional target and mediator of c-myc-induced apoptosis
-
Mitchell KO, Ricci MS, Miyashita T et al (2000) Bax is a transcriptional target and mediator of c-myc-induced apoptosis. Cancer Res 60:6318-6325
-
(2000)
Cancer Res
, vol.60
, pp. 6318-6325
-
-
Mitchell, K.O.1
Ricci, M.S.2
Miyashita, T.3
-
17
-
-
0033499801
-
BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M
-
Yamamoto K, Ichijo H, Korsmeyer SJ (1999) BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. Mol Cell Biol 19:8469-8478
-
(1999)
Mol Cell Biol
, vol.19
, pp. 8469-8478
-
-
Yamamoto, K.1
Ichijo, H.2
Korsmeyer, S.J.3
-
18
-
-
0035968287
-
Novel role for JNK as a stress-activated Bcl2 kinase
-
Deng X, Xiao L, Lang W et al (2001) Novel role for JNK as a stress-activated Bcl2 kinase. J Biol Chem 276:23681-23688
-
(2001)
J Biol Chem
, vol.276
, pp. 23681-23688
-
-
Deng, X.1
Xiao, L.2
Lang, W.3
-
19
-
-
0035914312
-
Nerve growth factor inhibits apoptosis in memory B lymphocytes via inactivation of p38 MAPK, prevention of Bcl-2 phosphorylation, and cytochrome c release
-
Torcia M, De Chiara G, Nencioni L et al (2001) Nerve growth factor inhibits apoptosis in memory B lymphocytes via inactivation of p38 MAPK, prevention of Bcl-2 phosphorylation, and cytochrome c release. J Biol Chem 276:39027-39036
-
(2001)
J Biol Chem
, vol.276
, pp. 39027-39036
-
-
Torcia, M.1
De Chiara, G.2
Nencioni, L.3
-
20
-
-
0035158131
-
Involvement of p38 in Apoptosis-associated Membrane Blebbing and Nuclear Condensation
-
Deschesnes RG, Huot J, Valerie K, Landry J (2001) Involvement of p38 in Apoptosis-associated Membrane Blebbing and Nuclear Condensation. Mol Biol Cell 12:1569-1582
-
(2001)
Mol Biol Cell
, vol.12
, pp. 1569-1582
-
-
Deschesnes, R.G.1
Huot, J.2
Valerie, K.3
Landry, J.4
-
21
-
-
0038338315
-
c-Myc potentiates the mitochondrial pathway of apoptosis by acting upstream of apoptosis signal-regulating kinase 1 (Ask1) in the p38 signalling cascade
-
Desbiens KM, Deschesnes RG, Labrie MM et al (2003) c-Myc potentiates the mitochondrial pathway of apoptosis by acting upstream of apoptosis signal-regulating kinase 1 (Ask1) in the p38 signalling cascade. Biochem J 372:631-641
-
(2003)
Biochem J
, vol.372
, pp. 631-641
-
-
Desbiens, K.M.1
Deschesnes, R.G.2
Labrie, M.M.3
-
22
-
-
0030791513
-
Regulation of Myc-dependent apoptosis by p53, c-Jun N-terminal kinases/stress-activated protein kinases, and Mdm-2
-
Yu K, Ravera CP, Chen YN, McMahon G (1997) Regulation of Myc-dependent apoptosis by p53, c-Jun N-terminal kinases/stress-activated protein kinases, and Mdm-2. Cell Growth Differ 8:731-742
-
(1997)
Cell Growth Differ
, vol.8
, pp. 731-742
-
-
Yu, K.1
Ravera, C.P.2
Chen, Y.N.3
McMahon, G.4
-
23
-
-
0033152390
-
c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release
-
Juin P, Hueber AO, Littlewood T, Evan G (1999) c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release. Genes Dev 13:1367-1381
-
(1999)
Genes Dev
, vol.13
, pp. 1367-1381
-
-
Juin, P.1
Hueber, A.O.2
Littlewood, T.3
Evan, G.4
-
24
-
-
0034948677
-
Myc potentiates apoptosis by stimulating bax activity at the mitochondria
-
Soucie EL, Annis MG, Sedivy J et al (2001) Myc potentiates apoptosis by stimulating bax activity at the mitochondria. Mol Cell Biol 21:4725-4736
-
(2001)
Mol Cell Biol
, vol.21
, pp. 4725-4736
-
-
Soucie, E.L.1
Annis, M.G.2
Sedivy, J.3
-
25
-
-
0036333713
-
c-Myc functionally cooperates with Bax to induce apoptosis
-
Juin P, Hunt A, Littlewood T et al (2002) c-Myc functionally cooperates with Bax to induce apoptosis. Mol Cell Biol 22:6158-6169
-
