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Volumn 173, Issue 12, 2006, Pages 1348-1355

Oral decontamination with chlorhexidine reduces the incidence of ventilator-associated pneumonia

Author keywords

Chlorhexidine; Prevention; Ventilator associated pneumonia

Indexed keywords

CHLORHEXIDINE; COLISTIN; PLACEBO;

EID: 33745132106     PISSN: 1073449X     EISSN: 1073449X     Source Type: Journal    
DOI: 10.1164/rccm.200505-820OC     Document Type: Article
Times cited : (332)

References (51)
  • 1
    • 0033023730 scopus 로고    scopus 로고
    • Nosocomial infections in medical intensive care units in the United States
    • National Nosocomial Infections Surveillance System
    • Richards MJ, Edwards JR, Culver DH, Gaynes RP. Nosocomial infections in medical intensive care units in the United States. National Nosocomial Infections Surveillance System. Crit Care Med 1999;27:887-892.
    • (1999) Crit Care Med , vol.27 , pp. 887-892
    • Richards, M.J.1    Edwards, J.R.2    Culver, D.H.3    Gaynes, R.P.4
  • 2
    • 0029148091 scopus 로고
    • The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) study
    • EPIC International Advisory Committee
    • Vincent JL, Bihari DJ, Suter PM, Bruining HA, White J, Nicolas-Chanoin MH, Wolff M, Spencer RC, Hemmer M. The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) study. EPIC International Advisory Committee. JAMA 1995;274:639-644.
    • (1995) JAMA , vol.274 , pp. 639-644
    • Vincent, J.L.1    Bihari, D.J.2    Suter, P.M.3    Bruining, H.A.4    White, J.5    Nicolas-Chanoin, M.H.6    Wolff, M.7    Spencer, R.C.8    Hemmer, M.9
  • 5
    • 0032939662 scopus 로고    scopus 로고
    • The attributable morbidity and mortality of ventilator-associated pneumonia in the critically ill patient
    • The Canadian Critical Trials Group
    • Heyland DK, Cook DJ, Griffith L, Keenan SP, Brun-Buisson C. The attributable morbidity and mortality of ventilator-associated pneumonia in the critically ill patient. The Canadian Critical Trials Group. Am J Respir Crit Care Med 1999;159:1249-1256.
    • (1999) Am J Respir Crit Care Med , vol.159 , pp. 1249-1256
    • Heyland, D.K.1    Cook, D.J.2    Griffith, L.3    Keenan, S.P.4    Brun-Buisson, C.5
  • 6
  • 7
  • 8
    • 0015429633 scopus 로고
    • Nosocomial respiratory infections with Gram-negative bacilli: The significance of colonization of the respiratory tract
    • Johanson WG Jr, Pierce AK, Sanford JP, Thomas GD. Nosocomial respiratory infections with Gram-negative bacilli: the significance of colonization of the respiratory tract. Ann Intern Med 1972;77:701-706.
    • (1972) Ann Intern Med , vol.77 , pp. 701-706
    • Johanson Jr., W.G.1    Pierce, A.K.2    Sanford, J.P.3    Thomas, G.D.4
  • 9
    • 0014685840 scopus 로고
    • Changing pharyngeal bacterial flora of hospitalized patients: Emergence of gram-negative bacilli
    • Johanson WG Jr, Pierce AK, Sanford JP. Changing pharyngeal bacterial flora of hospitalized patients: emergence of gram-negative bacilli. N Engl J Med 1969;281:1137-1140.
    • (1969) N Engl J Med , vol.281 , pp. 1137-1140
    • Johanson Jr., W.G.1    Pierce, A.K.2    Sanford, J.P.3
  • 10
    • 0031019793 scopus 로고    scopus 로고
    • Role of colonization of the upper intestinal tract in the pathogenesis of ventilator-associated pneumonia
    • Bonten MJM, Gaillard CA, de Leeuw PW, Stobberingh EE. Role of colonization of the upper intestinal tract in the pathogenesis of ventilator-associated pneumonia. Clin Infect Dis 1997;24:309-319.
