The emergence of molecular gynecology: Homeobox and Wnt genes in the female reproductive tract

BioEssays

Volumn 22, Issue 10, 2000, Pages 902-910

  Kitajewski, Jan ^a   Sassoon, David ^b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; MURINAE;

EID: 0033780112     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-1878(200010)22:10<902::aid-bies5>3.0.co;2-%23     Document Type: Review

References (90)

1. F. Epstein-Barr virus in normal, pre-malignant, and malignant lesions of the uterine cervix
2. Diethylstilbestrol-induced immortalization of human endometrial cells: Alterations in p53 and estrogen receptor
3. Treatment of tall girls with estrogen
4. Estrogen treatment of adolescent tall girls; short term side effects
5. The germ layer origin of mouse vaginal epithelium restricts its responsiveness to mesencnymal inductors: Uterine induction
6. Stromal induction and specification of morphogenesis and cytodifferentiation of the epithelia of the Mullerian ducts and urogenital sinus during development of the uterus and vagina in mice
7. Epithelial-stromal interactions in development of the urogenital tract
8. Developmental response of adult mammary epithelial cells to various fetal and neonatal mesenchymes
9. Msx1 (Hox-7.1) in the adult mouse uterus: Cellular interactions underlying regulation of expression
10. Estrogen stimulation of deoxyribonucleic acid synthesis in uterine epithelial cells which lack estrogen receptors
11. Differential expression patterns of Wnt genes in the murine female reproductive tract during development and the estrous cycle
12. Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene
13. Stromal estrogen receptors mediate mitogenic effects of estradiol on uterine epithelium
14. Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities
15. Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene
16. Sexually dimorphic sterility phenotypes in Hoxa 10-deficient mice
17. Hoxa-11 structure, extensive antisense transcription, and function in male and female fertility
18. The molecular basis of hypodactyly (Hd): A deletion in Hoxa 13 leads to arrest of digital arch formation
19. HOX-4 genes and the morphogenesis of mammalian genitalia
20. Human HOX4E: A gene strongly expressed in the adult male and female urogenital tracts
21. Expression of the murine homeobox-containing gene Hox-2.3 suggests multiple time-dependent and tissue-specific roles during development
22. A conserved Hox axis in the mouse and human female reproductive system: Late establishment and persistent adult expression of the Hoxa cluster genes
23. Mechanisms of reduced fertility in Hoxa-10 mutant mice: Uterine homeosis and loss of maternal Hoxa-10 expression
24. HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium
25. Abdominal B (AbdB) hoxa genes: Regulation in adult uterus by estrogen and progesterone and repression in mullerian duct by the synthetic estrogen Diethylstilbestrol (DES)
26. Abnormal uterine stromal and glandular function associated with maternal reproductive defects in hoxa-11 null mice
27. Uterine expression of leukemia inhibitory factor coincides with the onset of blastocyst implantation
28. Blastocyst implantation depends on maternal expression of leukemia inhibitory factor
29. Mutation of HOXA13 in hand-foot-genital syndrome
30. Gene dosage-dependent effects of the hoxa-13 and hoxd-13 mutations on morphogenesis of the terminal parts of the digestive and urogenital tracts
31. Disruption of the hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs
32. WNTs modulate cell fate and behavior during vertebrate development
33. Wnt signaling: A common theme in animal development
34. Wnt genes
35. WNT targets. Repression and activation
36. From cortical rotation to organizer gene expression: Toward a molecular explanation of axis specification in Xenopus
37. Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds
38. Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development
39. Differential regulation of the Wnt gene family during pregnancy and lactation suggests a role in postnatal development of the mammary gland
40. Developmental and hormonal regulation of Wnt gene expression in the mouse mammary gland
41. Wnt-1 induces growth, cytosolic β-catenin, and Tcf/Lef transcriptional activation in rat-1 fibroblasts
42. The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells
43. Notch4 and Wnt-1 proteins function to regulate branching morphogenesis of mammary epithelial cells in opposing fashion
44. Control of neural crest cell fate by the Wnt signalling pathway
45. Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4
46. Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb
47. Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice
48. Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in mate and female mice
49. Signal transduction by the Wnt family of ligands
50. Wnt signalling: Pathway or network?
51. Regulation of LEF-1/TCF transcription factors by Wnt and other signals
52. Wnt signaling: Why is everything so negative?
53. Transformation by Wnt family proteins correlates with regulation of β-catenin
54. Down-regulation of beta-catenin by human Axin and its association with the APC Tumor suppressor, beta-catenin and GSK3 beta
55. Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin
56. Lessons from hereditary colorectal cancer
57. The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation in mammals and amphibians
58. Molecular cloning and expression of glycogen synthase kinase-3/factor A
59. Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1
60. The axis-inducing activity, stability, and subcellular distribution of β-catenin is regulated in Xenopus embryos by glycogen synthase kinase
61. Casein kinase I transduces Wnt signals
62. Modulation of transcriptional regulation By LEF-1 in response to Wnt-1 signaling and association with beta-catenin
63. Identification of c-MYC as a target of the APC pathway
64. Transcriptional activation of cyclooxygenase-2 in Wnt-1-transformed mouse mammary epithelial cells
65. The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors
66. 2+ pathways
67. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
68. Stabilization of beta-catenin by genetic defects in melanoma cell lines
69. Beta-catenin mutation in carcinoma of the uterine endometrium
70. Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice
71. Mode of proviral activaton of a putative mammary oncogene (int-1) on mouse chromosome 15
72. A new nomenclature for int-1 and related genes: The Wnt gene family
73. A human breast cancer cell line with an APC mutation and elevated β-catenin
74. Nuclear localization of beta-catenin in normal and carcinogenic endometrium
75. Wnt-7a maintains appropriate uterine patterning during the development of the mouse female reproductive tract
76. Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a
77. Interaction between the signaling molecules WNT7a and SHH during vertebrate limb development: Dorsal signals regulate anterior-posterior pattening
78. Vaginal adenosis and other diethylstilbestrol-related abnormalities
79. Upper genital tract changes associated with exposure in utero to diethylstilbestrol
80. Diethylstilbestrol-induced upper genital tract abnormalities
81. Follow-up study of male and female offspring of DES-exposed mothers
82. Upper genital tract changes and pregnancy outcome in offspring exposed in utero to diethylstilbestrol
83. Long-term effects on the female mouse genital tract associated with prenatal exposure to Diethylstilbestrol
84. Development of vaginal adenosis-like lesions and uterine epithelial stratification in mice exposed perinatally to Diethylstilbestrol
85. The estrous cycle in the mouse
86. Fetal exposure to DES results in de-regulation of Wnt-7a during a critical period of uterine morphogenesis
87. Epithelial-mesenchymal interactions in uterus and vagina alter the expression of the cell surface proteoglycan, syndecan
88. Vaginal and uterine stroma maintain their inductive properties following primary culture
89. Restoration of normal morphology and estrogen responsiveness in cultured vaginal and uterine epithelia transplanted with stroma