메뉴 건너뛰기




Volumn 17, Issue 7, 2006, Pages 3187-3196

The docking protein Cas links tyrosine phosphorylation signaling to elongation of cerebellar granule cell axons

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CRK ASSOCIATED SUBSTRATE PROTEIN; CRK PROTEIN; DOCKING PROTEIN; MUTANT PROTEIN; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

EID: 33745621899     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E05-12-1122     Document Type: Article
Times cited : (24)

References (54)
  • 2
    • 23044500874 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of paxillin affects the metastatic potential of human osteosarcoma
    • Azuma, K., Tanaka, M., Uekita, T., Inoue, S., Yokota, J., Ouchi, Y., and Sakai, R. (2005). Tyrosine phosphorylation of paxillin affects the metastatic potential of human osteosarcoma. Oncogene 24, 4754-4764.
    • (2005) Oncogene , vol.24 , pp. 4754-4764
    • Azuma, K.1    Tanaka, M.2    Uekita, T.3    Inoue, S.4    Yokota, J.5    Ouchi, Y.6    Sakai, R.7
  • 3
    • 0030887348 scopus 로고    scopus 로고
    • NCAM140 interacts with the focal adhesion kinase p125(fak) and the SRC-related tyrosine kinase p59(fyn)
    • Beggs, H. E., Baragona, S. C., Hemperly, J. J., and Maness, P. F. (1997). NCAM140 interacts with the focal adhesion kinase p125(fak) and the SRC-related tyrosine kinase p59(fyn). J. Biol. Chem. 272, 8310-8319.
    • (1997) J. Biol. Chem. , vol.272 , pp. 8310-8319
    • Beggs, H.E.1    Baragona, S.C.2    Hemperly, J.J.3    Maness, P.F.4
  • 4
    • 0027971705 scopus 로고
    • NCAM-dependent neunte outgrowth is inhibited in neurons from Fyn-minus mice
    • Beggs, H. E., Soriano, P., and Maness, P. F. (1994). NCAM-dependent neunte outgrowth is inhibited in neurons from Fyn-minus mice. J. Cell. Biol. 127, 825-833.
    • (1994) J. Cell. Biol. , vol.127 , pp. 825-833
    • Beggs, H.E.1    Soriano, P.2    Maness, P.F.3
  • 5
    • 21844475890 scopus 로고    scopus 로고
    • Constitutively active cytoplasmic c-Jun N-terminal kinase 1 is a dominant regulator of dendritic architecture: Role of microtubule-associated protein 2 as an effector
    • Bjorkblom, B., Ostman, N., Hongisto, V., Komarovski, V., Filen, J. J., Nyman, T. A., Kallunki, T., Courtney, M. J., and Coffey, E. T. (2005). Constitutively active cytoplasmic c-Jun N-terminal kinase 1 is a dominant regulator of dendritic architecture: role of microtubule-associated protein 2 as an effector. J. Neurosci. 25, 6350-6361.
    • (2005) J. Neurosci. , vol.25 , pp. 6350-6361
    • Bjorkblom, B.1    Ostman, N.2    Hongisto, V.3    Komarovski, V.4    Filen, J.J.5    Nyman, T.A.6    Kallunki, T.7    Courtney, M.J.8    Coffey, E.T.9
  • 7
    • 0032509565 scopus 로고    scopus 로고
    • Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration
    • Cary, L. A., Han, D. C., Polte, T. R., Hanks, S. K., and Guan, J. L. (1998). Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration. J. Cell. Biol. 140, 211-221.
    • (1998) J. Cell. Biol. , vol.140 , pp. 211-221
    • Cary, L.A.1    Han, D.C.2    Polte, T.R.3    Hanks, S.K.4    Guan, J.L.5
  • 8
    • 0346037264 scopus 로고    scopus 로고
    • JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins
    • Chang, L., Jones, Y., Ellisman, M. H., Goldstein, L. S., and Karin, M. (2003). JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. Dev. Cell. 4, 521-533.
