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Volumn 91, Issue 6, 2006, Pages 757-764

Single cell analysis of phosphoinositide 3-kinase/Akt and ERK activation in acute myeloid leukemia by flow cytometry

Author keywords

AML; ERK kinase; Flow cytometry; Phospho protein; PI3K Akt

Indexed keywords

CD123 ANTIGEN; CD34 ANTIGEN; CD38 ANTIGEN; CD45 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

EID: 33745755905     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (52)

References (37)
  • 3
    • 0032929762 scopus 로고    scopus 로고
    • Signalling through phosphoinositide 3-kinases: The lipids take centre stage
    • Leevers SJ, Vanhaesebroeck B, Waterfield MD. Signalling through phosphoinositide 3-kinases: the lipids take centre stage. Curr Opin Cell Biol 1999;11:219-25.
    • (1999) Curr Opin Cell Biol , vol.11 , pp. 219-225
    • Leevers, S.J.1    Vanhaesebroeck, B.2    Waterfield, M.D.3
  • 4
    • 0037866476 scopus 로고    scopus 로고
    • Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation
    • Bouscary D, Pene F, Claessens YE, Muller O, Chretien S, Fontenay-Roupie M, et al. Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation. Blood 2003;101:3436-43.
    • (2003) Blood , vol.101 , pp. 3436-3443
    • Bouscary, D.1    Pene, F.2    Claessens, Y.E.3    Muller, O.4    Chretien, S.5    Fontenay-Roupie, M.6
  • 5
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002;2:489-501.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 6
    • 0142227019 scopus 로고    scopus 로고
    • Targeting the PI3K-Akt pathway in human cancer: Rationale and promise
    • Luo J, Manning BD, Cantley LC. Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell 2003;4:257-62.
    • (2003) Cancer Cell , vol.4 , pp. 257-262
    • Luo, J.1    Manning, B.D.2    Cantley, L.C.3
  • 7
    • 0037179847 scopus 로고    scopus 로고
    • Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma
    • Pene F, Claessens YE, Muller O, Viguie F, Mayeux P, Dreyfus F, et al. Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma. Oncogene 2002;21:6587-97.
    • (2002) Oncogene , vol.21 , pp. 6587-6597
    • Pene, F.1    Claessens, Y.E.2    Muller, O.3    Viguie, F.4    Mayeux, P.5    Dreyfus, F.6
  • 8
    • 0037513474 scopus 로고    scopus 로고
    • Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: Its significance as a prognostic variable
    • Min YH, Eom JI, Cheong JW, Maeng HO, Kim JY, Jeung HK, et al. Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: its significance as a prognostic variable. Leukemia 2003;17:995-7.
    • (2003) Leukemia , vol.17 , pp. 995-997
    • Min, Y.H.1    Eom, J.I.2    Cheong, J.W.3    Maeng, H.O.4    Kim, J.Y.5    Jeung, H.K.6
  • 9
    • 0042744837 scopus 로고    scopus 로고
    • Survival of acute myeloid leukemia cells requires PI3 kinase activation
    • Xu Q, Simpson SE, Scialla TJ, Bagg A, Carroll M. Survival of acute myeloid leukemia cells requires PI3 kinase activation. Blood 2003;102:972-80.
    • (2003) Blood , vol.102 , pp. 972-980
    • Xu, Q.1    Simpson, S.E.2    Scialla, T.J.3    Bagg, A.4    Carroll, M.5
  • 10
    • 1242285048 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias
    • Zhao S, Konopleva M, Cabreira-Hansen M, Xie Z, Hu W, Milella M, et al. Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias. Leukemia 2004;18:267-75.
    • (2004) Leukemia , vol.18 , pp. 267-275
    • Zhao, S.1    Konopleva, M.2    Cabreira-Hansen, M.3    Xie, Z.4    Hu, W.5    Milella, M.6
  • 11
    • 17144387901 scopus 로고    scopus 로고
    • PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Map kinase and p53 pathways
