Electrophysiological properties and modeling of murine vomeronasal sensory neurons in acute slice preparations

Chemical Senses

Volumn 31, Issue 5, 2006, Pages 425-435

  Shimazaki, Ranken ^a   Boccaccio, Anna ^a   Mazzatenta, Andrea ^a   Pinato, Giulietta ^a   Migliore, Michele ^b,c   Menini, Anna ^a  

^a SISSA   (Italy)

^b CNR   (Italy)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Action potential; Firing; Mouse; Pheromone; Voltage gated current; Vomeronasal organ

Indexed keywords

PHEROMONE;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; ELECTRIC ACTIVITY; MAMMAL; MEMBRANE STEADY POTENTIAL; MICHAELIS MENTEN KINETICS; MOUSE; NERVE CELL STIMULATION; NONHUMAN; OLFACTORY BULB; PRIORITY JOURNAL; REPRODUCIBILITY; SENSORY NERVE CELL; SENSORY SYSTEM ELECTROPHYSIOLOGY; SIGNAL TRANSDUCTION; TISSUE SLICE; VOLTAGE CLAMP; VOMERONASAL ORGAN; WHOLE CELL;

ACTION POTENTIALS; ANIMALS; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; MICE; MICE, INBRED STRAINS; MODELS, NEUROLOGICAL; NEURONS, AFFERENT; ORGAN CULTURE TECHNIQUES; PATCH-CLAMP TECHNIQUES; SPECIES SPECIFICITY; VOMERONASAL ORGAN;

MAMMALIA; MURINAE;

EID: 33745583760     PISSN: 0379864X     EISSN: 14643553     Source Type: Journal    
DOI: 10.1093/chemse/bjj047     Document Type: Article

References (53)