    • (2003) Dev. Cell. , vol.4 , pp. 521-533
    • Chang, L.1    Jones, Y.2    Ellisman, M.H.3    Goldstein, L.S.4    Karin, M.5
  • 9
    • 0030007022 scopus 로고    scopus 로고
    • Transient expression of lyn gene in Purkinje cells during cerebellar development
    • Chen, S., Ren, Y. Q., and Hillman, D. E. (1996). Transient expression of lyn gene in Purkinje cells during cerebellar development. Brain Res. Dev. Brain Res. 92, 140-146.
    • (1996) Brain Res. Dev. Brain Res. , vol.92 , pp. 140-146
    • Chen, S.1    Ren, Y.Q.2    Hillman, D.E.3
  • 10
    • 0141953237 scopus 로고    scopus 로고
    • Cytoskeletal dynamics and transport in growth cone motility and axon guidance
    • Dent, E. W., and Gertler, F. B. (2003). Cytoskeletal dynamics and transport in growth cone motility and axon guidance. Neuron 40, 209-227.
    • (2003) Neuron , vol.40 , pp. 209-227
    • Dent, E.W.1    Gertler, F.B.2
  • 11
    • 0035253071 scopus 로고    scopus 로고
    • Rho GTPases in growth cone guidance
    • Dickson, B. J. (2001). Rho GTPases in growth cone guidance. Curr. Opin. Neurobiol. 11, 103-110.
    • (2001) Curr. Opin. Neurobiol. , vol.11 , pp. 103-110
    • Dickson, B.J.1
  • 13
    • 0035796480 scopus 로고    scopus 로고
    • A direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activation
    • Girardin, S. E., and Yaniv, M. (2001). A direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activation. EMBO J. 20, 3437-3446.
    • (2001) EMBO J. , vol.20 , pp. 3437-3446
    • Girardin, S.E.1    Yaniv, M.2
  • 14
    • 3042730952 scopus 로고    scopus 로고
    • Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neuntes
    • Haglund, K., Ivankovic-Dikic, I., Shimokawa, N., Kruh, G. D., and Dikic, I. (2004). Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neuntes. J. Cell. Sci. 117, 2557-2568.
    • (2004) J. Cell. Sci. , vol.117 , pp. 2557-2568
    • Haglund, K.1    Ivankovic-Dikic, I.2    Shimokawa, N.3    Kruh, G.D.4    Dikic, I.5
  • 15
    • 1242271191 scopus 로고    scopus 로고
    • Protein kinase C signaling mediates global enhancement of excitatory synaptogenesis in neurons triggered by local contact with astrocytes
    • Hama, H., Hara, C., Yamaguchi, K., and Miyawaki, A. (2004). Protein kinase C signaling mediates global enhancement of excitatory synaptogenesis in neurons triggered by local contact with astrocytes. Neuron 41, 405-415.
    • (2004) Neuron , vol.41 , pp. 405-415
    • Hama, H.1    Hara, C.2    Yamaguchi, K.3    Miyawaki, A.4
  • 16
    • 0028956797 scopus 로고
    • Mechanisms of neural patterning and specification in the developing cerebellum
    • Hatten, M. E., and Heintz, N. (1995). Mechanisms of neural patterning and specification in the developing cerebellum. Annu. Rev. Neurosci. 18, 385-408.
    • (1995) Annu. Rev. Neurosci. , vol.18 , pp. 385-408
    • Hatten, M.E.1    Heintz, N.2
  • 17
    • 0036154848 scopus 로고    scopus 로고
    • Isolation and characterization of detergent-resistant microdomains responsive to NCAM-mediated signaling from growth cones
    • He, Q., and Meiri, K. F. (2002). Isolation and characterization of detergent-resistant microdomains responsive to NCAM-mediated signaling from growth cones. Mol. Cell. Neurosci. 19, 18-31.
