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Volumn 87, Issue 6, 1996, Pages 2579-2587

A gene transfer strategy for making bone marrow cells resistant to trimetrexate

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; COMPLEMENTARY DNA; DIHYDROFOLATE REDUCTASE; HEXADIMETHRINE BROMIDE; INTERLEUKIN 3; INTERLEUKIN 6; LEUCINE; METHOTREXATE; MUTANT PROTEIN; TRIMETREXATE; TYROSINE; VIRUS VECTOR;

EID: 0029865455     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.6.2579.bloodjournal8762579     Document Type: Article
Times cited : (93)

References (45)
  • 1
    • 0000899457 scopus 로고
    • Folates and pterins
    • Blakley RL, Benkovic SJ (eds): New York, NY, Wiley
    • Blakley RL: Folates and pterins, in Blakley RL, Benkovic SJ (eds): Chemistry and Biochemistry of Folates New York, NY, Wiley, 1984, p 191
    • (1984) Chemistry and Biochemistry of Folates , pp. 191
    • Blakley, R.L.1
  • 2
    • 0024272695 scopus 로고
    • Characterization of trimetrexate transport in human lymphoblastoid cells and development of impaired influx as a mechanism of resistance to lipophilic antifolates
    • Fry DW, Besserer JA: Characterization of trimetrexate transport in human lymphoblastoid cells and development of impaired influx as a mechanism of resistance to lipophilic antifolates. Cancer Res 48:6986, 1988
    • (1988) Cancer Res , vol.48 , pp. 6986
    • Fry, D.W.1    Besserer, J.A.2
  • 3
    • 0029053314 scopus 로고
    • Selective treatment of SCIDmice bearing methotrexate-transport-resistant human acute lymphoblastic leukemia tumors with trimetrexate and leucovorin protection
    • Lacerda JF, Goker E, Kheradpour A, Dennig D, Elisseyeff Y, Jagiello C, O'Reilly RJ, Bertino JR. Selective treatment of SCIDmice bearing methotrexate-transport-resistant human acute lymphoblastic leukemia tumors with trimetrexate and leucovorin protection. Blood 85:2675, 1995
    • (1995) Blood , vol.85 , pp. 2675
    • Lacerda, J.F.1    Goker, E.2    Kheradpour, A.3    Dennig, D.4    Elisseyeff, Y.5    Jagiello, C.6    O'Reilly, R.J.7    Bertino, J.R.8
  • 4
    • 0028174048 scopus 로고
    • An Eastern Cooperative Oncology Group phase II trial of trimetrexate in the treatment of advanced urothelial carcinoma
    • Witte RS, Elson P, Khandakar J, Trump DL: An Eastern Cooperative Oncology Group phase II trial of trimetrexate in the treatment of advanced urothelial carcinoma Cancer 73:688, 1994
    • (1994) Cancer , vol.73 , pp. 688
    • Witte, R.S.1    Elson, P.2    Khandakar, J.3    Trump, D.L.4
  • 5
    • 0028800680 scopus 로고
    • A phase II study of continuous infusion of trimetrexate in patients with refractory acute leukemia
    • Kheradpour A, Berman E, Goker E, Lin JT, Tong WP, Bertino JR: A phase II study of continuous infusion of trimetrexate in patients with refractory acute leukemia. Cancer Invest 13:36, 1995
    • (1995) Cancer Invest , vol.13 , pp. 36
    • Kheradpour, A.1    Berman, E.2    Goker, E.3    Lin, J.T.4    Tong, W.P.5    Bertino, J.R.6
  • 6
    • 0028072605 scopus 로고
    • Trimetrexate in advanced hormone-refractory prostate cancer. An ECOG phase II trial
    • Witte RS, Yeap BY, Trump DL: Trimetrexate in advanced hormone-refractory prostate cancer. An ECOG phase II trial. Invest New Drugs 12:255, 1994
    • (1994) Invest New Drugs , vol.12 , pp. 255
    • Witte, R.S.1    Yeap, B.Y.2    Trump, D.L.3
  • 7
    • 0027461778 scopus 로고
    • Phase I trial of trimetrexate in pediatric solid tumors: A Pediatric Oncology Group study
    • Pappo AS, Vats T, Williams TE, Bernstein M, Kamen BA: Phase I trial of trimetrexate in pediatric solid tumors: A Pediatric Oncology Group study. Med Pediatr Oncol 21:280, 1993
    • (1993) Med Pediatr Oncol , vol.21 , pp. 280
    • Pappo, A.S.1    Vats, T.2    Williams, T.E.3    Bernstein, M.4    Kamen, B.A.5
  • 8
    • 0017839684 scopus 로고
    • Optimization of high-dose methotrexate with leucovorin rescue therapy in the L1210 leukemia and sarcoma 180 murine tumor models
