Tissue distribution, toxicokinetics and induction of hepatic drug metabolizing enzymes in male rats after a single S.C. dose of 3,4,3',4'-tetrachlorobiphenyl (PCB-77)

Chemosphere

Volumn 34, Issue 5-7, 1997, Pages 1523-1534

  Heinrich Hirsch, B ^a   Beck, H ^a   Chahoud, I ^b   Grote, K ^b   Hartmann, J ^b   Mathar, W ^a  

^a Bundesinstitut Gesundheitlichen V   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLIZING ENZYME; ETHOXYRESORUFIN DEETHYLASE; POLYCHLORINATED BIPHENYL; TETRACHLOROBIPHENYL;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; BLOOD; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; LIVER; MALE; NONHUMAN; RAT; TESTIS; TIME; TISSUE DISTRIBUTION; TOXICOKINETICS;

ANIMALIA;

EID: 0030890133     PISSN: 00456535     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0045-6535(97)00448-7     Document Type: Conference Paper

References (19)

1. Chahoud, I., Hartmann, J., Grote, K., Mathar, W., Beck, H., Merker, H.-J. (1994). Effects of a single dose of 3,3′,4,4′-tetrachlorobiphenyl (PCB 77) on rat testis. Organohalogen Compounds 21: 21-24.
2. Ahlborg, U.G., Becking, G.G., Birnbaum, L.S. Brouwer, A., Derks, H.J.G.M., Feeley, M. Golor, G., Hanberg, A., Larsen, L.C., Liem, A.K.D., Safe, S.H., Schlatter, C., Waern, F., Younes, M., Yrjänheikki, E. (1994). Toxic equivalency factors for dioxin-like PCBs. Chemosphere 28: 1049-1067.
3. Chahoud, I., Hartmann, J., Rune, G. M., Neubert, D. (1992). Reproductive toxicity and toxicokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin. 3. Effects of single doses on the testis of male rats. Arch. Toxicol. 66: 567-572.
4. Beck, H. and W. Mathar (1985). Analysenverfahren zur Bestimmung von ausgewählten PCB-Einzelkomponenten in Lebensmitteln [Analytical procedure for the determination of selected PCB components in food]. Bundesgesundheitsblatt 28: 1-12.
5. Päpke, O., Ball, M., Lis, Z.A. and K. Scheunert (1989). PCDD/PCDF in whole blood samples of unexposed persons. Chemosphere 19: 941-948.
6. Smith, L.M., Stalling, D.L. and J.L. Johnson (1984). Determination of part-per-trillion levels of polychlorinated dibenzofurans and dioxins in environmental samples. Anal. Chem. 56: 1830.
7. Specht, W.: Organochlorine, organophosphorus, nitrogen-containing and other pesticides. In: Deutsche Forschungsgemeinschaft (Eds.: H.-P. Thier and H. Zeumer), Manual of pesticide residue analysis, VCH Verlagsgesellschaft Weinheim 1987, Vol. 1, pp. 383-400, Cleanup method S 19.
8. Burke M.D., and Mayer R.T. (1974). Ethoxyresorufin: Direct fluorimetric assay of microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene. Drug Metab. Dispos. 2: 583-588.
9. Schulz-Schalge, T., Koch, E., Schwind, K.-H., Hutzinger, O., Neubert, D. (1991). Inductive potency of TCDD, TBDD and three 2,3,7,8-mixed-halogenated dioxins in liver microsomes of male rats. Enzyme kinetic considerations. Chemosphere 23 (11-12): 1925-1931.
10. Burke, M.D., Thompson S., Elcombe, C.R. Halpert, J. Haaparanta, T., and Mayer R.T. (1985). Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: A series of substrates to distinguish between different induced cytochrome(s) P450. Biochem. Pharmacol. 34: 3337-3345.
11. Namkung, M.J., Yang, H.L., Hulla, J.E., Juchau, M.R. (1988). On the substrate specificity of cytochrome P450IIIA1. Mol. Pharmacol. 34: 628-637.
12. Nerurkar, P.V., Park, S.S., Thomas, P.E., Nimus, R.W., and Lubet, R.A. (1993). Methoxyresorufin and benzyloxyresorufin: Substrates preferentially metabolized by cytochromes P4501A2 and B2, respectively in the rat and mouse. Biochem. Pharmacol. 46: 933-943.
13. Lubet, R.A., Mayer, R.T., Cameron, J.W., Burke, M.D., Wolff, T., and Guengerich, F.P. (1985). Dealkylation of pentoxyresorufin: A rapid and sensitive assay for measuring induction of cytochromes(s) P450 by phenobarbital and other xenobiotics in the rat. Arch. Biochem. Biophys. 238: 43-48.
14. Hartmann, J., Grote, K., Mathar, W., Heinrich-Hirsch, B., Beck, H., and Chahoud I. (1995) Toxicicty of a single dose of 3,4,3′,4′-tetrachlorobiphenyl (PCB 77) in male rats. Organohalogen Compounds 21: 21-24.
15. Abdel-Hamid, F.M., Moore, J.A., Matthews, H.B. (1981). Comparative study of 3,4,3′,4′-tetrachlorobiphenyl in male and female rats and female monkeys. J. Toxicol. Environ. Health 7: 181-191.
16. Clevenger, M. A., Roberts, S. M., Lattin, D. L., Harbison, R. D., James, R. C. (1989). The pharmacokinetics of 2,2′,5,5′-tetrachlorobiphenyl and 3,3′,4,4′-tetrachlorobiphenyl and its relationships to toxicity. Toxicol. Appl. Pharmacol. 100: 315-327.
17. Clarke, D.W., Brien, J.F., Racz, W.J., Nakatsu, K., Marks, G.S. (1984). The disposition and the liver and thymus gland toxicity of 3,4,3',4'-tetrachlorobiphenyl in the female rat.
18. Rose, J.Q., Ramsey, J.C., Wentzler, T.H., Hummel, R.A., Gehring, P.J. (1976). The fate of 2,3,7,8-tetrachlorodibenzo-p-dioxin following single and repeated oral doses to the rat. Toxicol. Appl. Pharmacol. 36: 209-226.
19. Abraham, K., Krowke, R., Neubert, D. (1988). Pharmacokinetics and biological activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Dose-dependent tissue distribution and induction of hepatic ethoxyresorufin O-deethylase in rats following a single injection. Arch. Toxicol. 62: 359-368.