N2 and P3 components of event-related potential in first-episode schizophrenic patients: Scalp topography, medication, and latency effects

Psychiatry Research

Volumn 111, Issue 2-3, 2002, Pages 167-179

  Demiralp, Tamer ^a   Üçok, Alp ^a   Devrim, Müge ^a   Isoglu Alkaç, Ümmühan ^a   Tecer, Alper ^a   Polich, John ^b  

^a ISTANBUL UNIVERSITY   (Turkey)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Auditory oddball paradigm; Event related potentials; First episode schizophrenia; Frontal lobe; N2; P3

Indexed keywords

CHLORPROMAZINE; PSYCHOTROPIC AGENT;

ARTICLE; ATTENUATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; EVENT RELATED POTENTIAL; FEMALE; FRONTAL CORTEX; HUMAN; LATENT PERIOD; MALE; MEMORY; PRIORITY JOURNAL; SCHIZOPHRENIA; STIMULUS; STIMULUS RESPONSE;

ACOUSTIC STIMULATION; ADULT; ANTIPSYCHOTIC AGENTS; CEREBRAL CORTEX; ELECTROENCEPHALOGRAPHY; EVENT-RELATED POTENTIALS, P300; EVOKED POTENTIALS, AUDITORY; FEMALE; FRONTAL LOBE; HUMANS; MALE; PATIENT ADMISSION; PSYCHIATRIC STATUS RATING SCALES; REACTION TIME; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 0037200627     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1781(02)00133-6     Document Type: Article

References (74)

