Tissue engineering strategies for the future generation of dental implants

Periodontology 2000

Volumn 41, Issue 1, 2006, Pages 157-176

  Moradian Oldak, Janet ^a   Wen, Hai Bo ^a   Schneider, Galen B ^a   Stanford, Clark M ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMELOGENIN; BIOMATERIAL; BIOMIMETIC MATERIAL; CALCIUM PHOSPHATE; ENAMEL PROTEIN; SCLEROPROTEIN;

ANIMAL; BONE REGENERATION; CYTOLOGY; DRUG EFFECT; HUMAN; OSTEOBLAST; PHYSIOLOGY; REVIEW; SURFACE PROPERTY; TISSUE ENGINEERING; TOOTH IMPLANTATION; TOOTH PROSTHESIS;

AMELOGENIN; ANIMALS; BIOMIMETIC MATERIALS; CALCIUM PHOSPHATES; COATED MATERIALS, BIOCOMPATIBLE; DENTAL ENAMEL PROTEINS; DENTAL IMPLANTS; DENTAL PROSTHESIS DESIGN; EXTRACELLULAR MATRIX PROTEINS; HUMANS; OSSEOINTEGRATION; OSTEOBLASTS; SURFACE PROPERTIES; TISSUE ENGINEERING;

EID: 33745297625     PISSN: 09066713     EISSN: 16000757     Source Type: Journal    
DOI: 10.1111/j.1600-0757.2006.00153.x     Document Type: Review

References (157)

1. Abron A, Hopfensperger M, Thompson J, Cooper LF. Evaluation of a predictive model for implant surface topography effects on early osseointegration in the rat tibia model. J Prosthet Dent 2001: 85: 40 46.
2. Albrektsson T. Direct bone anchorage of dental implants. J Prosthet Dent 1983: 50: 255 261.
3. Boden SD. Clinical application of the BMPs. J Bone Joint Surg Am 2001: 83-A ( Suppl. 1 S161.
4. Bostrom MP, Camacho NP. Potential role of bone morphogenetic proteins in fracture healing. Clin Orthop Relat Res 1998: 355 ( Suppl. 1 S274 S282.
5. Bowers KT, Keller JC, Randolph BA, Wick DG, Michaels CM. Optimization of surface micromorphology for enhanced osteoblast responses in vitro. Int J Oral Maxillofac Implants 1992: 7: 302 310.
6. Boyan BD, Batzer R, Kieswetter K, Liu Y, Cochran DL, Szmuckler-Moncler S, Dean DD, Schwartz Z. Titanium surface roughness alters responsiveness of MG63 osteoblast-like cells to 1 alpha,25-(OH)2D3. J Biomed Mater Res 1998: 39: 77 85.
7. Boyan BD, Weesner TC, Lohmann CH, Andreacchio D, Carnes DL, Dean DD, Cochran DL, Schwartz Z. Porcine fetal enamel matrix derivative enhances bone formation induced by demineralized freeze dried bone allograft in vivo. J Periodontol 2000: 71: 1278 1286.
8. Boyde A. A 3-D model of enamel development at the scale of one inch to the micron. Adv Dent Res 1987: 1: 135 140.
9. Branemark PI. Osseointegration and its experimental background. J Prosthet Dent 1983: 50: 399 410.
10. Branemark PI, Adell R, Breier U, Hansson BO, Lindstrom J, Ohlsson A. Intra-osseous anchorage of dental prostheses. I. Experimental studies. Scand J Plast Reconstr Surg 1969: 3: 81 100.
11. Branemark PI, Hansson BO, Adell R, Breine U, Lindstrom J, Hallen O, Ohman A. Osseointegrated implants in the treatment of the edentulous jaw. Experience from a 10-year period. Scand J Plast Reconstr Surg Suppl 1977: 16: 1 132.
12. Buser D, Schenk RK, Steinemann S, Fiorellini JP, Fox CH, Stich H. Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs. J Biomed Mater Res 1991: 25: 889 902.
13. Campbell PA, Gledhill HC, Brown SR, Turner IG. Vacuum plasma sprayed hydroxyapatite coating on titanium alloy substrates: surface characterization and observation of dissolution processes using atomic force microscopy. J Vac Sci Technol B 1996: 14: 1167 1172.
