Ex Vivo Selection and Expansion of Cells Based on Expression of a Mutated Inosine Monophosphate Dehydrogenase 2 after HIV Vector Transduction: Effects on Lymphocytes, Monocytes, and CD34+ Stem Cells

Molecular Therapy

Volumn 14, Issue 2, 2006, Pages 236-244

  Yam, Priscilla ^a   Jensen, Michael ^a   Akkina, Ramesh ^b   Anderson, Joseph ^b   Villacres, Maria C ^c   Wu, Jerry ^a   Zaia, John A ^a   Yee, Jiing Kuan ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b Department of Environmental and Radiological Health Sciences   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

CD34+ cells; expansion IMPDH2; mycophenolic acid; selection; T cells

Indexed keywords

B7 ANTIGEN; CD34 ANTIGEN; CYTOKINE; GAG PROTEIN; GREEN FLUORESCENT PROTEIN; INOSINATE DEHYDROGENASE; INOSINATE DEHYDROGENASE INHIBITOR; LENTIVIRUS VECTOR; MYCOPHENOLIC ACID; PURINE; RETROVIRUS VECTOR; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; VIRUS VECTOR;

ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL GROWTH; CELL SELECTION; CELL STIMULATION; CELL TYPE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG TARGETING; EX VIVO STUDY; GENE EXPRESSION; GENE OVEREXPRESSION; GENE TARGETING; GENE THERAPY; GENETIC SELECTION; GENETIC TRANSDUCTION; GENETIC VARIABILITY; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INHIBITION KINETICS; LYMPHOCYTE; LYMPHOCYTE TRANSFER; MONOCYTE; MONONUCLEAR CELL; PHAGOCYTOSIS; PURINE SYNTHESIS; STEM CELL; UPREGULATION; VIRAL GENE DELIVERY SYSTEM; VIRUS REPLICATION; VIRUS RESISTANCE;

ANIMALS; ANTIGENS, CD34; ANTIGENS, CD80; CELL DIFFERENTIATION; CELL LINE; CELLS, CULTURED; CYTOKINES; DRUG RESISTANCE; FETAL BLOOD; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HEMATOPOIETIC STEM CELLS; HIV CORE PROTEIN P24; HIV-1; HUMANS; IMP DEHYDROGENASE; MACROPHAGES; MONOCYTES; MUTATION; MYCOPHENOLIC ACID; PHAGOCYTOSIS; RNA, SMALL INTERFERING; T-LYMPHOCYTES; TRANSDUCTION, GENETIC; UP-REGULATION; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33745357073     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2006.02.017     Document Type: Article

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