The function of alpha-crystallin in vision

Seminars in Cell and Developmental Biology

Volumn 11, Issue 1, 2000, Pages 53-60

  Horwitz, Joseph ^a  

^a JULES STEIN EYE INSTITUTE   (United States)

Author keywords

Aggregation; Alpha crystallin; Cataract; Molecular chaperones; Small heat shock protein

Indexed keywords

ALPHA CRYSTALLIN; CHAPERONE; DESMIN; HEAT SHOCK PROTEIN; LENS PROTEIN;

CATARACT; EYE REFRACTION; HUMAN; LENS; MYOPATHY; NONHUMAN; POINT MUTATION; PROTECTION; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN LOCALIZATION; REVIEW; STRESS; VISION;

EID: 0034486034     PISSN: 10849521     EISSN: None     Source Type: Journal    
DOI: 10.1006/scdb.1999.0351     Document Type: Article

References (85)

1. Do molecular chaperones have to be proteins?
2. Four small Drosophila heat shock proteins are related to each other and to the mammalian alpha-crystallin
3. Alpha B-crystallin is a small heat-shock protein
4. Evolution of the alpha-crystallin/small heat-shock protein family
5. Structure and modifications of the junior-chaperone alpha-crystallin: From lens transparency to molecular pathology
6. Expression of the alpha-crystallin/small heat-shock protein/molecular chaperone genes in the lens and other tissues
7. Alpha-crystallin as a molecular chaperone
8. Lens
9. Alpha B subunit of lens specific protein alpha-crystallin is present in other ocular and non ocular tissues
10. Expression of the marine alpha B-crystallin gene is not restricted to the lens
11. Immunoreactive alpha A-crystallin in rat non-lenticular tissues detected with a sensitive immunoassay method
12. Alpha A-crystallin is expressed in non-ocular tissues
13. Anti-serum to lens antigens immunostains Muller glia cells in the neural retina
14. An immunohistochemical comparison of Muller cells and astrocytes in the cat retina
15. Alpha A and alpha B-crystallin in the retina. Association with the post-Golgi compartment of frog retinal photoreceptors
16. A transient expression of alpha B-crystallin in the developing rat retinal pigment epithelium
17. Differential expression of alpha A and alpha B-crystallin during murine ocular development
18. Distribution of alpha B-crystallin in the anterior segment of primate and bovine eyes
19. Alpha B-crystallin in the primate ciliary muscle and trabecular meshwork
20. Lens alpha-crystallin: Chaperone-like properties
21. Circular dichroism and optical rotatory dispersion of the aggregates of purified polypeptides of alpha-crystallin
22. Some properties of the low molecular weight alpha-crystallin from normal human lens: Comparison with bovine lens
23. Spectroscopic investigations of bovine lens crystallins. Circular dichroism and intrinsic fluorescence
24. Structural homology of lens crystallin III. Secondary structure estimation from circular dichroism and prediction from amino acid sequences
25. Estimation of the secondary structure and conformation of bovine lens crystallins by infrared spectroscopy: Quantitative analysis and resolution by Fourier self-deconvolution and curve fit
26. Environmental factors influencing the chaperone-like activity of alpha-crystallin
27. Alpha-crystallin C-terminal domain: On the tack of an Ig fold
28. Folding pattern of the alpha-crystallin domain in alpha A-crystallin determined by site directed spin labeling
29. Crystal structure of a small heat-shock protein
30. A model for the architecture of alpha-crystallin
31. Calf lens alpha-crystallin quaternary structure: A three layer tetrahedral model
32. A possible structure for alpha-crystallin
33. Possible tetramer-based quaternary structure for the alpha-crystallins and small heat-shock proteins
34. A possible chaperone-like quaternary structure for alpha-crystallin
35. Computer-generated model of the quaternary structure of alpha-crystallin
36. Mutations and modifications support a 'pitted-flexiball' model for alpha-crystallin
37. The small heat-shock protein, alpha B-crystallin, has a variable quaternary structure
38. Lens alpha-crystallin function and structure
39. NMR spectroscopy of alpha-crystallin. Insights into the structure, interactions and chaperone action of small heat-shock proteins
40. A dynamic quaternary structure of bovine alpha-crystallin as indicated from intermolecular exchange of subunits
41. Subunit exchange of alpha A-crystallin
42. Quaternary structure of bovine alpha-crystallin: Influence of temperature
