CNS drug discovery in the 21st century: From genomics to combinatorial chemistry and back

British Journal of Psychiatry

Volumn 174, Issue FEB. SUPPL. 37, 1999, Pages 23-25

  Paul, Steven ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXNORFENFLURAMINE; SEROTONIN 1B RECEPTOR; SEROTONIN 1F RECEPTOR; SEROTONIN 2C RECEPTOR; ANTIDEPRESSANT AGENT; SEROTONIN RECEPTOR;

DEPRESSION; DRUG DELIVERY SYSTEM; DRUG RECEPTOR BINDING; DRUG RESEARCH; GENE TECHNOLOGY; HUMAN; NEUROTRANSMISSION; PSYCHOPHARMACOTHERAPY; REVIEW; SEROTONINERGIC SYSTEM; BRAIN LEVEL; DRUG DESIGN; DRUG EFFECT; DRUG SCREENING; FORECASTING; GENE EXPRESSION; METHODOLOGY; PHARMACEUTICS; PHYSIOLOGY;

ANTIDEPRESSIVE AGENTS; BRAIN CHEMISTRY; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; FORECASTING; GENE EXPRESSION; HUMANS; RECEPTORS, SEROTONIN; TECHNOLOGY, PHARMACEUTICAL;

EID: 0032990794     PISSN: 00071250     EISSN: None     Source Type: Journal    
DOI: 10.1192/s0007125000293628     Document Type: Review

References (17)

1. IF): a fifth 5-HTI receptor subtype coupled to the inhibition of adenylate cyclase. Proceedings of the National Academy of Sciences of the United States of America, 90, 408-412.
2. IA antagonists. Trends in Neurosciences, 19, 378-383.
3. Azmitia, E. C. & Whitaker-Azmitia, P. M. (1991) Awakening the sleeping giant: anatomy and plasticity of the brain serotonergic system. Journal of Clinical Psychopharmacology, 52, 4-16.
4. Blier, P., de Montigny, C. & Chaput, Y. (1990) A role for the serotonin system in the mechanism of action of antidepressant treatments: preclinical evidence. Journal of Clinical Psychiatry, 51, 14-10.
5. _ & de Montigny, C. (1994) Current advances and trends in the treatment of depression. Trends in Pharmacological Sciences, 15, 220-226.
6. IB serotonin receptors. Nature Genetics, 14, 98-101.
7. Fuller, R.W. & Wong, D.T. (1990) Serotonin uptake and serotonin uptake inhibition. Annals of the New York Academy of Sciences, 600, 68-78.
8. IF receptor agonists inhibit neurogenic dural inflammation in guinea pigs. Neuroreport, 8, 2237-2240.
9. Liang, P. & Pardee, A. B. (1992) Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science, 257, 967-971.
10. McCann, U. D., Seiden, L. S., Rubin, L. J., et al (1997) Brain serotonin neurotoxicity and primary pulmonary hypertension from fenfluramine and dexfenfluramine. Journal of the American Medical Association, 278, 666-672.
11. Nibuya, M., Nestler, E. J. & Duman, R. S. (1996) Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. Journal of Neuroscience, 316, 2365-2372.
12. 2c receptor gene. Nature Medicine, 4, 1152-1156.
13. Paul, S. M., Wu, X., Liang, Y., et al (1997) Molecular strategies to novel antidepressant discovery. In Antidepressants: New Pharmocologic of Strategies (ed. P. Skolnick), pp. 235-250. Totowa, NJ: Humana Press.
14. Potter, W. Z. & Manji, H. K. (1994) Clinical onset of antidepressant action: implications for new drug development. In Critical Issues in the Treatment of Affective Disorders (eds S. Z. Larger, N. Brunello, G. Racagni, et al), pp. 118-126. Basel: Karger.
15. Sanders-Bush, E. & Canton, H. (1995) Serotonin receptors: signal transduction pathways. In Psychopharmacology: The Fourth Generation of Progress (eds F. E. Bloom & D.J. Kupfer), pp. 431-441. New York: Raven Press.
16. IB receptor. Science, 265, 1875-1878.
17. 2c serotonin receptors. Nature, 374, 542-546.