1. Anderson J., Rennie C., Gordon E., Howson A., Meares R. Measurement of maximum variability within event related potentials in schizophrenia. Psychiatry Research. 39:1991;33-44.
2. Anderson J., Gordon E., Barry R.J., Rennie C., Beumont P.J., Meares R. Maximum variance of late component event related potentials in unmedicated schizophrenic patients. Psychiatry Research. 56:1995;229-236.
3. Baribeau-Braun J., Picton T.W., Gosselin J. Schizophrenia, a neurophysiological evaluation of abnormal information processing. Science. 227:1983;874-876.
4. Baribeau J., Laurent J.P., Decary A. Tardive dyskinesia and associated cognitive disorders: a convergent neuropsychological and neurophysiological approach. Brain and Cognition. 23:1993;40-55.
5. Barrett K., McCallum W.C., Pocock P.V. Brain indicators of altered attention and information processing in schizophrenic patients. British Journal of Psychiatry. 148:1986;414-420.
6. Baudena P., Halgren E., Heit G., Clarke J. Intracerebral potentials to rare target and distractor auditory and visual stimuli. III. Frontal cortex. Electroencephalopgraphy and Clinical Neurophysiology. 94:1995;251-264.
7. Biver F., Goldman S., Luxen A., Delvenne V., De Maertelaer V., De La Fuente J., Mendlewicz J., Lotstra F. Altered frontostriatal relationship in unmedicated schizophrenic patients. Psychiatry Research: Neuroimaging. 61:1995;161-171.
8. Brecher M., Porjesz B., Begleiter H. The N2 component of the event-related potential in schizophrenic patients. Electroencephalography and Clinical Neurophysiology. 66:1987;369-375.
9. Breier A., Buchanan R.W., Elkashef A., Munson R.C., Kirkpatrick B., Gellad F. Brain morphology and schizophrenia. A magnetic resonance imaging study of limbic prefrontal cortex, and caudate structures. Archives of General Psychiatry. 49:1992;921-926.
10. Buchsbaum M.S. The frontal lobes, basal ganglia, and temporal lobes as sites for schizophrenia. Schizophrenia Bulletin. 16:1990;379-384.
11. Coburn K.L., Shillcut S.D., Tucker K.A., Estes K.M., Brin F.B., Merai P., Moore N.C. P300 delay and attenuation in schizophrenia: reversal by neuroleptic medication. Biological Psychiatry. 44:1998;466-474.
12. Comerchero M.D., Polich J. P3a and P3b from typical auditory and visual stimuli. Clinical Neurophysiology. 110:1999;24-30.
13. Demiralp T., Ademoglu A., Comerchero M.D., Polich J. Wavelet analysis of P3a and P3b. Brain Topography. 13:2001;251-267.
14. Donchin E., Coles M.G.H. Is the P300 component a manifestation of context updating? Brain and Behavioral Science. 11:1988;357-374.
15. Duncan C.C., Perlstein W.M., Morihisa J.M. The P300 metric in schizophrenia: effects of probability and modality. Johnson R., Rohrbaugh J.W., Parasuraman R., Current Trends in Event-Related Potential Research (EEG suppl. 40). 1987;670-674 Elsevier, Amsterdam.
16. Ford J.M. Schizophrenia: the broken P300 and beyond. Psychophysiology. 36:1999;667-682.
17. Ford J.M., Pfefferbaum A., Roth W. P3 and schizophrenia. Friedman D., Bruder G., Psychophysiology and Experimental Psychophysiology: A Tribute to Samuel Sutton. 1992;146-162 New York Academy of Sciences, New York.
18. Ford J.M., White P.M., Csernansky J.G., Faustman W.O., Roth W.T., Pfefferbaum A. ERPs in schizophrenia: effects of antipsychotic medication. Biological Psychiatry. 36:1994;153-170.
19. Glabus M.F., Blackwood D.H.R., Ebmeier K.P., Souza V., Walker M.T., Sharp C.W., Dunan J.T., Muir W. Methodological considerations in measurement of the P300 component of the auditory oddball ERP in schizophrenia. Electroencephalography and Clinical Neurophysiology. 90:1994;123-134.
20. Grillon C., Courchesne E., Ameli R., Geyer M.A., Braff D.L. Increased distractibility in schizophrenic patients. Archives of General Psychiatry. 47:1990;171-179.
21. Hazlett E.A., Buchsbaum M.S., Jeu L.A., Nenadic I., Fleischman M.B., Shihabuddin L., Haznedar M.M., Harvey P.D. Hypofrontality in unmedicated schizophrenia patients studied with PET during performance of a serial verbal learning task. Schizophrenia Research. 43:2000;33-46.
22. Higashima M., Kawasaki Y., Urata K., Sakai N., Nagasawa T., Koshino Y., Sumiya H., Tonami N., Tsuji S., Matsuda H. Regional cerebral blood flow in male schizophrenic patients performing an auditory discrimination task. Schizophrenia Research. 42:2000;29-39.
23. Hirayasu Y., Asato N., Ohta H., Hokama H., Arakaki H., Ogura C. Abnormalities of auditory event-related potentials in schizophrenia prior to treatment. Biological Psychiatry. 43:1998;244-253.
24. Ingvar D.H., Franzén G. Abnormalities of cerebral blood flow distribution in patients with chronic schizophrenia. Acta Psychiatrica Scandinavica. 50:1974;425-462.
25. Jeon, Y.W., Polich, J. Meta-analysis of P300 schizophrenia studies: patients, paradigms and practical implications. Submitted.
26. Johnson R. On the neural generators of the P300 component of the event-related potential. Psychophysiology. 23:1993;33-40.
