Mechanical hyperalgesia in complex regional pain syndrome: A role for TNF-α?

Neurology

Volumn 65, Issue 2, 2005, Pages 311-313

  Maihöfner, Christian ^a   Handwerker, Hermann O ^a   Neundörfer, Bernhard ^a   Birklein, Frank ^b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 1;

ADULT; ARTICLE; CLINICAL FEATURE; COMPLEX REGIONAL PAIN SYNDROME; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; HUMAN; HYPERALGESIA; MAJOR CLINICAL STUDY; MALE; MECHANICAL HYPERALGESIA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

EID: 85026138179     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.wnl.0000168866.62086.8f     Document Type: Article

References (10)

1. Stanton-Hicks M, Janig W, Hassenbusch S, Haddox JD, Boas R, Wilson P. Reflex sympathetic dystrophy: changing concepts and taxonomy. Pain 1995;63:127-133.
2. Maihofner C, Handwerker HO, Neundorfer B, Birklein F. Patterns of cortical reorganization in complex regional pain syndrome. Neurology 2003;61:1707-1715.
3. Klede M, Handwerker HO, Schmelz M. Central origin of secondary mechanical hyperalgesia. J Neurophysiol 2003;90:353-359.
4. Sorkin LS, Xiao WH, Wagner R, Myers RR. Tumour necrosis factor-alpha induces ectopic activity in nociceptive primary afferent fibres. Neuroscience 1997;81:255-262.
5. Sommer C, Schmidt C, George A. Hyperalgesia in experimental neuropathy is dependent on the TNF receptor 1. Exp Neurol 1998;151:138-142.
6. Empl M, Renaud S, Erne B, et al. TNF-alpha expression in painful and nonpainful neuropathies. Neurology 2001;56:1371-1377.
7. Aderka D. The potential biological and clinical significance of the soluble tumor necrosis factor receptors. Cytokine Growth Factor Rev 1996; 7(3):231-240.
8. Birklein F, Schmelz M, Schifter S, Weber M. The important role of neuropeptides in complex regional pain syndrome. Neurology 2001;57: 2179-2184.
9. Huygen FJ, De Bruijn AG, De Bruin MT, Groeneweg JG, Klein J, Zijistra FJ. Evidence for local inflammation in complex regional pain syndrome type 1. Mediators Inflamm 2002;11:47-51.
10. Schafers M, Geis C, Brors D, Yaksh TL, Sommer C. Anterograde transport of tumor necrosis factor-alpha in the intact and injured rat sciatic nerve. J Neurosci 2002;22:536-545.