Increase in perforin-positive peripheral blood lymphocytes in extrinsic and intrinsic asthma

American Journal of Respiratory and Critical Care Medicine

Volumn 161, Issue 1, 2000, Pages 182-186

  Arnold, Verena ^a   Balkow, Sandra ^a   Staats, Richard ^a   Matthys, Heinrich ^a   Luttmann, Werner ^a   Virchow Jr , Johann Christian ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD16 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; PERFORIN;

ADULT; AGED; ALLERGIC ASTHMA; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LYMPHOCYTOSIS; MALE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

EID: 0033978511     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.161.1.9902104     Document Type: Article

References (38)

1. 1. Walker, C., E. Bode, L. Boer, T. T. Hansel, K. Blaser, and J. C. Virchow, Jr. 1992, Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. Am. Rev. Respir. Dis. 146:109-115.
2. 2. Virchow, J. C., Jr., C. Walker, D. Hafner, C. Kortsik, P. Werner, H. Matthys, and C. Kroegel. 1995. T cells and cytokines in bronchoalveolar lavage fluid after segmental allergen provocation in atopic asthma. Am. J. Respir. Crit. Care Med. 151:960-968.
3. 3. Szczeklik, A., E. Nizankowska, A. Serafin, A. Dyczek, M. Duplaga, and J. Musial. 1995. Autoimmune phenomena in bronchial asthma with special reference to aspirin intolerance. Am. J. Respir. Crit. Care Med. 152:1753-1756.
4. 4. Turner-Warwick, M., and P. Haslam. 1970. Smooth muscle antibody in bronchial asthma. Clin. Exp. Immunol. 7:31-38.
5. 5. Egeskjold, E. M., H. Permin, I. Nielsen, H. J. Sorensen, O. Osterballe, and H. E. Kallerup. 1981. Anti-IgG antibodies and antinuclear antibodies in allergic patients. Eur. J. Allergy Clin. Immunol. 36:573-581.
6. 6. Lidor, Y., M. Topilsky, S. A. Spitzer, and H. Yehoshua. 1980. Autoimmune antibodies in intrinsic (non-atopic) asthma. Ann. Allergy 44:296-298.
7. 7. Menon, P., V. Menon, B. C. Hilman, R. Wolf, and L. Bairnsfather. 1989. Antinuclear antibodies and anticytoplasmic antibodies in bronchial asthma. J. Allergy Clin. Immunol. 84:937-943.
8. 8. Venter, J. C., C. M. Fraser, and L. C. Harrison. 1980. Autoantibodies to beta 2-adrenergic receptors: a possible cause of adrenergic hyporesponsiveness in allergic rhinitis and asthma. Science 207:1361-1363.
9. 9. Bousquet, J., P. Chanez, J. Y. Lacoste, G. Barneon, N. Ghavanian, I. Enander, P. Venge, S. Ahlstedt, J. Simony-Lafontaine, P. Godard, and F. B. Michel. 1990. Eosinophilic inflammation in asthma. N. Engl. J. Med. 323:1033-1039.
10. 10. Krejsek, J., B. Kral, D. Vokurkova, V. Derner, M. Touskova, Z. Parakova, and O. Kopecky. 1998. Decreased peripheral blood gamma delta T cells in patients with bronchial asthma. Eur. J. Allergy Clin. Immunol. 53:73-77.
11. 11. Lichtenheld, M. G., K. J. Olsen, P. Lu, D. M. Lowrey, A. Hameed, H. Hengartner, and E. R. Podack. 1988. Structure and function of human perforin. Nature 335:448-451.
12. 12. Millard, P. J., M. P. Henkart, C. W. Reynolds, and P. A. Henkart. 1984. Purification and properties of cytoplasmic granules from cytotoxic rat LGL tumors. J. Immunol. 132:3197-3204.
13. 13. Shinkai, Y., K. Takio, and K. Okumura. 1988. Homology of perforin to the ninth component of complement (C9). Nature 334:525-527.
14. 14. Koizumi, H., C. C. Liu, L. M. Zheng, S. V. Joag, N. K. Bayne, J. Holoshitz, and J. D. Young. 1991. Expression of perforin and serine esterases by human gamma/delta T cells. J. Exp. Med. 173:499-502.
15. 15. Konjevic, G., B. Schlesinger, L. Cheng, K. J. Olsen, E. R. Podack, and I. Spuzic. 1995. Analysis of perforin expression in human peripheral blood lymphocytes, CD56+ natural killer cell subsets and its induction by interleukin-2. Immunol Invest. 24:499-507.
16. 16. Nakata, M., A. Kawasaki, M. Azuma, K. Tsuji, H. Matsuda, Y. Shinkai, H. Yagita, and K. Okumura. 1992. Expression of perforin and cytolytic potential of human peripheral blood lymphocyte subpopulations. Int. Immunol. 4:1049-1054.
17. 17. Rubesa, G., E. R. Podack, J. Sepcic, and D. Rukavina. 1997. Increased perforin expression in multiple sclerosis patients during exacerbation of disease in peripheral blood lymphocytes. J. Neuroimmunol. 74:198-204.
18. 18. Matusevicius, D., P. Kivisakk, V. Navikas, M. Soderstrom, S. Fredrikson, and H. Link. 1998. Interleukin-12 and perforin mRNA expression is augmented in blood mononuclear cells in multiple sclerosis. Scand. J. Immunol. 47:582-590.