    • (2002) Mol. Cell. Neurosci. , vol.19 , pp. 18-31
    • He, Q.1    Meiri, K.F.2
  • 18
    • 0031696486 scopus 로고    scopus 로고
    • SRC binding to the cytoskeleton, triggered by growth cone attachment to laminin, is protein tyrosine phosphatase-dependent
    • Helmke, S., Lohse, K., Mikule, K., Wood, M. R., and Pfenninger, K. H. (1998). SRC binding to the cytoskeleton, triggered by growth cone attachment to laminin, is protein tyrosine phosphatase-dependent. J. Cell. Sci. 111(Pt 16), 2465-2475.
    • (1998) J. Cell. Sci. , vol.111 , Issue.PART 16 , pp. 2465-2475
    • Helmke, S.1    Lohse, K.2    Mikule, K.3    Wood, M.R.4    Pfenninger, K.H.5
  • 19
    • 0022448305 scopus 로고
    • Differential contributions of Ng-CAM and N-CAM to cell adhesion in different neural regions
    • Hoffman, S., Friedlander, D. R., Chuong, C. M., Grumet, M., and Edelman, G. M. (1986). Differential contributions of Ng-CAM and N-CAM to cell adhesion in different neural regions. J. Cell. Biol. 103, 145-158.
    • (1986) J. Cell. Biol. , vol.103 , pp. 145-158
    • Hoffman, S.1    Friedlander, D.R.2    Chuong, C.M.3    Grumet, M.4    Edelman, G.M.5
  • 20
    • 17344362766 scopus 로고    scopus 로고
    • Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas
    • Honda, H. et al. (1998). Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas. Nat. Genet. 19, 361-365.
    • (1998) Nat. Genet. , vol.19 , pp. 361-365
    • Honda, H.1
  • 21
    • 0037178809 scopus 로고    scopus 로고
    • Differential regulation of cell migration, actin stress fiber organization, and cell transformation by functional domains of Crk-associated substrate
    • Huang, J., Hamasaki, H., Nakamoto, T., Honda, H., Hirai, H., Saito, M., Takato, T., and Sakai, R. (2002). Differential regulation of cell migration, actin stress fiber organization, and cell transformation by functional domains of Crk-associated substrate. J. Biol. Chem. 277, 27265-27272.
    • (2002) J. Biol. Chem. , vol.277 , pp. 27265-27272
    • Huang, J.1    Hamasaki, H.2    Nakamoto, T.3    Honda, H.4    Hirai, H.5    Saito, M.6    Takato, T.7    Sakai, R.8
  • 22
    • 0028347820 scopus 로고
    • Impaired neunte outgrowth of src-minus cerebellar neurons on the cell adhesion molecule L1
    • Ignelzi, M. A., Jr., Miller, D. R., Soriano, P., and Maness, P. F. (1994). Impaired neunte outgrowth of src-minus cerebellar neurons on the cell adhesion molecule L1. Neuron 12, 873-884.
    • (1994) Neuron , vol.12 , pp. 873-884
    • Ignelzi Jr., M.A.1    Miller, D.R.2    Soriano, P.3    Maness, P.F.4
  • 24
    • 0032559562 scopus 로고    scopus 로고
    • CAS/Crk coupling serves as a "molecular switch" for induction of cell migration
    • Klemke, R. L., Leng, J., Molander, R., Brooks, P. C., Vuori, K., and Cheresh, D. A. (1998). CAS/Crk coupling serves as a "molecular switch" for induction of cell migration. J. Cell Biol. 140, 961-972.
    • (1998) J. Cell Biol. , vol.140 , pp. 961-972
    • Klemke, R.L.1    Leng, J.2    Molander, R.3    Brooks, P.C.4    Vuori, K.5    Cheresh, D.A.6
  • 25
    • 0033868390 scopus 로고    scopus 로고
    • From the growth cone surface to the cytoskeleton: One journey, many paths
    • Korey, C. A., and Van Vactor, D. (2000). From the growth cone surface to the cytoskeleton: one journey, many paths. J. Neurobiol. 44, 184-193.