14. Campbell AA, Deatherage BL, Li BL, Nelson XS, Bottoni C, DeJong ES. Hydroxyapatite coatings produced by surface-induced mineralization. Trivandrum, India: Research Singpost, 2002.
15. Casati MZ, Sallum EA, Nociti FH Jr., Caffesse RG, Sallum AW. Enamel matrix derivative and bone healing after guided bone regeneration in dehiscence-type defects around implants. A histomorphometric study in dogs. J Periodontol 2002: 73: 789 796.
16. Choi SH, Kim CK, Cho KS, Huh JS, Sorensen RG, Wozney JM, Wikesjo UM. Effect of recombinant human bone morphogenetic protein-2/absorbable collagen sponge (rhBMP-2/ACS) on healing in 3-wall intrabony defects in dogs. J Periodontol 2002: 73: 63 72.
17. Cochran DL, Wozney JM. Biological mediators for periodontal regeneration. Periodontol 2000 2000: 19: 40 58.
18. Cochran DL, Nummikoski PV, Jones AA, Makins SR, Turek TJ, Buser D. Radiographic analysis of regenerated bone around endosseous implants in the canine using recombinant human bone morphogenetic protein-2. Int J Oral Maxillofac Implants 1997: 12: 739 748.
19. Cook SD, Barrack RL. The use of the OP-1 implant in reconstructive surgery of the hip and knee. Paris, France: Springer, 2004.
20. Cooper LF. Cellular interactions at commercially pure titanium implants. In: Ellingsen JE, Lyngstadaas SP, editors. Bio-implant interface: improving biomaterials and tissue reactions. Boca Raton, FL: CRC Press, 2003: 165 179.
21. Cooper LF, Yliheikkila PK, Felton DA, Whitson SW. Spatiotemporal assessment of fetal bovine osteoblast culture differentiation indicates a role for BSP in promoting differentiation. J Bone Miner Res 1998: 13: 620 632.
22. Cooper LF, Masuda T, Whitson SW, Yliheikkila P, Felton DA. Formation of mineralizing osteoblast cultures on machined, titanium oxide grit-blasted, and plasma-sprayed titanium surfaces. Int J Oral Maxillofac Implants 1999: 14: 37 47.
23. Dalby MJ, Riehle MO, Yarwood SJ, Wilkinson CD, Curtis AS. Nucleus alignment and cell signaling in fibroblasts: response to a micro-grooved topography. Exp Cell Res 2003: 284: 274 282.
24. Daniels K, Solursh M. Modulation of chondrogenesis by the cytoskeleton and extracellular matrix. J Cell Sci 1991: 100: 249 254.
25. Daniels K, Reiter R, Solursh M. Micromass cultures of limb and other mesenchyme. Methods Cell Biol 1996: 51: 237 247.
26. Davies JE. Mechanisms of endosseous integration. Int J Prosthodont 1998: 11: 391 401.
27. Diekwisch TGH, David S, Bringas P, Santos V, Slavkin HC. Antisense inhibition of amelogenin translation demonstrates supramolecular controls for enamel OHAPP crystal-growth during embryonic mouse molar development. Development 1993: 117: 471 482.
28. Douglass CW, Watson AJ. Future needs for fixed and removable partial dentures in the United States. J Prosthet Dent 2002: 87: 9 14.
29. Douglass CW, Shih A, Ostry L. Will there be a need for complete dentures in the United States in 2020 J Prosthet Dent 2002: 87: 5 8.
30. Du C, Falini G, Fermani S, Abbott C, Moradian-Oldak J. Supramolecular assembly of amelogenin nanospheres into birefringent microribbons. Science 2005: 307: 1450 1454.
31. Du C, Schneider GB, Zaharias R, Abbott C, Seabold D, Stanford C, Moradian-Oldak J. Apatite/amelogenin coating on titanium promotes osteogenic gene expression. J Dent Res 2005: 84: 1070 1074.
32. Ducheyne P, Bianco PD, Kim C. Bone tissue growth enhancement by calcium phosphate coatings on porous titanium alloys: the effect of shielding metal dissolution product [published erratum appears in Biomaterials 1992; 13(11): 800]. Biomaterials 1992: 13: 617 624.
33. Ducy P, Karsenty G. Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene. Mol Cell Biol 1995: 15: 1858 1869.
34. Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 1997: 89: 747 754.
