Effect of testosterone suppression on the pharmacokinetics of a potent GnRH receptor antagonist

Pharmaceutical Research

Volumn 19, Issue 2, 2002, Pages 202-208

  Iatsimirskaia, E A ^a   Gregory, M L ^a   Anderes, K L ^a   Castillo, R ^a   Milgram, K E ^a   Luthin, D R ^a   Pathak, V P ^a   Christie, L C ^a   Vazir, H ^a   Anderson, M B ^a   May, J M ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Cytochrome P450 3A; GnRH antagonist; Hormonal regulation; Testosterone

Indexed keywords

AG 045572; CYTOCHROME P450; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; GONADORELIN ANTAGONIST; GROWTH HORMONE; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CASTRATION; DRUG BIOAVAILABILITY; DRUG METABOLISM; DRUG STRUCTURE; ENZYME KINETICS; FEMALE; HORMONE METABOLISM; HUMAN; MALE; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ALGORITHMS; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; FURANS; GROWTH HORMONE; HORMONE ANTAGONISTS; HUMANS; MALE; MICROSOMES, LIVER; OXIDOREDUCTASES, N-DEMETHYLATING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, LHRH; TESTOSTERONE; TETRAHYDRONAPHTHALENES;

EID: 0036176265     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1014281018271     Document Type: Article

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