Potent nonpeptide GnRH receptor antagonists derived from substituted indole-5-carboxamides and -acetamides bearing a pyridine side-chain terminus

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 13, 2001, Pages 1727-1731

  Ashton, Wallace T ^a   Sisco, Rosemary M ^a   Yang, Yi Tien ^a   Lo, Jane Ling ^a   Yudkovitz, Joel B ^a   Gibbons, Patrice H ^a   Mount, George R ^a   Ren, Rena Ning ^a   Butler, Bridget S ^a   Cheng, Kang ^a   Goulet, Mark T ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAMIDE DERIVATIVE; AMIDE; AMINE; GONADORELIN; GONADORELIN RECEPTOR; HORMONE RECEPTOR BLOCKING AGENT; INDOLE 5 ACETAMIDE DERIVATIVE; INDOLE 5 CARBOXAMIDE DERIVATIVE; INDOLE DERIVATIVE; NONPEPTIDE GONADOTROPIN RELEASING HORMONE RECEPTOR ANTAGONIST; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; LUTEINIZING HORMONE RELEASE; NONHUMAN; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; CHO CELLS; CRICETINAE; HUMANS; INDOLES; PYRIDINES; RATS; RECEPTORS, LHRH;

EID: 0035833042     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00275-X     Document Type: Article

References (15)