Class C Vps protein complex regulates vacuolar SNARE pairing and is required for vesicle docking/fusion

Molecular Cell

Volumn 6, Issue 3, 2000, Pages 661-671

  Sato, Trey K ^a   Rehling, Peter ^a   Peterson, Michael R ^a   Emr, Scott D ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SNARE PROTEIN; SYNAPTOBREVIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; SYNTAXIN; ZINC FINGER PROTEIN;

ARTICLE; BINDING KINETICS; CELL FUSION; CELL VACUOLE; CHROMOSOME PAIRING; GENE MUTATION; GOLGI COMPLEX; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE; YEAST;

SACCHAROMYCES CEREVISIAE;

EID: 0033634646     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)00064-2     Document Type: Article

References (45)

1. A novel Sec18p/NSF-dependent complex required for Golgi-to-endosome transport in yeast
2. Novel pathways, membrane coats and PI kinase regulation in yeast lysosomal trafficking
3. Novel Golgi to vacuole delivery pathway in yeast: Identification of a sorting determinant and required transport component
4. A multispecificity syntaxin homolog, Vam3p, essential for autophagic and biosynthetic protein transport to the vacuole
5. The yeast v-SNARE Vti1p mediates two vesicle transport pathways through interactions with the t-SNAREs Sed5p and Pep12p
6. The Saccharomyces cerevisiae v-SNARE Vti1p is required for multiple membrane transport pathways to the vacuole
7. Tomosyn: A syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process
8. A new beat for the SNARE drum
9. The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis
10. A quantitative assay to measure homotypic vacuole fusion in vitro
11. The GTPase Ypt7p of Saccharomyces cerevisiae is required on both partner vacuoles for the homotypic fusion step of vacuole inheritance
12. The Sec1 family: A novel family of proteins involved in synaptic transmission and general secretion
13. Synaptic vesicle fusion complex contains unc-18 homolog bound to syntaxin
14. The VPS16 gene product associates with a sedimentable protein complex and is essential for vacuolar protein sorting in yeast
15. Membrane fusion and exocytosis
16. Syntaphilin: A syntaxin-1 clamp that controls SNARE assembly
17. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae
18. Sec18p (NSF)-driven release of Sec17p (alpha-SNAP) can precede docking and fusion of yeast vacuoles
19. Docking of yeast vacuoles is catalyzed by the Ras-like GTPase Ypt7p after symmetric priming by Sec18p (NSF)
20. Intracellular membrane fusion: SNAREs only?
21. Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13
22. Complexins: Cytosolic proteins that regulate SNAP receptor function
23. Homotypic vacuolar fusion mediated by t- and v-SNAREs
24. The diversity of Rab proteins in vesicle transport
25. Vac1p coordinates Rab and phosphatidylinositol 3-kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome
26. Transport vesicle docking: SNAREs and associates
27. The docking stage of yeast vacuole fusion requires the transfer of proteins from a cis-SNARE complex to a rab/ypt protein
28. Proteins needed for vesicle budding from the Golgi complex are also required for the docking step of homotypic vacuole fusion
29. Formation of AP-3 transport intermediates requires Vps41 function
30. A novel RING finger protein complex essential for a late step in protein transport to the yeast vacuole
31. TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion
32. Vam7p, a SNAP-25-like molecule, and Vam3p, a syntaxin homolog, function together in yeast vacuolar protein trafficking
33. A role for the deep orange and carnation eye color genes in lysosomal delivery in Drosophila
34. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
35. A novel complex of nucleoporins, which includes Sec13p and a Sec13p homolog, is essential for normal nuclear pores
36. Vam7p, a vacuolar SNAP-25 homolog, is required for SNARE complex integrity and vacuole docking and fusion
37. A vacuolar v-t-SNARE complex, the predominant form in vivo and on isolated vacuoles, is disassembled and activated for docking and fusion
38. Three v-SNAREs and two t-SNAREs, present in a pentameric cis-SNARE complex on isolated vacuoles, are essential for homotypic fusion
39. A cell-free assay allows reconstitution of Vps33p-dependent transport to the yeast vacuole/lysosome
40. Endocytosis in yeast: Evidence for the involvement of a small GTP-binding protein (Ypt7p)
41. ROP, the Drosophila Sec1 homolog, interacts with syntaxin and regulates neurotransmitter release in a dosage-dependent manner
42. Phosphoinositide signaling and turnover: Ptdlns(3)P, a regulator of membrane traffic, is transported to the vacuole and degraded by a process that requires lumenal vacuolar hydrolase activities
43. nSec1 binds a closed conformation of syntaxin1A