Neuropathic pain: Translational research and impact for patient care

Current Pain and Headache Reports

Volumn 10, Issue 3, 2006, Pages 191-198

  Maag, Rainer ^b   Baron, Ralf ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; ANTICONVULSIVE AGENT; CAPSAICIN DERIVATIVE; CARBAMAZEPINE; GABAPENTIN; GLUTAMIC ACID; LAMOTRIGINE; LIDOCAINE; LOCAL ANESTHETIC AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NOCICEPTIN RECEPTOR; OXALIPLATIN; SODIUM CHANNEL BLOCKING AGENT; STREPTOZOCIN; VANILLOID RECEPTOR 1; VOLTAGE GATED SODIUM CHANNEL;

ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; COLD SENSITIVITY; DEAFFERENTATION; DRUG EFFICACY; DRUG TARGETING; ELECTROSTIMULATION; EVOKED SOMATOSENSORY RESPONSE; GENE MUTATION; GENETIC CODE; HUMAN; HYPOALGESIA; MECHANORECEPTOR; MEDICAL RESEARCH; NERVE BLOCK; NERVE CELL STIMULATION; NERVE EXCITABILITY; NEUROLOGIC EXAMINATION; NEUROPATHIC PAIN; NEUROTRANSMISSION; NOCICEPTION; NONHUMAN; PARESTHESIA; PATHOPHYSIOLOGY; PATIENT CARE; PERIPHERAL NEUROPATHY; POSTHERPETIC NEURALGIA; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE DIAGNOSIS; SENSORY NERVE CONDUCTION; SYMPATHETIC BLOCKING;

AFFERENT PATHWAYS; HUMANS; NEURAL INHIBITION; NEURALGIA; NOCICEPTORS;

EID: 33745299644     PISSN: 15313433     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11916-006-0045-8     Document Type: Article

References (63)

