Muscarinic cationic current in gastrointestinal smooth muscles: Signal transduction and role in contraction

Autonomic and Autacoid Pharmacology

Volumn 26, Issue 3, 2006, Pages 203-217

  Unno, T ^a   Matsuyama, H ^a   Okamoto, H ^a   Sakamoto, T ^a   Yamamoto, M ^a   Tanahashi, Y ^a   Yan, H D ^a,b   Komori, S ^a  

^a GIFU UNIVERSITY   (Japan)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cationic channel; Contraction; Gastrointestinal smooth muscle; Muscarinic receptor; Signal transduction

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; [4 [(3 CHLOROPHENYL)CARBAMOYLOXY] 2 BUTYNYL]TRIMETHYLAMMONIUM; ACETYLCHOLINE; ARECOLINE; CARBACHOL; CHOLINERGIC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC RECEPTOR; MYOSIN LIGHT CHAIN KINASE; OXOTREMORINE; PERTUSSIS TOXIN; PILOCARPINE; PROTEIN TYROSINE KINASE; VOLTAGE GATED CALCIUM CHANNEL;

CALCIUM TRANSPORT; ELECTROPHYSIOLOGY; GASTROINTESTINAL TRACT; MEMBRANE DEPOLARIZATION; MOLECULAR DYNAMICS; MUSCLE CONTRACTION; NEUROTRANSMISSION; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

ACETYLCHOLINE; ANIMALS; CALCIUM SIGNALING; GASTROINTESTINAL TRACT; GTP-BINDING PROTEINS; HUMANS; ION CHANNEL GATING; MEMBRANE POTENTIALS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MYOSIN-LIGHT-CHAIN KINASE; PARASYMPATHETIC NERVOUS SYSTEM; PHOSPHOLIPASE C; PROTEIN-TYROSINE KINASES; RECEPTORS, MUSCARINIC; TRPC CATION CHANNELS;

EID: 33745170039     PISSN: 14748665     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1474-8673.2006.00366.x     Document Type: Review

References (95)

1. ALBERT A.P. LARGE W.A. ( 2003). Synergism between inositol phosphates and diacylglycerol on native TRPC6-like channels in rabbit portal vein myocytes. J. Physiol., 552, 789 795.
2. ALBERT A.P. AROMOLARAN A.S. LARGE W.A. ( 2001). Agents that increase tyrosine phosphorylation activate a non-selective cation current in single rabbit portal vein smooth muscle cells. J. Physiol., 530, 207 217.
3. AROMOLARAN A.S. ALBERT A.P. LARGE W.A. ( 2000). Evidence for myosin light chain kinase mediating noradrenaline-evoked cation current in rabbit portal vein myocytes. J. Physiol., 524, 853 863.
4. BEECH D.J. MURAKI K. FLEMMING R. ( 2004). Non-selective cationic channels of smooth muscle and the mammalian homologues of Drosophila TRP. J. Physiol., 559, 685 706.
5. BENHAM C.D. BOLTON T.B. LANG R.J. ( 1985). Acetylcholine activates an inward current in single mammalian smooth muscle cells. Nature, 316, 345 347.
6. BLACKWOOD A.M. BOLTON T.B. ( 1993). Mechanism of carbachol-evoked contractions of guinea-pig ileal smooth muscle close to freezing point. Br. J. Pharmacol., 109, 1029 1037.
7. BOLTON T.B. ( 1979). Mechanisms of action of transmitters and other substances on smooth muscle. Physiol. Rev., 59, 647 671.
8. BOLTON T.B. ZHOLOS A.V. ( 1997). Activation of M2 muscarinic receptors in guinea-pig ileum opens cationic channels modulated by M3 muscarinic receptors. Life Sci., 60, 1121 1128.
9. BRADING A.F. SNEDDON P. ( 1980). Evidence for multiple sources of calcium for activation of the contractile mechanism of guinea-pig taenia coli on stimulation with carbachol. Br. J. Pharmacol., 70, 229 240.
10. CARL A. LEE H.K. SANDERS K.M. ( 1996). Regulation of ion channels in smooth muscles by calcium. Am. J. Physiol., 271, C9 34.