35. Ducy P, Starbuck M, Priemel M, Shen J, Pinero G, Geoffroy V, Amling M, Karsenty G. A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development. Genes Dev 1999: 13: 1025 1036.
36. Eisenbarth E, Linez P, Biehl V, Velten D, Breme J, Hildebrand HF. Cell orientation and cytoskeleton organisation on ground titanium surfaces. Biomol Eng 2002: 19: 233 237.
37. 2. Biomaterials 1991: 12: 593 596.
38. Ellingsen JEL. Increasing biocompatibility by chemical modification of titanium surfaces. In: Ellingsen JEL, editor. Bio-implant interface: improving biomaterials and tissue reactions. Boca Raton, FL: CRC Press, 2003: 323 335.
39. Epinette JA, Manley MT, D'Antonio JA, Edidin AA, Capello WN. A 10-year minimum follow-up of hydroxyapatite-coated threaded cups: clinical, radiographic and survivorship analyses with comparison to the literature. J Arthroplasty 2003: 18: 140 148.
40. Erratum. Corrections and clarifications. Science 2005: 309: 2166.
41. Fincham AG, Hu Y, Lau EC, Slavkin HC, Snead ML. Amelogenin post-secretory processing during biomineralization in the postnatal mouse molar tooth. Arch Oral Biol 1991: 36: 305 317.
42. Fincham AG, Moradian-Oldak J, Simmer JP, Sarte P, Lau EC, Diekwisch T, Slavkin HC. Self-assembly of a recombinant amelogenin protein generates supramolecular structures. J Struct Biol 1994: 112: 103 109.
43. Fincham AG, Moradian-Oldak J, Diekwisch TG, Lyaruu DM, Wright JT, Bringas P Jr., Slavkin HC. Evidence for amelogenin ''nanospheres'' as functional components of secretory-stage enamel matrix. J Struct Biol 1995: 115: 50 59.
44. Fincham AG, Moradian-Oldak J, Simmer JP. The structural biology of the developing dental enamel matrix. J Struct Biol 1999: 126: 270 299.
45. Franceschi RT, Iyer BS. Relationship between collagen synthesis and expression of the osteoblast phenotype in MC3T3-E1 cells. J Bone Miner Res 1992: 7: 235 246.
46. Franke Stenport V, Johansson CB. Enamel matrix derivative and titanium implants. J Clin Periodontol 2003: 30: 359 363.
47. Gallucci GO, Belser UC, Bernard JP, Magne P. Modeling and characterization of the CEJ for optimization of esthetic implant design. Int J Periodontics Restorative Dent 2004: 24: 19 29.
48. Gibson CW, Yuan ZA, Hall B, Longenecker G, Chen E, Thyagarajan T, Sreenath T, Wright JT, Decker S, Piddington R, Harrison G, Kulkarni AB. Amelogenin-deficient mice display an amelogenesis imperfecta phenotype. J Biol Chem 2001: 276: 31871 31875.
49. de Groot K, Wolke JG, Jansen JA. Calcium phosphate coatings for medical implants. Proc Inst Mech Eng [H] 1998: 212: 137 147.
50. Haddow DB, Kothari S, James PF, Short RD, Hatton PV, van Noort R. Synthetic implant surfaces. 1. The formation and characterization of sol-gel titania films. Biomaterials 1996: 17: 501 507.
51. Hammarstrom L. Enamel matrix, cementum development and regeneration. J Clin Periodontol 1997: 24: 658 668.
52. Hammarstrom L. The role of enamel matrix proteins in the development of cementum and periodontal tissues. Ciba Found Symp 1997: 205: 246 255 discussion 255 260.
53. He J, Jiang J, Safavi KE, Spangberg LS, Zhu Q. Emdogain promotes osteoblast proliferation and differentiation and stimulates osteoprotegerin expression. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004: 97: 239 245.
54. Henry SL, Galloway KP. Local antibacterial therapy for the management of orthopaedic infections. Pharmacokinetic considerations. Clin Pharmacokinet 1995: 29: 36 45.
55. Heuer AH, Fink DJ, Laraia VJ, Arias JL, Calvert PD, Kendall K, Messing GL, Blackwell J, Rieke PC, Thompson DH, Wheeler AP, Veis A, Caplan AI. Innovative materials processing strategies: a biomimetic approach. Science 1992: 255: 1098 1105.
