Structure-based optimization of MurF inhibitors

Chemical Biology and Drug Design

Volumn 67, Issue 1, 2006, Pages 58-65

  Stamper, Geoffrey F ^a   Longenecker, Kenton L ^a   Fry, Elizabeth H ^a   Jakob, Clarissa G ^a   Florjancic, Alan S ^a   Gu, Yu Gui ^a   Anderson, David D ^a   Cooper, Curt S ^a   Zhang, Tianyuan ^a   Clark, Richard F ^a   Cia, Yingna ^a   Black Schaefer, Candace L ^a   McCall, J Owen ^a   Lerner, Claude G ^a   Hajduk, Philip J ^a   Beutel, Bruce A ^a   Stoll, Vincent S ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

MurF; Structure based lead optimization

Indexed keywords

BACTERIAL ENZYME; DEXTRO ALANINE DEXTRO ALANINE LIGASE; LIGASE INHIBITOR;

ARTICLE; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG STRUCTURE; MEDICAL INFORMATION; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PEPTIDE SYNTHASES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; SULFONAMIDES;

BACTERIA (MICROORGANISMS); STREPTOCOCCUS PNEUMONIAE;

EID: 33745068955     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2005.00317.x     Document Type: Article

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