27. Kasai K., Okazawa K., Nakagome K., Hiramatsu K., Hata A., Fukuda M., Honda M., Miyauchi M. Mismatch negativity and N2b attenuation as an indicator for dysfunction of the preattentive and controlled processing for deviance detection in schizophrenia: a topographic event-related potential study. Schizophrenia Research. 35:1999;141-156.
28. Katayama J., Polich J. Stimulus context determines P3a and P3b. Psychophysiology. 35:1998;23-33.
29. Katsanis J., Iacono W.G., Beiser M. Visual event-related potentials in first-episode psychotic patients and their relatives. Psychophysiology. 33:1996;207-217.
30. Kemali D., Galderisi S., Maj M., Mucci A., Di Gregorio M. Lateralization patterns of event-related potential and performance indices in schizophrenia: relationship to clinical state and neuroleptic treatment. International Journal of Psychophysiology. 10:1991;225-230.
31. Knight R. Decreased response to novel stimuli after prefrontal lesions in man. Electroencephalography and Clinical Neurophysiology. 59:1984;9-20.
32. Knight R. Contribution of human hippocampal region to novelty detection. Nature. 383:1996;256-259.
33. Knight R., Grabowecky M., Scabini D. Role of human prefrontal cortex in attention control. Advances in Neurology. 66:1995;21-34.
34. Laurent A., Garcia-Larrea L., d'Amato T., Bosson J.L., Saoud M., Marie-Cardine M., Maugiere F., Dalery J. Auditory event-related potentials and clinical scores in unmedicated schizophrenic patients. Psychiatry Research. 86:1999;229-238.
35. Manoach D.S., Press D.Z., Thangaraj V., Searl M.M., Goff D.C., Halpern E., Saper C.B., Warach S. Schizophrenic subjects activate dorsolateral prefrontal cortex during a working memory task, as measured by fMRI. Biological Psychiatry. 45:1999;1128-1137.
36. Mathalon D.H., Ford J.M., Pfefferbaum A. Trait and state aspects of P300 amplitude reduction in schizophrenia: a retrospective longitudinal study. Biological Psychiatry. 47:2000;434-449.
37. McCarley R.W., Faux S.F., Shenton M.E., Nestor P.G., Adams J. Event-related potentials in schizophrenia, their biological and clinical correlates and a new model of schizophrenic pathophysiology. Schizophrenia Research. 4:1991;209-231.
38. McCarthy G., Wood C.C. Scalp distributions of event-related potentials: an ambiguity associated with analysis of variance models. Electroencephalography and Clinical Neurophysiology. 62:1985;203-208.
39. McCarthy G., Luby M., Gore J., Goldman-Rakic P. Infrequent events transiently activate human prefrontal and parietal cortex as measured by functional MRI. Journal of Neurophysiology. 77:1997;1630-1634.
40. Merrin E.L., Floyd T.C. P300 responses to novel auditory stimuli in hospitalized schizophrenic patients. Biological Psychiatry. 36:1994;527-542.
41. Mintz M., Hermesh H., Glicksohn J., Munitz H., Radwan M. First month of neuroleptic treatment in schizophrenia: only partial normalization of the late positive components of visual ERP. Biological Psychiatry. 37:1995;402-409.
42. Morstyn R., Duffy F.H., McCarley R.W. Altered P300 topography in schizophrenia. Archives of General Psychiatry. 40:1983;729-734.
43. Muir W.J., St. Clair D.M., Blackwood D.H. Long-latency auditory event-related potentials in schizophrenia and in bipolar and unipolar affective disorder. Psychological Medicine. 21:1991;867-879.
44. Nopoulos P., Torres I., Flaum M., Andreasen N.C., Ehrhardt J.C., Yuh W.T. Brain morphology in first-episode schizophrenia. American Journal of Psychiatry. 152:1995;1721-1723.
45. O'Donnell B.F., Shenton M.E., McCarley R.W., Faux S.F., Smith R.S., Salisbury D.F., Nestor P.G., Pollak S.D., Kikinis R., Jolesz F.A. The auditory N2 component in schizophrenia: relationship to MRI temporal lobe gray matter and to other ERP abnormalities. Biological Psychiatry. 34:1993;26-40.
46. O'Donnell B.F., Hokama H., McCarley R.W., Smith R.S., Salisbury D.F., Mondrow E., Nestor P.G., Shenton M.E. Auditory ERPs to non-target stimuli in schizophrenia: relationship to probability, task-demands, and target ERPs. International Journal of Psychophysiology. 17:1994;219-231.
47. O'Donnell B.F., Faux S.F., McCarley R., Kimble M.O., Salisbury D.F., Nestor P.G., Kikinis R., Jolesz F.A., Shenton M.E. Increased rate of P300 latency with age in schizophrenia: electrophysiological evidence for neurodegenerative process. Archives of General Psychiatry. 52:1995;544-549.
48. Ogura C., Nageishi Y., Matsubayashi M., Omura F., Mura F., Kishimoto A., Shimokochi M. Abnormalities of event-related potentials, N100, P200, P3 and slow wave in schizophrenia. Japan Journal of Psychiatry and Neurology. 45:1991;57-65.
49. Olichney J.M., Iragui V.J., Kutas M., Nowacki R., Morris S., Jeste D.V. Relationship between auditory P300 amplitude and age of onset of schizophrenia in older patients. Psychiatry Research. 79:1998;241-254.