56. Hughes DE, Salter DM, Dedhar S, Simpson R. Integrin expression in human bone. J Bone Miner Res 1993: 8: 527 533.
57. Hultenby K, Reinholt FP, Heinegard D. Distribution of integrin subunits on rat metaphyseal osteoclasts and osteoblasts. Eur J Cell Biol 1993: 62: 86 93.
58. Iijima M, Moradian-Oldak J. Interactions of amelogenins with octacalcium phosphate crystal faces are dose dependent. Calcif Tissue Int 2004: 74: 522 531.
59. Iijima M, Moriwaki Y, Wen HB, Fincham AG, Moradian-Oldak J. Elongated growth of octacalcium phosphate crystals in recombinant amelogenin gels under controlled ionic flow. J Dent Res 2002: 81: 69 73.
60. Ilic D, Almeida EA, Schlaepfer DD, Dazin P, Aizawa S, Damsky CH. Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis. J Cell Biol 1998: 143: 547 560.
61. 2 blasted and turned titanium microimplants in humans. Clin Oral Implants Res 2001: 12: 128 134.
62. Juliano RL, Haskill S. Signal transduction from the extracellular matrix. J Cell Biol 1993: 120: 577 585.
63. Kawana F, Sawae Y, Sahara T, Tanaka S, Debari K, Shimizu M, Sasaki T. Porcine enamel matrix derivative enhances trabecular bone regeneration during wound healing of injured rat femur. Anat Rec 2001: 264: 438 446.
64. King GN, Hughes FJ. Bone morphogenetic protein-2 stimulates cell recruitment and cementogenesis during early wound healing. J Clin Periodontol 2001: 28: 465 475.
65. Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y, Bronson RT, Gao YH, Inada M, Sato M, Okamoto R, Kitamura Y, Yoshiki S, Kishimoto T. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 1997: 89: 755 764.
66. Kragh-Hansen U. Structure and ligand binding properties of human serum albumin. Dan Med Bull 1990: 37: 57 84.
67. Ku CH, Browne M, Gregson PJ, Corbeil J, Pioletti DP. Large-scale gene expression analysis of osteoblasts cultured on three different Ti-6Al-4V surface treatments. Biomaterials 2002: 23: 4193 4202.
68. Lacefield WR. Current status of ceramic coatings for dental implants. Implant Dent 1998: 7: 315 322.
69. Lau EC, Mohandas T, Shapiro LJ, Slavkin HC, Snead ML. Human and mouse amelogenin gene loci are on the sex chromosome. Genomics 1989: 4: 162 168.
70. Lee KS, Hong SH, Bae SC. Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-beta and bone morphogenetic protein. Oncogene 2002: 21: 7156 7163.
71. Li P. Biomimetic nano-apatite coating capable of promoting bone in-growth. J Biomed Mater Res A 2003: 66: 79 85.
72. Li RH, Wozney JM. Delivering on the promise of bone morphogenetic proteins. Ophthalmic Genet 2001: 19: 255 265.
73. Li P, Wakeland K, Zou L. Biomimetic apatite coating as an alternative to plasma sprayed hydroxyapatite coating for promotion of bone apposition - the coating formation and in vitro study. 49th Annual Meeting of the Orthopaedic Research Society, Dallas, TX, 2002.
74. Licata AA. Bisphosphonate therapy. Am J Med Sci 1997: 313: 17 22.
75. Lin S, Shi S, LeGeros RZ, LeGeros JP. Three-dimensional finite element analyses of four designs of a high-strength silicon nitride implant. Implant Dent 2000: 9: 53 60.
76. Lincks J, Boyan BD, Blanchard CR, Lohmann CH, Liu Y, Cochran DL, Dean DD, Schwartz Z. Response of MG63 osteoblast-like cells to titanium and titanium alloy is dependent on surface roughness and composition. Biomaterials 1998: 19: 2219 2232.
77. Liu F, Malaval L, Aubin JE. The mature osteoblast phenotype is characterized by extensive plasticity. Exp Cell Res 1997: 232: 97 105.
78. Liu Y, Layrolle P, de Bruijn J, van Blitterswijk C, de Groot K. Biomimetic coprecipitation of calcium phosphate and bovine serum albumin on titanium alloy. J Biomed Mater Res 2001: 57: 327 335.