1. Berghard, A. and Buck, L.B. (1996) Sensory transduction in vomeronasal neurons: Evidence for G alpha o, G alpha i2, and adenylyl cyclase // as major components of a pheromone signaling cascade. J. Neurosci., 16, 909-918.
2. Bigiani,A., Mucignat-Caretta, C., Montani,G. and Tirindelli, R. (2005) Pheromone reception in mammals. Rev. Physiol. Biochem. Pharmacol., 10.1007/S10254-004-0038-00.
3. Bigiani, A. and Roper, S.D. (1993) Identification of electrophysiologically distinct cell subpopulations in Necturus taste buds. J. Gen. Physiol, 102, 143-170.
4. Boschat, C., Pelofi, C., Randin, O., Roppolo, D., Luscher, C., Broillet, M.C. and Rodriguez, I. (2002) Pheromone detection mediated by a V1r vomeronasal receptor. Nat. Neurosci., 5, 1261-1262.
5. Brennan, P.A. and Keverne, E.B. (2004) Something in the air? New insights into mammalian pheromones. Curr. Biol., 14, R81-R89.
6. Cinelli, A.R., Wang, D., Chen, P., Liu, W. and Halpern, M. (2002) Calcium transients in the garter snake vomeronasal organ. J. Neurophysiol., 87, 1449-1472.
7. Dean, D.M., Mazzatenta, A. and Menini, A. (2004) Voltage-activated current-properties of mate and female mouse vomeronasal sensory neurons: sexually dichotomous? J. Comp. Physiol. A Neuroethol. Sens. Neural Behav. Physiol., 190, 491-499.
8. Del Punta, K., Leinders-Zufall, T., Rodriguez, I., Jukam, D., Wysocki, C.J., Ogawa, S., Zufall, F. and Mombaerts, P. (2002) Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes. Nature, 419, 70-74.
9. Døving, K.B. and Trotier, D. (1998) Structure and function of the vomeronasal organ. J. Exp. Biol., 201, 2913-2925.
10. Dulac, C. and Axel, R. (1995) A novel family of genes encoding putative pheromone receptors in mammals. Cell, 83, 195-206.
11. Dulac, C. and Torello, A.T. (2003) Molecular detection of pheromone signals in mammals: From genes to behaviour Nat. Rev. Neurosci., 4, 551-562.
12. Fadool, D.A., Wachowiak, M. and Brann, J.H. (2001) Patch-clamp analysis of voltage-activated and chemically activated currents in the vomeronasal organ of Sternotherus odoratus (stinkpot/musk turtle). J. Exp. Biol., 204, 4199-4212.
13. Fieni, F., Ghiaroni, V., Tirindelli, R., Pietra, P. and Bigiani, A. (2003) Apical and basal neurones isolated from the mouse vomeronasal organ differ for voltage-dependent currents. J. Physiol., 552, 425-436.
14. Ghiaroni, V., Fieni, F., Tirindelli, R., Pietra, P. and Bigiani, A. (2003) Ion conductances in supporting cells isolated from the mouse vomeronasal organ. J. Neurophysiol., 89, 118-127.
15. Halpern, M. and Martinez-Marcos, A. (2003) Structure and function of the vomeronasal system: An update. Prog. Neurobiol., 70, 245-318.
16. Herrada, G. and Dulac, C. (1997) A novel family of putative pheromone receptors in mammals with a topographically organized and sexually dimorphic distribution. Cell, 90, 763-773.
17. Hines, M.L. and Carnevale, N.T. (1997) The NEURON simulation environment Neural Comput., 9, 1179-1209.
18. Holy, T.E., Dulac, C. and Meister, M. (2000) Responses of vomeronasal neurons to natural stimuli. Science, 289, 1569-1572.
19. Inamura, K. and Kashiwayanagi, M. (2000) Inward current responses to urinary substances in rat vomeronasal sensory neurons. Eur. J. Neurosci., 12, 3529-3536.
20. Inamura, K., Matsumoto, Y., Kashiwayanagi, M. and Kurihara, K. (1997) Inositol-1,4,5-trisphosphate induces responses in receptor neurons in rat vomeronasal sensory slices. Chem. Senses, 22, 93-103.
21. Inamura, K., Matsumoto, Y., Kashiwayanagi, M. and Kurihara, K. (1999) Laminar distribution of pheromone-receptive neurons in rat vomeronasal epithelium. J. Physiol., 517(Pt 3), 731-739.
22. Jacobson, L, Trotier, D. and Døving, K.B. (1998) Anatomical description of a new organ in the nose of domesticated animals by Ludvig Jacobson (1813). Chem. Senses, 23, 743-754.
23. Jia, C. and Halpern, M. (1996) Subclasses of vomeronasal receptor neurons: Differential expression of G proteins (Gi alpha 2 and G(o alpha)) and segregated projections to the accessory olfactory bulb. Brain Res., 719, 117-128.
24. Johnston, D. and Wu, S.M. (1995) Foundations of Cellular Neurophysiology. MIT Press, Cambridge, MA.
25. Keverne, E.B. (2002) Mammalian pheromones: From genes to behaviour Curr. Biol., 12, R807-R809.
26. Labra, A., Brann, J.H. and Fadool, D.A. (2005) Heterogeneity of voltage-and chemosignal-activated response profiles in vomeronasal sensory neurons. J. Neurophysiol., 94, 2535-2548.