50. Parellada E., Catafau A.M., Bernardo M., Lomena F., Catarineu S., Gonzales-Monclus E. The resting and activation issue of hypofrontality: a single photon emission computed tomography study in neuroleptic-naïve and neuroleptic-free schizophrenic female patients. Biological Psychiatry. 44:1998;787-790.
51. Pfefferbaum A., Marsh L. Structural brain imaging in schizophrenia. Clinical Neuroscience. 3:1995;105-111.
52. Pfefferbaum A., Wenegrat B.G., Ford J.M., Roth W.T., Kopell B.S. Clinical application of the P3 component of the event-related potentials. II. Dementia, depression and schizophrenia. Electroencephalography and Clinical Neurophysiology. 59:1984;104-124.
53. Pfefferbaum A., Ford J.M., White P.M., Roth W.T., Mathalon D.H. P3 in schizophrenia is affected by stimulus modality, response requirements, medication status, and negative symptoms. Archives of General Psychiatry. 46:1989;1035-1044.
54. Picton T.W. The P3 wave of the human event-related potential. Journal of Clinical Neurophysiology. 9:1992;456-479.
55. Polich J. Task difficulty, probability, and inter-stimulus interval as determinants of P300 latency from auditory stimuli. Electroencephalography and Clinical Neurophysiology. 63:1986;251-259.
56. Polich J. P300 clinical utility and control of variability. Journal of Clinical Neurophysiology. 15:1998;14-33.
57. Polich J., Pitzer A. P300 and Alzheimer's disease: oddball task difficulty and modality effects. Electroencephalography and Clinical Neurophysiology. 50:(Suppl.):1999;281-287.
58. Pritchard W.S. Cognitive event-related potential correlates of schizophrenia. Psychological Bulletin. 100:1986;43-66.
59. Ravizza L., Zanalda E., Bogetto F. Changes in rCBF HMPAO SPECT Studies According to the Course of Schizophrenic Illness. 1995;Kruger Press, Basel.
60. Roth W.T., Pfefferbaum A., Horvath T.B., Berger P.A., Kopell B.S. P3 reduction in auditory evoked potentials of schizophrenics. Electroencephalography and Clinical Neurophysiology. 49:1980;497-505.
61. Salisbury D.F., O'Donnell B.F., McCarley R.W., Shenton M.E., Benavage A. The N2 event-related potential reflects attention deficit in schizophrenia. Biological Psychology. 39:1994a;1-13.
62. Salisbury D.F., O'Donnell B.F., McCarley R.W., Nestor P.G., Faux S.F., Smith R.S. Parametric manipulations of auditory stimuli differentially affect P3 amplitude in schizophrenics and controls. Psychophysiology. 31:1994b;29-36.
63. Salisbury D.F., Shenton M.E., Sherwood A.R., Fischer I.A., Yurgelun-Todd D.A., Tohen M., McCarley R.W. First-episode schizophrenic psychosis differs from first-episode affective psychosis and controls in P300 amplitude over left temporal lobe. Archives of General Psychiatry. 55:1998;173-180.
64. Schröder J., Buchsbaum M.S., Siegel B.V., Geider F.J., Lohr J., Tang C., Wu J., Potkin S.G. Cerebral metabolic activity correlates of subsyndromes in chronic schizophrenia. Schizophrenia Research. 19:1996;41-53.
65. Schwartz F., Carr A.C., Munich R.L., Glauber S., Lesser B., Murray J. Reaction time impairment in schizophrenia and affective illness: the role of attention. Biological Psychiatry. 25:1989;540-548.
66. Shelley A.M., Grochowski S., Lieberman J.A., Javitt D.C. Premature disinhibition of P3 generation in schizophrenia. Biological Psychiatry. 39:1996;714-719.
67. Spence S.A., Hirsch S.R., Brooks D.J., Grasby P.M. Prefrontal cortex activity in people with schizophrenia and control subjects. Evidence from positron emission tomography of 'hypofrontality' with recovery from acute schizophrenia. British Journal of Psychiatry. 172:1998;316-323.
68. Spitzer R.L., Williams J.B.W., Gibbon M., First M.B. The Structured Clinical Interview for DSM-III-R (SCID), I: history, rationale, and description. Archives of General Psychiatry. 49:1992;624-629.
69. Sponheim S.C., Clementz B.A., Iacono W.G., Beiser M. Resting EEG in first-episode and chronic schizophrenia. Psychophysiology. 31:1994;37-43.
70. Sugg M.J., Polich J. P300 from auditory stimuli: intensity and frequency effects. Biological Psychology. 41:1995;255-269.
71. Turetsky B., Colbath E.A., Gur R.E. P300 subcomponent abnormalities in schizophrenia: II. Longitudinal stability and relationship to symptom change. Biological Psychiatry. 43:1998;31-39.
72. Velakoulis D., Pantelis C. What have we learned from functional imaging studies in schizophrenia? The role of frontal, striatal and temporal areas. Australian and New Zealand Journal of Psychiatry. 30:1996;195-209.
73. Vesco K.K., Bone R.C., Ryan J.C., Polich J. P300 in young and elderly subjects: auditory frequency and intensity effects. Electroencephalography and Clinical Neurophysiology. 88:1993;302-308.
74. Volz H., Gaser C., Hager F., Rzanny R., Ponisch J., Mentzel H., Kaiser W.A., Sauer H. Decreased frontal activation in schizophrenics during stimulation with the continuous performance test - a functional magnetic resonance imaging study. European Psychiatry. 14:1999;17-24.