79. Liu Y, Hunziker EB, Layrolle P, De Bruijn JD, De Groot K. Bone morphogenetic protein 2 incorporated into biomimetic coatings retains its biological activity. Tissue Eng 2004: 10: 101 108.
80. Lohmann CH, Sagun R Jr., Sylvia VL, Cochran DL, Dean DD, Boyan BD, Schwartz Z. Surface roughness modulates the response of MG63 osteoblast-like cells to 1,25-(OH)(2)D(3) through regulation of phospholipase A(2) activity and activation of protein kinase A. J Biomed Mater Res 1999: 47: 139 151.
81. Lohmann CH, Bonewald LF, Sisk MA, Sylvia VL, Cochran DL, Dean DD, Boyan BD, Schwartz Z. Maturation state determines the response of osteogenic cells to surface roughness and 1,25-dihydroxyvitamin D3. J Bone Miner Res 2000: 15: 1169 1180.
82. Ludwig SC, Kowalski JM, Boden SD. Osteoinductive bone graft substitutes. Eur Spine J 2000: 9: S119 S125.
83. Lyngstadaas SP, Risnes S, Sproat BS, Thrane PS, Prydz HP. A synthetic, chemically modified ribozyme eliminates amelogenin, the major translation product in developing mouse enamel in vivo. EMBO J 1995: 14: 5224 5229.
84. Marshall GW Jr., Balooch M, Gallagher RR, Gansky SA, Marshall SJ. Mechanical properties of the dentinoenamel junction: AFM studies of nanohardness, elastic modulus, and fracture. J Biomed Mater Res 2001: 54: 87 95.
85. Matsuzaka K, Walboomers F, de Ruijter A, Jansen JA. Effect of microgrooved poly-l-lactic (PLA) surfaces on proliferation, cytoskeletal organization, and mineralized matrix formation of rat bone marrow cells. Clin Oral Implants Res 2000: 11: 325 333.
86. Meraw SJ, Reeve CM, Wollan PC. Use of alendronate in peri-implant defect regeneration. J Periodontol 1999: 70: 151 158.
87. Midura RJ, McQuillan DJ, Benham KJ, Fisher LW, Hascall VC. A rat osteogenic cell line (UMR 106-01) synthesizes a highly sulfated form of bone sialoprotein. J Biol Chem 1990: 265: 5285 5291.
88. Moradian-Oldak J, Du C, Falini G. On the formation of amelogenin micro-ribbons. Eur J Oral Sci 2006, 114 ( Suppl. 1 in press.
89. Moradian-Oldak J, Simmer JP, Lau EC, Sarte PE, Slavkin HC, Fincham AG. Detection of monodisperse aggregates of a recombinant amelogenin by dynamic light scattering. Biopolymers 1994: 34: 1339 1347.
90. Moradian-Oldak J, Tan J, Fincham AG. Interaction of amelogenin with hydroxyapatite crystals: an adherence effect through amelogenin molecular self-association. Biopolymers 1998: 46: 225 238.
91. Morimoto Y, Fujimoto S. Albumin microspheres as drug carriers. Crit Rev Ther Drug Carrier Syst 1985: 2: 19 63.
92. Moursi AM, Globus RK, Damsky CH. Interactions between integrin receptors and fibronectin are required for calvarial osteoblast differentiation in vitro. J Cell Sci 1997: 110: 2187 2196.
93. Murphy WL, Kohn DH, Mooney DJ. Growth of continuous bonelike mineral within porous poly(lactide-co-glycolide) scaffolds in vitro. J Biomed Mater Res 2000: 50: 50 58.
94. Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng JM, Behringer RR, de Crombrugghe B. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 2002: 108: 17 29.
95. Ogawa T, Nishimura I. Different bone integration profiles of turned and acid-etched implants associated with modulated expression of extracellular matrix genes. Int J Oral Maxillofac Implants 2003: 18: 200 210.
96. Okamoto K, Matsuura T, Hosokawa R, Akagawa Y. RGD peptides regulate the specific adhesion scheme of osteoblasts to hydroxyapatite but not to titanium. J Dent Res 1998: 77: 481 487.
97. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR. Multilineage potential of adult human mesenchymal stem cells. Science 1999: 284: 143 147.