11. CAULFIELD M.P. ( 1993). Muscarinic receptors-characterization, coupling and function. Pharmacol. Ther., 58, 319 379.
12. CHEN S. INOUE R. ITO Y. ( 1993). Pharmacological characterization of muscarinic receptor-activated cation channels in guinea-pig ileum. Br. J. Pharmacol., 109, 793 801.
13. CHIACCHIO S. SCARSELLI M. ARMOGIDA M. MAGGIO R. ( 2000). Pharmacological evidence of muscarinic receptor heterodimerization. Pharmaceutica Acta Helvetae, 74, 315 326.
14. CLAPHAM D.E. RUNNELS L.W. STRUBING C. ( 2001). The TRP ion channel family. Nature Rev. Neurosci., 2, 387 396.
15. DEVI L.A. ( 2001). Heterodimerization of G-protein-coupled receptors: pharmacology, signaling and trafficking. Trend Pharmacol. Sci., 22, 532 537.
16. EGLEN R.M. HEGDE S.S. WATSON N. ( 1996). Muscarinic receptor subtypes and smooth muscle function. Pharmacol. Rev., 48, 531 565.
17. EHLERT F.J. OSTROM R.S. SAWYER G.W. ( 1997). Subtypes of the muscarinic receptor in smooth muscle. Life Sci., 61, 1729 1740.
18. EHLERT F.J. SAWYER G.W. ESQUEDA E.E. ( 1999). Contractile role of M2 and M3 muscarinic receptors in gastrointestinal smooth muscle. Life Sci., 64, 387 394.
19. ELORRIAGA M. ANSELMI E. HERNANDEZ J.M. D'OCON P. IVORRA D. ( 1996). The sources of Ca2+ for muscarinic receptor-induced contraction in the rat ileum. J. Pharm. Pharmacol., 48, 817 819.
20. GARDNER A.L. CHOO L.K. MITCHELSON F. ( 1988). Comparison of the effects of some muscarinic agonists on smooth muscle function and phosphatidylinositol turnover in the guinea-pig taenia caeci. Br. J. Pharmacol., 94, 199 211.
21. GOMEZA J. SHANNON H. KOSTENIS E. FELDER C. ZHANG L. BRODKIN J. GRINGERG A. SHENG H. WESS J. ( 1999). Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice. Proc. Natl Acad. Sci. USA, 96, 1692 1697.
22. GORDIENKO D.V. ZHOLOS A.V. ( 2004). Regulation of muscarinic cationic current in myocytes from guinea-pig ileum by intracellular Ca2+ release: a central role of inositol 1,4,5-trisphosphate receptors. Cell Calcium, 36, 367 386.
23. GORDIENKO D.V. ZHOLOS A.V. BOLTON T.B. ( 1999). Membrane ion channels as physiological targets for local Ca2+ signalling. J. Microsc., 196, 305 316.
24. HARDIE R.C. ( 2003). Regulation of TRP channels via lipid second messengers. Annu. Rev. Physiol., 65, 735 759.
25. HELLIWELL R.M. LARGE W.A. ( 1997). α1-adrenoceptor activation of a non-selective cation current in rabbit portal vein by 1,2-diacyl-sn-glycerol. J. Physiol., 499, 417 428.
26. HISHINUMA S. HONGO I. MATSUMOTO Y. NARITA F. KUROKAWA M. ( 1997). Contracting effects of carbachol, McN-A-343 and Ahr-602 on Ca2+-mobilization and Ca2+-influx pathways in taenia caeci. Br. J. Pharmacol., 122, 985 992.
27. INOUE R. ISENBERG G. ( 1990). Acetylcholine activates nonselective cation channels in guinea pig ileum through a G protein. Am. J. Physiol., 258, C1173 1178.
28. INOUE R. KURIYAMA H. ( 1993). Dual regulation of cation-selective channels by muscarinic and a1-adrenergic receptors in the rabbit portal vein. J. Physiol., 465, 427 448.
29. INOUE R. WANIISHI Y. YAMADA K. ITO Y. ( 1994). A possible role of tyrosine kinases in the regulation of muscarinic receptor-activated cation channels in guinea pig ileum. Biochem. Biophys. Res. Commun., 203, 1392 1397.