1. Daousi C, MacFarlane IA, Woodward A, et al.: Chronic painful peripheral neuropathy in an urban community: a controlled comparison of people with and without diabetes. Diabet Med 2004, 21:976-982.
2. McDermott AM, Toelle TR, Rowbotham DJ, et al.: The burden of neuropathic pain: results from a cross-sectional survey. Eur J Pain 2006, 10:127-135.
3. Jensen TS, Baron R: Translation of symptoms and signs into mechanisms in neuropathic pain. Pain 2003, 102:1-8.
4. Woolf CJ, Bennett GJ, Doherty M, et al.: Towards a mechanism-based classification of pain? Pain 1998, 77:227-229.
5. Baron R: Mechanisms of disease: neuropathic pain: a clinical perspective. Nat Clin Pract Neurol 2006, in press.
6. Wood JN, Boorman JP, Okuse K, Baker MD: Voltage-gated sodium channels and pain pathways. J Neurobiol 2004, 61:55-71.
7. Amir R, Liu CN, Kocsis JD, Devor M: Oscillatory mechanism in primary sensory neurones. Brain 2002, 125:421-435.
8. Nystrom B, Hagbarth KE: Microelectrode recordings from transected nerves in amputees with phantom limb pain. Neurosci Lett 1981, 27:211-216.
9. Orstavik K, Weidner C, Schmidt R, et al.: Pathological C-fibres in patients with a chronic painful condition. Brain 2003, 126:567-578.
10. Dib-Hajj SD, Rush AM, Cummins TR, et al.: Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons. Brain 2005, 128:1847-1854.
11. Catarina MJ, Leffler A, Malmberg AB, et al.: Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 2000, 288:306-313.
12. Hudson LJ, Bevan S, Wotherspoon G, et al.: VR1 protein expression increases in undamaged DRG neurons after partial nerve injury. Eur J Neurosci 2001, 13:2105-2114.
13. Hong S, Wiley JW: Early painful diabetic neuropathy is associated with differential changes in the expression and function of vanilloid receptor 1. J Biol Chem 2005, 280:618-627.
14. Ma W, Zhang Y, Bantel C, Eisenach JC: Medium and large injured dorsal root ganglion cells increase TRPV-1, accompanied by increased alpha2C-adrenoceptor co-expression and functional inhibition by clonidine. Pain 2005, 113:386-394.
15. Davis JB, Gray J, Gunthorpe MJ, et al.: Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature 2000, 405:183-187.
16. Baron R: Capsaicin and nociception: from basic mechanisms to novel drugs. Lancet 2000, 356:785-787.
17. Petersen KL, Fields HL, Brennum J, et al.: Capsaicin-evoked pain and allodynia in post-herpetic neuralgia. Pain 2000, 88:125-133.
18. Baron R, Schwarz K, Kleinert A, et al.: Histamine-induced itch converts into pain in neuropathic hyperalgesia. Neuroreport 2001, 12:3475-3478.
19. Patapoutian A, Peier AM, Story GM, Viswanath V: ThermoTRP channels and beyond: mechanisms of temperature sensation. Nat Rev Neurosci 2003, 4:529-539.
20. Obata K, Katsura H, Mizushima T, et al.: TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury. J Clin Invest 2005, 115:2393-2401.
21. Wasner G, Schattschneider J, Binder A, Baron R: Topical menthol: a human model for cold pain by activation and sensitization of C nociceptors. Brain 2004, 127:1159-1171.
22. Lehky TJ, Leonard GD, Wilson RH, et al.: Oxaliplatin-induced neurotoxicity: acute hyperexcitability and chronic neuropathy. Muscle Nerve 2004, 29:387-392.
23. Habler HJ, Janig W, Koltzenburg M: Activation of unmyelinated afferents in chronically lesioned nerves by adrenaline and excitation of sympathetic efferents in the cat. Neurosci Lett 1987, 82:35-40.
24. Raja SN, Abatzis V, Frank SM: Role of a-adrenoceptors in neuroma pain in amputees. Anesthesiology 1998, 89:A1083.
25. Choi B, Rowbotham MC: Effect of adrenergic receptor activation on post-herpetic neuralgia pain and sensory disturbances. Pain 1997, 69:55-63.
26. Ali Z, Raja SN, Wesselmann U, et al.: Intradermal injection of norepinephrine evokes pain in patients with sympathetically maintained pain. Pain 2000, 88:161-168.
27. Torebjork E, Wahren L, Wallin G, et al.: Noradrenaline-evoked pain in neuralgia. Pain 1995, 63:11-20.
28. Baron R, Schattschneider J, Binder A, et al.: Relation between sympathetic vasoconstrictor activity and pain and hyperalgesia in complex regional pain syndromes: a case-control study. Lancet 2002, 359:1655-1660.
29. Luo ZD, Chaplan SR, Higuera ES, et al.: Upregulation of dorsal root ganglion (alpha)2(delta) calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats. J Neurosci 2001, 21:1868-1875.
30. Hains BC, Saab CY, Klein JP, et al.: Altered sodium channel expression in second-order spinal sensory neurons contributes to pain after peripheral nerve injury. J Neurosci 2004, 24:4832-4839.
31. Ji RR, Woolf CJ: Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain. Neurobiol Dis 2001, 8:1-10.
32. Wieseler-Frank J, Maier SF, Watkins LR: Immune-to-brain communication dynamically modulates pain: physiological and pathological consequences. Brain Behav Immun 2005, 19:104-111.
