Human UDP-glucuronosyltransferase, UGT1A8, glucuronidates dihydrotestosterone to a monoglucuronide and further to a structurally novel diglucuronide

Drug Metabolism and Disposition

Volumn 34, Issue 7, 2006, Pages 1102-1108

  Murai, Takahiro ^a   Samata, Naozumi ^a   Iwabuchi, Haruo ^a   Ikeda, Toshihiko ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANOLONE; COMPLEMENTARY DNA; DIGLUCURONIDE; GLUCURONIDE; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A8; GLUCURONOSYLTRANSFERASE 1A9; ISOENZYME; MONOGLUCURONIDE; RECOMBINANT ENZYME; RECOMBINANT GLUCURONOSYLTRANSFERASE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GLUCURONIC ACID;

ANIMAL CELL; ARTICLE; DOG; DRUG ACTIVITY; DRUG CONJUGATION; DRUG METABOLISM; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; GLUCURONIDATION; INTESTINE CELL; LIVER MICROSOME; MICHAELIS CONSTANT; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; DIHYDROTESTOSTERONE; DOGS; GLUCURONOSYLTRANSFERASE; HUMANS; INTESTINES; ISOENZYMES; KINETICS; MICROSOMES, LIVER; MOLECULAR STRUCTURE; RATS; RECOMBINANT PROTEINS;

EID: 33745241871     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.106.009621     Document Type: Article

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