98. Puleo DA, Holleran LA, Doremus RH, Bizios R. Osteoblast responses to orthopedic implant materials in vitro. J Biomed Mater Res 1991: 25: 711 723.
99. Radin S, Campbell JT, Ducheyne P, Cuckler JM. Calcium phosphate ceramic coatings as carriers of vancomycin. Biomaterials 1997: 18: 777 782.
100. Reszka AA, Rodan GA. Bisphosphonate mechanism of action. Curr Rheumatol Rep 2003: 5: 65 74.
101. Robinson C, Brookes SJ, Shore RC, Kirkham J. The developing enamel matrix: nature and function. Eur J Oral Sci 1998: 106 ( Suppl. 1 282 291.
102. Schlaepfer DD, Hunter T. Integrin signalling and tyrosine phosphorylation: just the FAKs Trends Cell Biol 1998: 8: 151 157.
103. Schlaepfer DD, Hauck CR, Sieg DJ. Signaling through focal adhesion kinase. Prog Biophys Mol Biol 1999: 71: 435 478.
104. Schneider G, Burridge K. Formation of focal adhesions by osteoblasts adhering to different substrata. Exp Cell Res 1994: 214: 264 269.
105. Schneider GB, Whitson SW, Cooper LF. Restricted and coordinated expression of beta3-integrin and bone sialoprotein during cultured osteoblast differentiation. Bone 1999: 24: 321 327.
106. Schneider GB, Zaharias R, Stanford C. Osteoblast integrin adhesion and signaling regulate mineralization. J Dent Res 2001: 80: 1540 1544.
107. Schneider GB, Perinpanayagam H, Clegg M, Zaharias R, Seabold D, Keller J, Stanford C. Implant surface roughness affects osteoblast gene expression. J Dent Res 2003: 82: 372 376.
108. Schneider GB, Zaharias R, Seabold D, Keller J, Stanford C. Differentiation of preosteoblasts is affected by implant surface microtopographies. J Biomed Mater Res A 2004: 69: 462 468.
109. Schramm CA, Reiter RS, Solursh M. Role for short-range interactions in the formation of cartilage and muscle masses in transfilter micromass cultures. Dev Biol 1994: 163: 467 479.
110. Schroeder A, Pohler O, Sutter F. Tissue reaction to an implant of a titanium hollow cylinder with a titanium surface spray layer. SSO Schweiz Monatsschr Zahnheilkd 1976: 86: 713 727.
111. Schroeder A, van der Zypen E, Stich H, Sutter F. The reactions of bone, connective tissue, and epithelium to endosteal implants with titanium-sprayed surfaces. J Maxillofac Surg 1981: 9: 15 25.
112. Schwartz MA, Schaller MD, Ginsberg MH. Integrins: emerging paradigms of signal transduction. Ann Rev Cell Dev Biol 1995: 11: 549 599.
113. Schwartz Z, Carnes DL Jr., Pulliam R, Lohmann CH, Sylvia VL, Liu Y, Dean DD, Cochran DL, Boyan BD. Porcine fetal enamel matrix derivative stimulates proliferation but not differentiation of pre-osteoblastic 2T9 cells, inhibits proliferation and stimulates differentiation of osteoblast-like MG63 cells, and increases proliferation and differentiation of normal human osteoblast NHOst cells. J Periodontol 2000: 71: 1287 1296.
114. Shinto Y, Uchida A, Korkusuz F, Araki N, Ono K. Calcium hydroxyapatite ceramic used as a delivery system for antibiotics. J Bone Joint Surg Br 1992: 74: 600 604.
115. Simon Z, Watson PA. Biomimetic dental implants - new ways to enhance osseointegration. J Can Dent Assoc 2002: 68: 286 288.
116. Sinha RK, Tuan RS. Regulation of human osteoblast integrin expression by orthopedic implant materials. Bone 1996: 18: 451 457.
117. Solursh M. Formation of cartilage tissue in vitro. J Cell Biochem 1991: 45: 258 260.
118. Stanford CM. Surface modification of implants. In: Buckley M, Keller J, editors. Oral Maxillofacial Surgery Clinic N. America. Philadelphia, Saunders (Elsevier), 14 ( 2002 39 51.
119. Stanford CM, Brand RA. Toward an understanding of implant occlusion and strain adaptive bone modeling and remodeling. J Prosthet Dent 1999: 81: 553 561.