    • (1997) Clin Infect Dis , vol.24 , pp. 309-319
    • Bonten, M.J.M.1    Gaillard, C.A.2    De Leeuw, P.W.3    Stobberingh, E.E.4
  • 11
    • 0025863441 scopus 로고
    • Oropharyngeal decontamination decreases incidence of ventilator- associated pneumonia: A randomized, placebo-controlled, double-blind clinical trial
    • Pugin J, Auckenthaler R, Lew DP, Suter PM. Oropharyngeal decontamination decreases incidence of ventilator-associated pneumonia: a randomized, placebo-controlled, double-blind clinical trial. JAMA 1991;265:2704-2710.
    • (1991) JAMA , vol.265 , pp. 2704-2710
    • Pugin, J.1    Auckenthaler, R.2    Lew, D.P.3    Suter, P.M.4
  • 13
    • 1642525257 scopus 로고    scopus 로고
    • Guidelines for preventing health-care-associated pneumonia, 2003: Recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee
    • Tablan OC, Anderson LJ, Besser R, Bridges C, Hajjeh R. Guidelines for preventing health-care-associated pneumonia, 2003: recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee. MMWR Recomm Rep 2004;53:1-36.
    • (2004) MMWR Recomm Rep , vol.53 , pp. 1-36
    • Tablan, O.C.1    Anderson, L.J.2    Besser, R.3    Bridges, C.4    Hajjeh, R.5
  • 14
    • 84984471593 scopus 로고
    • Susceptibility of various microorganisms to chlorhexidine
    • Emilson CG. Susceptibility of various microorganisms to chlorhexidine. Scand J Dent Res 1977;85:255-265.
    • (1977) Scand J Dent Res , vol.85 , pp. 255-265
    • Emilson, C.G.1
  • 15
    • 0023191920 scopus 로고
    • Comparative susceptibility of hospital isolates of gram-negative bacteria to antiseptics and disinfectants
    • Hammond SA, Morgan JR, Russell AD. Comparative susceptibility of hospital isolates of gram-negative bacteria to antiseptics and disinfectants. J Hosp Infect 1987;9:255-264.
    • (1987) J Hosp Infect , vol.9 , pp. 255-264
    • Hammond, S.A.1    Morgan, J.R.2    Russell, A.D.3
  • 16
    • 0035129138 scopus 로고    scopus 로고
    • Nebulizer choice for inhaled colistin treatment in cystic fibrosis
    • Katz SL, Ho SL, Coates AL. Nebulizer choice for inhaled colistin treatment in cystic fibrosis. Chest 2001;119:250-255.
    • (2001) Chest , vol.119 , pp. 250-255
    • Katz, S.L.1    Ho, S.L.2    Coates, A.L.3
  • 17
    • 0023265976 scopus 로고
    • Colistin inhalation therapy in cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection
    • Jensen T, Pedersen SS, Garne S, Heilmann C, Hoiby N, Koch C. Colistin inhalation therapy in cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection. J Antimicrob Chemother 1987;19:831-838.
    • (1987) J Antimicrob Chemother , vol.19 , pp. 831-838
    • Jensen, T.1    Pedersen, S.S.2    Garne, S.3    Heilmann, C.4    Hoiby, N.5    Koch, C.6
  • 19
    • 0029931655 scopus 로고    scopus 로고
    • Chlorhexidne gluconate 0.12% oral rinse reduces the incidence of total nosocomial respiratory infection and nonprophylactic systemic antibiotic use in patients undergoing heart surgery
    • DeRiso AJ, Ladowski JS, Dillon TA, Justice JW, Peterson AC. Chlorhexidne gluconate 0.12% oral rinse reduces the incidence of total nosocomial respiratory infection and nonprophylactic systemic antibiotic use in patients undergoing heart surgery. Chest 1996;109:1556-1561.
    • (1996) Chest , vol.109 , pp. 1556-1561
    • DeRiso, A.J.1    Ladowski, J.S.2    Dillon, T.A.3    Justice, J.W.4    Peterson, A.C.5
  • 20
    • 0031058053 scopus 로고    scopus 로고
    • Reproducibility of quantitative cultures of endotracheal aspirates from mechanically ventilated patients
    • Bergmans DCJJ, Bonten MJM, de Leeuw PW, Stobberingh EE. Reproducibility of quantitative cultures of endotracheal aspirates from mechanically ventilated patients. J Clin Microbiol 1997;35:796-798.