    • Sirotnak FM, Moccio DM, Dorick DM: Optimization of high-dose methotrexate with leucovorin rescue therapy in the L1210 leukemia and sarcoma 180 murine tumor models. Cancer Res 38:345, 1978
    • (1978) Cancer Res , vol.38 , pp. 345
    • Sirotnak, F.M.1    Moccio, D.M.2    Dorick, D.M.3
  • 9
    • 0025020239 scopus 로고
    • Modulation of the and tumor effect of methotrexate by low-dose leucovorin in squamous cell head and neck cancer: A randomized placebo-controlled clinical trial
    • Browman GP, Goodyear MD, Levine MN, Russell R, Archibald SD, Young JE: Modulation of the and tumor effect of methotrexate by low-dose leucovorin in squamous cell head and neck cancer: A randomized placebo-controlled clinical trial. J Clin Oncol 8:203, 1990
    • (1990) J Clin Oncol , vol.8 , pp. 203
    • Browman, G.P.1    Goodyear, M.D.2    Levine, M.N.3    Russell, R.4    Archibald, S.D.5    Young, J.E.6
  • 10
    • 0023503165 scopus 로고
    • High-dose methotrexate: A critical reappraisal
    • Ackland SP, Schilsky RL: High-dose methotrexate: A critical reappraisal. J Clin Oncol 5:2017, 1987
    • (1987) J Clin Oncol , vol.5 , pp. 2017
    • Ackland, S.P.1    Schilsky, R.L.2
  • 12
    • 0025089990 scopus 로고
    • Serial transplantation of methotrexate-resistant bone marrow: Protection of murine recipients from drug toxicity by progeny of transduced stem cells
    • Corey CA, DeSilva AD, Holland CA, Williams DA: Serial transplantation of methotrexate-resistant bone marrow: Protection of murine recipients from drug toxicity by progeny of transduced stem cells. Blood 75:337, 1990
    • (1990) Blood , vol.75 , pp. 337
    • Corey, C.A.1    DeSilva, A.D.2    Holland, C.A.3    Williams, D.A.4
  • 13
    • 0023250381 scopus 로고
    • Protection of bone marrow transplant recipients from lethal doses of methotrexate by the generation of methotrexate-resistant bone marrow
    • Williams DA, Hsieh K, DeSilva A, Mulligan RC: Protection of bone marrow transplant recipients from lethal doses of methotrexate by the generation of methotrexate-resistant bone marrow J Exp Med 166:210, 1987
    • (1987) J Exp Med , vol.166 , pp. 210
    • Williams, D.A.1    Hsieh, K.2    DeSilva, A.3    Mulligan, R.C.4
  • 14
    • 0028340408 scopus 로고
    • Development of a retroviral construct containing a human mutated dihydrofolate reductase cDNA for hematopoietic stem cell transduction
    • Li MX, Banerjee D, Zhao SC, Schweitzer BI, Mineishi S, Gilboa E, Bertino JR. Development of a retroviral construct containing a human mutated dihydrofolate reductase cDNA for hematopoietic stem cell transduction. Blood 83:3403, 1994
    • (1994) Blood , vol.83 , pp. 3403
    • Li, M.X.1    Banerjee, D.2    Zhao, S.C.3    Schweitzer, B.I.4    Mineishi, S.5    Gilboa, E.6    Bertino, J.R.7
  • 15
    • 0028403232 scopus 로고
    • Long-term protection of recipient mice from lethal doses of methotrexate by marrow infected with a double-copy vector retrovirus containing a mutant dihydrofolate reductase
    • Zhao SC, Li MX, Banerjee D, Schweitzer BI, Mineishi S, Gilboa E, Bertino JR: Long-term protection of recipient mice from lethal doses of methotrexate by marrow infected with a double-copy vector retrovirus containing a mutant dihydrofolate reductase. Cancer Gene Therapy 1:27, 1994
    • (1994) Cancer Gene Therapy , vol.1 , pp. 27
    • Zhao, S.C.1    Li, M.X.2    Banerjee, D.3    Schweitzer, B.I.4    Mineishi, S.5    Gilboa, E.6    Bertino, J.R.7
  • 16
    • 0008200829 scopus 로고
    • Isolation and expression of an altered mouse dihydrofolate reductase cDNA
    • Simonsen CC, Levinson AD: Isolation and expression of an altered mouse dihydrofolate reductase cDNA. Proc Natl Acad Sci USA 80:2495, 1983
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 2495
    • Simonsen, C.C.1    Levinson, A.D.2
  • 17
    • 0028230635 scopus 로고
