Antimutagenicity of Tochu tea (an aqueous extract of Eucommia ulmoides leaves) : 1. The clastogen-suppressing effects of Tochu tea in CHO cells and mice

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 388, Issue 1, 1997, Pages 7-20

  Nakamura, Takanori ^a   Nakazawa, Yoshihisa ^a   Onizuka, Shigenori ^a   Satoh, Saori ^b,c   Chiba, Aki ^b,d   Sekihashi, Kaoru ^b,e   Miura, Ayako ^b   Yasugahira, Noriko ^b   Sasaki, Yu F ^b  

^a HITACHI ZOSEN CORPORATION   (Japan)

^b HACHINOHE NATIONAL COLLEGE OF TECHNOLOGY   (Japan)

^c Shinto Paint Co   (Japan)

^d Shirakaba Farm Co Ltd   (Japan)

^e NAGAOKA UNIVERSITY OF TECHNOLOGY   (Japan)

Author keywords

Anticlastogenicity; Chromosome aberration; Eucommia ulmoides; Micronucleus; Tochu tea extract; Unsaturated carbonyl

Indexed keywords

ANTIMUTAGENIC AGENT; COUMARIC ACID; FLAVONOID; GENIPOSIDE; LIGNAN; MITOMYCIN C; PHENOL DERIVATIVE; PLANT EXTRACT; PROTOCATECHUIC ACID; PYROGALLOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHO CELL; CHROMOSOME ABERRATION; CONTROLLED STUDY; FEMALE; HERB; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MICRONUCLEUS; MICRONUCLEUS TEST; MOUSE; MUTAGENESIS; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; TEA;

ANIMALIA; EUCOMMIA ULMOIDES;

EID: 0031011446     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(96)00096-4     Document Type: Article

References (29)