    • (1997) J Clin Microbiol , vol.35 , pp. 796-798
    • Bergmans, D.C.J.J.1    Bonten, M.J.M.2    De Leeuw, P.W.3    Stobberingh, E.E.4
  • 22
    • 0025809112 scopus 로고
    • Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchoscopic "blind" bronchoalveolar lavage fluid
    • Pugin J, Auckenthaler R, Mili N, Janssens JP, Lew PD, Suter PM. Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchoscopic "blind" bronchoalveolar lavage fluid. Am Rev Respir Dis 1991;143:1121-1129.
    • (1991) Am Rev Respir Dis , vol.143 , pp. 1121-1129
    • Pugin, J.1    Auckenthaler, R.2    Mili, N.3    Janssens, J.P.4    Lew, P.D.5    Suter, P.M.6
  • 23
    • 0020399170 scopus 로고
    • Tables of the number of patients required in clinical trials using the logrank test
    • Freedman LS. Tables of the number of patients required in clinical trials using the logrank test. Stat Med 1982;1:121-129.
    • (1982) Stat Med , vol.1 , pp. 121-129
    • Freedman, L.S.1
  • 25
    • 0004009706 scopus 로고    scopus 로고
    • Reading, UK: The University of Reading
    • MPS Research Unit. PEST 4: operating manual. Reading, UK: The University of Reading; 2000.
    • (2000) PEST 4: Operating Manual
  • 27
    • 0030719853 scopus 로고    scopus 로고
    • Oropharyngeal or gastric colonization and nosocomial pneumonia in adult intensive care unit patients: A prospective study based on genomic DNA analysis
    • Garrouste-Org M, Chevret S, Arlet G, Marie O, Rouveau M, Popoff N, Schlemmer B. Oropharyngeal or gastric colonization and nosocomial pneumonia in adult intensive care unit patients: a prospective study based on genomic DNA analysis. Am J Respir Crit Care Med 1997;156:1647-1655.
    • (1997) Am J Respir Crit Care Med , vol.156 , pp. 1647-1655
    • Garrouste-Org, M.1    Chevret, S.2    Arlet, G.3    Marie, O.4    Rouveau, M.5    Popoff, N.6    Schlemmer, B.7
  • 28
    • 0033848058 scopus 로고    scopus 로고
    • Impact of quantitative invasive diagnostic techniques in the management and outcome of mechancally ventilated patients with suspected pneumonia
    • Violán JS, Fernández JA, Bordes-Benítez A, Cardenosa-Cendrero JA, de Castro FR. Impact of quantitative invasive diagnostic techniques in the management and outcome of mechancally ventilated patients with suspected pneumonia. Crit Care Med 2000;28:2737-2741.
    • (2000) Crit Care Med , vol.28 , pp. 2737-2741
    • Violán, J.S.1    Fernández, J.A.2    Bordes-Benítez, A.3    Cardenosa-Cendrero, J.A.4    De Castro, F.R.5
  • 29
    • 0027741166 scopus 로고
    • Antibacterial activity of chlorhexidine
    • Russell AD, Day MJ. Antibacterial activity of chlorhexidine. J Hosp Infect 1993;25:229-238.
    • (1993) J Hosp Infect , vol.25 , pp. 229-238
    • Russell, A.D.1    Day, M.J.2
  • 30
    • 3843109382 scopus 로고    scopus 로고
    • Use of parenteral colistin for the treatment of serious infection due to antimicrobial-resistant Pseudomonas aeruginosa
    • Linden PK, Kusne S, Coley K, Fontes P, Kramer DJ, Paterson D. Use of parenteral colistin for the treatment of serious infection due to antimicrobial-resistant Pseudomonas aeruginosa. Clin Infect Dis 2003;37:e154-e160.
    • (2003) Clin Infect Dis , vol.37
    • Linden, P.K.1    Kusne, S.2    Coley, K.3    Fontes, P.4    Kramer, D.J.5    Paterson, D.6
  • 31
    • 0036789297 scopus 로고    scopus 로고
    • Colistin: An antimicrobial for the 21st century?
    • Stein A, Raoult D. Colistin: an antimicrobial for the 21st century? Clin Infect Dis 2002;35:901-902.
    • (2002) Clin Infect Dis , vol.35 , pp. 901-902
    • Stein, A.1    Raoult, D.2
  • 32
    • 0032939527 scopus 로고    scopus 로고
    • Intravenous colistin as therapy for nosocomial infections caused by multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii
    • Levin AS, Barone AA, Penco J, Santos MV, Marinho IS, Arruda EA, Manrique EI, Costa SF. Intravenous colistin as therapy for nosocomial infections caused by multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii. Clin Infect Dis 1999;28:1008-1011.
