Neurobiology of TRPC2: From gene to behavior

Pflugers Archiv European Journal of Physiology

Volumn 451, Issue 1, 2005, Pages 61-71

  Zufall, Frank ^a   Ukhanov, Kyrill ^a   Lucas, Philippe ^a,b   Leinders Zufall, Trese ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b CEMAGREF   (France)

Author keywords

Diacylglycerol; Diacylglycerol kinase; Phospholipase C; TRP channel; TRPC2; Vomeronasal organ

Indexed keywords

CALCIUM; CATION CHANNEL; DIACYLGLYCEROL; MEMBRANE PROTEIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL;

BEHAVIOR; GENE; GENE FUNCTION; GENETICS; NERVOUS SYSTEM; NEUROBIOLOGY; NONHUMAN; OLFACTORY SYSTEM; PRIORITY JOURNAL; REVIEW; SENSORY NERVE CELL; SEXUAL BEHAVIOR; SOCIAL BEHAVIOR; TRANSIENT RECEPTOR POTENTIAL CANONICAL 2 GENE; VOMERONASAL ORGAN;

AGGRESSION; ANIMALS; BEHAVIOR, ANIMAL; DIACYLGLYCEROL KINASE; DIGLYCERIDES; FEMALE; MALE; MICE; OLFACTORY RECEPTOR NEURONS; PHEROMONES; PHOSPHOLIPASE C; RATS; SIGNAL TRANSDUCTION; SMELL; TRPC CATION CHANNELS; VOMERONASAL ORGAN;

EID: 26444573722     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-005-1432-4     Document Type: Review

References (53)