43. Alpha-crystallin can function as a molecular chaperone
44. Small heart-shock proteins are molecular chaperones
45. Structure and function of small heat-shock proteins
46. Supervising the fold: Functional principles of molecular chaperones
47. Binding of non-native protein to HSP25 during heat-shock creates a reservoir of folding intermediates for reactivation
48. A small heat-shock protein stably binds beat-denatured model substrates and can maintain a substrate in a folding-competent state
49. Alpha-crystallin prevents irreversible heat-shock protein denaturation and stabilizes conformational species that can be renatured by other chaperones
50. A short-range order of crystallin proteins accounts for eye lens transparency
51. Effect of changes in concentration upon lens turbidity as predicted by the random fluctuation theory
52. Alpha-crystallin quaternary structure and interactive properties control eye lens transparency
53. Embryology and anatomy of the lens
54. The lens: Development, proteins, metabolism and cataract,
55. Aspect of the biochemistry of cataract
56. Characterization of the alpha-gamma, and alpha-beta complex evidence for an in vivo functional role of alpha-crystallin as a molecular chaperone
57. Evidence that alpha-crystallin prevents non-specific protein aggregation in the intact eye lens
58. Hierarchy of lens proteins requiring protection against heat-induced precipitation by the alpha-crystallin chaperone
59. Biochemistry of lens plasma membranes and cytoskeleton
60. Ultrastructural localization of alpha A-crystallin to the bovine lens fiber cytoskeleton
61. Alpha B-crystallin selectively targets intermediate filament proteins during thermal stress
62. Human and monkey trabecular meshwork accumulate alpha B-crystallin in response to heat shock and oxidative stress
63. Localization of the stress proteins alpha B-crystallin and trabecular meshwork inducible glucocorticoid response protein in normal and glaucomatous trabecular meshwork
64. Autoantibodies to small heat-shock proteins in glaucoma
65. Alpha B-crystallin is expressed in non-lenticular tissues and accumulates in Alexander's disease brain
66. Accumulation of alpha B-crystallin in central nervous system glia and neurons in pathologic conditions
67. Alpha B-crystallin is present in reactive glia in Creutzfeldt-Jakob disease
68. Alpha B-crystallin expression in non-lenticular tissues and selective presence in ubiguinated inclusion bodies in human disease
69. The small heat-shock protein alpha B-crystallin as key autoantigen in multiple sclerosis
70. Abundance and location of the small heat shock proteins HSP25 and alpha B-crystallin in rat and human heart
71. Small heat shock proteins and protection against ischemic injury in cardiac myocytes
72. Alpha B-crystallin and HSP25 in neonatal cardiac cells-difference in cellular localization under stress conditions
73. Binding of the stress protein alpha B-crystallin to cardiac myofibrils correlates with the degree of myocardial damage during ischemia/reperfusion in vivo
74. Autosomal dominant congenital cataract associated with a missense mutation in the human alpha-crystallin gene CRYAA
75. A missense mutation in the alpha-B-crystallin chaperone gene causes a desmin-related myopathy
76. Mutation RI20G in alpha B-crystallin which is linked to a desmin-related myopathy, results in an irregular structure and detective chaperone-like function
77. The cardiomyopathy and lens cataract mutation in alpha B-crystallin alters its protein structure, chaperone activity, and interaction with intermediate filaments in vitro
78. Structural and functional consequences of the mutation of a conserved arginine residue in alpha A and alpha B-crystallin
79. Mutation of arginine 116 to cysteine generates a highly aggregated alpha A-crystallin with partial loss of the chaperone function: Probable cause of congenital cataract
80. Molecular chaperones: Small heat shock proteins in the limelight
81. Lens crystallins: The evolution and expression of proteins for a highly specialized tissue
82. Gene sharing in lens and cornea: Facts and implications
83. Targeted disruption of the mouse alpha A-crystallin gene induces cataract and cytoplasmic inclusion bodies containing the small heat-shock protein alpha B
84. Ectopic expression of alpha B-crystallin in Chinese hamster ovary cells suggests a nuclear role for this protein