    • Transfection with a cDNA encoding a Ser31 or Ser34 mutant human dihydrofolate reductase into Chinese hamster ovary and mouse marrow progenitor cells confers methotrexate resistance
    • Banerjee D, Schweitzer BI, Volkenandt M, Li MX, Waltham M, Mineishi S, Zhao SC, Bertino JR: Transfection with a cDNA encoding a Ser31 or Ser34 mutant human dihydrofolate reductase into Chinese hamster ovary and mouse marrow progenitor cells confers methotrexate resistance. Gene 139:269, 1994
    • (1994) Gene , vol.139 , pp. 269
    • Banerjee, D.1    Schweitzer, B.I.2    Volkenandt, M.3    Li, M.X.4    Waltham, M.5    Mineishi, S.6    Zhao, S.C.7    Bertino, J.R.8
  • 18
    • 0027136096 scopus 로고
    • Allelic variation in the dihydrofolate reductase gene at amino acid position 95 contributes to antifolate resistance in Chinese hamster cells
    • Yu M, Melera PW: Allelic variation in the dihydrofolate reductase gene at amino acid position 95 contributes to antifolate resistance in Chinese hamster cells. Cancer Res 53:6031, 1993
    • (1993) Cancer Res , vol.53 , pp. 6031
    • Yu, M.1    Melera, P.W.2
  • 19
    • 0026510218 scopus 로고
    • Construction of a dominant selectable marker using a novel dihydrofolate reductase
    • Hussain A, Lewis D, Yu M, Melera PW: Construction of a dominant selectable marker using a novel dihydrofolate reductase Gene 112:179, 1992
    • (1992) Gene , vol.112 , pp. 179
    • Hussain, A.1    Lewis, D.2    Yu, M.3    Melera, P.W.4
  • 20
    • 0028221796 scopus 로고
    • Saturation mutagenesis at dihydrofolate reductase codons 22 and 31. A variety of amino acid substitutions conferring methotrexate resistance
    • Morris JA, McIvor RS: Saturation mutagenesis at dihydrofolate reductase codons 22 and 31. A variety of amino acid substitutions conferring methotrexate resistance. Biochem Pharmacol 47:1207, 1994
    • (1994) Biochem Pharmacol , vol.47 , pp. 1207
    • Morris, J.A.1    McIvor, R.S.2
  • 21
    • 0025343839 scopus 로고
    • Identification and characterization of a mutation in the dihydrofolate reductase gene from the methotrexate-resistant Chinese hamster ovary cell line Pro-3 MtxRIII
    • Dicker AP, Volkenandt M, Schweitzer BI, Banerjee D, Bertino JR: Identification and characterization of a mutation in the dihydrofolate reductase gene from the methotrexate-resistant Chinese hamster ovary cell line Pro-3 MtxRIII. J Biol Chem 265:8317, 1990
    • (1990) J Biol Chem , vol.265 , pp. 8317
    • Dicker, A.P.1    Volkenandt, M.2    Schweitzer, B.I.3    Banerjee, D.4    Bertino, J.R.5
  • 22
    • 0028241517 scopus 로고
    • Methotrexate-resistant variants of human dihydrofolate reductase. Effects of Phe31 substitutions
    • Chunduru SK, Cody V, Luft JR, Pangborn W, Appleman JR, Blakley RL: Methotrexate-resistant variants of human dihydrofolate reductase. Effects of Phe31 substitutions. J Biol Chem 269:9547, 1994
    • (1994) J Biol Chem , vol.269 , pp. 9547
    • Chunduru, S.K.1    Cody, V.2    Luft, J.R.3    Pangborn, W.4    Appleman, J.R.5    Blakley, R.L.6
  • 23
    • 0028920025 scopus 로고
    • Methotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22. Kinetics, crystallography, and potential as selectable markers
    • Lewis WS, Cody V, Galitsky N, Luft JR, Pangborn W, Chunduru SK, Spencer HT, Appleman JR, Blakley RL: Methotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22. Kinetics, crystallography, and potential as selectable markers. J Biol Chem 270:5057, 1995
    • (1995) J Biol Chem , vol.270 , pp. 5057
    • Lewis, W.S.1    Cody, V.2    Galitsky, N.3    Luft, J.R.4    Pangborn, W.5    Chunduru, S.K.6    Spencer, H.T.7    Appleman, J.R.8    Blakley, R.L.9
  • 24
    • 0024408798 scopus 로고
    • Probing the role of two hydrophobic active site residues in the human dihydrofolate reductase by site-directed mutagenesis
    • Schweitzer BI, Srimatkandada S, Gritsman H, Sheridan R, Venkataraghavan R, Bertino JR: Probing the role of two hydrophobic active site residues in the human dihydrofolate reductase by site-directed mutagenesis. J Biol Chem 264:20786, 1989
