Mechanism of a hereditary cataract phenotype: Mutations in αA-crystallin activate substrate binding

Journal of Biological Chemistry

Volumn 281, Issue 20, 2006, Pages 14273-14279

  Koteiche, Hanane A ^a   Mchaourab, Hassane S ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CRYSTALLINE MATERIALS; MATHEMATICAL MODELS; MOLECULAR BIOLOGY; PROTEINS; SUBSTRATES;

CHAPERONE-SUBSTRATE COMPLEX; CRYSTALLIN GENE; HEAT SHOCK; MOLECULAR CHAPERONE;

MUTAGENESIS;

ALPHA CRYSTALLIN; CHAPERONE; HEAT SHOCK PROTEIN 27; LENS PROTEIN; LYSOZYME; MUTANT PROTEIN;

ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; BINDING AFFINITY; BINDING ASSAY; BINDING SITE; CATARACT; GENE MUTATION; GENETIC DISORDER; LENS; METHODOLOGY; MOLECULAR MECHANICS; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN FUNCTION; STEADY STATE; THERMODYNAMICS;

ALPHA-CRYSTALLIN A CHAIN; ANISOTROPY; BACTERIOPHAGE T4; BINDING SITES; CATARACT; HUMANS; KINETICS; LENS, CRYSTALLINE; MOLECULAR CHAPERONES; MURAMIDASE; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN BINDING; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 33744903422     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M512938200     Document Type: Article

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