Identification of potent and highly selective chiral tri-amine and tetra-amine μ opioid receptors ligands: An example of lead optimization using mixture-based libraries

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 16, 2006, Pages 4331-4338

  Nefzi, Adel ^a   Ostresh, John M ^a   Appel, Jon R ^a   Bidlack, Jean ^a   Dooley, Colette T ^a   Houghten, Richard A ^a  

^a TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

Author keywords

Opiate receptors; Amide reduction; Libraries; Polyamines; Positional scanning libraries

Indexed keywords

MU OPIATE RECEPTOR AGONIST; MU OPIATE RECEPTOR ANTAGONIST; POLYAMINE; TYROSYLTYROSYLPHENYLALANINAMIDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BIOASSAY; CHIRALITY; CONTROLLED STUDY; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; GUINEA PIG; ILEUM; NONHUMAN; REACTION OPTIMIZATION; STRUCTURE ACTIVITY RELATION;

ANIMALS; BIOLOGICAL ASSAY; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; GENE LIBRARY; GUINEA PIGS; ILEUM; INHIBITORY CONCENTRATION 50; LIGANDS; MODELS, CHEMICAL; PEPTIDES; POLYAMINES; RECEPTORS, OPIOID; RECEPTORS, OPIOID, MU; STRUCTURE-ACTIVITY RELATIONSHIP;

CAVIA PORCELLUS; TETRA;

EID: 33745699204     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.05.053     Document Type: Article

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