120. Stanford CM, Keller JC, Solursh M. Bone cell expression on titanium surfaces is altered by sterilization treatments. J Dent Res 1994: 73: 1061 1071.
121. Stanford CM, Jacobson PA, Eanes ED, Lembke LA, Midura RJ. Rapidly forming apatitic mineral in an osteoblastic cell line (UMR 106-01 BSP). J Biol Chem 1995: 270: 9420 9428.
122. Stanford CM, Stevens JW, Brand RA. Cellular deformation reversibly depresses RT-PCR detectable levels of bone-related mRNA. J Biomech 1995: 28: 1419 1427.
123. Stanford CM, Solursh M, Keller JC. Significant role of adhesion properties of primary osteoblast-like cells in early adhesion events for chondroitin sulfate and dermatan sulfate surface molecules. J Biomed Mater Res 1999: 47: 345 352.
124. Stanford CM, Schneider G, Perinpanayagam H, Keller JC, Midura R. Biomedical implant surface topography and its effects on osteoblast differentiation in vitro. In: Bio-implant interface: improving biomaterials and tissue reactions 2003: 141 164.
125. Stigter M, de Groot K, Layrolle P. Incorporation of tobramycin into biomimetic hydroxyapatite coating on titanium. Biomaterials 2002: 23: 4143 4153.
126. Sukotjo C, Abanmy AA, Ogawa T, Nishimura I. Molecular cloning of Wound Inducible Transcript (wit 3.0) differentially expressed in edentulous oral mucosa undergoing tooth extraction wound-healing. J Dent Res 2002: 81: 229 235.
127. Sul YT, Johansson C, Wennerberg A, Cho LR, Chang BS, Albrektsson T. Optimum surface properties of oxidized implants for reinforcement of osseointegration: surface chemistry, oxide thickness, porosity, roughness, and crystal structure. Int J Oral Maxillofac Implants 2005: 20: 349 359.
128. Suzawa M, Tamura Y, Fukumoto S, Miyazono K, Fujita T, Kato S, Takeuchi Y. Stimulation of Smad1 transcriptional activity by Ras-extracellular signal-regulated kinase pathway: a possible mechanism for collagen-dependent osteoblastic differentiation. J Bone Miner Res 2002: 17: 240 248.
129. Sykaras N, Iacopino AM, Marker VA, Triplett RG, Woody RD. Implant materials, designs, and surface topographies: their effect on osseointegration. A literature review. Int J Oral Maxillofac Implants 2000: 15: 675 690.
130. Takeuchi Y, Nakayama K, Matsumoto T. Differentiation and cell surface expression of transforming growth factor-beta receptors are regulated by interaction with matrix collagen in murine osteoblastic cells. J Biol Chem 1996: 271: 3938 3944.
131. Takeuchi Y, Suzawa M, Kikuchi T, Nishida E, Fujita T, Matsumoto T. Differentiation and transforming growth factor-beta receptor down-regulation by collagen-alpha2beta1 integrin interaction is mediated by focal adhesion kinase and its downstream signals in murine osteoblastic cells. J Biol Chem 1997: 272: 29309 29316.
132. Tompkins K, George A, Veis A. Characterization of a mouse amelogenin [A-4]/M59 cell surface receptor. Bone 2006: 38: 172 180.
133. Toyosawa S, O'HUigin C, Figueroa F, Tichy H, Klein J. Identification and characterization of amelogenin genes in monotremes, reptiles, and amphibians. Proc Natl Acad Sci U S A 1998: 95: 13056 13061.
134. Triplett RG, Frohberg U, Sykaras N, Woody RD. Implant materials, design, and surface topographies: their influence on osseointegration of dental implants. J Long Term Eff Med Implants 2003: 13: 485 501.
135. Uludag H, Gao T, Porter TJ, Friess W, Wozney JM. Delivery systems for BMPs: factors contributing to protein retention at an application site. J Bone Joint Surg Am 2001: 83-A ( Suppl. 1 S128 S135.
136. Valentin-Opran A, Wozney J, Csimma C, Lilly L, Riedel GE. Clinical evaluation of recombinant human bone morphogenetic protein-2. Clin Orthop Relat Res 2002: 395: 110 120.