    • (2000) J. Neurobiol. , vol.44 , pp. 184-193
    • Korey, C.A.1    Van Vactor, D.2
  • 26
    • 0021046979 scopus 로고
    • L1 mono- and polyclonal antibodies modify cell migration in early postnatal mouse cerebellum
    • Lindner, J., Rathjen, F. G., and Schachner, M. (1983). L1 mono- and polyclonal antibodies modify cell migration in early postnatal mouse cerebellum. Nature 305, 427-430.
    • (1983) Nature , vol.305 , pp. 427-430
    • Lindner, J.1    Rathjen, F.G.2    Schachner, M.3
  • 28
    • 0036441201 scopus 로고    scopus 로고
    • Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticity
    • Luo, L. (2002). Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticity. Annu. Rev. Cell Dev. Biol. 18, 601-635.
    • (2002) Annu. Rev. Cell Dev. Biol. , vol.18 , pp. 601-635
    • Luo, L.1
  • 29
    • 0024040966 scopus 로고
    • c-src gene product in developing rat brain is enriched in nerve growth cone membranes
    • Maness, P. F., Aubry, M., Shores, C. G., Frame, L., and Pfenninger, K. H. (1988). c-src gene product in developing rat brain is enriched in nerve growth cone membranes. Proc. Natl. Acad. Sci. USA 85, 5001-5005.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 5001-5005
    • Maness, P.F.1    Aubry, M.2    Shores, C.G.3    Frame, L.4    Pfenninger, K.H.5
  • 31
    • 0037164899 scopus 로고    scopus 로고
    • Migration of nerve growth cones requires detergent-resistant membranes in a spatially defined and substrate-dependent manner
    • Nakai, Y., and Kamiguchi, H. (2002). Migration of nerve growth cones requires detergent-resistant membranes in a spatially defined and substrate-dependent manner. J. Cell Biol. 159, 1097-1108.
    • (2002) J. Cell Biol. , vol.159 , pp. 1097-1108
    • Nakai, Y.1    Kamiguchi, H.2
  • 32
    • 0029945648 scopus 로고    scopus 로고
    • Direct binding of C-terminal region of p130Cas to SH2 and SH3 domains of Src kinase
    • Nakamoto, T., Sakai, R., Ozawa, K., Yazaki, Y., and Hirai, H. (1996). Direct binding of C-terminal region of p130Cas to SH2 and SH3 domains of Src kinase. J. Biol. Chem. 271, 8959-8965.
    • (1996) J. Biol. Chem. , vol.271 , pp. 8959-8965
    • Nakamoto, T.1    Sakai, R.2    Ozawa, K.3    Yazaki, Y.4    Hirai, H.5
  • 33
    • 0034160011 scopus 로고    scopus 로고
    • Integrin signalling: A new Cas. (t) of characters enters the stage
    • O'Neill, G. M., Fashena, S. J., and Golemis, E. A. (2000). Integrin signalling: a new Cas. (t) of characters enters the stage. Trends Cell Biol. 10, 111-119.
    • (2000) Trends Cell Biol. , vol.10 , pp. 111-119
    • O'Neill, G.M.1    Fashena, S.J.2    Golemis, E.A.3
  • 35
    • 0030880596 scopus 로고    scopus 로고
    • Filopodia and growth cones in the vertically migrating granule cells of the postnatal mouse cerebellum
    • Ono, K., Shokunbi, T., Nagata, I., Tokunaga, A., Yasui, Y., and Nakatsuji, N. (1997). Filopodia and growth cones in the vertically migrating granule cells of the postnatal mouse cerebellum. Exp. Brain Res. 117, 17-29.
