Solid phase synthesis of 1,3,4,7-tetrasubstituted perhydro- 1,4- diazepine-2,5-diones

Tetrahedron Letters

Volumn 38, Issue 28, 1997, Pages 4943-4946

  Nefzi, Adel ^a   Ostresh, John M ^a   Houghten, Richard A ^a  

^a TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIAZEPINE DERIVATIVE;

ALKYLATION; ARTICLE; MASS SPECTROMETRY; REACTION ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLID; SYNTHESIS;

EID: 0030765141     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)01086-1     Document Type: Article

References (11)

1. For a review, see a) Sardina, F. M.; Rapoport, H. Chem. Rev. 1996, 96, 1825.
2. b) Nefzi, A.; Ostresh, J. M.; Houghten, R. A. Chem. Rev. 1997, 97, 449.
3. Barany, G.; Merrifield, R.B. In The Peptides: Analysis, Synthesis, Biology, Vol. 2, Gross, E.; Meienhofer, J. Eds.; Academic Press, New York, 1979, pp. 1-284.
4. Nefzi, A.; Ostresh, J. M.; Meyer, J-P.; Houghten, R. A. Tetrahedron Lett. 1996, 38, 931.
5. Ho, P. T.; Ngu k.-Y. J. Org. Chem. 1993, 58, 2313.
6. Krchňàk, V.; Weichsel, A. S.; Cabel, D.; Lebl, M. In Molecular Diversity and Combinatorial Chemistry: Libraries and Drug Discovery, Chaiken, I. M.; Janda, K. D. Eds.; American Chemical Society, Washington, DC, 1996; pp. 99-117.
7. Carpino, L. A.; El-Faham, A.; Minor, C. A.; Albericio, F. J. Chem. Soc., Chem. Commun. 1994, 201.
8. Ostresh, J. M.; Winkle, J. H.; Hamashin, V. T.; Houghten, R. A. Biopolymers. 1994, 34, 1681.
9. Houghten, R. A. Proc Nat Acad Sci. USA. 1985, 82, 5131.
10. Houghten, R. A.; Bray, M. K.; DeGraw, S. T.; Kirby, C. J. Int. J. Pep. Prot. Res. 1986, 27, 673.
11. 1H-NMR and LCQ-MS.