Absence of in vivo genotoxic potential and tumor initiation activity of kojic acid in the rat thyroid

Toxicology

Volumn 222, Issue 3, 2006, Pages 213-224

  Tamura, Toru ^a   Mitsumori, Kunitoshi ^a,b   Totsuka, Yukari ^c   Wakabayashi, Keiji ^c   Kido, Rie ^d   Kasai, Hiroshi ^d   Nasu, Masahiro ^e   Hirose, Masao ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b Faculty of Agriculture   (Japan)

^c NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^d UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^e Panapharm Laboratories Co Ltd   (Japan)

Author keywords

Genotoxicity; Initiation activity; Kojic acid; Rat; Thyroid tumorigenesis

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; BIS(2 HYDROXYPROPYL)NITROSAMINE; DRINKING WATER; KOJIC ACID; PHOSPHORUS 32; SULFADIMETHOXINE; TUMOR PROMOTER; 8-HYDROXY-2'-DEOXYGUANOSINE; CARCINOGEN; DEOXYGUANOSINE; DRUG DERIVATIVE; PYRONE DERIVATIVE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; CONVALESCENCE; DIETARY INTAKE; DNA ADDUCT; ELECTROCHEMICAL DETECTION; GENOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; THYROID CARCINOMA; THYROID FOLLICLE CELL; THYROID HYPERPLASIA; ADENOMA; ANIMAL; CARCINOMA; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; FISCHER 344 RAT; HYPERPLASIA; METABOLISM; PATHOLOGY; THYROID GLAND; THYROID TUMOR;

ADENOMA; ANIMALS; CARCINOGENS; CARCINOMA; DEOXYGUANOSINE; DNA ADDUCTS; HYPERPLASIA; MALE; PYRONES; RATS; RATS, INBRED F344; THYROID GLAND; THYROID NEOPLASMS;

EID: 33745095974     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2006.02.023     Document Type: Article

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