Vomeronasal organ detects odorants in absence of signaling through main olfactory epithelium

Nature Neuroscience

Volumn 6, Issue 5, 2003, Pages 519-525

  Trinh, Kien ^a   Storm, Daniel R ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; PHEROMONE; VOLATILE AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMOSENSITIVITY; CONTROLLED STUDY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; ODOR; OLFACTOMETRY; OLFACTORY EPITHELIUM; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMELLING; VOMERONASAL ORGAN;

EID: 0037408448     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn1039     Document Type: Article

References (48)

1. Amoore, J. Molecular Basis of Odor 28-87 (Charles C. Thomas, Springfield, Illinois, 1970).
2. Ressler, K.J., Sullivan, S.L. & Buck, L.B. Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb. Cell 79, 1245-1255 (1994).
3. Vassar, R. et al. Topographic organization of sensory projections to the olfactory bulb. Cell 79, 981-991 (1994).
4. Firestein, S. How the olfactory system makes sense of scents. Nature 413, 211-218 (2001).
5. Dulac, C. Sensory coding of pheromone signals in mammals. Curr. Opin. Neurobiol. 10, 511-518 (2000).
6. Buck, L.B. The molecular architecture of odor and pheromone sensing in mammals. Cell 100, 611-618 (2000).
7. Zufall, F. & Munger, S.D. From odor and pheromone transduction to the organization of the sense of smell. Trends Neurosci. 24, 191-193 (2001).
8. Rodriguez, I., Feinstein, P. & Mombaerts, P. Variable patterns of axonal projections of sensory neurons in the mouse vomeronasal system. Cell 97, 199-208 (1999).
9. Dudley, C.A., Chakravarty, S. & Barnea, A. Female odors lead to rapid activation of mitogen-activated protein kinase (MAPK) in neurons of the vomeronasal system. Brain Res. 915, 32-46 (2001).
10. Buck, L. & Axel, R. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 65, 175-187 (1991).
11. Vassar, R., Ngai, J. & Axel, R. Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium. Cell 74, 309-318 (1993).
12. Jones, D.T. & Reed, R.R. Golf: an olfactory neuron specific G protein involved in odorant signal transduction. Science 244, 790-795 (1989).
13. Belluscio, L., Gold, G.H., Nemes, A. & Axel, R. Mice deficient in G(olf) are anosmic. Neuron 20, 69-81 (1998).
14. Wong, S.T. et al. Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice. Neuron 27, 487-497 (2000).
15. Bakalyar, H.A. & Reed, R.R. Identification of a specialized adenylyl cyclase that may mediate odorant detection. Science 250, 1403-1406 (1990).
16. Wei, J., Wayman, G. & Storm, D.R. Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo. J. Biol. Chem. 271, 24231-24235 (1996).
17. Wei, J. et al. Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in neurons: a mechanism for attenuation of olfactory signals. Neuron 21, 495-504 (1998).
18. Brunet, L.J., Gold, G.H. & Ngai, J. General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel. Neuron 17, 681-693 (1996).
19. Lowe, G. & Gold, G.H. Contribution of the ciliary cyclic nucleotide-gated conductance to olfactory transduction in the salamander. J. Physiol. 462, 175-196 (1993).
20. Dhallan, R.S., Yau, K.W., Schrader, K.A. & Reed, R.R. Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons. Nature 347, 184-187 (1990).
21. Berghard, A. & Buck, L.B. Sensory transduction in vomeronasal neurons: evidence for G alpha o, G alpha i2, and adenylyl cyclase II as major components of a pheromone signaling cascade. J. Neurosci. 16, 909-918 (1996).
22. Berghard, A., Buck, L.B. & Liman, E.R. Evidence for distinct signaling mechanisms in two mammalian olfactory sense organs. Proc. Natl. Acad. Sci. USA 93, 2365-2369 (1996).
23. Mombaerts, P. et al. Visualizing an olfactory sensory map. Cell 87, 675-686 (1996).
24. Puche, A.C. & Shipley, M.T. Odor-induced, activity-dependent transneuronal gene induction in vitro: mediation by NMDA receptors. J. Neurosci. 19, 1359-1370 (1999).