33. Tal M, Bennett GJ: Extra-territorial pain in rats with a peripheral mononeuropathy: mechano-hyperalgesia and mechano-allodynia in the territory of an uninjured nerve. Pain 1994, 57:375-382.
34. Lindblom U, Verrillo RT. Sensory functions in chronic neuralgia. J Neurol Neurosurg Psychiatry 1979, 42:422-435.
35. Campbell JN, Raja SN, Meyer RA, Mackinnon SE: Myelinated afferents signal the hyperalgesia associated with nerve injury. Pain 1988, 32:89-94.
36. Price DD, Long S, Huitt C: Sensory testing of pathophysiological mechanisms of pain in patients with reflex sympathetic dystrophy. Pain 1992, 49:163-173.
37. Gracely RH, Lynch SA, Bennett GJ: Painful neuropathy: altered central processing maintained dynamically by peripheral input. Pain 1992, 51:175-194.
38. Ochoa JL, Yarnitsky D: Mechanical hyperalgesias in neuropathic pain patients: dynamic and static subtypes. Ann Neurol 1993, 33:465-472.
39. Fields HL, Rowbotham M, Baron R: Postherpetic neuralgia: irritable nociceptors and deafferentation. Neurobiol Dis 1998, 5:209-227.
40. Vanegas H, Schaible HG: Descending control of persistent pain: inhibitory or facilitatory? Brain Res Brain Res Rev 2004, 46:295-309.
41. Ossipov MH, Lai J, Malan TP Jr, Porreca F: Spinal and supraspinal mechanisms of neuropathic pain. Ann N Y Acad Sci 2000, 909:12-24.
42. Zambreanu L, Wise RG, Brooks JC, et al.: A role for the brainstem in central sensitisation in humans: evidence from functional magnetic resonance imaging. Pain 2005, 114:397-407.
43. Ochoa JL, Yarnitsky D: The triple cold syndrome: cold hyperalgesia, cold hypoaesthesia and cold skin in peripheral nerve disease. Brain 1994, 117:185-197.
44. Zochodne DW. Epineurial peptides: a role in neuropathic pain? Can J Neurol Sci 1993, 20:69-72.
45. Sommer C, Myers RR: Vascular pathology in CCI neuropathy: a quantitative temporal study. Exp Neurol 1996, 141:113-119.
46. Lu X, Richardson PM: Responses of macrophages in rat dorsal root ganglia following peripheral nerve injury. J Neurocytol 1993, 22:334-341.
47. Sorkin LS, Xiao WH, Wagner R, Myers RR: Tumor necrosis factor-alpha induces ectopic activity in nociceptive primary afferent fibres. Neurosci 1997, 81:255-262.
48. Sommer C: Painful neuropathies. Curr Opin Neurol 2003, 16:623-628.
49. Lindenlaub T, Sommer C: Cytokines in sural nerve biopsies from inflammatory and non-inflammatory neuropathies. Acta Neuropathol (Berl) 2003, 105:593-602.
50. Maihofner C, Handwerker HO, Neundorfer B, Birklein F: Mechanical hyperalgesia in complex regional pain syndrome: a role for TNF-alpha? Neurology 2005, 65:311-313.
51. Alexander GM, van Rijn MA, van Hilten JJ, et al.: Changes in cerebrospinal fluid levels of pro-inflammatory cytokines in CRPS. Pain 2005, 116:213-219.
52. Lombard MC, Larabi Y: Electrophysiological study of cervical dorsal horn cells in partially deafferented rats. In Advances in Pain Research and Therapy. Edited by Bonica JJ. New York: Raven Press; 1983:147-154.
53. Loeser JD, Ward AA, White LE: Chronic deafferentation of human spinal cord neurons. J Neurosurg 1967, 29:48-50.
54. Wasner G, Kleinert A, Binder A, et al.: Postherpetic neuralgia: topical lidocaine is effective in nociceptor-deprived skin. J Neurol 2005, 252:677-686.
55. Oaklander AL: The density of remaining nerve endings in human skin with and without postherpetic neuralgia after shingles. Pain 2001, 92:139-145.
56. Oaklander AL: Unilateral postherpetic neuralgia is associated with bilateral sensory neuron damage. Neurology 1998, 44:789-795.
57. Rowbotham MC, Yosipovitch G, Connolly MK, et al.: Cutaneous innervation density in the allodynic form of postherpetic neuralgia. Neurobiol Dis 1996, 3:205-214.
58. Baron R, Saguer M: Axon-reflex reactions in affected and homologous contralateral skin after unilateral peripheral injury of thoracic segmental nerves in humans. Neurosci Lett 1994, 165:97-100.
59. Baron R, Saguer M: Postherpetic neuralgia: Are C-nociceptors involved in signaling and maintenance of tactile allodynia? Brain 1993, 116:1477-1496.
60. Nurmikko T, Wells C, Bowsher D: Sensory dysfunction in postherpetic neuralgia. In Touch, Temperature, and Pain in Health and Disease: Mechanisms and Assessments, vol 3. Edited by Boivie J, Hansson P, Lindblom U. Seattle: IASP Press; 1994:133-141.
61. Rolke R, Baron R: Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values. Pain 2006, in press.
62. Pappagallo M, Oaklander AL, Quatrano-Piacentini AL, et al.: Heterogenous patterns of sensory dysfunction in postherpetic neuralgia suggest multiple pathophysiologic mechanisms. Anesthesiology 2000, 92:691-698.
63. Herrmann DN, Pannoni V, Barbano RL, et al.: Skin biopsy and quantitative sensory testing do not predict response to lidocaine patch in painful neuropathies. Muscle Nerve 2006, 33:42-48.