In vitro and direct in vivo testing of mixture-based combinatorial libraries for the identification of highly active and specific opiate ligands

AAPS Journal

Volumn 8, Issue 2, 2006, Pages

  Houghten, Richard A ^a   Dooley, Colette T ^a   Appel, Jon R ^a  

^a TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

Author keywords

Mixtures; Opioid receptor in vivo screening; Peptides; Peptidomimetics; Positional scanning libraries

Indexed keywords

AMINO ACID; DELTA OPIATE RECEPTOR; DELTA OPIATE RECEPTOR AGONIST; DERMORPHIN DERIVATIVE; DEXTRO AMINO ACID; DIPEPTIDE; GUANIDINE DERIVATIVE; KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR AGONIST; KAPPA OPIATE RECEPTOR ANTAGONIST; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; MU OPIATE RECEPTOR ANTAGONIST; NOCICEPTIN RECEPTOR; NOCICEPTIN RECEPTOR AGONIST; OPIATE; OPIATE AGONIST; OPIATE RECEPTOR; PEPTIDE LIBRARY; PEPTOID; POLYAMINE; SIGMA OPIATE RECEPTOR; TPI 27 12; TPI 418 1; TPI 419 19; TPI 452 19; TPI 614 1; TPI GH 137; UNCLASSIFIED DRUG; UNINDEXED DRUG; UREA;

ANTINOCICEPTION; BINDING AFFINITY; COMBINATORIAL LIBRARY; DRUG ABUSE; DRUG DETERMINATION; FLUORESCENCE ANALYSIS; GUINEA PIG; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PHARMACOPHORE; RECEPTOR BINDING; REVIEW; STRUCTURE ACTIVITY RELATION;

AMINO ACIDS; COMBINATORIAL CHEMISTRY TECHNIQUES; LIGANDS; NARCOTICS; PEPTIDES; RECEPTORS, OPIOID;

EID: 33744946826     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/aapsj080242     Document Type: Review

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