Lens proteomics: Analysis of rat crystallin sequences and two-dimensional electrophoresis map

Investigative Ophthalmology and Visual Science

Volumn 43, Issue 1, 2002, Pages 216-224

  Lampi, K J ^a   Shih, M ^a   Ueda, Y ^a   Shearer, T R ^a   David, L L ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BETA CRYSTALLIN; COMPLEMENTARY DNA; CRYSTALLIN; PROTEIN; PROTEOME;

AGING; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; CATARACT; DISEASE PREDISPOSITION; DNA SEQUENCE; IMAGE ANALYSIS; LENS; MASS SPECTROMETRY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN POLYMORPHISM; PROTEIN PROCESSING; RAT; SEQUENCE ANALYSIS; SOLUBILITY; TANDEM MASS SPECTROMETRY; TWO DIMENSIONAL ELECTROPHORESIS;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CRYSTALLINS; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; LENS, CRYSTALLINE; MOLECULAR SEQUENCE DATA; PROTEOME; RATS; RATS, SPRAGUE-DAWLEY; SEQUENCE ANALYSIS, DNA; SEQUENCE ANALYSIS, PROTEIN;

EID: 0036137567     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Lens proteomics: The accumulation of crystallin modifications in the mouse lens with age
2. Differential effects of galactoseinduced cataractogenesis on the soluble crystallins of rat lens
3. Quantitative assessment of the cataractogenic potential of very low closes of neutrons
4. Calcium activated proteolysis and protein modification in the U18666A cataract
5. Steroid-induced cataract: New perspective from in vitro and lens culture studies
6. Selenite nuclear cataract: Review of the model
7. Oxidation enhances calpain-induced turbidity in young rat lenses
8. Modelling cortical cataractogenesis 21: In diabetic rat lenses taurine supplementation partially reduces damage resulting from osmotic compensation leading to osmolyte loss and antioxidant depletion
9. SJA6017, a newly synthesized peptide aldehyde inhibitor of calpain: Amelioration of cataract in cultured rat lenses
10. Further studies on the dynamic changes of glutathione and protein-thiol mixed disulfides in H2O2 induced cataract in rat lenses: Distributions and effect of aging
11. Inhibition of cataracts in moderately diabetic rats by aminoguanidine
12. UV laser photodamage to whole lenses
13. Lys-17 is the amine-donor substrate site for transglutaminase in beta A3-crystallin
14. Inter- and intramolecular disulfide bond formation and related structural changes in the lens proteins a Raman spectroscopic study in vivo of lens aging
15. Sequence analysis of lens betacrystallins suggests involvement of calpain in cataract formation
16. AlphaB-crystallin in the rat lens is phosphorylated at an early post-natal age
17. A post-genomic challenge: Learning to read patterns of protein synthesis
18. Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens
19. The sequence of human betaB1-crystallin cDNA allows mass spectrometric detection of betaB1 protein missing portions of its N-terminal extension
20. Automated protein identification using microcolumn liquid chromatography-tandem mass spectrometry
21. Environmentally benign staining procedure for electrophoresis gels using Coomassie brilliant blue
22. Staining of preparative 2-D gels: Coomassie blue and imidazole-zinc negative staining
23. Internal standards for 2-D
24. Identification of proteins by matrix-assisted laser desorption/ionization mass spectrometry using peptide and fragment ion masses
25. Different evolution rates within the lens-specific beta-crystallin gene family
26. Cataract and the acceleration of calpain-induced beta-crystallin insolubilization occurring during normal maturation of rat lens
27. Rapid separation of bovine beta-crystallin subunits beta B1, beta B2, beta B3, beta A3 and beta A4
28. Differential synthesis of crystallins in the developing rat eye lens
29. Beta-crystallins insolubilized by calpain II in vitro contain cleavage sites similar to beta-crystallins insolubilized during cataract
30. Changes in lens protein in concentric fractions from individual normal human lenses
31. Resistance of human betaB2-crystallin to in vivo modification
32. Autosomal dominant cerulean cataract is associated with a chain termination mutation in the human beta-crystallin gene CRYBB2
33. Autosomal dominant congenital cataract associated with a missense mutation in the human alpha crystallin gene CRYAA
34. Autosomal-dominant congenital cataract associated with a deletion mutation in the human beaded filament protein gene BFSP2