(2002)
Mol Cell Biol
, vol.22
, pp. 6158-6169
-
-
Juin, P.1
Hunt, A.2
Littlewood, T.3
-
26
-
-
0034775395
-
Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis
-
Eischen CM, Roussel MF, Korsmeyer SJ, Cleveland JL (2001) Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis. Mol Cell Biol 21:7653-7662
-
(2001)
Mol Cell Biol
, vol.21
, pp. 7653-7662
-
-
Eischen, C.M.1
Roussel, M.F.2
Korsmeyer, S.J.3
Cleveland, J.L.4
-
27
-
-
0028263811
-
c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines
-
Harrington EA, Bennett MR, Fanidi A, Evan GI (1994) c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. Embo J 13:3286-3295
-
(1994)
Embo J
, vol.13
, pp. 3286-3295
-
-
Harrington, E.A.1
Bennett, M.R.2
Fanidi, A.3
Evan, G.I.4
-
28
-
-
0031028730
-
Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
-
Kauffmann-Zeh A, Rodriguez-Viciana P, Ulrich E et al (1997) Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB. Nature 385:544-548
-
(1997)
Nature
, vol.385
, pp. 544-548
-
-
Kauffmann-Zeh, A.1
Rodriguez-Viciana, P.2
Ulrich, E.3
-
29
-
-
0030890933
-
Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase
-
USA
-
Ahmed NN, Grimes HL, Bellacosa A, Chan TO, Tsichlis PN (1997) Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase. Proc Natl Acad Sci USA 94:3627-3632
-
(1997)
Proc Natl Acad Sci
, vol.94
, pp. 3627-3632
-
-
Ahmed, N.N.1
Grimes, H.L.2
Bellacosa, A.3
Chan, T.O.4
Tsichlis, P.N.5
-
30
-
-
0037229714
-
Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells
-
Arboleda MJ, Lyons JF, Kabbinavar FF et al (2003) Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells. Cancer Res 63:196-206
-
(2003)
Cancer Res
, vol.63
, pp. 196-206
-
-
Arboleda, M.J.1
Lyons, J.F.2
Kabbinavar, F.F.3
-
31
-
-
0029002136
-
A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins
-
Littlewood TD, Hancock DC, Danielian PS, Parker MG, Evan GI (1995) A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res 23:1686-1690
-
(1995)
Nucleic Acids Res
, vol.23
, pp. 1686-1690
-
-
Littlewood, T.D.1
Hancock, D.C.2
Danielian, P.S.3
Parker, M.G.4
Evan, G.I.5
-
32
-
-
0037222386
-
Dietary cod protein restores insulin-induced activation of phosphatidylinositol 3-kinase/Akt and GLUT4 translocation to the T-tubules in skeletal muscle of high-fat-fed obese rats
-
Tremblay F,Lavigne C, Jacques H, Marette A (2003) Dietary cod protein restores insulin-induced activation of phosphatidylinositol 3-kinase/Akt and GLUT4 translocation to the T-tubules in skeletal muscle of high-fat-fed obese rats. Diabetes 52:29-37
-
(2003)
Diabetes
, vol.52
, pp. 29-37
-
-
Tremblay, F.1
Lavigne, C.2
Jacques, H.3
Marette, A.4
-
33
-
-
0037862006
-
Unravelling the activation mechanisms of protein kinase B/Akt
-
Scheid MP, Woodgett JR (2003) Unravelling the activation mechanisms of protein kinase B/Akt. FEBS Lett 546:108-112
-
(2003)
FEBS Lett
, vol.546
, pp. 108-112
-
-
Scheid, M.P.1
Woodgett, J.R.2
-
34
-
-
16244393685
-
Signalling by PI3K isoforms: Insights from gene-targeted mice
-
Vanhaesebroeck B, Ali K, Bilancio A, Geering B, Foukas LC (2005) Signalling by PI3K isoforms: insights from gene-targeted mice. Trends Biochem Sci 30:194-204
-
(2005)
Trends Biochem Sci
, vol.30
, pp. 194-204
-
-
Vanhaesebroeck, B.1
Ali, K.2
Bilancio, A.3
Geering, B.4
Foukas, L.C.5
-
35
-
-
0035133227
-
Akt Phosphorylates and Negatively Regulates Apoptosis Signal-Regulating Kinase 1
-
Kim AH, Khursigara G, Sun X, Franke TF, Chao MV (2001) Akt Phosphorylates and Negatively Regulates Apoptosis Signal-Regulating Kinase 1. Mol Cell Biol 21:893-901
-
(2001)
