MHC class I peptides as chemosensory signals in the vomeronasal organ

Science

Volumn 306, Issue 5698, 2004, Pages 1033-1037

  Leinders Zufall, Trese ^a   Brennan, Peter ^b   Widmayer, Patricia ^c   Chandramani S , Prashanth ^c   Maul Pavicic, Andrea ^d   Jäger, Martina ^d   Li, Xiao Hong ^a   Breer, Heinz ^c   Zufall, Frank ^a   Boehm, Thomas ^d  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF HOHENHEIM   (Germany)

^d MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; BIOMEDICAL ENGINEERING; GENES; NEUROLOGY; RESPIRATORY SYSTEM;

CHEMOSENSORY SIGNALS; VOMEROPNASAL ORGANS;

POLYPEPTIDES;

LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

BIOLOGY;

ACTION POTENTIAL; ANIMAL BEHAVIOR; ARTICLE; BREEDING; EXCITATORY POSTSYNAPTIC POTENTIAL; GENDER; GENETIC VARIABILITY; INDIVIDUALITY; MAMMAL; MOLECULAR BIOLOGY; NONHUMAN; NOSE MUCOSA; PRIORITY JOURNAL; SENSORY NERVE CELL; SENSORY STIMULATION; SEXUAL BEHAVIOR; SOCIAL BEHAVIOR; SOCIAL STATUS; VOMERONASAL ORGAN;

ACTION POTENTIALS; ANIMALS; CHEMORECEPTORS; FEMALE; H-2 ANTIGENS; HISTOCOMPATIBILITY ANTIGENS CLASS I; LIGANDS; MALE; MICE; MICE, INBRED C57BL; OLFACTORY RECEPTOR NEURONS; PEPTIDES; RECEPTORS, VASOPRESSIN; SIGNAL TRANSDUCTION; SMELL; URINE; VOMERONASAL ORGAN;

ANIMALIA; MAMMALIA;

EID: 8344278842     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1102818     Document Type: Article

References (36)

1. C. J. Wysocki, M. Meredith, in Neurobiology of Taste and Smell, T. E. Finger, W. L. Silver, Eds. (Wiley, New York, 1987), pp. 125-150.
2. R. Tirindelli, C. Mucignat-Caretta, N. J. Ryba, Trends Neurosci. 21, 482 (1998).
3. P. A. Brennan, E. B. Keverne, Curr. Biol. 14, R81 (2004).
4. T. Leinders-Zufall et al., Nature 405, 792 (2000).
5. T. E. Holy, C. Dulac, C. M. Meister, Science 289, 1569 (2000).
6. L. Stowers, T. E. Holy, M. Meister, C. Dulac, G. Koentges, Science 295, 1493 (2002); published online 31 January 2002 (10.1126/science.1069259).
7. B. G. Leypold et al., Proc. Natl. Acad. Sci. U.S.A. 99, 6376 (2002).
8. K. Del Punta et al., Nature 419, 70 (2002).
9. M. Luo, M. S. Fee, L. C. Katz, Science 299, 1196 (2003).
10. C. I. Bargmann, Cell 90, 585 (1997).
11. C. Dulac, A. T. Torello, Nature Rev. Neurosci. 4, 551 (2003).
12. P. Mombaerts, Nature Rev. Neurosci. 5, 263 (2004).
13. C. Boschat et al., Nature Neurosci. 5, 1261 (2002).
14. H. G. Rammensee, J. Bachmann, S. Stefanovic, MHC Ligands and Peptide Motifs (Landes Bioscience, Georgetown, TX, 1997).
15. P. B. Singh, R. E. Brown, B. Roser, Nature 327, 161 (1987).
16. T. Boehm, C. C. Bleul, M. Schorpp, Immunol. Rev. 195, 15 (2003).
17. Materials and methods are available as supporting material on Science Online.
18. Single-letter abbreviations for the amino acid residues are as follows: A, Ala; C, Cys; D, Asp; E, Glu; F, Phe; G, Gly; H, His; I, Ile; K, Lys; L, Leu; M, Met; N, Asn; P, Pro; Q, Gln; R, Arg; S, Ser; T, Thr; V, Val; W, Trp; and Y, Tyr.
19. P. Lucas, K. Ukhanov, T. Leinders-Zufall, F. Zufall, Neuron 40, 551 (2003).
20. S. M. Potter et al., J. Neurosci. 21, 9713 (2001).
21. M. Spehr, H. Hatt, C. H. Wetzel, J. Neurosci. 22, 8429 (2002).
22. Y. E. Lau, J. A. Cherry, Neuroreport 11, 27 (2000).
23. T. Leinders-Zufall et al., data not shown.
24. S. Martini, L. Silvotti, A. Shirazi, N. J. Ryba, R. Tirindelli, J. Neurosci. 21, 843 (2001).
25. D. J. Speca et al., Neuron 23, 487 (1999).
26. H. M. Bruce, Nature 184, 105 (1959).
27. A. Lloyd-Thomas, E. B. Keverne, Neuroscience 7, 907 (1982).
28. The efficiency of pregnancy block by direct application of unfamiliar urine is similar to that caused by the presence of unfamiliar mice (for instance, when BALB/c females are mated with C57BL/6 males, presence of BALB/c males causes pregnancy failure in 9 of 12 mice).
29. R. J. O'Connell, M. Meredith, Behav. Neurosci. 98, 1083 (1984).
30. T. Ishii, J. Hirota, P. Mombaerts, Curr. Biol. 13, 394 (2003).
31. J. Loconto et al., Cell 112, 607 (2003).
32. X. L. He, P. Tabaczewski, J. Ho, I. Stroynowski, K. C. Garcia, Structure 9, 1213 (2001).
33. D. Penn, W. Potts, Adv. Immunol. 69, 411 (1998).
34. G. K. Beauchamp, K. Yamazaki, Biochem. Soc. Trans. 31, 147 (2003).
35. J. L. Hurst et al., Nature 414, 631 (2001).
36. We thank R. Escher for peptide synthesis, J. Cherry for PDE4A antibodies, R. Tirindelli for V2R2 antibodies. P. Mombaerts for OMP-GFP mice, and K. Kelliher for the demonstration that nonvolatile chemicals can reach the VNO in vivo. This work was supported by the Leibniz program of the Deutsche Forschungsgemeinschaft (T.B. and H.B.), by NIH/National Institute on Deafness and other Communication Disorders (T.L.-Z. and F.Z.), and by the Hochshut- und Wissenschafts-Programm (P.W.).