Genotypic association between the dopamine D3 receptor and tardive dyskinesia in chronic schizophrenia

Molecular Psychiatry

Volumn 4, Issue 3, 1999, Pages 247-253

  Segman, R ^a   Neeman, T ^a   Heresco Levy, U ^b   Finkel, B ^c   Karagichev, L ^a   Schlafman, M ^d   Dorevitch, A ^e   Yakir, A ^a   Lerner, A ^c   Shelevoy, A ^a   Lerer, B ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b HERZOG HOSPITAL   (Israel)

^c HASHARON HOSPITAL   (Israel)

^d Kfar Shaul Hospital   (Israel)

^e Talbieh Hospital   (Israel)

Author keywords

Dopamine D3 receptor; Genetic association; Schizophrenia; Tardive dyskinesia

Indexed keywords

DOPAMINE 3 RECEPTOR; GLYCINE; NEUROLEPTIC AGENT; SERINE;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENOTYPE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RECEPTOR GENE; SCHIZOPHRENIA; TARDIVE DYSKINESIA; VARIANCE;

EID: 0033046439     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000511     Document Type: Article

References (19)

1. 1 Le Conait M, Sokoloff P, Hillion J, Martres MP, Giros B, Pilon C et al. Chromosomal localization of the human dopamine D3 receptor gene. Hum Genet 1991; 87: 618-620.
2. 2 Lannfelt L, Sokololf P, Martres MP, Pilon C, Giros B, Johnsson E et al. Amino acid substitution in the dopamine D3 receptor as R useful polymorphism for investigating psychiatric disorders. Psychiatr Genet 1992; 2: 249-256.
3. 3 Williams J, Spurlock G, Holmans P, Mant R, Murphy K, Jones L et al. A meta-analysis and transmission disequilibrium study of association between the dopamine D3 receptor gene and schizophrenia. Mol Psychiatry 1998; 3: 141-149.
4. 4 Windl O, Dempser M, Estiberio JP et al. Genetic basis of Cruezfeldt-Jakob disease in the United Kingdom: a systematic analysis of predisposing mutations and allelic variation in the PRNP gene. Hum Genet 1996; 98: 259-264.
5. 5 Hawai Z, McCabe U, Straub RE, O'Neill A, Kendler KS, Walsh D et al. Examination of new and reported data of the DRD3/MScl polymorphism: no support for the proposed association with schizophrenia. Mol Psychiatry 1998; 2: 150-155.
6. 6 Krebs MO, Sautel F, Bourdel MC, Sokoloff P, Schwartz JC, Olie JP et al. Dopamine D3 receptor gene variants and substance abuse in schizophrenia. Mol Psychiatry 1998; 4: 337-341.
7. 7 Duaux E, Gorwood P, Griffon N, Bourdel MC, Sautel F, Sokoloff P et al. Homozygosity at the dopamine D3 receptor gene is associated with opiate dependence. Mol Psychiatry 1998; 4: 333-336.
8. 8 Steen VM, Lovelie R, MacEwan T, McCreadie RG. Dopamine D3-receptor gene variant and susceptibility to tardive dyskinesia in schizophrenic patients. Mol Psychiatry 1997; 2: 139-145.
9. 9 Kane JM, Smith J. Tardive dyskinesia: prevalence and risk factors, 1959 to 1979. Arch Gen Psychiatry 1982; 37: 473-481.
10. 10 Bannon MJ, Granneman JG, Kapatos G. The dopamine transporter: potential involvement in neuropsychiatric disorders. In: Bloom FE, Kupfer DJ (eds). Psychopharmacology: The 4th Generation of Progress. Raven Press: New York, 1995, pp 179-188.
11. 11 Kennedy JL, Billett E, Macciardi FM, Verga M, Parsons T, Meltzer HY et al. Association study of the dopamine D3 receptor gene and schizophrenia. Am J Med Genet (Neuropsychiatr Genet) 1995; 60: 558-562.
12. 12 Ebstein KP, Macciardi F, Blaine D, Serretti A, Gur E, Verga M et al. Evidence for an association between the dopamine D3 receptor gene (DRD3) and schizophrenia. Hum Hered 1997; 47: 6-16.
13. 13 Schooler NR, Kane JM. Research diagnoses for tardive dyskinesia. Arch Gen Psychiatry 1982; 39: 486-487.
14. 14 Guy W. ECDEU Assessment Manual for Psychopharmacology, revised edition. Department of Health, Education and Welfare: Washington DC, 1976.
15. 15 Kay SR, Opler LA. Positive and Negative Syndrome Scale (PANSS) Rating Manual. Social and Behavioral Sciences Documents: San Rafael CA, 1987.
16. 16 Simpson GM, Angus JWS. A rating scale for extrapyramidal side effects. Acta Psychiatr Scand 1970; 212 (Suppl): 11-19.
17. 17 Mant R, Williams, J, Asherson P, Parfitt E, McGuffin P, Owen J. Relationship between homozygosity at the dopamine D3 receptor gene and schizophrenia. Am J Med Genet (Neuropsychiatr Genet) 1994; 54: 21-26.
18. 18 Lundsrom K, Turpin MP. Proposed schizophrenia related gene polymorphism: expression of the Ser9Gly mutant human dopamine D3 receptor with the Semliki forest virus system. BBRC 1996; 225: 1068-1072.
19. 19 Kane JM. Tardive dyskinesia: epidemiological and clinical presentation. In: Bloom FE, Kupfer DJ (eds). Psychopharmacology: The 4th Generation of Progress. Raven Press: New York, 1995, pp 1485-1495.