Mol Cell Biol
, vol.21
, pp. 893-901
-
-
Kim, A.H.1
Khursigara, G.2
Sun, X.3
Franke, T.F.4
Chao, M.V.5
-
36
-
-
0038342509
-
AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: Implication of AKT2 in chemoresistance
-
Yuan ZQ, Feldman RI, Sussman GE et al (2003) AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance. J Biol Chem 278:23432-23440
-
(2003)
J Biol Chem
, vol.278
, pp. 23432-23440
-
-
Yuan, Z.Q.1
Feldman, R.I.2
Sussman, G.E.3
-
37
-
-
0141781090
-
Regulation of the activity of p38 mitogen-activated protein kinase by Akt in cancer and adenoviral protein E1A-mediated sensitization to apoptosis
-
Liao Y, Hung MC (2003) Regulation of the activity of p38 mitogen-activated protein kinase by Akt in cancer and adenoviral protein E1A-mediated sensitization to apoptosis. Mol Cell Biol 23:6836-6848
-
(2003)
Mol Cell Biol
, vol.23
, pp. 6836-6848
-
-
Liao, Y.1
Hung, M.C.2
-
38
-
-
0035920129
-
Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase
-
Cuevas BD, Lu Y, Mao M et al (2001) Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase. J Biol Chem 276:27455-27461
-
(2001)
J Biol Chem
, vol.276
, pp. 27455-27461
-
-
Cuevas, B.D.1
Lu, Y.2
Mao, M.3
-
39
-
-
0035932985
-
Analysis of gene expression during myc oncogene-induced lymphomagenesis in the bursa of Fabricius
-
US A
-
Neiman PE, Ruddell A, Jasoni C et al (2001) Analysis of gene expression during myc oncogene-induced lymphomagenesis in the bursa of Fabricius. Proc Natl Acad Sci US A 98:6378-6383.
-
(2001)
Proc Natl Acad Sci
, vol.98
, pp. 6378-6383
-
-
Neiman, P.E.1
Ruddell, A.2
Jasoni, C.3
-
40
-
-
0038185378
-
Genomic targets of the human c-Myc protein
-
Fernandez PC, Frank SR, Wang L et al (2003)Genomic targets of the human c-Myc protein. Genes Dev 17:1115-1129
-
(2003)
Genes Dev
, vol.17
, pp. 1115-1129
-
-
Fernandez, P.C.1
Frank, S.R.2
Wang, L.3
-
41
-
-
4344686261
-
A new role of protein phosphatase 2a in adenoviral E1A protein-mediated sensitization to anticancer drug-induced apoptosis in human breast cancer cells
-
Liao Y, Hung MC (2004) A new role of protein phosphatase 2a in adenoviral E1A protein-mediated sensitization to anticancer drug-induced apoptosis in human breast cancer cells. Cancer Res 64:5938-5942
-
(2004)
Cancer Res
, vol.64
, pp. 5938-5942
-
-
Liao, Y.1
Hung, M.C.2
-
42
-
-
0141994820
-
PTEN: Tumour suppressor, multifunctional growth regulator and more
-
Goberdhan DC, Wilson C (2003) PTEN: tumour suppressor, multifunctional growth regulator and more. Hum Mol Genet 12:R239-R248
-
(2003)
Hum Mol Genet
, vol.12
-
-
Goberdhan, D.C.1
Wilson, C.2
-
43
-
-
4043117002
-
Wip1-deficient mice are resistant to common cancer genes
-
Harrison M, Li J, Degenhardt Y, Hoey T, Powers S (2004) Wip1-deficient mice are resistant to common cancer genes. Trends Mol Med 10:359-361
-
(2004)
Trends Mol Med
, vol.10
, pp. 359-361
-
-
Harrison, M.1
Li, J.2
Degenhardt, Y.3
Hoey, T.4
Powers, S.5
-
44
-
-
0033485261
-
Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation
-
Bulavin DV, Saito S, Hollander MC et al (1999) Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. Embo J 18:6845-6854
-
(1999)
Embo J
, vol.18
, pp. 6845-6854
-
-
Bulavin, D.V.1
Saito, S.2
Hollander, M.C.3
-
45
-
-
0037057320
-
Modulation of PI3K/Akt pathway by E1a mediates sensitivity to cisplatin
-
Viniegra JG, Losa JH, Sanchez-Arevalo VJ et al (2002) Modulation of PI3K/Akt pathway by E1a mediates sensitivity to cisplatin. Oncogene 21:7131-7136
-
(2002)
Oncogene
, vol.21
, pp. 7131-7136
-
-
Viniegra, J.G.1
Losa, J.H.2
Sanchez-Arevalo, V.J.3
|