Clinical, immunophenotypic, and molecular profiling of trisomy 12 in chronic lymphocytic leukemia and comparison with other karyotypic subgroups defined by cytogenetic analysis

Cancer Genetics and Cytogenetics

Volumn 168, Issue 2, 2006, Pages 109-119

  Athanasiadou, Anastasia ^a,b   Stamatopoulos, Kostas ^b   Tsompanakou, Aliki ^b   Gaitatzi, Maria ^b   Kalogiannidis, Panagiotis ^b   Anagnostopoulos, Achilles ^b   Fassas, Athanasios ^b   Tsezou, A ^a  

^a UNIVERSITY OF THESSALY   (Greece)

^b G PAPANICOLAOU HOSPITAL   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

CD38 ANTIGEN; IMMUNOGLOBULIN HEAVY CHAIN;

ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CANCER GROWTH; CANCER STAGING; CANCER SURVIVAL; CHROMOSOME 11Q; CHROMOSOME 13Q; CHROMOSOME 17P; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CHRONIC LYMPHATIC LEUKEMIA; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE COURSE; DISEASE FREE SURVIVAL; FEMALE; GENE DELETION; GENE EXPRESSION PROFILING; GENE ISOLATION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; HUMAN; IMMUNOPHENOTYPING; KARYOTYPING; MAJOR CLINICAL STUDY; MALE; MOLECULAR PROBE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE; TRISOMY 12;

ADULT; AGED; CELLS, CULTURED; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 17; DISEASE PROGRESSION; FEMALE; HUMANS; IMMUNOGLOBULINS; IMMUNOPHENOTYPING; KARYOTYPING; LEUKEMIA, LYMPHOCYTIC, CHRONIC; MALE; MIDDLE AGED; MUTATION; SURVIVAL ANALYSIS; TRISOMY;

EID: 33745726055     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2006.02.001     Document Type: Article

References (47)