1. Chien, T.H. (1957) Pharmacological action of Eucommia ulmoides Oliv., Jpn. J. Pharmacol., 6, 122-137.
2. Kin, K.C. and K.S. Ting (1956) Drugs for the treatment of hypertension. II Toxicity and experimental therapy of Eucommia ulmoides, Acta. Physiol. Sin., 20, 247-254.
3. Kada, T., K. Kaneko, S. Matsuzaki, T. Matsuzaki and Y. Hara (1985) Detection and chemical identification of natural bio-antimutagens. A case of green tea factor, Mutation Res., 150, 127-132.
4. Ito, Y., S. Ohnishi and K. Fujiie (1989) Chromosome aberrations II induced by aflatoxin B1 in rat bone marrow cells in vivo and their suppression by green tea, Mutation Res., 222, 253-261.
5. Shimoi, K., Y. Nakamura, I. Tomita, Y. Hara and T. Kada (1986) The pyrogallol related compounds reduced UV-induced mutations in Echerichia coli B/r WP2, Mutation Res., 173, 239-244.
6. Wang, Z.Y., S.J. Cheng, Z.C. Zhou, M. Athar, W.A. Khan, D.R. Bickers and H. Mukhtar (1989) Antimutagenic activity of green tea polyphenols, Mutation Res., 223, 273-285.
7. Imanishi, H., Y.F. Sasaki, T. Ohta, M. Watanabe, T. Kato and Y. Shirasu (1991) Tea tannin components modify the induction of sisterchromatid exchanges and chromosome aberrations in mutagen-treated cultured mammalian cells and mice, Mutation Res., 259, 79-87.
8. Sasaki, Y.F., H. Yamada, K. Shimoi, K. Kator and N. Kinae (1993) The clastogen-suppressing effects of green tea, Po-lei tea, and Rooibos tea in CHO in CHO cells and mice, Mutation Res., 286, 221-232.
9. Nakamura, T., H. Nakazawa, S. Onizuka, M. Ohta, C. Tanaka, S. Yahara and T. Nohara (1995) Identification of Tochu tea leaf components, Abstract papers of The 42nd Annual Meeting of Japanese Society of Phamacognosy, 120.
10. Hayashi, M., T. Morita, Y. Kodama, T. Sofuni and M. Ishidate Jr. (1990) The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides, Mutation Res., 245, 245-249.
11. CSGMT (Collaborative Study Group for the Micronucleus Test) (1992) Micronucleus test with mouse pheripheral blood erythrocytes by acridine orange supravital staining: The summary report of the 5th collaborative study by CSGMT/JEMS.MMS, Mutation Res., 278, 83-98.
12. Kada, T., T. Inoue and M. Namiki (1982) Environmental desmutagens and antimutagens, in: Klekowski (Ed.), Environmental Mutagenesis, Carcinogenesis and Plant Biology, Praeger Scientific, New York, pp. 133-152.
13. Kada, T., T. Inoue, T. Ohta and Y. Shirasu (1986) Antimutagens and their modes of action, in D.M. Shankel et al. (Eds.), Antimutagenesis and Anticarcinogenesis Mechanisms, Plenum Press, New York, pp. 181-196.
14. Kuroda, M., D. Yoshida and S. Mizuaki (1986) Bio-antimutagenic effect of Iactones on chemical mutagenesis in Escherichia coli, Agric. Biol. Chem., 50, 243-245.
15. Kakinuma, K., J. Koike, K. Ishibashi, W. Takahashi and H. Takei (1986) Structure-activity relationship and design of an antimutagen against the UV-induced mutations of Escherichia coli, Agric. Biol. Chem., 50, 625-631.
16. Sasaki, Y.F., H. Imanishi, T. Ohta and Y. Shirasu (1987) Effects of antimutagenic flavourings on SCEs induced by chemical mutagens in cultured Chinese hamster cells, Mutation Res., 189, 313-318.
17. Sasaki, Y.F., H. Imanishi, T. Ohta and Y. Shirasu (1987) Effects of vanillin on sister chromatid exchanges and chromosome aberrations induced by mitomycin C in cultured Chinese hamster ovary cells, Mutation Res., 191, 193-200.
18. Sasaki, Y.F., H. Imanishi, T. Ohta and Y. Shirasu (1989) Modifying effects of components of plant essences on the induction of sister chromatid exchanges in cultured Chinese hamster ovary cells, Mutation Res., 226, 103-110.
19. Sasaki, Y.F., H. Imanishi, T. Ohta, M. Watanabe and Y. Shirasu (1990) Suppressing effect of antimutagenic flavourings on chromosome aberrations induced by UV-light or X-rays in cultured Chinese hamster cells, Mutation Res., 229, 1-10.
20. Rahimtula, A.D., P.K. Zachariah and P.J. O'Brien (1977) The effects of antioxidants on the metabolism and mutagenicity of benzo[a]pyrene in vitro, Biochem. J., 164, 473-475.
21. San, R.H.C. and R.I.M. Chan (1987) Inhibitory effect of phenolic compounds on aflatoxin B1 metabolism and induced mutagenesis, Mutation Res., 177, 229-239.
22. Wood, A.W., M.-T. Hung, R.L. Chang, H.L. Newmark, R.E., Lehr, H. Yagi, J.M, Sayer, D.M. Jerina and A.L. Conney (1982) Inhibition of the mutagenicity of bay-region diol epoxides of polycyclic aromatic hydrocarbons by naturally occurring plant phenols; Exceptional activity of ellagic acid, Proc. Natl. Acad. Sci. USA, 79, 5513-5517.
23. Sayer, J.M., H. Yagi, A.W. Wood, A.H. Conney and D.M. Jerina (1982) Extremely facile reaction between the ultimate carcinogen benzo[a]pyrene-7,8-diol 9,10-epoxide and ellagic acid, J. Am. Chem. Soc., 104, 5562-5564.
24. Abraham, S.K., L. Sarma and P.C. Kesavan (1993) Protective effects of chiorogenic acid, curcumin and (γ-carotene against γ-radiation-induced in vivo chromosome damage, Mutation Res., 303, 109-112.
25. Haung, M.-T., A.W. Wood, H.I. Newmark, J.M. Sayer, H. Yagi, D.M. Jerina and A.M. Conney (1983) Inhibition of the mutagenicity of bay-region diol-epoxides of polycyclic aromatic hydrocarbons by phenolic flavonoids, Carcinogenesis, 4, 1631-1637.
26. Alldrick, A.J., J. Flynn and I.R. Rowland (1986) Effects of plantderived flavonoids and polyphenoloc acids on the activity of mutagens from cooked food, Mutation Res., 163, 225-232.
27. Francis, A.R., T.K. Shetty and R.K. Bhattacharya (1989) Modifying role of dietary factors on the mutagenicity of aflatoxin B1: in vitro effect of plant flavonoids, Mutation Res., 222, 393-401.
28. Heo, M.Y., K.S. Yu, K.H. Kim, H.P. Kim and W.W. Au (1992) Anticlastogenic effect of flavon oids against mutagen-induced micronuclei in mice, Mutation Res., 284, 243-249.
29. Edenharder, R., I. von Petersdorff and R. Rauscher (1993) Antimutagenic effects of flavonoids, chalcones and structurally related compounds on the activity of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and other heterocyclic amine mutagens from cooked food, Mutation Res. 287, 261-274.