    • Grandage VL, Gale RE, Linch DC, Khwaja A. PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Map kinase and p53 pathways. Leukemia 2005;19:586-94.
    • (2005) Leukemia , vol.19 , pp. 586-594
    • Grandage, V.L.1    Gale, R.E.2    Linch, D.C.3    Khwaja, A.4
  • 12
    • 22544444889 scopus 로고    scopus 로고
    • Essential role for the p110delta isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia
    • Sujobert P, Bardet V, Cornillet-Lefebvre P, Hayflick JS, Prie N, Verdier F, et al. Essential role for the p110delta isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia. Blood 2005;106:1063-6.
    • (2005) Blood , vol.106 , pp. 1063-1066
    • Sujobert, P.1    Bardet, V.2    Cornillet-Lefebvre, P.3    Hayflick, J.S.4    Prie, N.5    Verdier, F.6
  • 13
    • 31444434588 scopus 로고    scopus 로고
    • Constitutive phosphoinositide 3-kinase activation in acute myeloid leukemia is not due to p110δ mutations
    • Cornillet-Lefebvre P, Cuccuini W, Bardet V, Tamburini J, Gillot L, Ifrah N, et al. Constitutive phosphoinositide 3-kinase activation in acute myeloid leukemia is not due to p110δ mutations. Leukemia 2006;20:374-6.
    • (2006) Leukemia , vol.20 , pp. 374-376
    • Cornillet-Lefebvre, P.1    Cuccuini, W.2    Bardet, V.3    Tamburini, J.4    Gillot, L.5    Ifrah, N.6
  • 14
    • 0141502208 scopus 로고    scopus 로고
    • Downmodulation of ERK activity inhibits the proliferation and induces the apoptosis of primary acute myelogenous leukemia blasts
    • Lunghi P, Tabilio A, Dall'Aglio PP, Ridolo E, Carlo-Stella C, Pelicci PG, et al. Downmodulation of ERK activity inhibits the proliferation and induces the apoptosis of primary acute myelogenous leukemia blasts. Leukemia 2003;17:1783-93.
    • (2003) Leukemia , vol.17 , pp. 1783-1793
    • Lunghi, P.1    Tabilio, A.2    Dall'Aglio, P.P.3    Ridolo, E.4    Carlo-Stella, C.5    Pelicci, P.G.6
  • 15
    • 0035001867 scopus 로고    scopus 로고
    • Expression and activation of SHC/MAP kinase pathway in primary acute myeloid leukemia blasts
    • Lunghi P, Tabilio A, Pinelli S, Valmadre G, Ridolo E, Albertini R, et al. Expression and activation of SHC/MAP kinase pathway in primary acute myeloid leukemia blasts. Hematol J 2001;2:70-80.
    • (2001) Hematol J , vol.2 , pp. 70-80
    • Lunghi, P.1    Tabilio, A.2    Pinelli, S.3    Valmadre, G.4    Ridolo, E.5    Albertini, R.6
  • 16
    • 0034823632 scopus 로고    scopus 로고
    • Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia
    • Milella M, Kornblau SM, Estrov Z, Carter BZ, Lapillonne H, Harris D, et al. Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia. J Clin Invest 2001;108:851-9.
    • (2001) J Clin Invest , vol.108 , pp. 851-859
    • Milella, M.1    Kornblau, S.M.2    Estrov, Z.3    Carter, B.Z.4    Lapillonne, H.5    Harris, D.6
  • 17
    • 22044443911 scopus 로고    scopus 로고
    • Acute myeloid leukemia stem cells
    • Dick JE. Acute myeloid leukemia stem cells. Ann N Y Acad Sci 2005;1044:1-5.
    • (2005) Ann N Y Acad Sci , vol.1044 , pp. 1-5
    • Dick, J.E.1
  • 18
    • 21744462604 scopus 로고    scopus 로고
    • Cancer biology: Summing up cancer stem cells
    • Huntly BJ, Gilliland DG. Cancer biology: summing up cancer stem cells. Nature 2005;435:1169-70.
    • (2005) Nature , vol.435 , pp. 1169-1170
    • Huntly, B.J.1    Gilliland, D.G.2
  • 19
    • 0033815950 scopus 로고    scopus 로고
    • The interleukin-3 receptor α chain is a unique marker for human acute myelogenous leukemia stem cells
    • Jordan CT, Upchurch D, Szilvassy SJ, Guzman ML, Howard DS, Pettigrew AL, et al. The interleukin-3 receptor α chain is a unique marker for human acute myelogenous leukemia stem cells. Leukemia 2000;14:1777-84.