30. INOUE R. OKADA T. ONOUE H. HARA Y. SHIMIZU S. NAITOH S. ITO Y. MORI Y. ( 2001). The transient receptor potential protein homologue TRP6 is the essential component of vascular α1-adrenoceptor-activated Ca2+-permeable cation channel. Circ. Res., 88, 325 332.
31. INOUE R. HANANO T. SHI J. MORI Y. ITO Y. ( 2003). Transient receptor potential protein as a novel non-voltage-gated Ca2+ entry channel involved in diverse pathophysiological functions. J. Pharmacol. Sci., 91, 271 276.
32. ITO S. OHTA T. NAKAZATO Y. ( 1993). Inward current activated by carbachol in rat intestinal smooth muscle cells. J. Physiol., 470, 395 409.
33. JANSSEN L.J. SIMS S.M. ( 1992). Acetylcholine activates non-selective cation and chloride conductances in canine and guinea-pig tracheal myocytes. J. Physiol., 453, 197 218.
34. KEEF K.D. WARD S.M. STEVENS R.J. FREY B.W. SANDERS K.M. ( 1992). Electrical and mechanical effects of acetylcholine and substance P in subregions of canine colon. Am. J. Physiol., 262, G298 307.
35. KIM S.J. AHN S.C. SO I. KIM K.W. ( 1995a). Quinidine blockade of the carbachol-activated nonselective cationic current in guinea-pig gastric myocytes. Br. J. Pharmacol., 115, 1407 1414.
36. KIM S.J. AHN S.C. SO I. KIM K.W. ( 1995b). Role of calmodulin in the activation of carbachol-activated cationic current in guinea-pig gastric antral myocytes. Pflugers Arch., 430, 757 762.
37. KIM Y.C. KIM S.J. KANG T.M. SUH S.H. SO I. KIM K.W. ( 1997). Effects of myosin light chain kinase inhibitors on carbachol-activated nonselective cationic current in guinea-pig gastric myocytes. Pflugers Arch., 434, 346 353.
38. KIM Y.C. KIM S.J. SIM J.H. CHO C.H. JUHNN Y.S. SUH S.H. SO I. KIM K.W. ( 1998). Suppression of the carbachol-activated nonselective cationic current by antibody against alpha subunit of Go protein in guinea-pig gastric myocytes. Pflugers Arch., 436, 494 496.
39. KOHDA M. KOMORI S. UNNO T. OHASHI H. ( 1997). Characterization of action potential-triggered [Ca2+]i transients in single smooth muscle cells of guinea-pig ileum. Br. J. Pharmacol., 122, 477 486.
40. KOMORI S. BOLTON T.B. ( 1990). Role of G proteins in muscarinic receptor inward and outward currents in rabbit jejunal smooth muscle. J. Physiol., 427, 395 419.
41. KOMORI S. KAWAI M. TAKEWAKI T. OHASHI H. ( 1992). GTP-binding protein involvement in membrane currents evoked by carbachol and histamine in guinea-pig ileal muscle. J. Physiol., 450, 105 126.
42. KOMORI S. KAWAI M. PACAUD P. OHASHI H. BOLTON T.B. ( 1993). Oscillations of receptor-operated cationic current and internal calcium in single guinea-pig ileal smooth muscle cells. Pflugers Arch., 424, 431 438.
43. KOMORI S. UNNO T. NAKAYAMA T. OHASHI H. ( 1998). M2 and M3 muscarinic receptors couple, respectively, with activation of nonselective cationic channels and potassium channels in intestinal smooth muscle cells. Jpn. J. Pharmacol., 76, 213 218.
44. KOMORI S. UNNO T. MATSUYAMA H. SAKAMOTO T. YAMADA M. WESS J. ( 2005). Muscarinic receptor-mediated cationic current in intestinal smooth muscle of M2 or M3 receptor knockout mouse. The Physiological Society Focused Meeting - Ion Channels, Gene and Regulation in Smooth Muscle, Oxford, 11 p.
45. KURIYAMA H. KITAMURA K. ITOH T. INOUE R. ( 1998). Physiological features of visceral smooth muscle cells, with special reference to receptors and ion channels. Physiol. Rev., 78, 811 920.
46. LARGE W.A. ( 2002). Receptor-operated Ca2+-permeable nonselective cation channels in vascular smooth muscle: a physiologic perspective. J. Cardiovasc. Electrophysiol., 13, 493 501.