    • (1997) Exp. Brain Res. , vol.117 , pp. 17-29
    • Ono, K.1    Shokunbi, T.2    Nagata, I.3    Tokunaga, A.4    Yasui, Y.5    Nakatsuji, N.6
  • 36
    • 0035958959 scopus 로고    scopus 로고
    • Processive phosphorylation of p130Cas by Src depends on SH3-polyproline interactions
    • Pellicena, P., and Miller, W. T. (2001). Processive phosphorylation of p130Cas by Src depends on SH3-polyproline interactions. J. Biol. Chem. 276, 28190-28196.
    • (2001) J. Biol. Chem. , vol.276 , pp. 28190-28196
    • Pellicena, P.1    Miller, W.T.2
  • 37
    • 0021089398 scopus 로고
    • Nerve growth cones isolated from fetal rat brain: Subcellular fractionation and characterization
    • Pfenninger, K. H., Ellis, L., Johnson, M. P., Friedman, L. B., and Somlo, S. (1983). Nerve growth cones isolated from fetal rat brain: subcellular fractionation and characterization. Cell 35, 573-584.
    • (1983) Cell , vol.35 , pp. 573-584
    • Pfenninger, K.H.1    Ellis, L.2    Johnson, M.P.3    Friedman, L.B.4    Somlo, S.5
  • 38
    • 0037459075 scopus 로고    scopus 로고
    • Cellular motility driven by assembly and disassembly of actin filaments
    • Pollard, T. D., and Borisy, G. G. (2003). Cellular motility driven by assembly and disassembly of actin filaments. Cell 112, 453-465.
    • (2003) Cell , vol.112 , pp. 453-465
    • Pollard, T.D.1    Borisy, G.G.2
  • 40
    • 0029871329 scopus 로고    scopus 로고
    • Nerve growth factor stimulates the tyrosine phosphorylation of endogenous Crk-II and augments its association with p130Cas in PC-12 cells
    • Ribon, V., and Saltiel, A. R. (1996). Nerve growth factor stimulates the tyrosine phosphorylation of endogenous Crk-II and augments its association with p130Cas in PC-12 cells. J. Biol. Chem. 271, 7375-7380.
    • (1996) J. Biol. Chem. , vol.271 , pp. 7375-7380
    • Ribon, V.1    Saltiel, A.R.2
  • 42
    • 0042858569 scopus 로고    scopus 로고
    • New insights into the diversity and function of neuronal immunoglobulin (Ig) superfamily molecules
    • Rougon, G., and Hobert, O. (2003). New insights into the diversity and function of neuronal immunoglobulin (Ig) superfamily molecules. Annu. Rev. Neurosci. 26, 207-238.
    • (2003) Annu. Rev. Neurosci. , vol.26 , pp. 207-238
    • Rougon, G.1    Hobert, O.2
  • 43
    • 0034769929 scopus 로고    scopus 로고
    • Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src
    • Ruest, P. J., Shin, N. Y., Polte, T. R., Zhang, X., and Hanks, S. K. (2001). Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src. Mol. Cell. Biol. 21, 7641-7652.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 7641-7652
    • Ruest, P.J.1    Shin, N.Y.2    Polte, T.R.3    Zhang, X.4    Hanks, S.K.5
  • 44
    • 0027990414 scopus 로고
    • A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner
    • Sakai, R., Iwamatsu, A., Hirano, N., Ogawa, S., Tanaka, T., Mano, H., Yazaki, Y., and Hirai, H. (1994). A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO J. 13, 3748-3756.
    • (1994) EMBO J. , vol.13 , pp. 3748-3756
    • Sakai, R.1    Iwamatsu, A.2    Hirano, N.3    Ogawa, S.4    Tanaka, T.5    Mano, H.6    Yazaki, Y.7    Hirai, H.8
  • 46
    • 0033215993 scopus 로고    scopus 로고
    • Cupidin, an isoform of Homer/Vesl, interacts with the actin cytoskeleton and activated rho family small GTPases and is expressed in developing mouse cerebellar granule cells
    • Shiraishi, Y., Mizutani, A., Bito, H., Fujisawa, K., Narumiya, S., Mikoshiba, K., and Furuichi, T. (1999). Cupidin, an isoform of Homer/Vesl, interacts with the actin cytoskeleton and activated rho family small GTPases and is expressed in developing mouse cerebellar granule cells. J. Neurosci. 19, 8389-8400.