25. Baker, H., Morel, K., Stone, D.M. & Maruniak, J.A. Adult naris closure profoundly reduces tyrosine hydroxylase expression in mouse olfactory bulb. Brain Res. 614, 109-116 (1993).
26. Brown, R.E., Singh, P.B. & Roser, B. The major histocompatibility complex and the chemosensory recognition of individuality in rats. Physiol. Behav. 40, 65-73 (1987).
27. Gregg, B. & Thiessen, D.D. A simple method of olfactory discrimination of urines for the Mongolian gerbil, Meriones unguiculatus. Physiol. Behav. 26, 1133-1136 (1981).
28. Breer, H., Boekhoff, I. & Tareilus, E. Rapid kinetics of second messenger formation in olfactory transduction. Nature 345, 65-68 (1990).
29. Sklar, P.B., Anholt, R.R. & Snyder, S.H. The odorant-sensitive adenylate cyclase of olfactory receptor cells. Differential stimulation by distinct classes of odorants. J. Biol. Chem. 261, 15538-15543 (1986).
30. Yamada, K., Itoh, R. & Ohta, A. Influence ofpyrazine derivatives on the day of vaginal opening in juvenile female rats. Jpn. J. Pharmacol. 49, 529-530 (1989).
31. Sam, M. et al. Odorants may arouse instinctive behaviours. Nature 412, 142 (2001).
32. Leinders-Zufall, T. et al. Ultrasensitive pheromone detection by mammalian vomeronasal neurons. Nature 405, 792-796 (2000).
33. Novotny, M., Jemiolo, B., Harvey, S., Wiesler, D. & Marchlewska-Koj, A. Adrenal-mediated endogenous metabolites inhibit puberty in female mice. Science 231, 722-725 (1986).
34. 4-induced anosmia and vomeronasal organ removal. Horm. Behav. 29, 492-518 (1995).
35. 4 irrigation on behavior, biochemistry and morphology. Brain Res. 140, 271-285 (1978).
36. Leypold, B.G. et al. Altered sexual and social behaviors in trp2 mutant mice. Proc. Natl. Acad. Sci. USA 99, 6376-6381 (2002).
37. Stowers, L., Holy, T.E., Meister, M., Dulac, C. & Koentges, G. Loss of sex discrimination and male-male aggression in mice deficient for TRP2. Science 295, 1493-1500 (2002).
38. Gore, A.C., Wersinger, S.R. & Rissman, E.F. Effects of female pheromones on gonadotropin-releasing hormone gene expression and luteinizing hormone release in male wild-type and oestrogen receptor-alpha knockout mice. J. Neuroendocrinol. 12, 1200-1204 (2000).
39. Briand, L. et al. Odorant and pheromone binding by aphrodisin, a hamster aphrodisiac protein. FEBS Lett. 476, 179-185 (2000).
40. Hagino-Yamagishi, K. et al. The mouse putative pheromone receptor was specifically activated by stimulation with male mouse urine. J. Biochem. (Tokyo) 129, 509-512 (2001).
41. Dulac, C. & Axel, R. A novel family of genes encoding putative pheromone receptors in mammals. Cell 83, 195-206 (1995).
42. Dulac, C. & Axel, R. Expression of candidate pheromone receptor genes in vomeronasal neurons. Chem. Senses 23, 467-475 (1998).
43. Liman, E.R., Corey, D.P. & Dulac, C. TRP2: a candidate transduction channel for mammalian pheromone sensory signaling. Proc. Natl. Acad. Sci. USA 96, 5791-5796 (1999).
44. Fewell, G.D. & Meredith, M. Experience facilitates vomeronasal and olfactory influence on Fos expression in medial preoptic area during pheromone exposure or mating in male hamsters. Brain Res. 941, 91-106 (2002).
45. Petrulis, A., Peng, M. & Johnston, R.E. Effects ofvomeronasal organ removal on individual odor discrimination, sex-odor preference, and scent marking by female hamsters. Physiol. Behav. 66, 73-83 (1999).
46. Sipos, M.L., Wysocki, C.J., Nyby, J.G., Wysocki, L. & Nemura, T.A. An ephemeral pheromone of female house mice: perception via the main and accessory olfactory systems. Physiol. Behav. 58, 529-534 (1995).
47. Halpern, M. and Kubie, J.L. The role of the ophidian vomeronasal system in species-typical behavior. Trends Neurosci. 472-477 (1984).
48. Horowitz, L.F., Montmayeur, J.P., Echelard, Y. & Buck, L.B. A genetic approach to trace neural circuits. Proc. Natl. Acad. Sci. USA 96, 3194-3199 (1999).