1. Albert AP, Large WA (2003) Synergism between inositol phosphates and diacylglycerol on native TRPC6-like channels in rabbit portal vein myocytes. J Physiol (Lond) 552.3:789-795
2. Berghard A, Buck LB, Liman ER (1996) Evidence for distinct signaling mechanisms in two mammalian olfactory sense organs. Proc Natl Acad Sci USA 93:2365-2367
3. 2+ release. FASEB J 16:1145-1150
4. Boschat C, Pelofi C, Randin O, Roppolo D, Luscher C, Broillet MC, Rodriguez I (2002) Pheromone detection mediated by a V1r vomeronasal receptor. Nat Neurosci 5:1261-1262
5. Brann JH, Dennis JC, Morrison EE, Fadool DA (2002) Type-specific inositol 1,4,5-trisphosphate receptor localization in the vomeronasal organ and its interaction with a transient receptor potential channel, TRPC2. J Neurochem 83:1452-1460
6. Brose N, Betz A, Wegmeyer H (2004) Divergent and convergent signaling by the diacylglycerol second messenger pathway in mammals. Curr Opin Neurobiol 14:328-340
7. Chu X, Tong Q, Cheung JY, Wozney J, Conrad K, Mazack V, Zhang W, Stahl R, Barber DL, Miller BA (2004) Interaction of TRPC2 and TRPC6 in erythropoietin modulation of calcium influx. J Biol Chem 279:10514-10522
8. Ciges M, Labella T, Gayoso M, Sanchez G (1977) Ultrastructure of the organ of Jacobson and comparative study with olfactory mucosa. Acta Otolaryngol 83:47-58
9. Del Punta K, Leinders-Zufall T, Rodriguez I, Jukam D, Wysocki CJ, Ogawa S, Zufall F, Mombaerts P (2002) Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes. Nature 419:70-74
10. Dulac C, Torello AT (2003) Molecular detection of pheromone signals in mammals: from genes to behaviour. Nat Rev Neurosci 4:551-562
11. Freichel M, Vennekens R, Olausson J, Hoffmann M, Müller C, Stolz S, Scheunemann J, Weißgerber P, Flockerzi V (2004) Functional role of TRPC proteins in vivo: lessons from TRPC-deficient mouse models. Biochem Biophys Res Commun 322:1352-1358
12. Hofmann T, Obukhov AG, Schaefer M, Harteneck C, Gudermann T, Schultz G (1999) Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 397:259-263
13. Hofmann T, Schaefer M, Schultz G, Gudermann T (2000) Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2. Biochem J 351:115-122
14. Hofmann T, Schaefer M, Schultz G, Gudermann T (2002) Subunit composition of mammalian transient receptor potential channels in living cells. Proc Natl Acad Sci USA 99:7461-7466
15. Holy TE, Dulac C, Meister M (2000) Responses of vomeronasal neurons to natural stimuli. Science 289:1569-1572
16. 2+ into mouse sperm triggered by egg ZP3. Nat Cell Biol 3:499-502
17. Leinders-Zufall T, Lane AP, Puche AC, Ma W, Novotny M, Shipley MT, Zufall F (2000) Ultrasensitive pheromone detection by mammalian vomeronasal neurons. Nature 405:792-796
18. Leinders-Zufall T, Brennan P, Widmayer P, Chandramani PS, Maul-Pavicic A, Jäger M, Li X-H, Breer H, Zufall F, Boehm T (2004) MHC class I peptides as chemosensory signals in the vomeronasal organ. Science 306:1033-1037
19. Leypold BG, Yu CR, Leinders-Zufall T, Kim MM, Zufall F, Axel R (2002) Altered sexual and social behaviors in trp2 mutant mice. Proc Natl Acad Sci USA 99:6376-6381
20. Lewis RS (1999) Store-operated calcium channels. Adv Sec Messenger Phosphoprotein Res 33:279-307
21. Liman ER, Corey DP (1996) Electrophysiological characterization of chemosensory neurons from the mouse vomeronasal organ. J Neurosci 16:4625-4637
22. Liman ER, Corey DP, Dulac C (1999) TRP2: A candidate transduction channel for mammalian pheromone sensory signaling. Proc Natl Acad Sci USA 96:5791-5796
23. 2+-activated cation channel from hamster vomeronasal sensory neurons. J Physiol (Lond) 548.3:777-787
24. Liman ER, Innan H (2003) Relaxed selective pressure on an essential component of pheromone transduction in primate evolution. Proc Natl Acad Sci USA 100:3328-3332
25. Liman ER, Zufall F (2004) Transduction channels in the vomeronasal organ. In: Frings S, Bradley J (eds) Transduction channels in sensory cells. Wiley, Weinheim, pp 137-154
26. 2+-sensitive cation channels. J Biol Chem 275:27799-27805
27. Lucas P, Ukhanov K, Leinders-Zufall T, Zufall F (2003) A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction. Neuron 40:551-561
28. Luo B, Regier DS, Prescott SM, Topham MK (2004) Diacylglycerol kinases. Cell Signal 16:983-989
29. Menco BP, Carr VM, Ezeh PI, Liman ER, Yankova MP (2001) Ultrastructural localization of G-proteins and the channel protein TRP2 to microvilli of rat vomeronasal receptor cells. J Comp Neurol 438:468-489
30. Mombaerts P (2004) Genes and ligands for odorant, vomeronasal and taste receptors. Nat Rev Neurosci 5:263-278
31. Montell C (2005) The TRP superfamily of cation channels. Sci STKE 272:re3
32. Okada T, Inoue R, Yamazaki K, Maeda A, Kurosaki T, Yamakuni T, Tanaka I, Shimizu S, Ikenaka K, Imoto K, Mori Y (1999) Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. J Biol Chem 274:27359-27370
33. Pankevich DE, Baum MJ, Cherry JA (2004) Olfactory sex discrimination persists, whereas the preference for urinary odorants from estrous females disappears in male mice after vomeronasal organ removal. J Neurosci 24:9451-9457
34. Parekh AB, Penner R (1997) Store depletion and calcium influx. Physiol Rev 77:901-930
35. Raghu P, Usher K, Jonas S, Chyb S, Polyanovsky A, Hardie RC (2000) Constitutive activity of the light-sensitive channels TRP and TRPL in the Drosophila diacylglycerol kinase mutant, rdgA. Neuron 26:169-179
36. Riccio A, Medhurst AD, Mattei C, Kelsell RE, Calver AR, Randall AD, Benham CD, Pangalos MN (2002) mRNA distribution analysis of human TRPC family in CNS and peripheral tissues. Brain Res Mol Brain Res 109:95-104
37. Rodriguez I, Feinstein P, Mombaerts P (1999) Variable patterns of axonal projections of sensory neurons in the mouse vomeronasal system. Cell 97:199-208
38. Spehr M, Hatt H, Wetzel CH (2002) Arachidonic acid plays a role in rat vomeronasal signal transduction. J Neurosci 22:8429-8437
39. Stowers L, Holy TE, Meister M, Dulac C, Koentges G (2002) Loss of sex discrimination and male-male aggression in mice deficient for TRP2. Science 295:1493-1500
40. van Blitterswijk WJ, Houssa B (2000) Properties and functions of diacylglycerol kinases. Cell Signal 12:595-605
41. 2+ entry channel. Proc Natl Acad Sci USA 96:2060-2064
42. Vazquez G, Wedel B, Aziz O, Trebak M, Putney Jr JW (2004) The mammalian TRPC cation channels. Biochim Biophys Acta 1742:21-36
43. Webb DM, Cortes-Ortiz L, Zhang J (2004) Genetic evidence for the coexistence of pheromone perception and full trichromatic vision in howler monkeys. Mol Biol Evol 21:697-704
44. Wes PD, Chevesich J, Jeromin A, Rosenberg C, Stetten G, Montell C (1995) TRPC1, a human homolog of a Drosophila store-operated channel. Proc Natl Acad Sci USA 92:9652-9656
45. Wissenbach U, Schroth G, Philipp S, Flockerzi V (1998) Structure and mRNA expression of a bovine trp homologue related to mammalian trp2 transcripts. FEBS Lett 429:61-66
46. Yildirim E, Dietrich A, Birnbaumer L (2003) The mouse C-type transient receptor potential 2 (TRPC2) channel: alternative splicing and calmodulin binding to its N terminus. Proc Natl Acad Sci USA 100:2220-2225
47. Zhang J, Webb DM (2003) Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates. Proc Natl Acad Sci USA 100:8337-8341
48. 2+ entry. Cell 85:661-671
49. Zufall F, Firestein S, Shepherd GM (1994) Cyclic nucleotide-gated ion channels and sensory transduction in olfactory receptor neurons. Annu Rev Biophys Biomol Struct 23:577-607
50. 2+ release and its role in olfactory signal transduction. J Neurophysiol 83:501-512
51. Zufall F, Munger SD (2001) From odor and pheromone transduction to the organization of the sense of smell. Trends Neurosci 24:191-193
52. Zufall F, Kelliher KR, Leinders-Zufall T (2002) Pheromone detection by mammalian vomeronasal neurons. Microsc Res Tech 58:251-260
53. Zufall F (2005) The TRPC2 ion channel and pheromone sensing in the accessory olfactory system. N-S Arch Pharmacol (in press)