SOS-NMR: A Saturation Transfer NMR-Based Method for Determining the Structures of Protein-Ligand Complexes

Journal of the American Chemical Society

Volumn 126, Issue 8, 2004, Pages 2390-2398

  Hajduk, Philip J ^a   Mack, Jamey C ^a   Olejniczak, Edward T ^a   Park, Chang ^a   Dandliker, Peter J ^a   Beutel, Bruce A ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; COMPLEXATION; COMPOSITION; DRUG DOSAGE; NUCLEAR MAGNETIC RESONANCE; OLIGOMERS; RESONANCE; X RAY CRYSTALLOGRAPHY;

LIGANDS; SATURATION TRANSFER;

PROTEINS;

2 (3' PYRIDYL)BENZIMIDAZOLE; BENZIMIDAZOLE DERIVATIVE; FK 506 BINDING PROTEIN; LIGAND; PROTEIN DERIVATIVE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE;

AMINO ACID COMPOSITION; ARTICLE; COMPLEX FORMATION; LIGAND BINDING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PROTEIN BINDING; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ALKYL AND ARYL TRANSFERASES; BENZIMIDAZOLES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; TACROLIMUS BINDING PROTEINS; THERMODYNAMICS; URIDINE DIPHOSPHATE N-ACETYLGLUCOSAMINE;

EID: 1542366711     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja039480v     Document Type: Article

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