    • (1989) J Biol Chem , vol.264 , pp. 20786
    • Schweitzer, B.I.1    Srimatkandada, S.2    Gritsman, H.3    Sheridan, R.4    Venkataraghavan, R.5    Bertino, J.R.6
  • 25
    • 0028017548 scopus 로고
    • Critical role of phenylalanine 34 of human dihydrofolate reductase in substrate and inhibitor binding and in catalysis
    • Nakano T, Spencer HT, Appleman JR, Blakley RL: Critical role of phenylalanine 34 of human dihydrofolate reductase in substrate and inhibitor binding and in catalysis. Biochemistry 33:9945, 1994
    • (1994) Biochemistry , vol.33 , pp. 9945
    • Nakano, T.1    Spencer, H.T.2    Appleman, J.R.3    Blakley, R.L.4
  • 26
    • 0013508682 scopus 로고
    • A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells
    • Pastan I, Gottesman MM, Ueda K, Lovelace E, Rutherford AV, Willingham MC: A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells. Proc Natl Acad Sci USA 85:4486, 1988
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 4486
    • Pastan, I.1    Gottesman, M.M.2    Ueda, K.3    Lovelace, E.4    Rutherford, A.V.5    Willingham, M.C.6
  • 27
    • 0027202812 scopus 로고
    • Dihydrofolate reductase from the pathogenic fungus Pneumocystis carinii: Catalytic properties and interaction with antifolates
    • Margosiak SA, Appleman JR, Santi DV, Blakley RL: Dihydrofolate reductase from the pathogenic fungus Pneumocystis carinii: Catalytic properties and interaction with antifolates. Arch Biochem Biophys 305:499, 1993
    • (1993) Arch Biochem Biophys , vol.305 , pp. 499
    • Margosiak, S.A.1    Appleman, J.R.2    Santi, D.V.3    Blakley, R.L.4
  • 28
    • 0022767368 scopus 로고
    • Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production
    • Miller AD, Buttimore C: Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production. Mol Cell Biol 6:2895, 1986
    • (1986) Mol Cell Biol , vol.6 , pp. 2895
    • Miller, A.D.1    Buttimore, C.2
  • 29
    • 0023871422 scopus 로고
    • A safe packaging line for gene transfer: Separating viral genes on two different plasmids
    • Markowitz D, Goff S, Bank A: A safe packaging line for gene transfer: Separating viral genes on two different plasmids. J Virol 62:1120, 1988
    • (1988) J Virol , vol.62 , pp. 1120
    • Markowitz, D.1    Goff, S.2    Bank, A.3
  • 30
    • 0024380889 scopus 로고
    • Combination of interleukins 3 and 6 preserves stem cell function in culture and enhances retrovirus-mediated gene transfer into hematopoietic stem cells
    • Bodine DM, Karlsson S, Nienhuis AW: Combination of interleukins 3 and 6 preserves stem cell function in culture and enhances retrovirus-mediated gene transfer into hematopoietic stem cells. Proc Natl Acad Sci USA 86:8897, 1989
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 8897
    • Bodine, D.M.1    Karlsson, S.2    Nienhuis, A.W.3
  • 31
    • 0025832928 scopus 로고
    • Survival and retrovirus infection of murine hematopoietic stem cells in vitro: Effects of 5-FU and method of infection
    • Bodine DM, McDonagh KT, Seidel NE, Nienhuis AW: Survival and retrovirus infection of murine hematopoietic stem cells in vitro: Effects of 5-FU and method of infection. Exp Hematol 19:206, 1991
    • (1991) Exp Hematol , vol.19 , pp. 206
    • Bodine, D.M.1    McDonagh, K.T.2    Seidel, N.E.3    Nienhuis, A.W.4
  • 33
    • 0029058758 scopus 로고
    • Expression of retroviral vectors containing the human MDR1 cDNA in hematopoietic cells of transplanted mice
    • Sorrentino BP, McDonagh KT, Woods D, Orlic D: Expression of retroviral vectors containing the human MDR1 cDNA in hematopoietic cells of transplanted mice. Blood 86:491, 1995
    • (1995) Blood , vol.86 , pp. 491
    • Sorrentino, B.P.1    McDonagh, K.T.2    Woods, D.3    Orlic, D.4
  • 34
    • 0028661063 scopus 로고