    • (2000) Leukemia , vol.14 , pp. 1777-1784
    • Jordan, C.T.1    Upchurch, D.2    Szilvassy, S.J.3    Guzman, M.L.4    Howard, D.S.5    Pettigrew, A.L.6
  • 21
    • 28844456971 scopus 로고    scopus 로고
    • Hematopoietic stem cells express multiple myeloid markers: Implications for the origin and targeted therapy of acute myeloid leukemia
    • Taussig DC, Pearce DJ, Simpson C, Rohatiner AZ, Lister AT, Kelly G, et al. Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia. Blood 2005;166:4086-92.
    • (2005) Blood , vol.166 , pp. 4086-4092
    • Taussig, D.C.1    Pearce, D.J.2    Simpson, C.3    Rohatiner, A.Z.4    Lister, A.T.5    Kelly, G.6
  • 22
    • 0027421006 scopus 로고
    • Immunophenotyping of acute leukemia by flow cytometric analysis. Use of CD45 and right-angle light scatter to gate on leukemic blasts in three-color analysis
    • Borowitz MJ, Guenther KL, Shults KE, Stelzer GT. Immunophenotyping of acute leukemia by flow cytometric analysis. Use of CD45 and right-angle light scatter to gate on leukemic blasts in three-color analysis. Am J Clin Pathol 1993;100:534-40.
    • (1993) Am J Clin Pathol , vol.100 , pp. 534-540
    • Borowitz, M.J.1    Guenther, K.L.2    Shults, K.E.3    Stelzer, G.T.4
  • 23
    • 0036093058 scopus 로고    scopus 로고
    • Constitutive activity of signal transducer and activator of transcription 3 protein in acute myeloid leukemia blasts is associated with short disease-free survival
    • Benekli M, Xia Z, Donohue KA, Ford LA, Pixley LA, Baer MR, et al. Constitutive activity of signal transducer and activator of transcription 3 protein in acute myeloid leukemia blasts is associated with short disease-free survival. Blood 2002;99:252-7.
    • (2002) Blood , vol.99 , pp. 252-257
    • Benekli, M.1    Xia, Z.2    Donohue, K.A.3    Ford, L.A.4    Pixley, L.A.5    Baer, M.R.6
  • 24
    • 0038820386 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription proteins in leukemias
    • Benekli M, Baer MR, Baumann H, Wetzler M. Signal transducer and activator of transcription proteins in leukemias. Blood 2003;101:2940-54.
    • (2003) Blood , vol.101 , pp. 2940-2954
    • Benekli, M.1    Baer, M.R.2    Baumann, H.3    Wetzler, M.4
  • 26
    • 0035886024 scopus 로고    scopus 로고
    • Nuclear factor-κB is constitutively activated in primitive human acute myelogenous leukemia cells
    • Guzman ML, Neering SJ, Upchurch D, Grimes B, Howard DS, Rizzieri DA, et al. Nuclear factor-κB is constitutively activated in primitive human acute myelogenous leukemia cells. Blood 2001;98:2301-7.
    • (2001) Blood , vol.98 , pp. 2301-2307
    • Guzman, M.L.1    Neering, S.J.2    Upchurch, D.3    Grimes, B.4    Howard, D.S.5    Rizzieri, D.A.6
  • 27
    • 19944427042 scopus 로고    scopus 로고
    • Targeting NF-κB activation via pharmacologic inhibition of IKK2-induced apoptosis of human acute myeloid leukemia cells
    • Frelin C, Imbert V, Griessinger E, Peyron AC, Rochet N, Philip P, et al. Targeting NF-κB activation via pharmacologic inhibition of IKK2-induced apoptosis of human acute myeloid leukemia cells. Blood 2005;105:804-11.
    • (2005) Blood , vol.105 , pp. 804-811
    • Frelin, C.1    Imbert, V.2    Griessinger, E.3    Peyron, A.C.4    Rochet, N.5    Philip, P.6
  • 28
    • 0346244001 scopus 로고    scopus 로고
    • Intracellular phospho-protein staining techniques for flow cytometry: Monitoring single cell signaling events
    • Krutzik PO, Nolan GP. Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events. Cytometry A 2003;55:61-70.