27. Leinders-Zufall, T., Brennan, P., Widmayer, P., Chandramani, P.S., Maul-Pavicic, A., Jager, M., Li, X.H., Breer, H., Zufall, F. and Boehm, T. (2004) MHC class I peptides as chemosensory signals in the vomeronasal organ. Science, 306, 1033-1037.
28. Leinders-Zufall, T., Lane, A.P., Puche, A.C., Ma, W., Novotny, M.V., Shipley, M.T. and Zufall, F. (2000) Ultrasensitive pheromone detection by mammalian vomeronasal neurons. Nature, 405, 792-796,
29. Leypold, B.G., Yu, C.R., Leinders-Zufall, T., Kim, M.M., Zufall, F. and Axel, R. (2002) Altered sexual and social behaviors in trp2 mutant mice. Proc. Natl Acad. Sci. USA, 99, 6376-6381.
30. Liman, E.R. and Corey, D.P. (1996) Electrophysiological characterization of chemosensory neurons from the mouse vomeronasal organ. J. Neurosci., 16, 4625-4637.
31. Liman, E.R., Corey, D.P. and Dulac, C. (1999) TRP2: A candidate transduction channel for mammalian pheromone sensory signaling. Proc. Natl Acad. Sci. USA, 96, 5791-5796.
32. Lucas, P., Ukhanov, K., Leinders-Zufall, T. and Zufall, F. (2003) A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: Mechanism of pheromone transduction. Neuron, 40, 551-561.
33. Luo, M. and Katz, L.C. (2004) Encoding pheromonal signals in the mammalian vomeronasal system. Curr. Opin. Neurobiol., 14, 428-434.
34. Matsunami, H. and Buck, L.B. (1997) A multigene family encoding a diverse array of putative pheromone receptors in mammals. Cell, 90, 775-784.
35. Menco, B.P., Carr, V.M., Ezeh, P.I., Liman, E.R. and Yankova, M.P. (2001) Ultrastructural localization of G-proteins and the channel protein TRP2 to microvilli of rat vomeronasal receptor cells. J. Comp. Neurol., 438, 468-489.
36. Rodriguez, I. (2003) Nosing into pheromone detectors. Nat. Neurosci., 6, 438-440.
37. Rodriguez, I. (2004) Pheromone receptors in mammals. Horm. Behav., 46, 219-230.
38. Ryba, N.J. and Tirindelli, R. (1997) Anew multigene family of putative pheromone receptors. Neuron, 19, 371-379.
39. Sam, M., Vora, S., Malnic, B., Ma, W., Novotny, M.V. and Buck, L.B. (2001) Neuropharmacology Odorants may arouse instinctive behaviours. Nature, 412, 142.
40. Schild, D. (1989) Whole-cell currents in olfactory receptor cells of Xenopus laevis. Exp. Brain Res., 78, 223-232.
41. Schild, D. and Restrepo, D. (1998) Transduction mechanisms in vertebrate olfactory receptor cells. Physiol. Rev., 78, 429-466.
42. Spehr, M., Hatt, H. and Wetzel, C.H. (2002) Arachidonic acid plays a role in rat vomeronasal signal transduction. J. Neurosci., 22, 8429-8437.
43. Stowers, L., Holy, T.E., Meister, M., Dulac, C. and Koentges. G. (2002) Loss of sex discrimination and male-male aggression in mice deficient for TRP2. Science, 295, 1493-1500.
44. Taniguchi, M., Kashiwayanagi. M. and Kurihara, K. (1995) Intracellular injection of inositol 1,4,5-trisphosphate increases a conductance in membranes of turtle vomeronasal receptor neurons in the slice preparation. Neurosci. Lett., 188, 5-8.
45. Taniguchi, M., Kashiwayanagi, M. and Kurihara, K. (1996) Intracellular dialysis of cyclic nucleotides induces inward currents in turtle vomeronasal receptor neurons. J. Neurosci., 16, 1239-1246.
46. Taniguchi, M., Wang, D. and Halpern, M. (2000) Chemosensitive conductance and inositol 1,4,5-trisphosphate-induced conductance in snake vomeronasal receptor neurons. chem. Senses, 25, 67-76.
47. Trinh, K. and Strom, D.R. (2003) Vomeronasal organ detects odorants in absence of signaling through main olfactory epithelium. Nat. Neurosci., 6, 519-525.
48. Trotier, D. and Døving, K.B. (1996) Direct influence of the sodium pump on the membrane potential of vomeronasal chemoreceptor neurones in frog. J. Physiol., 490, 611-621.
49. Trotier, D., Døving, K.B., Ore, K. and Shalchian-Tabrizi, C. (1998) Scanning electron microscopy and gramicidin patch clamp recordings of microvillous receptor neurons dissociated from the rat vomeronasal organ. Chem. Senses, 23, 49-57.
50. Trotier, D., Døving, K.B. and Rosin, J.F. (1993) Voltage-dependent currents in microvillar receptor cells of the frog vomeronasal organ. Eur J. Neurosci., 5, 995-1002.
51. Vogalis, F., Hegg, C.C. and Lucero, M.T. (2005) Ionic conductances in sustentacular cells of the mouse olfactory epithelium. J. Physiol., 562, 785-799.
52. Zufall, F., Kelliher, K.R. and Leinders-Zufall, T. (2002) Pheromone detection by mammalian vomeronasal neurons. Microsc. Res. Tech., 58, 251-260.
53. Zufall, F., Ukhanov, K., Lucas, P. and Leinders-Zufall, T. (2005) Neurobiology of TRPC2: From gene to behavior Pflugers Arch., 451, 61-71.