    • (1999) Clin Infect Dis , vol.28 , pp. 1008-1011
    • Levin, A.S.1    Barone, A.A.2    Penco, J.3    Santos, M.V.4    Marinho, I.S.5    Arruda, E.A.6    Manrique, E.I.7    Costa, S.F.8
  • 34
    • 0036834162 scopus 로고    scopus 로고
    • Effectiveness of 0.12% chlorhexidine gluconate oral rinse in reducing prevalence of nosocomial pneumonia in patients undergoing heart surgery
    • Houston S, Hougland P, Anderson JJ, LaRocco M, Kennedy V, Gentry LO. Effectiveness of 0.12% chlorhexidine gluconate oral rinse in reducing prevalence of nosocomial pneumonia in patients undergoing heart surgery. Am J Crit Care 2002;11:567-570.
    • (2002) Am J Crit Care , vol.11 , pp. 567-570
    • Houston, S.1    Hougland, P.2    Anderson, J.J.3    LaRocco, M.4    Kennedy, V.5    Gentry, L.O.6
  • 35
    • 23844508830 scopus 로고    scopus 로고
    • Effect of gingival and dental plaque antiseptic decontamination on nosocomial infections acquired in the intensive care unit: A double-blind placebo-controlled multicenter study
    • Fourrier F, Dubois D, Pronnier P, Herbecq P, Leroy O, Desmettre T, Pottier-Cau E, Boutigny H, Di Pompeo C, Durocher A, et al.; PIRAD Study Group. Effect of gingival and dental plaque antiseptic decontamination on nosocomial infections acquired in the intensive care unit: a double-blind placebo-controlled multicenter study. Crit Care Med 2005;33:1728-1735.
    • (2005) Crit Care Med , vol.33 , pp. 1728-1735
    • Fourrier, F.1    Dubois, D.2    Pronnier, P.3    Herbecq, P.4    Leroy, O.5    Desmettre, T.6    Pottier-Cau, E.7    Boutigny, H.8    Di Pompeo, C.9    Durocher, A.10
  • 36
    • 0037453115 scopus 로고    scopus 로고
    • Prevention of ventilator-associated pneumonia: An evidence-based systematic review
    • Collard HR, Saint S, Matthay MA. Prevention of ventilator-associated pneumonia: an evidence-based systematic review. Ann Intern Med 2003;138:494-501.
    • (2003) Ann Intern Med , vol.138 , pp. 494-501
    • Collard, H.R.1    Saint, S.2    Matthay, M.A.3
  • 38
    • 0035908622 scopus 로고    scopus 로고
    • Relationship between methodological trial quality and the effects of selective digestive decontamination on pneumonia and mortality in critically ill patients
    • van Nieuwenhoven CA, Buskens E, van Tiel FH, Bonten MJM. Relationship between methodological trial quality and the effects of selective digestive decontamination on pneumonia and mortality in critically ill patients. JAMA 2001;286:335-340.
    • (2001) JAMA , vol.286 , pp. 335-340
    • Van Nieuwenhoven, C.A.1    Buskens, E.2    Van Tiel, F.H.3    Bonten, M.J.M.4
  • 39
    • 0141537234 scopus 로고    scopus 로고
    • Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: A randomised controlled trial
    • de Jonge E, Schultz MJ, Spanjaard L, Bossuyt PM, Vroom MB, Dankert J, Kesecioglu J. Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial. Lancet 2003;362:1011-1016.
    • (2003) Lancet , vol.362 , pp. 1011-1016
    • Jonge, E.1    Schultz, M.J.2    Spanjaard, L.3    Bossuyt, P.M.4    Vroom, M.B.5    Dankert, J.6    Kesecioglu, J.7
  • 40
    • 1542673037 scopus 로고    scopus 로고
    • Selective decontamination of digestive tract in intensive care
    • Verbrugh A. Selective decontamination of digestive tract in intensive care. Lancet 2003;362:2117-2118.
    • (2003) Lancet , vol.362 , pp. 2117-2118
    • Verbrugh, A.1
  • 41
    • 1542673037 scopus 로고    scopus 로고
    • Selective decontamination of digestive tract in intensive care
    • Kim SW, Kami M, Kobayashi K, Takaue Y, Honda O. Selective decontamination of digestive tract in intensive care. Lancet 2003;362:2118-2120.