1. Byrd J.C., Stilgenbauer S., and Flinn I.W. Chronic lymphocytic leukemia. Hematology (Am Soc Hematol Educ Program) (2004) 163-183
2. Rai K.R., Sawitsky A., Cronkite E.P., Chanana A.D., Levy R.N., and Pasternack B.S. Clinical staging of chronic lymphocytic leukemia. Blood 46 (1975) 219-234
3. Binet J.L., Lepoprier M., Dighiero G., Charron D., D'Athis P., Vaugier G., Beral H.M., Natali J.C., Raphael M., Nizet B., and Follezou J.Y. A clinical staging system for chronic lymphocytic leukemia: prognostic significance. Cancer 40 (1977) 855-864
4. Damle R.N., Wasil T., Fais F., Ghiotto F., Valetto A., Allen S.L., Buchbinder A., Budman D., Dittmar K., Kolitz J., Lichtman S.M., Schulman P., Vinciguerra V.P., Rai K.R., Ferrarini M., and Chiorazzi N. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 94 (1999) 1840-1847
5. Hamblin T.J., Davis Z., Gardiner A., Oscier D.G., and Stevenson F.K. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 94 (1999) 1848-1854
6. Dohner H., Stilgenbauer S., Benner A., Leupolt E., Krober A., Bullinger L., Dohner K., Bentz M., and Lichter P. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 343 (2000) 1910-1916
7. Hamblin T.J., Orchard J.A., Ibbotson R.E., Davis Z., Thomas P.W., Stevenson F.K., and Oscier D.G. CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease. Blood 99 (2002) 1023-1029
8. Crespo M., Bosch F., Villamor N., Bellosillo B., Colomer D., Rozman M., Marce S., Lopez-Guillermo A., Campo E., and Montserrat E. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med 348 (2003) 1764-1775
9. Oscier D.G., Gardiner A.C., Mould S.J., Glide S., Davis Z.A., Ibbotson R.E., Corcoran M.M., Chapman R.M., Thomas P.W., Copplestone J.A., Orchard J.A., and Hamblin T.J. Multivariate analysis of prognostic factors in CLL: clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors. Blood 100 (2002) 1177-1184
10. Krober A., Seiler T., Benner A., Bullinger L., Bruckle E., Lichter P., Dohner H., and Stilgenbauer S. V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia. Blood 100 (2002) 1410-1416
11. Stilgenbauer S., Bullinger L., Lichter P., and Dohner H. Genetics of chronic lymphocytic leukemia: genomic aberrations and V(H) gene mutation status in pathogenesis and clinical course. Leukemia 16 (2002) 993-1007
12. Ghia P., Guida G., Stella S., Gottardi D., Geuna M., Strola G., Scielzo C., and Caligaris-Cappio F. The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression. Blood 101 (2003) 1262-1269
13. Rassenti L.Z., Huynh L., Toy T.L., Chen L., Keating M.J., Gribben J.G., Neuberg D.S., Flinn I.W., Rai K.R., Byrd J.C., Kay N.E., Greaves A., Weiss A., and Kipps T.J. ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia. N Engl J Med 351 (2004) 893-901
14. Que T.H., Marco J.G., Ellis J., Matutes E., Babapulle V.B., Boyle S., and Catovsky D. Trisomy 12 in chronic lymphocytic leukemia detected by fluorescence in situ hybridization: analysis by stage, immunophenotype, and morphology. Blood 82 (1993) 571-575
15. Escudier S.M., Pereira-Leahy J.M., Drach J.W., Weier H.U., Goodacre A.M., Cork M.A., Trujillo J.M., Keating M.J., and Andreeff M. Fluorescent in situ hybridization and cytogenetic studies of trisomy 12 in chronic lymphocytic leukemia. Blood 81 (1993) 2702-2707
16. Liso V., Capalbo S., Lapietra A., Pavone V., Guarini A., and Specchia G. Evaluation of trisomy 12 by fluorescence in situ hybridization in peripheral blood, bone marrow and lymph nodes of patients with B-cell chronic lymphocytic leukemia. Haematologica 84 (1999) 212-217
17. Criel A., Verhoef G., Vlietinck R., Mecucci C., Billiet J., Michaux L., Meeus P., Louwagie A., Van Orshoven A., Van Hoof A., Boogaerts M., Van den Berghe H., and De Wolf-Peeters C. Further characterization of morphologically defined typical and atypical CLL: a clinical, immunophenotypic, cytogenetic and prognostic study on 390 cases. Br J Haematol 97 (1997) 383-391
18. Hjalmar V., Kimby E., Matutes E., Sundstrom C., Jacobsson B., Arvidsson I., and Hast R. Trisomy 12 and lymphoplasmacytoid lymphocytes in chronic leukemic B-cell disorders. Haematologica 83 (1998) 602-609
19. Hjalmar V., Hast R., and Kimby E. Sequential fluorescence in situ hybridization analyses for trisomy 12 in chronic leukemic B-cell disorders. Haematologica 86 (2001) 174-180
20. Chena C., Arrossagaray G., Scolnik M., Palacios M.F., and Slavutsky I. Interphase cytogenetic analysis in Argentinean B-cell chronic lymphocytic leukemia patients: association of trisomy 12 and del(13q14). Cancer Genet Cytogenet 146 (2003) 154-160
21. Matutes E., Oscier D., Garcia-Marco J., Ellis J., Copplestone A., Gillingham R., Hamblin T., Lens D., Swansbury G.J., and Catovsky D. Trisomy 12 defines a group of CLL with atypical morphology: Correlation between cytogenetic, clinical and laboratory features in 544 patients. Br J Haematol 92 (1996) 382-388
22. Su'ut L., O'Connor S.J., Richards S.J., Jones R.A., Roberts B.E., Davies F.E., Fegan C.D., Jack A.S., and Morgan G.J. Trisomy 12 is seen within a specific subtype of B-cell chronic lymphoproliferative disease affecting the peripheral blood/bone marrow and co-segregates with elevated expression of CD11a. Br J Haematol 101 (1998) 165-170
23. Cheson B.D., Bennett J.M., Grever M., Kay N., Keating M.J., O'Brien S., and Rai K.R. National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood 87 (1996) 4990-4997