    • Use of safety-modified retroviruses to introduce chemotherapy resistance sequences into normal hematopoietic cells for chemoprotection during the therapy of ovarian cancer: A pilot trial
    • Deisseroth AB, Kavanagh J, Champlin R: Use of safety-modified retroviruses to introduce chemotherapy resistance sequences into normal hematopoietic cells for chemoprotection during the therapy of ovarian cancer: A pilot trial. Hum Gene Trier 5:1507, 1994
    • (1994) Hum Gene Trier , vol.5 , pp. 1507
    • Deisseroth, A.B.1    Kavanagh, J.2    Champlin, R.3
  • 39
    • 0028967307 scopus 로고
    • Ex vivo expansion and selection of human CD34+ peripheral blood progenitor cells after introduction of a mutated dihydrofolate reductase cDNA via retroviral gene transfer
    • Flasshove M, Banerjee D, Mineishi S, Li MX, Bertino JR, Moore MA: Ex vivo expansion and selection of human CD34+ peripheral blood progenitor cells after introduction of a mutated dihydrofolate reductase cDNA via retroviral gene transfer. Blood 85:566, 1995
    • (1995) Blood , vol.85 , pp. 566
    • Flasshove, M.1    Banerjee, D.2    Mineishi, S.3    Li, M.X.4    Bertino, J.R.5    Moore, M.A.6
  • 41
    • 0029016285 scopus 로고
    • Retrovirus-mediated expression of a DNA repair protein in bone marrow protects hematopoietic cells from nitrosourea-induced toxicity in vitro and in vivo
    • Moritz T, Mackay W, Glassner BJ, Williams DA, Samson L: Retrovirus-mediated expression of a DNA repair protein in bone marrow protects hematopoietic cells from nitrosourea-induced toxicity in vitro and in vivo. Cancer Res 55:2608, 1995
    • (1995) Cancer Res , vol.55 , pp. 2608
    • Moritz, T.1    Mackay, W.2    Glassner, B.J.3    Williams, D.A.4    Samson, L.5
  • 42
    • 0029163531 scopus 로고
    • Protection of mice from lethal doses of methotrexate by transplantation with transgenic marrow expressing drug-resistant dihydrofolate reductase activity
    • May C, Gunther R, McIvor, RS: Protection of mice from lethal doses of methotrexate by transplantation with transgenic marrow expressing drug-resistant dihydrofolate reductase activity. Blood 86:2439, 1995
    • (1995) Blood , vol.86 , pp. 2439
    • May, C.1    Gunther, R.2    McIvor, R.S.3
  • 43
    • 0025325955 scopus 로고
    • Unusual transient- and steady-state kinetic behavior is predicted by the kinetic scheme operational for recombinant human dihydrofolate reductase
    • Appleman JR, Beard WA, Delcamp TJ, Prendergast NJ, Freisheim JH, Blakley RL: Unusual transient- and steady-state kinetic behavior is predicted by the kinetic scheme operational for recombinant human dihydrofolate reductase. J Biol Chem 265:2740, 1990
    • (1990) J Biol Chem , vol.265 , pp. 2740
    • Appleman, J.R.1    Beard, W.A.2    Delcamp, T.J.3    Prendergast, N.J.4    Freisheim, J.H.5    Blakley, R.L.6
  • 44
    • 0023730578 scopus 로고
    • Kinetics of the formation and isomerization of methotrexate complexes of recombinant human dihydrofolate reductase
    • Appleman JR, Prendergast N, Delcamp TJ, Freisheim JH, Blakley RL: Kinetics of the formation and isomerization of methotrexate complexes of recombinant human dihydrofolate reductase. J Biol Chem 263:10304, 1988
    • (1988) J Biol Chem , vol.263 , pp. 10304
    • Appleman, J.R.1    Prendergast, N.2    Delcamp, T.J.3    Freisheim, J.H.4    Blakley, R.L.5
  • 45
    • 85044548709 scopus 로고    scopus 로고
    • Mutations in the gene for human dihydrofolate reductase: An infrequent cause of clinical relapse in pediatric leukemia after therapy with methotrexate
    • in press
    • Spencer HT, Sorrentino BP, Pui C, Chunduru SK, Sleep SEH, Blakley RL: Mutations in the gene for human dihydrofolate reductase: An infrequent cause of clinical relapse in pediatric leukemia after therapy with methotrexate. Leukemia (in press)
    • Leukemia
    • Spencer, H.T.1    Sorrentino, B.P.2    Pui, C.3    Chunduru, S.K.4    Sleep, S.E.H.5    Blakley, R.L.6


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