Perforin down-regulation and adhesion molecules activation in pulmonary sarcoidosis: An induced sputum and BAL study

Chest

Volumn 129, Issue 6, 2006, Pages 1592-1598

  Antoniou, Katerina M ^a   Tsiligianni, Ioanna ^a   Kyriakou, Despina ^b   Tzanakis, Nikolaos ^a   Tzouvelekis, Argyris ^c   Siafakas, Nikolaos M ^a   Bouros, Demosthenes ^d,e  

^a UNIVERSITY OF CRETE   (Greece)

^b UNIVERSITY OF THESSALY   (Greece)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

^e DEMOCRITUS UNIVERSITY OF THRACE MEDICAL SCHOOL   (Greece)

Author keywords

BAL fluid; CD62; CD71; Induced sputum; Pathophysiology; Perforin; Sarcoidosis; Tc1 Tc2 profile

Indexed keywords

CD71 ANTIGEN; CELL ADHESION MOLECULE; GAMMA INTERFERON; INTERLEUKIN 4; PADGEM PROTEIN; PERFORIN; PHORBOL 13 ACETATE 12 MYRISTATE;

ADULT; AGED; ARTICLE; CD8+ T LYMPHOCYTE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DEMOGRAPHY; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; GREECE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG LAVAGE; LUNG SARCOIDOSIS; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; SPIROMETRY; SPUTUM ANALYSIS; STATISTICAL ANALYSIS; T LYMPHOCYTE ACTIVATION; TH1 CELL; UNIVERSITY HOSPITAL;

EID: 33745165620     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.129.6.1592     Document Type: Article

References (41)