    • (2003) Cytometry A , vol.55 , pp. 61-70
    • Krutzik, P.O.1    Nolan, G.P.2
  • 30
    • 24944560467 scopus 로고    scopus 로고
    • Whole blood fixation and permeabilization protocol with red blood cell lysis for flow cytometry of intracellular phosphorylated epitopes in leukocyte subpopulations
    • Chow S, Hedley D, Grom P, Magari R, Jacobberger JW, Shankey TV. Whole blood fixation and permeabilization protocol with red blood cell lysis for flow cytometry of intracellular phosphorylated epitopes in leukocyte subpopulations. Cytometry A 2005;67:4-17.
    • (2005) Cytometry A , vol.67 , pp. 4-17
    • Chow, S.1    Hedley, D.2    Grom, P.3    Magari, R.4    Jacobberger, J.W.5    Shankey, T.V.6
  • 31
    • 26944451381 scopus 로고    scopus 로고
    • Quantitative single cell determination of ERK phosphorylation and regulation in relapsed and refractory primary acute myeloid leukemia
    • Ricciardi MR, McQueen T, Chism D, Milella M, Estey E, Kaldjian E, et al. Quantitative single cell determination of ERK phosphorylation and regulation in relapsed and refractory primary acute myeloid leukemia. Leukemia 2005;19:1543-9.
    • (2005) Leukemia , vol.19 , pp. 1543-1549
    • Ricciardi, M.R.1    McQueen, T.2    Chism, D.3    Milella, M.4    Estey, E.5    Kaldjian, E.6
  • 32
  • 33
    • 4544224035 scopus 로고    scopus 로고
    • Detection of serine 473 phosphorylated Akt in acute myeloid leukaemia blasts by flow cytometry
    • Tazzari PL, Cappellini A, Grafone T, Mantovani I, Ricci F, Billi AM, et al. Detection of serine 473 phosphorylated Akt in acute myeloid leukaemia blasts by flow cytometry. Br J Haematol 2004;126:675-81.
    • (2004) Br J Haematol , vol.126 , pp. 675-681
    • Tazzari, P.L.1    Cappellini, A.2    Grafone, T.3    Mantovani, I.4    Ricci, F.5    Billi, A.M.6
  • 34
    • 0025132588 scopus 로고
    • Prognostic importance of immunophenotyping in adults with acute myelocytic leukaemia: The significance of the stem-cell glycoprotein CD34 (My10)
    • Geller RB, Zahurak M, Hurwitz CA, Burke PJ, Karp JE, Piantadosi S, et al. Prognostic importance of immunophenotyping in adults with acute myelocytic leukaemia: the significance of the stem-cell glycoprotein CD34 (My10). Br J Haematol 1990;76:340-7.
    • (1990) Br J Haematol , vol.76 , pp. 340-347
    • Geller, R.B.1    Zahurak, M.2    Hurwitz, C.A.3    Burke, P.J.4    Karp, J.E.5    Piantadosi, S.6
  • 35
    • 0030968613 scopus 로고    scopus 로고
    • Incidence and prognostic relevance of CD34 expression in acute myeloblastic leukemia: Analysis of 141 cases
    • Raspadori D, Lauria F, Ventura MA, Rondelli D, Visani G, de Vivo A, et al. Incidence and prognostic relevance of CD34 expression in acute myeloblastic leukemia: analysis of 141 cases. Leuk Res 1997;21:603-7.
    • (1997) Leuk Res , vol.21 , pp. 603-607
    • Raspadori, D.1    Lauria, F.2    Ventura, M.A.3    Rondelli, D.4    Visani, G.5    De Vivo, A.6
  • 36
    • 0141483064 scopus 로고    scopus 로고
    • Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem cell characteristics¿
    • Passegue E, Jamieson CH, Ailles LE, Weissman IL. Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics¿ Proc Natl Acad Sci USA 2003;100 Suppl 1:11842-9.
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.SUPPL. 1 , pp. 11842-11849
    • Passegue, E.1    Jamieson, C.H.2    Ailles, L.E.3    Weissman, I.L.4
  • 37
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997;3:730-7.
    • (1997) Nat Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2


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