Phosphatidylinositol 3-kinase in the G protein-coupled receptor-induced chemokinesis and chemotaxis of MDA-MB-468 breast carcinoma cells: A comparison with leukocytes

Molecular Cancer Research

Volumn 4, Issue 6, 2006, Pages 411-421

  Bastian, Philipp ^a   Posch, Birte ^b   Lang, Kerstin ^a   Niggemann, Bernd ^a   Zaenker, Kurt S ^a   Hart, Hanns ^b   Entschladen, Frank ^a  

^a UNIVERSITY OF WITTEN HERDECKE   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

F ACTIN; G PROTEIN COUPLED RECEPTOR; MYOSIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE SHP 1; WORTMANNIN;

ARTICLE; BREAST CARCINOMA; CANCER CELL; CANCER RESEARCH; CELL DIFFERENTIATION; CELL MIGRATION; CELL MOTILITY; CELL TYPE; CHEMOKINESIS; CHEMOTAXIS; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LOCALIZATION; HUMAN; HUMAN CELL; LEUKOCYTE; NEUTROPHIL; POLARIZATION; PRIORITY JOURNAL; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; CELL POLARITY; CHEMOTAXIS; CHEMOTAXIS, LEUKOCYTE; HUMANS; NEUTROPHILS; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHORIC MONOESTER HYDROLASES; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RECEPTORS, G-PROTEIN-COUPLED; T-LYMPHOCYTES, CYTOTOXIC;

EID: 33745856228     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-06-0030     Document Type: Article

References (52)