19. 19. Seko, Y., S. Minota, A. Kawasaki, Y. Shinkai, K. Maeda, H. Yagita, K. Okumura, O. Sato, A. Takagi, Y. Tada, and Y. Yazaki. 1994. Perforin secreting killer cell infiltration and expression of a 65-kD heat-shock protein in aortic tissue of patients with Takayasu's arteritis. J. Clin. Invest. 93:750-758.
20. 20. Wu, Z., E. R. Podack, J. M. McKenzie, K. J. Olsen, and M. Zakarija. 1994. Perforin expression by thyroid-infiltrating T cells in autoimmune thyroid disease. Clin. Exp. Immunol. 98:470-477.
21. 21. Darmon, A. J., D. W. Nicholson, and R. C. Bleackley. 1995. Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B. Nature 377:446-448.
22. 22. Darmon, A. J., T. J. Ley, D. W. Nicholson, and R. C. Bleackley. 1996. Cleavage of CPP32 by granzyme B represents a critical role for granzyme B in the induction of target cell DNA fragmentation. J. Biol. Chem. 271:21709-21712.
23. 23. Spaner, D., K. Raju, L. Radvanyi, Y. Lin, and R. G. Miller. 1998. A role for perforin in activation-induced cell death. J. Immunol. 160:2655-2664.
24. 24. Topham, D. J., R. A. Tripp, and P. C. Doherty. 1997. CD8+ T cells clear influenza virus by perforin or Fas-dependent processes. J. Immunol. 159:5197-5200.
25. 25. Sambhara, S., I. Switzer, A. Kurichh, R. Miranda, L. Urbanczyk, O. James, B. Underdown, M. Klein, and D. Burt. 1998. Enhanced antibody and cytokine responses to influenza viral antigens in perforin-deficient mice. Cell. Immunol. 187:13-18.
26. 26. Virchow, J. C., Jr., C. Kroegel, C. Walker, and H. Matthys. 1996. Inflammatory determinants of asthma severity: mediator and cellular changes in bronchoalveolar lavage fluid of patients with severe asthma. J. Allergy Clin. Immunol. 98:S27-S33.
27. 27. Anonymous. 1992. International consensus report on diagnosis and treatment of asthma. Eur. Respir. J. 5:601-641.
28. 28. Luttmann, W., V. Herzog, J. C. Virchow, Jr., H. Matthys, K. H. Thierauch, and C. Kroegel. 1996. Prostacyclin modulates granulocyte/macrophage colony-stimulating factor release by human blood mononuclear cells. Pulm. Pharmacol. 9:43-48.
29. 29. Leung, D. Y. 1995. Atopic dermatitis: the skin as a window into the pathogenesis of chronic allergic diseases. J. Allergy Clin. Immunol. 96:302-318.
30. 30. Virchow, C. 1973. Intrinsic asthma: symptoms, IgE serum levels, pathophysiology. Prax. Pneumol. 27:578-591.
31. 31. Rukavina, D., G. Laskarin, G. Rubesa, N. Strbo, I. Bedenicki, D. Manestar, M. Glavas, S. E. Christmas, and E. R. Podack. 1998. Age-related decline of perforin expression in human cytotoxic T lymphocytes and natural killer cells. Blood 92:2410-2420.
32. 32. Rutella, S., C. Rumi, M. B. Lucia, B. Etuk, R. Cauda, and G. Leone. 1998. Flow cytometric detection of perforin in normal human lymphocyte subpopulations defined by expression of activation/differentiation antigens. Immunol. Lett. 60:51-55.
33. 33. Watanabe, N., S. C. De Rosa, A. Cmelak, R. Hoppe, L. A. Herzenberg, and M. Roederer. 1997. Long-term depletion of naive T cells in patients treated for Hodgkin's disease. Blood 90:3662-3672.
34. 34. Vergelli, M., B. Hemmer, P. A. Muraro, L. Tranquill, W. E. Biddison, A. Sarin, H. F. McFarland, and R. Martin. 1997. Human autoreactive CD4+ T cell clones use perforin-or Fas/Fas ligand-mediated pathways for target cell lysis. J. Immunol. 158:2756-2761.
35. 35. Muller, S., J. Lory, N. Corazza, G. M. Griffiths, K. Z'graggen, L. Mazzucchelli, A. Kappeler, and C. Mueller. 1998. Activated CD4+ and CD8+ cytotoxic cells are present in increased numbers in the intestinal mucosa from patients with active inflammatory bowel disease. Am. J. Palhol. 152:261-268.
36. 36. Truica, C. I., C. H. Hansen, D. F. Garvin, and K. R. Meehan. 1998. Idiopathic giant cell myocarditis after autologous hematopoietic stem cell transplantation and interleukin-2 immunotherapy: a case report. Cancer 83:1231-1236.
37. 37. Rafi, A. Q., A. Zeytun, M. J. Bradley, D. P. Sponenberg, R. L. Grayson, M. Nagarkatti, and P. S. Nagarkatti. 1998. Evidence for the involvement of Fas ligand and perforin in the induction of vascular leak syndrome. J. Immunol. 161:3077-3086.
38. 38. Peng, S. L., J. Moslehi, M. E. Robert, and J. Craft. 1998. Perforin protects against autoimmunity in lupus-prone mice. J. Immunol 160: 652-660.