1. Hunninghake GW, Costabel U, Ando M, et al. ATS/ERS/WASOG statement on sarcoidosis: American Thoracic Society/European Respiratory Society/World Association of Sarcoidosis and Granulomatous Disorders. Sarcoidosis Vasc Diffuse Lung Dis 1999; 16:149-173
2. Hunninghake GW, Crystal RG. Pulmonary sarcoidosis: a disorder mediated by excess helper T-lymphocyte activity at sites of disease activity. N Engl J Med 1981; 305:429-434
3. Agostini C, Costabel U, Semenzato G. Sarcoidosis news: immunologic frontiers for new immunosuppressive strategies. Clin Immunol Immunopathol 1998; 88:199-204
4. Inui N, Chida K, Suda T, et al. Th1/Th2 and Tc1/Tc2 profiles in peripheral blood and bronchoalveolar lavage fluid cells in pulmonary sarcoidosis. J Allergy Clin Immunol 2001; 107:337-344
5. Prasse A, Georges CG, Biller H, et al. Th1 cytokine pattern in sarcoidosis is expressed by bronchoalveolar CD4 and CD8 T cells. Clin Exp Immunol 2000; 122:241-248
6. Mollers M, Aries SP, Dromann D, et al. Intracellular cytokine repertoire in different T cell subsets from patients with sarcoidosis. Thorax 2001; 56:187-193
7. Baumer I, Zissel G, Schlaak M, et al. Th1/Th2 cell distribution in pulmonary sarcoidosis. Am J Respir Cell Mol Biol 1997; 16:171-177
8. Wahlström J, Katchar K, Wigzell H, et al. Analysis of intracellular cytokines in CD4+ and CD8+ lung and blood T cells in sarcoidosis. Am J Respir Crit Care Med 2001; 163:115-121
9. Tsiligianni I, Antoniou KM, Kyriakou D, et al. Th1/Th2 cytokine pattern in bronchoalveolar lavage fluid and induced sputum in pulmonary sarcoidosis. BMC Pulm Med 2005; 5:8
10. Carter LL, Dutton RW. Type 1 and type 2: a fundamental dichotomy for all T-cell subsets. Curr Opin Immunol 1996; 8:336-342
11. Sad S, Marcotte R, Mosmann TR. Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines. Immunity 1995; 2:271-279
12. Stanciu LA, Shute J, Promwong C, et al. Increased levels of IL-4 in CD8+ T cells in atopic asthma. J Allergy Clin Immunol 1997; 100:373-378
13. Ito N, Nakamura H, Tanaka Y, et al. Lung carcinoma: analysis of T helper type 1 and 2 cells and T cytotoxic type 1 and 2 cells by intracellular cytokine detection with flow cytometry. Cancer 1999; 85:2359-2367
14. Arnold V, Balkow S, Staats R, et al. Increase in perforin-positive peripheral blood lymphocytes in extrinsic and intrinsic asthma. Am J Respir Crit Care Med 2000; 161:182-186
15. Blanco P, Pitard V, Viallard JF, et al. Increase in activated CD8+ T lymphocytes expressing perform and granzyme B correlates with disease activity in patients with systemic lupus erythematosous. Arthritis Rheum 2005; 52:201-211
16. Miyazald H, Kuwano K, Yoshida K, et al. The perform mediated apoptotic pathway in lung injury and fibrosis. J Clin Pathol 2004; 57:1292-1298
17. Chrysofakis G, Tzanakis N, Kyriakou D, et al. Perform expression and cytotoxic activity of sputum CD8+ lymphocytes in patients with COPD. Chest 2004; 125:71-76
18. Griffin JD, Spertini O, Ernst TJ, et al. Granulocyte-macrophage colony-stimulating factor and other cytokines regulate surface expression of the leukocyte adhesion molecule-1 on human neutrophils, monocytes, and their precursors. J Immunol 1990; 145:576-584
19. Berlin M, Lundahl J, Skold CM, et al. The lymphocytic alveolitis in sarcoidosis is associated with increased amounts of soluble and cell-bound adhesion molecules in bronchoalveolar lavage fluid and serum. J Intern Med 1998; 244:333-340
20. Kaseda M, Kadota J, Mukae H, et al. Possible role of L-selectin in T lymphocyte alveolitis in patients with active pulmonary sarcoidosis. Clin Exp Immunol 2000; 121:146-150
21. Striz I, Wang YM, Svarcova I, et al. The phenotype of alveolar macrophages and its correlation with immune cells in bronchoalveolar lavage. Eur Respir J 1993; 6:1287-1294
22. Tsiligianni I, Tzanakis N, Kyriakou D, et al. Comparison of sputum induction with bronchoalveolar lavage cell differential counts in patients with sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 2002; 19:205-210
23. Tzanakis N, Chrysofakis G, Tsoumakidou M, et al. Induced sputum CD8+ T-lymphocyte subpopulations in chronic obstructive pulmonary disease. Respir Med 2004; 98:57-65
24. Antoniou KM, Alexandrakis M, Tzanakis N, et al. Induced sputum versus bronchoalveolar lavage fluid in the evaluation of patients with idiopathic pulmonary fibrosis. Respiration 2005; 72:32-38
25. American Thoracic Society. Standardization of spirometry, 1994 update. Am J Respir Crit Care Med 1995; 152:1107-1136
26. Popov T, Pizzichini M, Pizzichini E, et al. Some technical factors influencing the induction of sputum for cell analysis. Eur Respir J 1995; 8:559-565
27. Popov T, Gottschalk R, Kolendowicz R, et al. The evaluation of a cell dispersion method of sputum examination. Clin Exp Allergy 1994; 24:778-783
28. Kips JC, Fahy JV, Hargraeve FE, et al. Methods for sputum induction and analysis of induced sputum: a method for assessing airway inflammation in asthma. Eur Respir J 1998; 26:9S-12S
29. European Society of Pneumology. Technical recommendations and guidelines for bronchoalveolar lavage (BAL): report of the European Society of Pneumology Task Group. Eur Respir J 1989; 2:561-585
30. Kyriakou D, Liapi D, Kyriakou E, et al. Aberrant expression of the major sialoglycoprotein (CD43) on the monocytes of patients with myelodysplastic syndromes. Ann Hematol 2000; 79:198-205
31. Tzanakis N, Chrysofakis G, Tsoumakidou M, et al. Induced sputum CD8+ T-lymphocyte subpopulations in chronic obstructive disease. Respir Med 2004; 98:57-65
32. Li Y, Richards D, Noble A, et al. Cytokine production by highly purified human CD8+ T cells. Int Arch Allergy Immunol 1995; 107:354-355
33. Bresnitz EA, Stolley PD, Israel HL, et al. Possible risk factors for sarcoidosis: a case-control study. Ann N Y Acad Sci 1986; 465:632-642
34. Newman LS, Rose CS, Maier LA. Sarcoidosis. N Engl J Med 1997; 336:1224-1234
35. Harf RA, Ethevenaux C, Gleize J, et al. Reduced prevalence of smokers in sarcoidosis: results of a case-control study. Ann N Y Acad Sci 1986; 465:625-631
36. Ishii Y, Kitamura S. Elevated levels of soluble ICAM-1 in serum and BAL fluid in patients with active sarcoidosis. Chest 1995; 107:1636-1640
37. Uzaslan E, Guzman J, Costabel U. Cockade-like structures in alveolar macrophages in extrinsic allergic alveolitis. Respiration 2005; 72:46-51
38. Wahlström J, Berlin M, Sköld CM, et al. Phenotypic analysis of lymphocytes and monocytes/macrophages in peripheral blood and bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis. Thorax 1999; 54:339-346
39. McGrath DS, Foley PJ, Petrek M, et al. Ace gene I/D polymorphism and sarcoidosis pulmonary disease severity. Am J Respir Crit Care Med 2001; 164:197-201
40. Olivieri D, D'Ippolito R, Chetta A. Induced sputum: diagnostic value in interstitial lung disease. Curr Opin Pulm Med 2000; 4:411-414
41. D'Ippolito R, Chetta A, Olivieri D. Role of induced sputum in interstitial lung disease. Eur Respir J 2000; 16:573-574