Solid phase synthesis of heterocyclic compounds from linear peptides: Cyclic ureas and thioureas

Tetrahedron Letters

Volumn 38, Issue 6, 1997, Pages 931-934

  Nefzi, Adel ^a   Ostresh, John M ^a   Meyer, Jean Philippe ^a   Houghten, Richard A ^a  

^a TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HETEROCYCLIC COMPOUND; PEPTIDE DERIVATIVE; THIOUREA DERIVATIVE; UREA DERIVATIVE;

ARTICLE; CHIRALITY; CYCLIZATION; DIASTEREOISOMER; DRUG SYNTHESIS; IN VITRO STUDY; MASS SPECTROMETRY; METHODOLOGY; REACTION ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 0031562077     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(96)02516-6     Document Type: Article

References (13)

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7. (b) Ostresh, J.M.; Hamashin, V.T.; Husar, G.M.; Dörner, B; Houghten, R.A. In Peptides 1994, Proceedings of the 23rd European Peptide Symposium, Maia, H.L.S. Ed.; ESCOM, Leiden, 1995; pp. 416-417.
8. 3 also included β-Ala, and the D-and L-forms of Glu(tBu) and Trp(Boc).
9. 6. Houghten, R.A.; Pinilla, C.; Blondelle, S.E.; Appel, J.R.; Dooley, C.T.; Cuervo, J.H. Nature 1991, 354, 84.
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12. 10 the desired product was extracted and lyophilized.
13. 10. Houghten, R.A.; Bray, M.K.; DeGraw, S.T.; Kirby, C.J. Int. J. Pep. Prot. Res. 1986, 27, 673.