Solid phase synthesis of 2,4,5-trisubstituted thiomorpholin-3-ones

Tetrahedron Letters

Volumn 39, Issue 22, 1998, Pages 3671-3674

  Nefzi, Adel ^a   Giulianotti, Marc ^a   Houghten, Richard A ^a  

^a TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHOLINE DERIVATIVE;

ALKYLATION; AMIDATION; ARTICLE; DERIVATIZATION; DRUG SYNTHESIS; NONHUMAN; RECEPTOR BINDING; SOLID PHASE EXTRACTION; THERMODYNAMICS;

EID: 0032575156     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)00645-5     Document Type: Article

References (10)

1. 1. Nefzi, A.; Ostresh, J. M.; Houghten, R. A. Chem. Rev. 1997, 97, 449.
2. 2. Thompson, L. A.; Ellman, J. A. Chem. Rev. 1996, 96, 555.
3. 3. Fruchtel, J. S.; Jung, G. Chem Rev. 1996, 35, 17.
4. 4. Merrifield, R. B. Science. 1986, 232, 341.
5. 5. Ho, P. T.; Chang, D.; Zhong, J. W. X.; Musso, G. F. Pep. Res. 1993, 6, 10.
6. 6. Carpino, L. A.; El-Faham, A.; Minor, C. A.; Albericio, F. J. Chem. Soc.; Chem. Commun. 1994, 201.
7. 10 the desired product 5 was extracted, lyophilized and analyzed.
8. 8. Nefzi, A.; Ostresh, J. M.; Houghten, R. A. Tedrahedron Lett. 1997, 38,4943.
9. 9. Nefzi, A.; Ostresh, J. M.; Meyer, J-P.; Houghten, R. A. Tedrahedron Lett. 1997, 38, 931.
10. 10. Houghten, R. A.; Bray, M. K.; DeGraw, S. T.; Kirby, C. J. Int. J. Pep. Prot. Res. 1986, 27, 673.