Mesolimbic dopamine D3 receptors and use of antipsychotics in patients with schizophrenia: A postmortem study

Archives of General Psychiatry

Volumn 54, Issue 3, 1997, Pages 225-232

  Gurevich, Eugenia V ^a,b   Bordelon, Yvette ^a   Shapiro, Raymond M ^a   Arnold, Steven E ^a   Gur, Raquel E ^a   Joyce, Jeffrey N ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b SUN HEALTH RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 DIPROPYLAMINO 7 HYDROXYTETRALIN; DOMPERIDONE; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; DOPAMINE 4 RECEPTOR; HALOPERIDOL; NEUROLEPTIC AGENT; RACLOPRIDE; SPIPERONE; DIAGNOSTIC AGENT; DOPAMINE RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; DRD3 PROTEIN, HUMAN; RADIOACTIVE IODINE; TETRALIN DERIVATIVE;

AGED; ARTICLE; BASAL GANGLION; CLINICAL ARTICLE; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DRUG TARGETING; FEMALE; HUMAN; HUMAN TISSUE; LIMBIC CORTEX; MALE; RECEPTOR AFFINITY; RECEPTOR DENSITY; SCHIZOPHRENIA; ADULT; AUTORADIOGRAPHY; BINDING COMPETITION; CHEMISTRY; COMPARATIVE STUDY; CORPUS STRIATUM; DOWN REGULATION; DRUG EFFECT; FOREBRAIN; LIMBIC SYSTEM; METABOLISM; MIDDLE AGED; RADIOASSAY;

ADULT; AGED; ANTIPSYCHOTIC AGENTS; AUTORADIOGRAPHY; BASAL GANGLIA; BINDING, COMPETITIVE; CORPUS STRIATUM; DOPAMINE AGONISTS; DOPAMINE ANTAGONISTS; DOWN-REGULATION; FEMALE; HUMANS; IODINE RADIOISOTOPES; LIMBIC SYSTEM; MALE; MIDDLE AGED; PROSENCEPHALON; RADIOLIGAND ASSAY; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; SCHIZOPHRENIA; TETRAHYDRONAPHTHALENES;

EID: 0030615211     PISSN: 0003990X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archpsyc.1997.01830150047009     Document Type: Article

References (34)

