Lycopene, an antioxidant carotenoid modulates glutathione-dependent hepatic biotransformation enzymes during experimental gastric carcinogenesis

Nutrition Research

Volumn 21, Issue 8, 2001, Pages 1117-1124

  Velmurugan, B ^a   Bhuvaneswari, V ^a   Balasenthil, S ^a   Nagini, S ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Antioxidants; Chemoprevention; Gastric cancer; Lipid peroxidation; Lycopene; MNNG

Indexed keywords

ANTIOXIDANT; CAROTENOID; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; LIPID PEROXIDE; LIVER ENZYME; LYCOPENE; METHYLNITRONITROSOGUANIDINE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BIOTRANSFORMATION; CARCINOGENESIS; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DETOXIFICATION; ENZYME ACTIVITY; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; STOMACH CANCER;

ANIMALIA;

EID: 0034813803     PISSN: 02715317     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0271-5317(01)00321-9     Document Type: Article

References (29)

1. Fruits and vegetables, and human cancer
2. Diverse carotenoids protect against chemically induced neoplastic transformation
3. Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemia cells
4. Chemoprevention by lycopene of mouse lung neoplasia after combined initiation treatment with DEN, MNU and DMH
5. N-methyl-N′-nitro-N-nitrosoguanidine induced carcinogenesis: Differential pattern of upper gastrointestinal tract tumours in Wistar rats after single or chronic oral doses
6. Chemopreventive potential of garlic and neem during gastric carcinogenesis induced by N-methyl-N′-nitro-N-nitrosoguanidine
7. Modulatory effects of garlic and neem leaf extracts on circulatory lipid peroxides and antioxidants during N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)-induced gastric carcinogenesis
8. Garlic and neem leaf extracts enhance hepatic glutathione and glutathione dependent enzymes during N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)-induced gastric carcinogenesis
9. Modulatory effects of garlic and neem leaf extracts on N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)-induced oxidative stress in Wistar rats
10. Hypolipidemic drug clofibrate induces hepatic dedifferentiation
11. Chemoprotective effects of neem leaf extract on 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis
12. Biomonitoring the chemopreventive potential of the plant products neem and turmeric in 4-nitroquinoline 1-oxide induced oral carcinogenesis
13. Hepatoprotective effects of garlic during hamster buccal pouch carcinogenesis induced by 7,12-dimethylbenz[a]anthracene
14. Garlic exerts hepatoprotective effects during 4-nitroquinoline 1-oxide-induced oral carcinogenesis in rats
15. Potential preventive effects of Chelidonium majis L. (Papaveraceae) Herb extract on glandular stomach tumour development in rats treated with N-methyl-N′-nitro-N-nitrosoguanidine and hypertonic sodium chloride
16. Prevention of N-methylnitrosourea-induced colon carcinogenesis in F344 rats by lycopene and tomato juice rich in lycopene
17. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
18. Tissue sulfhydryl groups
19. Selenium: Biochemical roles as a component of glutathione peroxidase
20. Glutathione-S-transferases, the first enzymatic step in mercapturic acid formation
21. Glutathione reductase
22. Protein measurement with Folin phenol reagent
23. Production of the thiyl free radical by the reaction of N-methyl-N′-nitro-N-nitrosoguanidine with L-cysteine
24. Production of hydroxyl free radical by reaction of hydrogen peroxide with N-methyl-N′-nitro-N-nitrosoguanidine
25. Effect of oltipraz, α-tocopherol, β-carotene and phenylisothiocyanate on rat oesophageal, gastric colonic and hepatic glutathione, glutathione S-transferase and peroxidase
26. Is there an inter-organ glutathione redox cycle?
27. Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemia rats
28. Regulation of hepatic glutathione synthesis: Current concepts and controversies
29. Antioxidant activities of carotenes and xanthophylls