137. Vehof JW, Mahmood J, Takita H, van't Hof MA, Kuboki Y, Spauwen PH, Jansen JA. Ectopic bone formation in titanium mesh loaded with bone morphogenetic protein and coated with calcium phosphate. Plast Reconstr Surg 2001: 108: 434 443.
138. Veis A. Amelogenin gene splice products: potential signaling molecules. Cell Mol Life Sci 2003: 60: 38 55.
139. Vrouwenvelder WC, Groot CG, de Groot K. Histological and biochemical evaluation of osteoblasts cultured on bioactive glass, hydroxylapatite, titanium alloy, and stainless steel. J Biomed Mater Res 1993: 27: 465 475.
140. Wagner HD, Weiner S. On the relationship between the microstructure of bone and its mechanical stiffness. J Biomech 1992: 25: 1311 1320.
141. Wen HB, Moradian-Oldak J. Modification of calcium-phosphate coatings on titanium by recombinant amelogenin. J Biomed Mater Res A 2003: 64: 483 490.
142. Wen HB, de Wijn JR, Cui FZ, de Groot K. Preparation of calcium phosphate coatings on titanium implant materials by simple chemistry. J Biomed Mater Res 1998: 41: 227 236.
143. Wen HB, Fincham AG, Moradian-Oldak J, de Groot K. Crystal growth of calcium phosphate on biomaterials. Rec Res Dev Crystal Growth Res 1999: 1: 51 65.
144. Wen HB, de Wijn JR, van Blitterswijk CA, de Groot K. Incorporation of bovine serum albumin in calcium phosphate coating on titanium. J Biomed Mater Res 1999: 46: 245 252.
145. Wen HB, Moradian-Oldak J, Fincham AG. Modulation of apatite crystal growth on Bioglass by recombinant amelogenin. Biomaterials 1999: 20: 1717 1725.
146. Wen HB, Moradian-Oldak J, Zhong JP, Greenspan DC, Fincham AG. Effects of amelogenin on the transforming surface microstructures of Bioglass in a calcifying solution. J Biomed Mater Res 2000: 52: 762 773.
147. Wen HB, Hippensteel E, Li P. Biomimetic nanocrystalline apatite coating absorbs much more bovine serum proteins than plasma-sprayed hydroxyapatite coating. 49th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, 2003.
148. Wennerberg A, Albrektsson T, Andersson B. Design and surface characteristics of 13 commercially available oral implant systems. Int J Oral Maxillofac Implants 1993: 8: 622 633.
149. Wikesjo UM, Sorensen RG, Wozney JM. Augmentation of alveolar bone and dental implant osseointegration: clinical implications of studies with rhBMP-2. J Bone Joint Surg Am 2001: 83-A ( Suppl. 1 S136 S145.
150. Wozney JM. The bone morphogenetic protein family and osteogenesis. Mol Reprod Dev 1992: 32: 160 167.
151. Xiao G, Wang D, Benson MD, Karsenty G, Franceschi RT. Role of the alpha2-integrin in osteoblast-specific gene expression and activation of the Osf2 transcription factor. J Biol Chem 1998: 273: 32988 32994.
152. Xiao ZS, Hinson TK, Quarles LD. Cbfa1 isoform overexpression upregulates osteocalcin gene expression in non-osteoblastic and pre-osteoblastic cells. J Cell Biochem 1999: 74: 596 605.
153. Xiao G, Jiang D, Thomas P, Benson MD, Guan K, Karsenty G, Franceschi RT. MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1. J Biol Chem 2000: 275: 4453 4459.
154. Xiao G, Gopalakrishnan R, Jiang D, Reith E, Benson MD, Franceschi RT. Bone morphogenetic proteins, extracellular matrix, and mitogen-activated protein kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells. J Bone Miner Res 2002: 17: 101 110.
155. Yamada KM. Integrin signaling. Matrix Biol 1997: 16: 137 141.
156. Yoshinari M, Oda Y, Inoue T, Matsuzaka K, Shimono M. Bone response to calcium phosphate-coated and bisphosphonate-immobilized titanium implants. Biomaterials 2002: 23: 2879 2885.
157. Young CS, Terada S, Vacanti JP, Honda M, Bartlett JD, Yelick PC. Tissue engineering of complex tooth structures on biodegradable polymer scaffolds. J Dent Res 2002: 81: 695 700.