T- and L-type CA2+-channel antagonists reduce contractility in guinea pig cardiac myocytes

Journal of Cardiovascular Pharmacology

Volumn 32, Issue 2, 1998, Pages 323-330

  Hoischen, Susanne ^a   Brixius, Klara ^a   Schwinger, Robert H G ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Ca2+ channel; Diltiazem; Mibefradil; Myocardial contractility

Indexed keywords

CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; DILTIAZEM; MIBEFRADIL;

ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; GUINEA PIG; HEART MUSCLE CONTRACTILITY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BENZIMIDAZOLES; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CALCIUM CHANNELS, L-TYPE; DILTIAZEM; GUINEA PIGS; MALE; MIBEFRADIL; MYOCARDIAL CONTRACTION; MYOCARDIUM; TETRAHYDRONAPHTHALENES;

EID: 0031877839     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199808000-00022     Document Type: Article

References (39)

1. Bühler FR, Kiowski W. Calcium antagonists in hypertension. J Hypertens 1987;5(suppl 3):S3-10.
2. Reid JL, Meredith PA, Pasanisi F. Clinical pharmacological aspects of calcium antagonists and their therapeutic role in hypertension. J Cardiovasc Pharmacol 1995;7(suppl 4):S18-20.
3. Oparil S, Calhoun DA. The calcium antagonists in the 1990s: an overview. Am J Hypertens 1991;4:396S-405S.
4. McGrath BP, Newman R, Older R. Hemodynamic study of short- and long term isradipine treatment in patients with chronic congestive heart failure. Am J Med 1989;86(suppl 4A):75-80.
5. Nilius B, Hess P, Lansmann JB, Tsien RW. A novel type of cardiac calcium channel in ventricular cells. Nature 1985;316:443-6.
6. Mitra R, Morad M. Two types of calcium channels in guinea pig ventricular myocytes. Proc Natl Acad Sci USA 1986;83:5340-4.
7. Katz AM. Physiology of the heart, 2nd ed. New York: Raven Press, 1992:222-5.
8. Godfraind T. Calcium antagonists and vasodilatation. Pharmacol Ther 1994;64:37-75.
9. Opie LH. Calcium channel antagonists. 4. Side effects and contraindications, drug interactions and combinations. Cardiovasc Drugs Ther 1988;2:177-89.
10. Bean BP. Classes of calcium channels in vertebrate cells. Annu Rev Physiol 1989;51:367-84.
11. Tsien RW, Tsien RY. Calcium channels, stores, and oscillations. Annu Rev Cell Biol 1990;6:715-60.
12. 2+ channels in guinea pig hearts. J Physiol 1992;456:247-65.
13. 2+ channels by Ro 40-5967. Circ Res 1994;75:144-8.
14. 2+ channels. J Pharmacol Exp Ther 1994;271:1483-8.
15. 3H]desmethoxyverapamil receptor, is devoid of the negative inotropic effects of verapamil in normal and failing rat hearts. Cardiovasc Drugs Ther 1990;4:731-6.
16. Clozel JP, Osterrieder W, Kleinbloesem CH, et al. Ro 40-5967: a new nondihydropyridine calcium channel antagonist. Cardiovasc Drug Res 1991;9:4-17.
17. Véniant M, Clozel JP, Hess P, Wolfgang R. Ro 40-5967, in contrast to diltiazem, does not reduce left ventricular contractility in rats with chronic infarction. J Cardiovasc Pharmacol 1991;17:277-84.
18. Man in't Veld AJ. Calcium antagonist in hypertension. Am J Med 1989;86(suppl 4A):6-14.
19. The Multicenter Diltiazem Postinfarction Trial Research Group. The effect of diltiazem on mortality and reinfarction after myocardial infarction. N Engl J Med 1988;319:385-92.
20. 2+-Kanalantagonisten Mibefradil am Menschen. Cardiology 1997;88(suppl 6):37-44.
21. Harding SE, Jones SM, O'Gara P, del Monte F, Vescovo G, Poole-Wilson PA. Isolated ventricular myocytes from failing and non-failing human hearts; the relation of age and clinical status of patients to isoproterenol response. J Mol Cell Cardiol 1992;24:549-64.
22. Harding SE, O'Gara P, Jones SM, Brown LA, Vescovo G, Poole-Wilson PA. Species dependence of contraction velocity in single isolated cardiac myocytes. Cardioscience 1990;1:49-54.
23. 2+-channel blocker with potent vasodilator but weak inotropic action. J Cardiovasc Pharmacol 1989;13:754-9.
24. Henry PD. Comparative pharmacology of calcium antagonists: Nifedipine, verapamil and diltiazem. Am J Cardiol 1980;46:1047-58.
25. Harding SE, Gurden JM, Poole-Wilson PA. A comparison of contractile function between papillary muscles and isolated cardiomyocytes from the same human hearts. Cardioscience 1991;2:141-6.
26. Wang Z, Lam CF, Mukherjee R, Hebbar L, Wang Y, Spinale F. Relationship between external load and isolated myocyte contractile function with CHF in pigs. Am J Physiol 1997;273:H183-91.
27. Harding SE, Vescovo G, Kirby M, Jones SM, Gurden J, Poole-Wilson PA. Contractile responses of isolated adult rat and rabbit cardiac myocytes to isoproterenol and calcium. J Mol Cell Cardiol 1988;20:635-47.
28. Diochot S, Richard S, Baldy-Moulinier M, Nargeot J, Valmier J. Dihydropyridines, phenylalkylamines and henzothiazepines block N-, P/Q-, and R-type calcium currents. Pflugers Arch 1995;431:10-9.
29. 2+ channel blocker. Exp Opin Invest Drugs 1997;6:569-82.
30. Beuckelmann DJ, Näbauer M, Erdmann E. Characteristics of calcium current in isolated human ventricular myocytes from patients with terminal heart failure. J Mol Cell Cardiol 1991;23:929-37.
31. Hagiwara N, Irisawa H, Kameyama M. Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino-atrial node cells. J Physiol 1988;359:233-53.
32. Zhou Z, Lipsius SL. T-type calcium current in latent pacemaker cells isolated from cat right atrium. J Mol Cell Cardiol 1994;26:1211-9.
33. Véniant M, Clozel JP, Heudes D, Banken L, Menard J. Effects of Ro 40-5967, a new calcium antagonist, and enalapril on cardiac remodeling in renal hypertensive rats. J Cardiovasc Pharmacol 1993;21:544-51.
34. Vassort G, Alvarez J. Cardiac T-type calcium current: pharmacology and roles in cardiac tissues. J Cardiovasc Electrophysiol 1994;5:376-93.
35. Xu X, Best PM. Postnatal changes of T-type calcium current density in rat atrial myocytes. J Physiol (Lond) 1992;454:657-72.
36. 2+-channels are abnormal in genetically determined cardiomyopathic hamster hearts. Circ Res 1994;75:149-55.
37. Snyder SH, Reynolds I. Calcium antagonist drugs: receptor interactions that clarify therapeutic effects. N Engl J Med 1985;31:995-1002.
38. Schwinger RHG, Böhm M, Erdmann E. Negative inotropic properties of isradipine, nifedipine, diltiazem, and verapamil in diseased human myocardial tissue. J Cardiovasc Pharmacol 1990;15:892-9.
39. 2+-antagonists in human myocardial tissue. Klin Wochenschr 1990;68:797-805.