    • (1999) J. Neurosci. , vol.19 , pp. 8389-8400
    • Shiraishi, Y.1    Mizutani, A.2    Bito, H.3    Fujisawa, K.4    Narumiya, S.5    Mikoshiba, K.6    Furuichi, T.7
  • 47
    • 0023895343 scopus 로고
    • Differential developmental expression of cellular yes and cellular src proteins in cerebellum
    • Sudol, M., Alvarez-Buylla, A., and Hanafusa, H. (1988). Differential developmental expression of cellular yes and cellular src proteins in cerebellum. Oncogene Res. 2, 345-355.
    • (1988) Oncogene Res. , vol.2 , pp. 345-355
    • Sudol, M.1    Alvarez-Buylla, A.2    Hanafusa, H.3
  • 48
    • 0024460550 scopus 로고
    • Expression of the yes proto-oncogene in cerebellar Purkinje cells
    • Sudol, M., Kuo, C. F., Shigemitsu, L., and Alvarez-Buylla, A. (1989). Expression of the yes proto-oncogene in cerebellar Purkinje cells. Mol. Cell. Biol. 9, 4545-4549.
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 4545-4549
    • Sudol, M.1    Kuo, C.F.2    Shigemitsu, L.3    Alvarez-Buylla, A.4
  • 49
    • 0028863477 scopus 로고
    • Making the connection: Cytoskeletal rearrangements during growth cone guidance
    • Tanaka, E., and Sabry, J. (1995). Making the connection: cytoskeletal rearrangements during growth cone guidance. Cell 83, 171-176.
    • (1995) Cell , vol.83 , pp. 171-176
    • Tanaka, E.1    Sabry, J.2
  • 50
    • 0031004266 scopus 로고    scopus 로고
    • Downstream of Crk adaptor signaling pathway: Activation of Jun kinase by v-Crk through the guanine nucleotide exchange protein C3G
    • Tanaka, S., Ouchi, T., and Hanafusa, H. (1997). Downstream of Crk adaptor signaling pathway: activation of Jun kinase by v-Crk through the guanine nucleotide exchange protein C3G. Proc. Natl. Acad. Sci. USA 94, 2356-2361.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 2356-2361
    • Tanaka, S.1    Ouchi, T.2    Hanafusa, H.3
  • 51
    • 0031439129 scopus 로고    scopus 로고
    • Neural cell adhesion molecules of the Ig superfamily: Role in axon growth and guidance
    • Walsh, F. S., and Doherty, P. (1997). Neural cell adhesion molecules of the Ig superfamily: role in axon growth and guidance. Annu. Rev. Cell Dev. Biol. 13, 425-456.
    • (1997) Annu. Rev. Cell Dev. Biol. , vol.13 , pp. 425-456
    • Walsh, F.S.1    Doherty, P.2
  • 52
    • 0027362796 scopus 로고
    • Regulated tyrosine phosphorylation at the tips of growth cone filopodia
    • Wu, D. Y., and Goldberg, D. J. (1993). Regulated tyrosine phosphorylation at the tips of growth cone filopodia. J. Cell Biol. 123, 653-664.
    • (1993) J. Cell Biol. , vol.123 , pp. 653-664
    • Wu, D.Y.1    Goldberg, D.J.2
  • 53
    • 0025925135 scopus 로고
    • Localization of p62c-yes protein in mammalian neural tissues
    • Zhao, Y. H., Baker, H., Walaas, S. I., and Sudol, M. (1991). Localization of p62c-yes protein in mammalian neural tissues. Oncogene 6, 1725-1733.
    • (1991) Oncogene , vol.6 , pp. 1725-1733
    • Zhao, Y.H.1    Baker, H.2    Walaas, S.I.3    Sudol, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.