47. LEE H.K. BAYGUINOV O. SANDERS K.M. ( 1993). Role of nonselective cation current in muscarinic responses of canine colonic muscle. Am. J. Physiol., 265, C1463 1471.
48. LEE Y.M. KIM B.J. KIM H.J. YANG D.K. ZHU M.H. LEE K.P. SO I. KIM K.W. ( 2003). TRPC5 as a candidate for the nonselective cation channel activated by muscarinic stimulation in murine stomach. Am. J. Physiol., 284, G604 G616.
49. MAGGIO R. BARBIER P. COLELLI A. SALVADORI F. DEMONTIS G. CORSINI G.U. ( 1999). G protein-linked receptors: pharmacological evidence for the formation of heterodimers. J. Pharmacol. Exp. Ther., 291, 251 257.
50. MATSUI M. MOTOMURA D. KARASAWA H. FUJIKAWA T. JIANG J. KOMIYA Y. TAKAHASHI S. TAKETO M.M. ( 2000). Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype. Proc. Natl Acad. Sci. USA, 97, 9579 9584.
51. MATSUI M. MOTOMURA D. FUJIKAWA T. JIANG J. TAKAHASHI S. MANABE T. TAKETO M.M. ( 2002). Mice lacking M2 and M3 muscarinic acetylcholine receptors are devoid of cholinergic smooth muscle contractions but still viable. J. Neurosci., 22, 10627 10632.
52. MINKE B. COOK B. ( 2002). TRP channel proteins and signal transduction. Physiol. Rev., 82, 429 472.
53. MOREL J.L. MACREZ N. MIRONNEAU J. ( 1997). Specific Gq protein involvement in muscarinic M3 receptor-induced phophatidylinositol hydrolysis and Ca2+ release in mouse duodenal myocytes. Br. J. Pharmacol., 121, 451 458.
54. OKAMOTO H. PRESTWICH S.A. ASAI S. UNNO T. BOLTON T. B. KOMORI S. ( 2002). Muscarinic agonist potencies at three different effector systems linked to the M2 or M3 receptor in longitudinal smooth muscle of guinea-pig small intestine. Br. J. Pharmacol., 135, 1765 1775.
55. OKAMOTO H. UNNO T. ARIMA D. SUZUKI M. YAN H.-D. MATSUYAMA H. NISHIMURA M. KOMORI S. ( 2004). Phospholipase C involvement in activation of the muscarinic receptor-operated cationic current in guinea pig ileal smooth muscle cells. J. Pharmacol. Sci., 95, 203 213.
56. OSTROM R.S. EHLERT F.J. ( 1997). M2 muscarinic receptor inhibition of agonist-induced cyclic adenosine monophosphate accumulation and relaxation in the guinea pig ileum. J. Pharmacol. Exp. Ther., 280, 189 199.
57. PACAUD P. BOLTON T.B. ( 1991). Relation between muscarinic receptor cationic current and internal calcium in guinea-pig jejunal smooth muscle cells. J. Physiol., 441, 477 499.
58. PAREKH A.B. BRADING A.F. ( 1991). The sources of calcium for carbachol-induced contraction in the circular smooth muscle of guinea-pig stomach. Br. J. Pharmacol., 104, 412 418.
59. PUCOVSKY V. ZHOLOS A.V. BOLTON T.B. ( 1998). Muscarinic cation current and suppression of Ca2+ current in guinea pig ileal smooth muscle cells. Eur. J. Pharmacol., 346, 323 330.
60. RHEE J.C. RHEE P.L. PARK M.K. SO I. UHM D.Y. KIM K.W. KANG T.M. ( 2000). Muscarinic receptors controlling the carbachol-activated nonselective cationic current in guinea pig gastric smooth muscle cells. Jpn. J. Pharmacol., 82, 331 337.
61. SAWYER G.W. EHLERT F.J. ( 1998). Contractile role of the M2 and M3 muscarinic receptors in the guinea pig colon. J. Pharmacol. Exp. Ther., 284, 269 277.
62. SAWYER G.W. EHLERT F.J. ( 1999). Muscarinic M3 receptor inactivation reveals a pertussis toxin-sensitive contractile response in the guinea pig colon: Evidence for M2/M3 receptor interactions. J. Pharmacol. Exp. Ther., 289, 464 476.