24. Morgan R., Chen Z., Richkind K., Roherty S., Velasco J., and Sandberg A.A. PHA/IL2: an efficient mitogen cocktail for cytogenetic studies of non-Hodgkin lymphoma and chronic lymphocytic leukemia. Cancer Genet Cytogenet 109 (1999) 134-137
25. ISCN. An international system for human cytogenetic nomenclature. In: Mitelman F. (Ed) (1995), S. Karger, Basel
26. Smilevska T, Stamatopoulos K, Samara M, Belessi C, Tsompanakou A, Paterakis G, Stavroyianni N, Athanasiadou I, Chiotoglou I, Hadzidimitriou A, Athanasiadou A, Douka V, Saloum R, Laoutaris N, Anagnostopoulos A, Fassas A, Stathakis N, Kollia P. Transferrin receptor-1 and 2 expression in chronic lymphocytic leukemia. Leuk Res 2005 Jul 27; [Epub ahead of print].
27. Ghia P., Stamatopoulos K., Belessi C., Moreno C., Stella S., Guida G., Michel A., Crespo M., Laoutaris N., Montserrat E., Anagnostopoulos A., Dighiero G., Fassas A., Caligaris-Cappio F., and Davi F. Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene. Blood 105 (2005) 1678-1685
28. Stamatopoulos K., Belessi C., Hadzidimitriou A., Smilevska T., Kalagiakou E., Hatzi K., Stavroyianni N., Athanasiadou A., Tsompanakou A., Papadaki T., Kokkini G., Paterakis G., Saloum R., Laoutaris N., Anagnostopoulos A., and Fassas A. Immunoglobulin light chain repertoire in chronic lymphocytic leukemia. Blood 106 (2005) 3575-3583
29. Lefranc M.-P. IMGT databases, web resources and tools for immunoglobulin and T cell receptor sequence analysis, http://imgt.cines.fr. Leukemia 2003;17:260-266.
30. Lefranc M.P., Giudicelli V., Kaas Q., Duprat E., Jabado-Michaloud J., Scaviner D., Ginestoux C., Clement O., Chaume D., and Lefranc G. IMGT, the international ImMunoGeneTics information system. Nucleic Acids Res 33 (2005) D593-D597
31. Giudicelli V., Chaume D., and Lefranc M.-P. IMGT/V-QUEST, an integrated software for immunoglobulin and T cell receptor V-J and V-D-J rearrangement analysis. Nucleic Acids Res 32 (2004) W435-W440
32. Athanasiadou A., Stamatopoulos K., Tsompanakou A., Foutsitsakis D., Fassas A., Anagnostopoulos A., and Tsezou A. Report of two novel chromosomal translocations in chronic lymphocytic leukemia. Leuk Lymphoma 46 (2005) 133-136
33. Glassman A.B., and Hayes K.J. The value of fluorescence in situ hybridization in the diagnosis and prognosis of chronic lymphocytic leukemia. Cancer Genet Cytogenet 158 (2005) 88-91
34. Aoun P., Blair H.E., Smith L.M., Dave B.J., Lynch J., Weisenburger D.D., Pavletic S.Z., and Sanger W.G. Fluorescence in situ hybridization detection of cytogenetic abnormalities in B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma. Leuk Lymphoma 45 (2004) 1595-1603
35. Mould S., Gardiner A., Corcoran M., and Oscier D.G. Trisomy 12 and structural abnormalities of 13q14 occurring in the same clone in chronic lymphocytic leukaemia. Br J Haematol 92 (1996) 389-392
36. Oscier D.G., Thompsett A., Zhu D., and Stevenson F.K. Differential rates of somatic hypermutation in V(H) genes among subsets of chronic lymphocytic leukemia defined by chromosomal abnormalities. Blood 89 (1997) 4153-4160
37. Navarro B., Garcia-Marco J.A., Jones D., Price C.M., and Catovsky D. Association and clonal distribution of trisomy 12 and 13q14 deletions in chronic lymphocytic leukaemia. Br J Haematol 102 (1998) 1330-1334
38. Fegan C., Robinson H., Thompson P., Whittaker J.A., and White D. Karyotypic evolution in CLL: identification of a new sub-group of patients with deletions of 11q and advanced or progressive disease. Leukemia 9 (1995) 2003-2008
39. Finn W.G., Kay N.E., Kroft S.H., Church S., and Peterson L.C. Secondary abnormalities of chromosome 6q in B-cell chronic lymphocytic leukemia: a sequential study of karyotypic instability in 51 patients. Am J Hematol 59 (1998) 223-229
40. Schlette E., Medeiros L.J., Keating M., and Lai R. CD79b expression in chronic lymphocytic leukemia. Association with trisomy 12 and atypical immunophenotype. Arch Pathol Lab Med 127 (2003) 561-566
41. Tabernero M.D., San Miguel J.F., Garcia J.L., Garcia-Isidoro M., Wiegant J., Ciudad J., Gonzalez M., Rios A., Raap A., and Orfao A. Clinical, biological, and immunophenotypical characteristics of B-cell chronic lymphocytic leukemia with trisomy 12 by fluorescence in situ hybridization. Cytometry 22 (1995) 217-222
42. Nair C.N., Chougule A., Dhond S., Goyal R., Parikh P.M., Pai S., Telang D., and Advani S.H. Trisomy 12 in chronic lymphocytic leukemia-geographical variation. Leuk Res 22 (1998) 313-317
43. Goorha S., Glenn M.J., Drozd-Borysiuk E., and Chen Z. A set of commercially available fluorescent in-situ hybridization probes efficiently detects cytogenetic abnormalities in patients with chronic lymphocytic leukemia. Genet Med 6 (2004) 48-53
44. Fais F., Ghiotto F., Hashimoto S., Sellars B., Valetto A., Allen S.L., Schulman P., Vinciguerra V.P., Rai K., Rassenti L.Z., Kipps T.J., Dighiero G., Schroeder Jr. H.W., Ferrarini M., and Chiorazzi N. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest 102 (1998) 1515-1525
45. Chiorazzi N., and Ferrarini M. B cell chronic lymphocytic leukemia: lessons learned from studies of the B cell antigen receptor. Annu Rev Immunol 21 (2003) 841-894
46. Stevenson F.K., and Caligaris-Cappio F. Chronic lymphocytic leukemia: revelations from the B-cell receptor. Blood 103 (2004) 4389-4395
47. Juliusson G., Oscier D., and Gahrton G. Cytogenetic findings and survival in B-cell chronic lymphocytic leukemia. Second IWCCLL compilation of data on 662 patients. Leuk Lymphoma 5 Suppl (1991) 21-25