1. Lang K, Drell TL, Zaenker KS, Entschiaden F. Inhibitors for metastasis development. Recent Patents Anti-Cancer Drug Discov 2006;1:69-80.
2. Entschladen F, Zaenker KS. Locomotion of tumor cells: a molecular comparison to migrating pre- and postmitotic leukocytes. J Cancer Res Clin Oncol 2000;126:671-81.
3. Entschladen F, Drell TL, Palm D, et al. A comparative review on leukocyte and tumor cell migration with regard to the regulation by serpentine receptor ligands. Signal Transduction 2005;1-2:9-18.
4. Bastian P, Lang K, Niggemann B, Zaenker KS, Entschladen F. Myosin regulation in the migration of tumor cells and leukocytes within a three-dimensional collagen matrix. Cell Mol Life Sci 2005;62:65-76.
5. Friedl P, Brocker EB, Zanker KS. Integrins, cell matrix interactions and cell migration strategies: fundamental differences in leukocytes and tumor cells. Cell Adhes Commun 1998;6:225-36.
6. Masur K, Lang K, Niggemann B, Zaenker KS, Entschladen F. High PKCα and low E-cadherin expression contribute to high migratory activity of colon carcinoma cells. Mol Biol Cell 2001;12:1973-82.
7. Baier G. The PKC gene module: molecular biosystematics to resolve its T cell functions. Immunol Rev 2003;192:64-79.
8. Lang K, Hatt H, Niggemann B, Zaenker KS, Entschladen F. A novel function for chemokines: downregulation of neutrophil migration. Scand J Immunol 2003; 57:350-61.
9. Pettit EJ, Fay FS. Cytosolic free calcium and the cytoskeleton in the control of leukocyte chemotaxis. Physiol Rev 1998;78:949-67.
10. Stepanovic V, Wessels D, Daniels K, Loomis WF, Soil DR. Intracellular role of adenylyl cyclase in regulation of lateral pseudopod formation during Dictyostelium chemotaxis. Eukaryot Cell 2005;4:775-86.
11. Ridley AJ, Schwartz MA, Burridge K, et al. Cell migration: integrating signals from front to back. Science 2003;302:1704-9.
12. 3 to the leading edge of chemotaxing cells. Mol Biol Cell 2003;14:1913-22.
13. Ward SG. Do phosphoinositide 3-kinases direct lymphocyte navigation? Trends Immunol 2004;25:67-74.
14. Devreotes P, Janetopoulos C. Eukaryotic chemotaxis: distinctions between directional sensing and polarization. J Biol Chem 2003;278:20445-8.
15. Firtel RA, Chung CY. The molecular genetics of chemotaxis: sensing and responding to chemoattractant gradients. Bioessays 2000;22:603-15.
16. Merlot S, Firtel RA. Leading the way: directional sensing through phosphatidylinositol 3-kinase and other signaling pathways. J Cell Sci 2003; 116:3471-8.
17. Chung CY, Potikyan O, Firtel RA. Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa. Mol Cell 2001;7: 937-47.
18. Enomoto A, Murakami H, Asai N, et al. Akt/PKB regulates actin organization and cell motility via Girdin/APE. Dev Cell 2005;9:389-402.
19. Brock C, Schaefer M, Reusch HP, et al. Roles of Gβγ in membrane recruitment and activation of p110-γ/p101 phosphoinositide 3-kinase γ. J Cell Biol 2003;160:89-99.
20. Stephens L, Eguinoa A, Corey S, Jackson T, Hawkins PT. Receptor stimulated accumulation of phosphatidylinositol (3,4,5)-trisphosphate by G-protein mediated pathways in human myeloid derived cells. EMBO J 1993;12: 2265-73.
21. Reiske HR, Zhao J, Han DC, Cooper LA, Guan J. Analysis of FAK-associated signaling pathways in the regulation of cell cycle progression. FEBS Lett 2000;486:275-80.
22. Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z. The mechanism of action of the tumour suppressor gene PTEN. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2003;147:19-25.
23. Sly LM, Rauh MJ, Kalesnikoff J, Buchse T, Krystal G. SHIP, SHIP2, and PTEN activities are regulated in vivo by modulation of their protein levels: SHIP is up-regulated in macrophages and mast cells by lipopolysaccharide. Exp Hematol 2003;31:1170-81.
24. Kalesnikoff J, Sly LM, Hughes MR, et al. The role of SHIP in cytokine-induced signaling. Rev Physiol Biochem Pharmacol 2003;149:87-103.
25. Xu J, Wang F, Van Keymeulen A, et al. Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell 2003;114: 201-14.
26. Entschladen F, Gunzer M, Scheuffele CM, Niggemann B, Zaenker KS. T lymphocytes and neutrophil granulocytes differ in regulatory signaling and migratory dynamics with regard to spontaneous locomotion and chemotaxis. Cell Immunol 2000;199:104-14.
27. Drell TL, Joseph J, Lang K, Niggemann B, Zaenker KS, Entschladen F. Effects of neurotransmitters on the chemokinesis and chemotaxis of MDA-MB-468 human breast carcinoma cells. Breast Cancer Res Treat 2003;80:63-70.
28. 2+-dependent myosin II activation is required for uropod retraction during neutrophil migration. J Cell Sci 2000;113:1287-98.
29. Entschladen F, Drell TL, Lang K, Joseph J, Zaenker KS. Tumour-cell migration, invasion, and metastasis: navigation by neurotransmitters. Lancet Oncol 2004;5:254-8.
30. Osaki M, Oshimura M, Ito H. PI3K-Akt pathway: its functions and alterations in human cancer. Apoptosis 2004;9:667-76.
31. Entschladen F, Drell TL, Lang K, et al. Analysis methods of human cell migration. Exp Cell Res 2005;307:418-26.
32. Sanchez-Madrid F, del Pozo MA. Leukocyte polarization in cell migration and immune interactions. EMBO J 1999;18:501-11.
33. 1 integrin-independent strategies for polarization, interaction with collagen fibers and locomotion. Eur J Immunol 1998;28:2331-43.
34. 1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology. Proc Natl Acad Sci U S A 1998;95:14821-6.
35. Hannigan M, Zhan L, Li Z, Ai Y, Wu D, Huang CK. Neutrophils lacking phosphoinositide 3-kinase γ show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxis. Proc Natl Acad Sci U S A 2002;99:3603-8.
36. Comer FI, Parent CA. Phosphoinositide 3-kinase activity controls the chemoattractant-mediated activation and adaptation of adenylyl cyclase. Mol Biol Cell 2006;17:357-66.
37. Huttenlocher A. Cell polarization mechanisms during directed cell migration. Nat Cell Biol 2005;7:336-7.
38. Masur K, Niggemann B, Zanker KS, Entschladen F. Norepinephrine-induced migration of SW 480 colon carcinoma cells is inhibited by β-blockers. Cancer Res 2001;61:2866-9.
39. Lin HJ, Hsieh FC, Song H, Lin J. Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer. Br J Cancer 2005;93: 1372-81.
40. Neer EJ. Heterotrimeric G proteins: organizers of transmembrane signals. Cell 1995;80:249-57.
41. Kim CG, Park D, Rhee SG. The role of carboxyl-terminal basic amino acids in Gqα-dependent activation, particulate association, and nuclear localization of phospholipase C-β1. J Biol Chem 1996;271:21187-92.
42. Rochdi MD, Parent JL. Gαq-coupled receptor internalization specifically induced by Gαq signaling. Regulation by EBP50. J Biol Chem 2003;278: 17827-37.
43. Tan X, Sanders P, Bolado J, Jr., Whitney M. Integration of G-protein coupled receptor signaling pathways for activation of a transcription factor (EGR-3). Genomics Proteomics Bioinformatics 2003;1:173-9.
44. Wenzel-Seifert K, Hurt CM, Seifert R. High constitutive activity of the human formyl peptide receptor. J Biol Chem 1998;273:24181-9.
45. Lang K, Drell TL, Niggemann B, Zanker KS, Entschiaden F. Neurotransmitters regulate the migration and cytotoxicity in natural killer cells. Immunol Lett 2003;90:165-72.
46. Pierce KL, Premont RT, Lefkowitz RJ. Seven-transmembrane receptors. Nat Rev Mol Cell Biol 2002;3:639-50.
47. Luttrell LM, Ferguson SS, Daaka Y, et al. β-Arrestin-dependent formation of β2 adrenergic receptor-Src protein kinase complexes. Science 1999;283:655-61.
48. Lang K, Niggemann B, Zanker KS, Entschladen F. Signal processing in migrating T24 human bladder carcinoma cells: role of the autocrine interleukin-8 loop. Int J Cancer 2002;99:673-80.
49. Neri LM, Borgatti P, Tazzari PL, et al. The phosphoinositide 3-kinase/AKT1 pathway involvement in drug and all-trans-retinoic acid resistance of leukemia cells. Mol Cancer Res 2003;1:234-46.
50. Palm D, Lang K, Brandt B, Zaenker KS, Entschladen F. In vitro and in vivo imaging of cell migration: two interdepending methods to unravel metastasis formation. Semin Cancer Biol 2005;15:396-404.
51. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-5.
52. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A 1979;76:4350-4.