63. SIMS S.M. ( 1992). Cholinergic activation of a non-selective cation current in canine gastric smooth muscle is associated with contraction. J. Physiol., 449, 377 398.
64. SO I. KIM K.W. ( 2003). Nonselective cation channels activated by the stimulation of muscarinic receptors in mammalian gastric smooth muscle. J. Smooth Muscle Res., 39, 231 247.
65. STENGEL P.W. COHEN M.L. ( 2003). M1 receptor-mediated nitric oxide-dependent relaxation unmasked in stomach fundus from M3 receptor knockout mice. J. Pharmacol. Exp. Ther., 304, 675 682.
66. STENGEL P.W. GOMEZA J. WESS J. COHEN M.L. ( 2000). M2 and M4 receptor knockout mice: muscarinic receptor function in cardiac and smooth muscle in vitro. J. Pharmacol. Exp. Ther., 292, 877 885.
67. STENGEL P.W. YAMADA M. WESS J. COHEN M.L. ( 2002). M3 receptor knockout mice: muscarinic receptor function in atria, stomach fundus, urinary bladder and trachea in vitro. Am. J. Physiol., 282, R1443 1449.
68. STRUCKMANN N. SCHWERING S. WIEGAND S. GSCHNELL A. YAMADA M. KUMMER W. WESS J. HABERBERGER R.V. ( 2003). Role of muscarinic receptor subtypes in the constriction of peripheral airways: studies on receptor-deficient mice. Mol. Pharmacol., 64, 1444 1451.
69. SUI J.L. PETIT-JACQUES J. LOGOTHETIS D.E. ( 1998). Activation of the atrial KACh channel by the βγ subunits of G proteins or intracellular Na+ ions depends on the presence of phosphatidylinositol phosphates. Proc. Natl Acad. Sci. USA, 95, 1307 1312.
70. TAKAI Y. AWAYA S. TAKAI A. ( 1997). Activation of non-selective cation conductance by carbachol in freshly isolated bovine ciliary muscle cells. Pflugers Arch., 433, 705 712.
71. TAKAI Y. SUGAWARA R. OHINATA H. TAKAI A. ( 2004). Two types of non-selective cation channel opened by muscarinic stimulation with carbachol in bovine ciliary muscle cells. J. Physiol., 559, 899 922.
72. THOMAS E.A. EHLERT F.J. ( 1994). Pertussis toxin blocks M2 muscarinic receptor-mediated effects on contraction and cyclic AMP in the guinea pig ileum, but not M3-mediated contractions and phosphoinositide hydrolysis. J. Pharmacol. Exp. Ther., 271, 1042 1050.
73. THOMAS E.A. BAKER S.A. EHLERT F.J. ( 1993). Functional role for the M2 muscarinic receptor in smooth muscle of guinea pig ileum. Mol. Pharmacol., 44, 102 110.
74. UNNO T. KOMORI S. OHASHI H. ( 1995). Inhibitory effect of muscarinic receptor activation on Ca2+ channel current in smooth muscle cells of guinea-pig ileum. J. Physiol., 484, 567 581.
75. UNNO T. KWON S.-C. OKAMOTO H. IRIE Y. KATOH Y. MATSUYAMA H. KOMORI S. ( 2003a). Receptor signaling mechanisms underlying muscarinic agonist-evoked contraction in guinea-pig ileal longitudinal smooth muscle. Br. J. Pharmacol., 139, 337 350.
76. UNNO T. MATSUYAMA H. KOMORI S. ( 2003b). Muscarinic signal transduction in gastrointestinal smooth muscle. Recent Res. Dev. Physiol., 1, 577 597.
77. UNNO T. MATSUYAMA H. SAKAMOTO S. UCHIYAMA M. IZUMI Y. OKAMOTO H. YAMADA M. WESS J. KOMORI S. ( 2005). M2 and M3 muscarinic receptor-mediated contractions in longitudinal smooth muscle of the ileum studied with receptor knockout mice. Br. J. Pharmacol., 146, 98 108.
78. VOETS T. TALAVERA K. OWSIANIK G. NILIUS B. ( 2005). Sensing with TRP channels. Nat. Chem. Biol., 1, 85 92.
79. VOGALIS F. SANDERS K.M. ( 1990). Cholinergic stimulation activates a non-selective cation current in canine pyloric circular muscle cells. J. Physiol., 429, 223 236.