    • (2003) Lancet , vol.362 , pp. 2118-2120
    • Kim, S.W.1    Kami, M.2    Kobayashi, K.3    Takaue, Y.4    Honda, O.5
  • 42
    • 1542673037 scopus 로고    scopus 로고
    • Selective decontamination of digestive tract in intensive care
    • Bonten MJ, Kluytmans J, de Smet AM, Bootsma M, Hoes A. Selective decontamination of digestive tract in intensive care. Lancet 2003;362:2118-2119.
    • (2003) Lancet , vol.362 , pp. 2118-2119
    • Bonten, M.J.1    Kluytmans, J.2    De Smet, A.M.3    Bootsma, M.4    Hoes, A.5
  • 43
    • 0026955324 scopus 로고
    • Patient selection for clinical investigation of ventilator-associated pneumonia: Criteria for evaluating diagnostic techniques
    • Pingleton SK, Fagon JY, Leeper KV. Patient selection for clinical investigation of ventilator-associated pneumonia: criteria for evaluating diagnostic techniques. Chest 1992;102:553S-556S.
    • (1992) Chest , vol.102
    • Pingleton, S.K.1    Fagon, J.Y.2    Leeper, K.V.3
  • 44
    • 0025773337 scopus 로고
    • Antibiotic levels in bronchialtree and serum during selective digestive decontamination
    • Gastinne H, Wolff M, Lachatre G, Boiteau P, Savy FP. Antibiotic levels in bronchialtree and serum during selective digestive decontamination. Intensive Care Med 1991;17:215-218.
    • (1991) Intensive Care Med , vol.17 , pp. 215-218
    • Gastinne, H.1    Wolff, M.2    Lachatre, G.3    Boiteau, P.4    Savy, F.P.5
  • 45
  • 46
    • 0027466159 scopus 로고
    • Nosocomial pneumonia in ventilated patients: A cohort study evaluating attributal mortality and hospital stay
    • Fagon JY, Chastre J, Hance AJ, Montravers P, Novara A, Gibert C. Nosocomial pneumonia in ventilated patients: a cohort study evaluating attributal mortality and hospital stay. Am J Med 1993;94:281-288.
    • (1993) Am J Med , vol.94 , pp. 281-288
    • Fagon, J.Y.1    Chastre, J.2    Hance, A.J.3    Montravers, P.4    Novara, A.5    Gibert, C.6
  • 47
    • 0031028968 scopus 로고    scopus 로고
    • Relationship of microbiologic diagnostic criteria to morbidity and mortality in patients with ventilator-associated pneumonia
    • Bregeon F, Papazian L, Visconti A, Gregoire R, Thirion X, Gouin F. Relationship of microbiologic diagnostic criteria to morbidity and mortality in patients with ventilator-associated pneumonia. JAMA 1997;277:655-662.
    • (1997) JAMA , vol.277 , pp. 655-662
    • Bregeon, F.1    Papazian, L.2    Visconti, A.3    Gregoire, R.4    Thirion, X.5    Gouin, F.6
  • 50
    • 0034457796 scopus 로고    scopus 로고
    • Inadequate antimicrobial treatment: An important determinant of outcome for hospitalized patients
    • Kollef MH, Ward S. Inadequate antimicrobial treatment: an important determinant of outcome for hospitalized patients. Clin Infect Dis 2000;31:S131-S138.
    • (2000) Clin Infect Dis , vol.31
    • Kollef, M.H.1    Ward, S.2
  • 51
    • 0742302609 scopus 로고    scopus 로고
    • Effectiveness of topical chlorhexidine powder as an alternative to hexachlorophane for the control of Staphylococcus aureus in neonates
    • Wilcox MH, Hall J, Gill AB, Fawley WN, Parnell P, Verity P. Effectiveness of topical chlorhexidine powder as an alternative to hexachlorophane for the control of Staphylococcus aureus in neonates. J Hosp Infect 2004;56:156-159.
    • (2004) J Hosp Infect , vol.56 , pp. 156-159
    • Wilcox, M.H.1    Hall, J.2    Gill, A.B.3    Fawley, W.N.4    Parnell, P.5    Verity, P.6


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