1. Lieberman JA, Kinon BJ, Loebel AD. Dopaminergic mechanisms in idiopathic and drug-induced psychoses. Schizophr Bull. 1990;16:97-110.
2. Seeman P, Chau-Wong M, Tedesco J, Wong K. Brain receptors for antipsy-chotic drugs and dopamine: direct binding assays. Proc Natl Acad Sci USA. 1975;72:4376-4380.
3. 2 dopamine receptors in schizophrenia, Alzheimer's. Parkinson's and Huntington's disease. Neuropsychopharmacology. 1987;1:5-15.
4. 4 receptors elevated in schizophrenia. Nature. 1993;365:441-445.
5. 2 receptors in human striatum: receptor autobiographic studies in Huntington's disease and schizophrenia. Synapse. 1986;2:546-557.
6. Hogberg T, Ramsby S, Ogren SO, Norinder U. New selective dopamine D-2 antagonists as antipsychotic agents: pharmacological, chemical, structural, and theoretical considerations. Acta Pharm Suec. 1987;24:289-328.
7. Merchant KM, Dobie DJ, Dorsa DM. Expression of the proneurotensin gene in the rat brain and its regulation by antipsychotic drugs. Ann N Y Acad Sci. 1992;668:54-69.
8. Moghaddam B, Bunney BS. Acute effect of typical and atypical antipsychotic drugs on the release of dopamine from prefrontal cortex, nucleus accumbens, and striatum of the rat: an in vivo microdialysis study. J Neurochem. 1990;54:1755-1760.
9. Csernansky JG, Murphy GM, Faustman WO. Limbic/mesolimbic connections and the pathogenesis of schizophrenia. Biol Psychiatry. 1991;30:383-400.
10. Louilot A, Le Moal M. Lateralized interdependence between limbicotemporal and ventrostriatal dopaminergic transmission. Neuroscience. 1994;59:495-500.
11. 2 receptors to mesostriatal regions of human forebrain. Proc Natl Acad Sci U S A. 1994;91:11,271-11,275.
12. 3) as a target for neuroleptics. Nature. 1990;347:146-151.
13. 3H]7-hydroxy-N,N-di-n-propyl-2-aminotetralin. Brain Res. 1994;648:222-228.
14. Meador-Woodruff JH, Damask SP, Wang J, Haroutunian V, Davis KL, Watson SJ. Dopamine receptor mRNA expression in human striatum and neocortex. Neuropsychopharmacology. 1996;15:17-29.
15. 3 dopamine receptor ligand. J Med Chem. 1993;36:1490-1500.
16. 3 receptors in rat olfactory tubercle. J Pharmacol Exp Ther. 1994;268:939-942.
17. 125l]R(+)trans-7-OH-PIPAT in rat brain. Naunyn Schmiedebergs Arch Pharmacol. 1994;350:611-617.
18. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised. Washington, DC: American Psychiatric Association; 1987.
19. Arnold SE, Gur RE, Shapiro RM, Fisher KR, Moberg PJ, Gibney MR, Gur RC, Blackwell P, Trojanowski JQ. Prospective clinicopathological studies of schizophrenia: accrual and assessment, Am J Psychiatry. 1995;152:731-737.
20. Kane JM. In: Kapian HI, Sadock BJ, eds. Comprehensive Textbook of Psychiatry. 5th ed, Baltimore, Md: Williams & Wilkins; 1989:777-792.
21. McGonigle P, Neve KA, Molinoff PB. A quantitative method of analyzing the interaction of slightly selective radioligands with multiple receptor subtypes. Mol Pharmacol. 1986;30:329-337.
22. 2 receptor. Eur J Pharmacol. 1992;225:331-337.
23. Joyce JN, Sapp DW, Marshall JF. Human striatal dopamine receptors are organized in patches. Proc Natl Acad Sci USA. 1986;83:8002-8006.
24. 2 receptors and neuropeptides in striatonigal neurons of rats with neuroleptic induces dyskinesias. Synapse. 1994;18:178-189.
25. 2 dopamine receptor subtype mRNA levels in the brain. FEBS Lett. 1994;339:63-66.
26. 2 receptor modulation in rat striatum and nucleus accumbens after chronic haloperidol treatment. Brain Res. 1992;575:47-56.
27. 3 receptor expression suggests the involvement of an anterograde factor from dopamine neurons. Proc Natl Acad Sci USA. 1995;92:1719-1723.
28. 4 receptors by 2-fold in rats. Eur J Pharmacol. 1995;289:67-72.
29. Damask SP, Bovenkerk KA, de la Pena G, Hoversten KM, Peters DB, Valentine AM, Meador-Woodruff JH. Differential effects of clozapine and haloperidol on dopamine receptor mRNA expression in rat striatum and cortex. Mol Brain Res. 1996;41:241-249.
30. Joyce JN. The dopamine hypothesis of schizophrenia: limbic interactions with serotonin and norepinephrine. Psychopharmacology. 1993;112(suppl);S16-S34.
31. Alexander GE, Crutcher MD. Functional architecture of basal ganglia circuits: neural substrates of parallel processing. Trends Neurosci. 1990;13:266-271.
32. Amalric M, Koob GF. Functionally selective neurochemical afferents and efferents of the mesocorticolimbic and nigrostriatal dopamine system. Prog Brain Res. 1993;99:209-226.
33. Mogenson GJ, Yang CR, Yim CY. Influence of dopamine on limbic inputs to the nucleus accumbens. Ann N Y Acad Sci. 1988;537:86-100.
34. Mackay AVP, Iversen L, Rossor M, Spokes E, Bird E, Arregui A, Creese I, Snyder SH. increased brain dopamine and dopamine receptors in schizophrenia. Arch Gen Psychiatry. 1982;39:991-997.