80. WALKER R.L. HUME J.R. HOROWITZ B. ( 2001). Differential expression and alternative splicing of TRP channel gene in smooth muscles. Am. J. Physiol., 280, C1184 1192.
81. WANG Y.-X. KOTLIKOFF M.I. ( 2000). Signalling pathway for histamine activation of non-selective cation channels in equine tracheal myocytes. J. Physiol., 523, 131 138.
82. WANG Q. AKBARALI H.I. HATAKEYAMA N. GOYAL R.K. ( 1996). Caffeine- and carbachol-induced Cl- and cation currents in single opossum esophageal circular muscle cells. Am. J. Physiol., 271, C1725 1734.
83. WANG Y.-X. FLEISCHMANN B.K. KOTLIKOFF M.I. ( 1997). M2 receptor activation of non-selective cation channels in smooth muscle cells: calcium and Gi/Go requirements. Am. J. Physiol., 273, C500 508.
84. WAYMAN C.P. MCFADZEAN I. GIBSON A. TUCKER J.F. ( 1997). Cellular mechanisms underlying carbachol-induced oscillations of calcium-dependent membrane current in smooth muscle cells from mouse anococcygeus. Br. J. Pharmacol., 121, 1301 1308.
85. WINKS J.S. HUGHES S. FILIPPOV A.K. TATULIAN L. ABOGADIE F.C. BROWN D.A. MARSH S.J. ( 2005). Relationship between membrane phosphatidylinositol-4,5- bisphosphate and receptor-mediated inhibition of native neuronal M channels. J. Neurosci., 25, 3400 3413.
86. WRZOS H.F. TANDON T. OUYANG A. ( 2004). Mechanisms mediating cholinergic antral circular smooth muscle contraction in rats. World J. Gastroenterol., 10, 3292 3298.
87. XIE L.H. HORIE M. TAKANO M. ( 1999). Phospholipase C-linked receptor regulate the ATP-sensitive potassium channel by means of phosphatidylinositol 4,5-bisphosphate metabolism. Proc. Natl Acad. Sci. USA, 96, 15292 15297.
88. YAMADA M. MIYAKAWA T. DUTTAROY A. et al. ( 2001). Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean. Nature, 410, 207 212.
89. YAMASHITA T. KOKUBUN S. ( 1999). Nonselective cationic currents activated by acetylcholine in swine tracheal smooth muscle cells. Can. J. Physiol. Pharmacol., 77, 796 805.
90. YAN H.-D. OKAMOTO H. UNNO T. TSYTSYURA Y.D. PRESTWICH S.A. KOMORI S. ZHOLOS A.V. BOLTON T.B. ( 2003). Effects of G protein-specific antibodies and Gβγ subunits on the muscarinic receptor-operated cation current in guinea-pig ileal smooth muscle cells. Br. J. Pharmacol., 139, 605 615.
91. ZHOLOS A.V. BOLTON T.B. ( 1994). G-protein control of voltage dependence as well as gating of muscarinic metabotropic channels in guinea-pig ileum. J. Physiol., 478, 195 202.
92. ZHOLOS A.V. BOLTON T.B. ( 1997). Muscarinic receptor subtypes controlling the cationic current in guinea-pig ileal smooth muscle. Br. J. Pharmacol., 122, 885 893.
93. ZHOLOS A.V. KOMORI S. OHASHI H. BOLTON T.B. ( 1994). Ca2+ inhibition of inositol trisphosphate-induced Ca2+ release in single smooth muscle cells of guinea-pig small intestine. J. Physiol., 481, 97 109.
94. ZHOLOS A.V. TSYTSYURA Y.D. GORDIENKO D.V. TSVILVSKYY V.V. BOLTON T.B. ( 2004a). Phospholipase C, but not InsP3 or DAG, -dependent activation of the muscarinic receptor-operated cation current in guinea-pig ileal smooth muscle cells. Br. J. Pharmacol., 141, 23 36.
95. ZHOLOS A.V. ZHOLOS A.A. BOLTON T.B. ( 2004b). G-protein-gated TRP-like cationic channel activated by muscarinic receptors: effect of potential on single-channel gating. J. Gen. Physiol., 123, 581 598.